{"id":"https://openalex.org/W7163327770","doi":"https://doi.org/10.1080/03601234.2026.2680840","title":"Synthesis of N - alkylated hypoxanthine derivatives and their evaluation as antimicrobial agents","display_name":"Synthesis of N - alkylated hypoxanthine derivatives and their evaluation as antimicrobial agents","publication_year":2026,"publication_date":"2026-06-03","ids":{"openalex":"https://openalex.org/W7163327770","doi":"https://doi.org/10.1080/03601234.2026.2680840","pmid":"https://pubmed.ncbi.nlm.nih.gov/42234601"},"language":"en","primary_location":{"id":"doi:10.1080/03601234.2026.2680840","doi":"https://doi.org/10.1080/03601234.2026.2680840","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03601234.2026.2680840","pdf_url":null,"source":{"id":"https://openalex.org/S175163693","display_name":"Journal of Environmental Science and Health Part B","issn_l":"0360-1234","issn":["0360-1234","1532-4109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Environmental Science and Health, Part B","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7163327770"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Navpreet Kaur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I899646","display_name":"Punjab Agricultural University","ror":"https://ror.org/02qbzdk74","country_code":"IN","type":"education","lineage":["https://openalex.org/I899646"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Navpreet Kaur","raw_affiliation_strings":["Department of Chemistry, Punjab Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Punjab Agricultural University","institution_ids":["https://openalex.org/I899646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017153792","display_name":"Divya Utreja","orcid":"https://orcid.org/0000-0003-2286-9375","observed_orcids":["https://orcid.org/0000-0003-2286-9375"]},"institutions":[{"id":"https://openalex.org/I899646","display_name":"Punjab Agricultural University","ror":"https://ror.org/02qbzdk74","country_code":"IN","type":"education","lineage":["https://openalex.org/I899646"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Divya Utreja","raw_affiliation_strings":["Department of Chemistry, Punjab Agricultural University"],"raw_orcid":"https://orcid.org/0000-0003-2286-9375","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Punjab Agricultural University","institution_ids":["https://openalex.org/I899646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017867130","display_name":"Anu Kalia","orcid":"https://orcid.org/0000-0001-8367-1923","observed_orcids":["https://orcid.org/0000-0001-8367-1923"]},"institutions":[{"id":"https://openalex.org/I899646","display_name":"Punjab Agricultural University","ror":"https://ror.org/02qbzdk74","country_code":"IN","type":"education","lineage":["https://openalex.org/I899646"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anu Kalia","raw_affiliation_strings":["Department of Soil Science, Punjab Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Soil Science, Punjab Agricultural University","institution_ids":["https://openalex.org/I899646"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100741084","display_name":"Shivali Sharma","orcid":"https://orcid.org/0000-0002-7949-3850","observed_orcids":["https://orcid.org/0000-0002-7949-3850"]},"institutions":[{"id":"https://openalex.org/I899646","display_name":"Punjab Agricultural University","ror":"https://ror.org/02qbzdk74","country_code":"IN","type":"education","lineage":["https://openalex.org/I899646"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shivali Sharma","raw_affiliation_strings":["Department of Chemistry, Punjab Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Punjab Agricultural University","institution_ids":["https://openalex.org/I899646"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017153792"],"corresponding_institution_ids":["https://openalex.org/I899646"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"61","issue":"9","first_page":"659","last_page":"666"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.5062999725341797,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.5062999725341797,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.4332999885082245,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/purine-derivatives","display_name":"purine derivatives","score":0.6110000014305115},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/alkyl-halide-substitution","display_name":"alkyl halide substitution","score":0.8629999756813049},{"id":"https://openalex.org/keywords/potassium-carbonate-base","display_name":"potassium carbonate base","score":0.6100000143051147},{"id":"https://openalex.org/keywords/streptomyces","display_name":"Streptomyces","score":0.8980000019073486},{"id":"https://openalex.org/keywords/rhizoctonia-solani","display_name":"Rhizoctonia solani","score":1.0},{"id":"https://openalex.org/keywords/potato-pathogens","display_name":"potato pathogens","score":0.8289999961853027},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.859000027179718},{"id":"https://openalex.org/keywords/minimum-fungicidal-concentration","display_name":"minimum fungicidal concentration","score":0.9259999990463257},{"id":"https://openalex.org/keywords/alkyl-chain-length","display_name":"alkyl chain length","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7290999889373779},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6315000057220459},{"id":"https://openalex.org/C164361826","wikidata":"https://www.wikidata.org/wiki/Q177604","display_name":"Alkylation","level":3,"score":0.5309000015258789},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3711000084877014},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.31949999928474426},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2815000116825104},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25929999351501465},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.24690000712871552},{"id":"https://openalex.org/C2908569021","wikidata":"https://www.wikidata.org/wiki/Q2896740","display_name":"Anti-Infective Agents","level":3,"score":0.23409999907016754}],"mesh":[{"descriptor_ui":"D000478","descriptor_name":"Alkylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012232","descriptor_name":"Rhizoctonia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013302","descriptor_name":"Streptomyces","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019271","descriptor_name":"Hypoxanthine","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D019271","descriptor_name":"Hypoxanthine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019271","descriptor_name":"Hypoxanthine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/03601234.2026.2680840","doi":"https://doi.org/10.1080/03601234.2026.2680840","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03601234.2026.2680840","pdf_url":null,"source":{"id":"https://openalex.org/S175163693","display_name":"Journal of Environmental Science and Health Part B","issn_l":"0360-1234","issn":["0360-1234","1532-4109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Environmental Science and Health, Part B","raw_type":"journal-article"},{"id":"pmid:42234601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42234601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1553140901","https://openalex.org/W2016977086","https://openalex.org/W2282048741","https://openalex.org/W2417535199","https://openalex.org/W2443293851","https://openalex.org/W2494704835","https://openalex.org/W2804538335","https://openalex.org/W2986339158","https://openalex.org/W2986896118","https://openalex.org/W3012413368","https://openalex.org/W3016762617","https://openalex.org/W3042483327","https://openalex.org/W3087485468","https://openalex.org/W3092162843","https://openalex.org/W3093726557","https://openalex.org/W3105205855","https://openalex.org/W3128306944","https://openalex.org/W3158243097","https://openalex.org/W3178288224","https://openalex.org/W3186071229","https://openalex.org/W4213127420","https://openalex.org/W4224243702","https://openalex.org/W4306963236","https://openalex.org/W4307128000","https://openalex.org/W4312800862","https://openalex.org/W4312927384","https://openalex.org/W4316096395","https://openalex.org/W4320920545","https://openalex.org/W4385156731","https://openalex.org/W4385835409","https://openalex.org/W4386068441","https://openalex.org/W4391278470","https://openalex.org/W4391485761","https://openalex.org/W4396495098","https://openalex.org/W4400193745","https://openalex.org/W4400880977","https://openalex.org/W4401888293","https://openalex.org/W4402199102","https://openalex.org/W4403096611","https://openalex.org/W4403214455","https://openalex.org/W4407611839","https://openalex.org/W4413565417","https://openalex.org/W4413872254","https://openalex.org/W4414949447","https://openalex.org/W4415358254","https://openalex.org/W4415609973","https://openalex.org/W7108070305"],"related_works":["https://openalex.org/W2781771377","https://openalex.org/W4401026839","https://openalex.org/W7161403045","https://openalex.org/W2615794669","https://openalex.org/W2087387909","https://openalex.org/W2090774909","https://openalex.org/W2315368606","https://openalex.org/W3039537792","https://openalex.org/W2161232059","https://openalex.org/W4367297598"],"abstract_inverted_index":{"N-Alkylated":[0],"hypoxanthine":[1],"derivatives":[2,54],"were":[3,32],"synthesized":[4,30,113],"by":[5],"one-pot":[6],"substitution":[7],"of":[8,20,52,82],"different":[9],"alkyl":[10,120],"halides":[11],"on":[12],"hypoxanthine.":[13],"The":[14,29,47,80,115],"reaction":[15],"procedure":[16],"involved":[17],"the":[18,53,59,69,75,83,89,126],"utilization":[19],"mild":[21],"base":[22],"potassium":[23],"carbonate":[24],"to":[25,111],"facilitate":[26],"proton":[27],"extraction.":[28],"compounds":[31,84],"characterized":[33],"using":[34,58],"spectral":[35],"techniques":[36],"1H":[37],"and":[38,44,74,131],"13C":[39],"NMR,":[40],"FT-IR,":[41],"mass":[42],"spectrometry,":[43],"elemental":[45],"analysis.":[46],"in":[48,135],"vitro":[49],"antimicrobial":[50,129],"activity":[51,91],"(2a\u2013f)":[55],"was":[56,123],"evaluated":[57],"agar":[60],"well":[61,101],"diffusion":[62],"method,":[63],"targeting":[64],"potato":[65],"pathogens":[66],"such":[67],"as":[68,100,102,125],"bacterial":[70,94],"strain":[71,77],"Streptomyces":[72],"sp.":[73],"fungal":[76,103],"Rhizoctonia":[78],"solani.":[79],"screening":[81],"revealed":[85],"that":[86],"9-hexyl-1H-purin-6-(9H)-one":[87],"exhibited":[88],"highest":[90],"against":[92],"both":[93],"(MIC":[95],"=":[96,105],"120":[97],"\u03bcg":[98,107],"mL\u22121)":[99,108],"(MFC":[104],"1800":[106],"cultures":[109],"compared":[110],"other":[112],"compounds.":[114],"compound":[116],"possessing":[117],"a":[118,137],"longer":[119],"chain":[121],"(2f)":[122],"identified":[124],"most":[127],"effective":[128],"agent":[130],"holds":[132],"great":[133],"potential":[134],"designing":[136],"promising":[138],"therapeutic":[139],"drug.":[140]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-06-04T00:00:00"}
