{"id":"https://openalex.org/W7163205579","doi":"https://doi.org/10.1016/j.celrep.2026.117464","title":"An orally active dual CBP/p300 degrader targets core dependencies of multiple myeloma","display_name":"An orally active dual CBP/p300 degrader targets core dependencies of multiple myeloma","publication_year":2026,"publication_date":"2026-06-01","ids":{"openalex":"https://openalex.org/W7163205579","doi":"https://doi.org/10.1016/j.celrep.2026.117464","pmid":"https://pubmed.ncbi.nlm.nih.gov/42228563","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13366507"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2026.117464","doi":"https://doi.org/10.1016/j.celrep.2026.117464","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.117464","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.celrep.2026.117464","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045289694","display_name":"Praveen Kumar Tiwari","orcid":"https://orcid.org/0000-0003-2723-6323","observed_orcids":["https://orcid.org/0000-0003-2723-6323"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Praveen Kumar Tiwari","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020956857","display_name":"Bomin Ku","orcid":"https://orcid.org/0000-0003-3074-4804","observed_orcids":["https://orcid.org/0000-0003-3074-4804"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bomin Ku","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014651051","display_name":"Drew A. Harrison","orcid":"https://orcid.org/0009-0009-5232-0640","observed_orcids":["https://orcid.org/0009-0009-5232-0640"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drew A. Harrison","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113791294","display_name":"Sarah Rizvi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Rizvi","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038206760","display_name":"Samuel Ojeda","orcid":"https://orcid.org/0000-0001-7121-539X","observed_orcids":["https://orcid.org/0000-0001-7121-539X"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Ojeda","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060326516","display_name":"Jessica Duffy","orcid":"https://orcid.org/0000-0002-3595-5128","observed_orcids":["https://orcid.org/0000-0002-3595-5128"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Duffy","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060004543","display_name":"Leonie A. Cluse","orcid":"https://orcid.org/0000-0001-8613-0508","observed_orcids":["https://orcid.org/0000-0001-8613-0508"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Leonie Cluse","raw_affiliation_strings":["Peter MacCallum Cancer Center, Laboratory Research Division, Parkville, VIC 3052, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Center, Laboratory Research Division, Parkville, VIC 3052, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066522146","display_name":"Jennifer R. Devlin","orcid":"https://orcid.org/0000-0002-2933-6240","observed_orcids":["https://orcid.org/0000-0002-2933-6240"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jennifer R. Devlin","raw_affiliation_strings":["Peter MacCallum Cancer Center, Laboratory Research Division, Parkville, VIC 3052, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Center, Laboratory Research Division, Parkville, VIC 3052, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045627940","display_name":"Nenad Bartoni\u010dek","orcid":"https://orcid.org/0000-0003-2144-1887","observed_orcids":["https://orcid.org/0000-0003-2144-1887"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nenad Bartonicek","raw_affiliation_strings":["Peter MacCallum Cancer Center, Laboratory Research Division, Parkville, VIC 3052, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Center, Laboratory Research Division, Parkville, VIC 3052, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137706671","display_name":"Olga Motorna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Olga Motorna","raw_affiliation_strings":["Peter MacCallum Cancer Center, Laboratory Research Division, Parkville, VIC 3052, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Center, Laboratory Research Division, Parkville, VIC 3052, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I2800555584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014059692","display_name":"Ann-Sophie Koglin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann-Sophie Koglin","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051033903","display_name":"Barbara Karakyriakou","orcid":"https://orcid.org/0000-0001-7820-2567","observed_orcids":["https://orcid.org/0000-0001-7820-2567"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara Karakyriakou","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051054033","display_name":"Kaitlyn Gagnon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaitlyn Gagnon","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104301205","display_name":"Ramya S. Iyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramya S. Iyer","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055501408","display_name":"Regina K. Egan","orcid":"https://orcid.org/0000-0002-2977-5702","observed_orcids":["https://orcid.org/0000-0002-2977-5702"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Regina Egan","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137712585","display_name":"Pat Greninger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pat Greninger","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033570854","display_name":"Lauren Benz","orcid":"https://orcid.org/0000-0002-2197-2840","observed_orcids":["https://orcid.org/0000-0002-2197-2840"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Benz","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159857080","display_name":"Caroline Greco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Greco","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000519615","display_name":"Julia Norton","orcid":"https://orcid.org/0000-0001-6040-2835","observed_orcids":["https://orcid.org/0000-0001-6040-2835"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Norton","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101354433","display_name":"Amruth Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amruth Kumar","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075429307","display_name":"Eric F. Zaniewski","orcid":"https://orcid.org/0009-0007-9309-5481","observed_orcids":["https://orcid.org/0009-0007-9309-5481"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric F. Zaniewski","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085219735","display_name":"Soroush Hajizadeh","orcid":"https://orcid.org/0000-0002-4232-4690","observed_orcids":["https://orcid.org/0000-0002-4232-4690"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soroush Hajizadeh","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133261145","display_name":"Robert Morris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Morris","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137649229","display_name":"Genna Mullen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Genna Mullen","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103279014","display_name":"Ajinkya S. Kawale","orcid":"https://orcid.org/0000-0001-7154-2868","observed_orcids":["https://orcid.org/0000-0001-7154-2868"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajinkya S. Kawale","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137634671","display_name":"Sangwon Min","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sangwon Min","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074581420","display_name":"Sai Reddy Doda","orcid":"https://orcid.org/0000-0003-3471-8339","observed_orcids":["https://orcid.org/0000-0003-3471-8339"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sai Reddy Doda","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086632690","display_name":"Raghu Vannam","orcid":"https://orcid.org/0000-0002-6665-8548","observed_orcids":["https://orcid.org/0000-0002-6665-8548"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raghu Vannam","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026961383","display_name":"Lee Zou","orcid":"https://orcid.org/0000-0003-3094-1058","observed_orcids":["https://orcid.org/0000-0003-3094-1058"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee Zou","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007240376","display_name":"Wilhelm Haas","orcid":"https://orcid.org/0000-0001-8225-9099","observed_orcids":["https://orcid.org/0000-0001-8225-9099"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wilhelm Haas","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030353708","display_name":"Abner Louissaint","orcid":"https://orcid.org/0000-0001-6707-917X","observed_orcids":["https://orcid.org/0000-0001-6707-917X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abner Louissaint","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052829828","display_name":"Ricky W. Johnstone","orcid":"https://orcid.org/0000-0001-7053-9237","observed_orcids":["https://orcid.org/0000-0001-7053-9237"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ricky W. Johnstone","raw_affiliation_strings":["Peter MacCallum Cancer Center, Laboratory Research Division, Parkville, VIC 3052, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peter MacCallum Cancer Center, Laboratory Research Division, Parkville, VIC 3052, Australia; The Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I2800555584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5122786893","display_name":"Christopher J. Ott","orcid":"https://orcid.org/0000-0001-6142-7241","observed_orcids":["https://orcid.org/0000-0001-6142-7241"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher J. Ott","raw_affiliation_strings":["Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: christopher.ott@mgh.harvard.edu"],"raw_orcid":"https://orcid.org/0000-0001-6142-7241","affiliations":[{"raw_affiliation_string":"Krantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: christopher.ott@mgh.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5122786893"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28088991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"6","first_page":"117464","last_page":"117464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cbp-p300","display_name":"CBP/p300","score":0.7799999713897705},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/targeted-protein-degradation","display_name":"targeted protein degradation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/bromodomain","display_name":"bromodomain","score":0.6480000019073486},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.9729999899864197},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8169999718666077},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.7559000253677368},{"id":"https://openalex.org/C3017990168","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Orally active","level":3,"score":0.6963000297546387},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6712999939918518},{"id":"https://openalex.org/C2780980858","wikidata":"https://www.wikidata.org/wiki/Q110022","display_name":"Dual (grammatical number)","level":2,"score":0.5055000185966492},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.5013999938964844},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40540000796318054},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3506999909877777},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2888000011444092},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2694000005722046},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2669000029563904},{"id":"https://openalex.org/C2992769111","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Core protein","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.2653000056743622},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.26190000772476196},{"id":"https://openalex.org/C3019137385","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell survival","level":3,"score":0.2603999972343445},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25380000472068787},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2500999867916107}],"mesh":[{"descriptor_ui":"D000094243","descriptor_name":"Proteolysis Targeting Chimera","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050880","descriptor_name":"p300-CBP Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050881","descriptor_name":"E1A-Associated p300 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.celrep.2026.117464","doi":"https://doi.org/10.1016/j.celrep.2026.117464","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.117464","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:42228563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42228563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13366507","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13366507/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2026.117464","doi":"https://doi.org/10.1016/j.celrep.2026.117464","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.117464","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1427513074","display_name":"LC/MS Replacement for Institute for Innovation in Imaging Core Facility.","funder_award_id":"1s10od034259-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6512338984","display_name":"Electronics Upgrade for 11.7 T","funder_award_id":"1s10od025234-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000896581","display_name":"Targeting chromatin acetylation factors in multiple myeloma","funder_award_id":"R01CA288855","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000896853","display_name":"A Real-Time AI-Driven High-Throughput Proteomics Data Acquisition Method for Clinical Applications","funder_award_id":"R61CA287026","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000911608","display_name":"Dana-Farber/Harvard Cancer Center","funder_award_id":"P30CA006516","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320312952","display_name":"Worldwide Cancer Research","ror":"https://ror.org/031tfbz57"},{"id":"https://openalex.org/F4320316299","display_name":"Stichting Lymph&Co","ror":"https://ror.org/02pnjh277"},{"id":"https://openalex.org/F4320318510","display_name":"Paula and Rodger Riney Foundation","ror":"https://ror.org/050a7g229"},{"id":"https://openalex.org/F4320329919","display_name":"Kids' Cancer Project","ror":"https://ror.org/04yzh9160"},{"id":"https://openalex.org/F4320331509","display_name":"Snowdome Foundation","ror":"https://ror.org/05n61kq56"},{"id":"https://openalex.org/F4320331564","display_name":"Peter MacCallum Foundation","ror":"https://ror.org/0395ye519"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W2003179893","https://openalex.org/W2036897871","https://openalex.org/W2078448804","https://openalex.org/W2084620487","https://openalex.org/W2096057003","https://openalex.org/W2102619694","https://openalex.org/W2114104545","https://openalex.org/W2119522973","https://openalex.org/W2125789330","https://openalex.org/W2138207763","https://openalex.org/W2145412346","https://openalex.org/W2166021986","https://openalex.org/W2170551349","https://openalex.org/W2171808845","https://openalex.org/W2179438025","https://openalex.org/W2341539131","https://openalex.org/W2345356016","https://openalex.org/W2428381774","https://openalex.org/W2461427403","https://openalex.org/W2750049634","https://openalex.org/W2756301415","https://openalex.org/W2758743773","https://openalex.org/W2759506905","https://openalex.org/W2803754954","https://openalex.org/W2885130586","https://openalex.org/W2947249681","https://openalex.org/W2952481429","https://openalex.org/W2983017086","https://openalex.org/W3018207421","https://openalex.org/W3092181870","https://openalex.org/W3119760196","https://openalex.org/W3136200267","https://openalex.org/W3163735930","https://openalex.org/W3181847396","https://openalex.org/W3204843499","https://openalex.org/W3205041080","https://openalex.org/W3211820355","https://openalex.org/W4225539572","https://openalex.org/W4283657605","https://openalex.org/W4313592920","https://openalex.org/W4362665302","https://openalex.org/W4367599184","https://openalex.org/W4378070281","https://openalex.org/W4378417047","https://openalex.org/W4379390692","https://openalex.org/W4387114589","https://openalex.org/W4388915232","https://openalex.org/W4389894233","https://openalex.org/W4391247661","https://openalex.org/W4391543953","https://openalex.org/W4392126399","https://openalex.org/W4392748452","https://openalex.org/W4393074417","https://openalex.org/W4393186962","https://openalex.org/W4395008868","https://openalex.org/W4396642816","https://openalex.org/W4399303154","https://openalex.org/W4399676872","https://openalex.org/W4399737251","https://openalex.org/W4401089771","https://openalex.org/W4401418071","https://openalex.org/W4402996716","https://openalex.org/W4405043400","https://openalex.org/W4409633549","https://openalex.org/W4414777592","https://openalex.org/W4415297198"],"related_works":["https://openalex.org/W4405041795","https://openalex.org/W7169857430","https://openalex.org/W3119760196","https://openalex.org/W7148938781","https://openalex.org/W4405050261","https://openalex.org/W4417008404","https://openalex.org/W7203684718","https://openalex.org/W7213896596","https://openalex.org/W7148702106","https://openalex.org/W7148920822"],"abstract_inverted_index":{"The":[0],"enhancer":[1],"lysine":[2],"acetyltransferases":[3],"CBP/p300":[4,51,73],"are":[5],"compelling":[6],"targets":[7],"for":[8],"multiple":[9,84],"myeloma":[10],"therapy.":[11],"Chemical":[12,33],"inhibition":[13,134],"of":[14,69,107,129,135],"these":[15,101],"multidomain":[16],"factors,":[17],"either":[18],"through":[19],"the":[20,23,36],"bromodomain":[21],"or":[22],"catalytic":[24],"acetyltransferase":[25],"domain,":[26],"show":[27],"promising":[28],"activity":[29,82],"in":[30,116,144],"pre-clinical":[31],"models.":[32,146],"degradation":[34,53,74],"is":[35],"only":[37],"modality":[38],"that":[39,110],"can":[40],"completely":[41],"disrupt":[42],"all":[43],"functional":[44],"domains.":[45],"Our":[46],"previous":[47],"attempts":[48],"to":[49,55,76,92,124],"induce":[50],"targeted":[52],"led":[54,123],"a":[56,66,94],"potent":[57,125,133],"tool":[58],"compound,":[59],"dCBP-1.":[60],"Here":[61],"we":[62,102],"comprehensively":[63],"demonstrate":[64],"across":[65],"large":[67],"panel":[68],"cell":[70],"lines":[71],"how":[72],"compares":[75],"inhibition,":[77],"with":[78,96],"pronounced":[79],"selective":[80],"antiproliferative":[81],"toward":[83],"myeloma.":[85],"We":[86],"use":[87],"chemical":[88],"linker":[89],"optimization":[90],"strategies":[91],"create":[93],"compound":[95],"better":[97],"pharmacokinetic":[98],"properties.":[99],"Through":[100],"define":[103],"an":[104],"advanced":[105],"analog":[106],"dCBP-1,":[108],"dCBP-30,":[109],"has":[111],"improved":[112,115],"potency":[113],"and":[114,126,131,140],"vivo":[117],"properties":[118],"including":[119],"oral":[120],"bioavailability.":[121],"dCBP-30":[122],"sustained":[127],"loss":[128],"CBP":[130],"p300,":[132],"several":[136],"myeloma-specific":[137],"dependency":[138],"programs,":[139],"elicits":[141],"tumor":[142],"reduction":[143],"xenograft":[145]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-06-03T00:00:00"}
