{"id":"https://openalex.org/W7163190789","doi":"https://doi.org/10.3748/wjg.120681","title":"Clinical characteristics and treatment patterns of older and younger patients with inflammatory bowel disease","display_name":"Clinical characteristics and treatment patterns of older and younger patients with inflammatory bowel disease","publication_year":2026,"publication_date":"2026-06-02","ids":{"openalex":"https://openalex.org/W7163190789","doi":"https://doi.org/10.3748/wjg.120681"},"language":"en","primary_location":{"id":"doi:10.3748/wjg.120681","doi":"https://doi.org/10.3748/wjg.120681","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.120681","pdf_url":null,"source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.3748/wjg.120681","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025293044","display_name":"Fatih K\u0131vrako\u011flu","orcid":"https://orcid.org/0000-0002-5388-794X","observed_orcids":["https://orcid.org/0000-0002-5388-794X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fatih Kivrakoglu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102589311","display_name":"Vedat K\u0131l\u0131\u00e7","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vedat Kilic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071113562","display_name":"Mustafa Ergin","orcid":"https://orcid.org/0000-0002-9593-3705","observed_orcids":["https://orcid.org/0000-0002-9593-3705"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mustafa Ergin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086323437","display_name":"Harun K\u00fc\u00e7\u00fck","orcid":"https://orcid.org/0000-0003-3957-1778","observed_orcids":["https://orcid.org/0000-0003-3957-1778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harun Kucuk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137624902","display_name":"Cagdas Erdogan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cagdas Erdogan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068945644","display_name":"\u0130lhami Y\u00fcksel","orcid":"https://orcid.org/0000-0002-9730-2309","observed_orcids":["https://orcid.org/0000-0002-9730-2309"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilhami Yuksel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3607329,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"27","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13569","display_name":"Microscopic Colitis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.7609999775886536},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":1.0},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.6340000033378601},{"id":"https://openalex.org/keywords/thiopurines","display_name":"thiopurines","score":0.8930000066757202},{"id":"https://openalex.org/keywords/extraintestinal-manifestations","display_name":"extraintestinal manifestations","score":0.9909999966621399},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.6779999732971191},{"id":"https://openalex.org/keywords/family-history-medicine","display_name":"family history (medicine)","score":0.7400000095367432},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.8399999737739563}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8586999773979187},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.8341000080108643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.649399995803833},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5074999928474426},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.48820000886917114},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.3682999908924103},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.3402999937534332},{"id":"https://openalex.org/C2777572184","wikidata":"https://www.wikidata.org/wiki/Q15749161","display_name":"Inflammatory Bowel Diseases","level":4,"score":0.3278999924659729},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.32409998774528503},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.30329999327659607},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.30090001225471497},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2935999929904938},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2906999886035919},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.25189998745918274},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2515000104904175}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3748/wjg.120681","doi":"https://doi.org/10.3748/wjg.120681","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.120681","pdf_url":null,"source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3748/wjg.120681","doi":"https://doi.org/10.3748/wjg.120681","is_oa":true,"landing_page_url":"https://doi.org/10.3748/wjg.120681","pdf_url":null,"source":{"id":"https://openalex.org/S181459644","display_name":"World Journal of Gastroenterology","issn_l":"1007-9327","issn":["1007-9327","2219-2840"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1607497471","https://openalex.org/W2004608617","https://openalex.org/W2345812264","https://openalex.org/W2583633660","https://openalex.org/W2765763250","https://openalex.org/W2903319307","https://openalex.org/W2908787843","https://openalex.org/W2928271814","https://openalex.org/W2967907952","https://openalex.org/W3010470879","https://openalex.org/W3013106149","https://openalex.org/W3021513201","https://openalex.org/W3039393518","https://openalex.org/W3085959324","https://openalex.org/W3099706014","https://openalex.org/W4244626580","https://openalex.org/W4281712949","https://openalex.org/W4289921149","https://openalex.org/W4311931792"],"related_works":["https://openalex.org/W4405980134","https://openalex.org/W4391162916","https://openalex.org/W2606098361","https://openalex.org/W4417196750","https://openalex.org/W4406699752","https://openalex.org/W2292002414","https://openalex.org/W4405372707","https://openalex.org/W4413044512","https://openalex.org/W4207060586","https://openalex.org/W2790792587"],"abstract_inverted_index":{"BACKGROUND":[0],"Inflammatory":[1],"bowel":[2],"disease":[3,11,22,126,228,310],"(IBD),":[4],"including":[5],"ulcerative":[6],"colitis":[7],"(UC)":[8],"and":[9,35,39,57,62,84,89,103,110,127,190,260,269,274,308],"Crohn\u2019s":[10],"(CD),":[12],"presents":[13],"varying":[14],"clinical":[15,282,296],"characteristics":[16,55],"depending":[17],"on":[18,75],"the":[19,25,30,33,53,145,173,187],"age":[20,204,218,254],"at":[21,205,219,255],"onset.":[23,206],"With":[24],"aging":[26],"global":[27],"population,":[28],"understanding":[29],"differences":[31,171],"in":[32,144,160,172,213,239,288],"presentation":[34],"management":[36,311],"of":[37,56,108,115,120,175,194,267,272],"older-onset":[38,125,146,161],"younger-onset":[40,131],"IBD":[41,80,195,249],"has":[42],"become":[43],"increasingly":[44],"important":[45],"for":[46,60,298],"optimizing":[47],"patient":[48],"care.":[49],"AIM":[50],"To":[51],"evaluate":[52],"demographic":[54,259],"treatment":[58],"strategies":[59],"older":[61,98,217,253],"younger":[63,104,203,240],"adult":[64,76],"patients":[65,77,95,117,162,200,214,241,250,305],"with":[66,79,96,201,215,251],"IBD.":[67],"METHODS":[68],"A":[69,113],"retrospective":[70],"cohort":[71],"analysis":[72],"was":[73,137,141,156,237],"conducted":[74],"diagnosed":[78],"between":[81,94,186,233],"June":[82],"1993":[83],"February":[85],"2023.":[86],"Demographic,":[87],"clinical,":[88],"therapeutic":[90,261],"data":[91],"were":[92,118,184,196,210,231],"compared":[93],"an":[97,216,252,294],"onset":[99,105,220,256],"(\u2265":[100],"60":[101],"years)":[102,107],"(18-60":[106],"UC":[109,140],"CD.":[111],"RESULTS":[112],"total":[114],"1245":[116],"included,":[119],"whom":[121],"56":[122],"(4.5%)":[123],"had":[124,130],"1189":[128],"(95.5%)":[129],"disease.":[132],"The":[133],"median":[134],"follow-up":[135],"duration":[136],"11":[138],"years.":[139],"more":[142,197],"prevalent":[143],"group":[147],"(69.6%":[148],"vs":[149,164,222,243],"48.7%,":[150],"P":[151,166,224,245],"=":[152,167,225,246],"0.002).":[153],"Biological":[154],"therapy":[155],"used":[157],"less":[158,211],"frequently":[159],"(26.8%":[163],"49.3%,":[165],"0.001).":[168],"No":[169],"significant":[170],"extent":[174],"UC,":[176],"CD":[177],"location":[178],"or":[179,181],"behavior,":[180],"perianal":[182],"involvement":[183],"detected":[185],"groups.":[188,234],"Smoking":[189],"a":[191,202,264],"family":[192],"history":[193],"common":[198],"among":[199],"Extraintestinal":[207],"manifestations":[208],"(EIMs)":[209],"frequent":[212],"(32.1%":[221],"51%,":[223],"0.006).":[226],"Baseline":[227],"activity":[229],"scores":[230],"similar":[232],"Thiopurine":[235],"use":[236],"higher":[238],"(32.9%":[242],"16.1%,":[244],"0.008).":[247],"CONCLUSION":[248],"exhibit":[257],"distinct":[258],"characteristics,":[262],"particularly":[263],"lower":[265],"frequency":[266],"EIMs":[268],"decreased":[270],"utilization":[271],"immunosuppressive":[273],"biological":[275],"therapies.":[276],"This":[277],"conservative":[278],"approach":[279],"likely":[280],"reflects":[281],"precautions":[283],"against":[284],"treatment-related":[285],"adverse":[286],"events":[287],"elderly":[289],"individuals;":[290],"however,":[291],"it":[292],"highlights":[293],"urgent":[295],"need":[297],"age-specific":[299],"guidelines":[300],"to":[301],"ensure":[302],"that":[303],"these":[304],"receive":[306],"adequate":[307],"safe":[309],"without":[312],"compromising":[313],"long-term":[314],"outcomes.":[315]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2026-06-03T00:00:00"}