{"id":"https://openalex.org/W7163077862","doi":"https://doi.org/10.6082/9we81-a1848","title":"Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function","display_name":"Contributions of mirror-image hair cell orientation to mouse otolith organ and zebrafish neuromast function","publication_year":2024,"publication_date":"2024-11-12","ids":{"openalex":"https://openalex.org/W7163077862","doi":"https://doi.org/10.6082/9we81-a1848"},"language":"en","primary_location":{"id":"doi:10.6082/9we81-a1848","doi":"https://doi.org/10.6082/9we81-a1848","is_oa":true,"landing_page_url":"https://doi.org/10.6082/9we81-a1848","pdf_url":null,"source":{"id":"https://openalex.org/S7407053018","display_name":"University of Chicago","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6082/9we81-a1848","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006274271","display_name":"Kazuya Ono","orcid":"https://orcid.org/0000-0002-3857-0055","observed_orcids":["https://orcid.org/0000-0002-3857-0055"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ono, Kazuya","raw_affiliation_strings":["University of Chicago"],"raw_orcid":"https://orcid.org/0000-0002-3857-0055","affiliations":[{"raw_affiliation_string":"University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070051988","display_name":"Amandine Jarysta","orcid":"https://orcid.org/0000-0002-9519-3559","observed_orcids":["https://orcid.org/0000-0002-9519-3559"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jarysta, Amandine","raw_affiliation_strings":["The Jackson Laboratory"],"raw_orcid":"https://orcid.org/0000-0002-9519-3559","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137610141","display_name":"Natasha C. Hughes","orcid":"https://orcid.org/0000-0003-2031-3306","observed_orcids":["https://orcid.org/0000-0003-2031-3306"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hughes, Natasha C.","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":"https://orcid.org/0000-0003-2031-3306","affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046651147","display_name":"Alma Jukic","orcid":"https://orcid.org/0000-0003-1030-0798","observed_orcids":["https://orcid.org/0000-0003-1030-0798"]},"institutions":[{"id":"https://openalex.org/I4210156075","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jukic, Alma","raw_affiliation_strings":["National Institute on Deafness and Other Communication Disorders"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute on Deafness and Other Communication Disorders","institution_ids":["https://openalex.org/I4210156075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008131676","display_name":"Hui Ho Vanessa Chang","orcid":"https://orcid.org/0009-0005-9924-6143","observed_orcids":["https://orcid.org/0009-0005-9924-6143"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chang, Hui Ho Vanessa","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":"https://orcid.org/0009-0005-9924-6143","affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016494566","display_name":"Michael R. Deans","orcid":"https://orcid.org/0000-0001-6319-7945","observed_orcids":["https://orcid.org/0000-0001-6319-7945"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deans, Michael R.","raw_affiliation_strings":["University of Utah"],"raw_orcid":"https://orcid.org/0000-0001-6319-7945","affiliations":[{"raw_affiliation_string":"University of Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072429681","display_name":"Ruth Anne Eatock","orcid":"https://orcid.org/0000-0001-7547-2051","observed_orcids":["https://orcid.org/0000-0001-7547-2051"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eatock, Ruth Anne","raw_affiliation_strings":["University of Chicago"],"raw_orcid":"https://orcid.org/0000-0001-7547-2051","affiliations":[{"raw_affiliation_string":"University of Chicago","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023860476","display_name":"Kathleen E. Cullen","orcid":"https://orcid.org/0000-0002-9348-0933","observed_orcids":["https://orcid.org/0000-0002-9348-0933"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cullen, Kathleen E.","raw_affiliation_strings":["Johns Hopkins University"],"raw_orcid":"https://orcid.org/0000-0002-9348-0933","affiliations":[{"raw_affiliation_string":"Johns Hopkins University","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051747249","display_name":"Katie S. Kindt","orcid":"https://orcid.org/0000-0002-1065-8215","observed_orcids":["https://orcid.org/0000-0002-1065-8215"]},"institutions":[{"id":"https://openalex.org/I4210156075","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210156075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kindt, Katie S.","raw_affiliation_strings":["National Institute on Deafness and Other Communication Disorders"],"raw_orcid":"https://orcid.org/0000-0002-1065-8215","affiliations":[{"raw_affiliation_string":"National Institute on Deafness and Other Communication Disorders","institution_ids":["https://openalex.org/I4210156075"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052214589","display_name":"Basile Tarchini","orcid":"https://orcid.org/0000-0003-2708-6273","observed_orcids":["https://orcid.org/0000-0003-2708-6273"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tarchini, Basile","raw_affiliation_strings":["The Jackson Laboratory"],"raw_orcid":"https://orcid.org/0000-0003-2708-6273","affiliations":[{"raw_affiliation_string":"The Jackson Laboratory","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38379052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.6147000193595886,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.6147000193595886,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.36160001158714294,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hair-cell-orientation","display_name":"hair cell orientation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/emx2","display_name":"Emx2","score":0.7919999957084656},{"id":"https://openalex.org/keywords/otolith-organs","display_name":"otolith organs","score":0.9229999780654907},{"id":"https://openalex.org/keywords/neuromasts","display_name":"neuromasts","score":0.9589999914169312},{"id":"https://openalex.org/keywords/lateral-line","display_name":"lateral line","score":0.6340000033378601},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.7559999823570251},{"id":"https://openalex.org/keywords/vestibular-function","display_name":"vestibular function","score":0.777999997138977},{"id":"https://openalex.org/keywords/utricle","display_name":"utricle","score":0.777999997138977},{"id":"https://openalex.org/keywords/swimming-behavior","display_name":"swimming behavior","score":0.6499999761581421},{"id":"https://openalex.org/keywords/off-vertical-axis-rotation","display_name":"off-vertical axis rotation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.7099999785423279},{"id":"https://openalex.org/keywords/mouse-mutants","display_name":"mouse mutants","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.8847000002861023},{"id":"https://openalex.org/C2778079943","wikidata":"https://www.wikidata.org/wiki/Q974231","display_name":"Utricle","level":3,"score":0.8806999921798706},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8507999777793884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7827000021934509},{"id":"https://openalex.org/C190041318","wikidata":"https://www.wikidata.org/wiki/Q596832","display_name":"Vestibular system","level":2,"score":0.70660001039505},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.679099977016449},{"id":"https://openalex.org/C2780041246","wikidata":"https://www.wikidata.org/wiki/Q591800","display_name":"Otolith","level":3,"score":0.618399977684021},{"id":"https://openalex.org/C2778039178","wikidata":"https://www.wikidata.org/wiki/Q3494094","display_name":"Saccule","level":3,"score":0.5701000094413757},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5509999990463257},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.4756999909877777},{"id":"https://openalex.org/C11658465","wikidata":"https://www.wikidata.org/wiki/Q6414172","display_name":"Kinocilium","level":4,"score":0.4699000120162964},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4611000120639801},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4320000112056732},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4311000108718872},{"id":"https://openalex.org/C2780384893","wikidata":"https://www.wikidata.org/wiki/Q901804","display_name":"Danio","level":4,"score":0.3953000009059906},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3783000111579895},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.35910001397132874},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.3334999978542328},{"id":"https://openalex.org/C4001165","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Mechanosensitive channels","level":4,"score":0.3253999948501587},{"id":"https://openalex.org/C2778869571","wikidata":"https://www.wikidata.org/wiki/Q7108726","display_name":"Otic vesicle","level":5,"score":0.3215999901294708},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.31859999895095825},{"id":"https://openalex.org/C2780659331","wikidata":"https://www.wikidata.org/wiki/Q1128309","display_name":"Organ of Corti","level":3,"score":0.29350000619888306},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.2784999907016754},{"id":"https://openalex.org/C2779097085","wikidata":"https://www.wikidata.org/wiki/Q1348853","display_name":"Mechanoreceptor","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2703000009059906}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6082/9we81-a1848","doi":"https://doi.org/10.6082/9we81-a1848","is_oa":true,"landing_page_url":"https://doi.org/10.6082/9we81-a1848","pdf_url":null,"source":{"id":"https://openalex.org/S7407053018","display_name":"University of Chicago","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.6082/ya5hh-nch15","doi":"https://doi.org/10.6082/ya5hh-nch15","is_oa":true,"landing_page_url":"https://doi.org/10.6082/ya5hh-nch15","pdf_url":null,"source":{"id":"https://openalex.org/S7407053018","display_name":"University of Chicago","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.6082/9we81-a1848","doi":"https://doi.org/10.6082/9we81-a1848","is_oa":true,"landing_page_url":"https://doi.org/10.6082/9we81-a1848","pdf_url":null,"source":{"id":"https://openalex.org/S7407053018","display_name":"University of Chicago","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3163182788","https://openalex.org/W7124564378","https://openalex.org/W4313199136","https://openalex.org/W4307386023","https://openalex.org/W2594866467","https://openalex.org/W3202575081","https://openalex.org/W4323841137","https://openalex.org/W7159663620","https://openalex.org/W2594737395","https://openalex.org/W2069076912"],"abstract_inverted_index":{"Otolith":[0],"organs":[1,69,127,204,244],"in":[2,8,22,38,67,128,172],"the":[3,9,31,47,56,153],"inner":[4],"ear":[5],"and":[6,44,61,77,97,113,136,143,184,210,221],"neuromasts":[7],"fish":[10],"lateral-line":[11],"harbor":[12,71],"two":[13,199],"populations":[14],"of":[15,64,107,164,170,225],"hair":[16,41,74,87,121,140,161,218,250],"cells":[17,88],"oriented":[18],"to":[19,50,55,102,242,246,253],"detect":[20],"stimuli":[21,106],"opposing":[23,108],"directions.":[24],"The":[25],"underlying":[26],"mechanism":[27],"is":[28,35,205],"highly":[29],"conserved:":[30],"transcription":[32],"factor":[33],"EMX2":[34],"regionally":[36],"expressed":[37],"just":[39],"one":[40,73],"cell":[42,52,75,141,219,251],"population":[43],"acts":[45],"through":[46],"receptor":[48],"GPR156":[49,101,115,165,216],"reverse":[51],"orientation":[53,76,220],"relative":[54],"other":[57,117],"population.":[58],"In":[59,82,147],"mouse":[60,96,130,173],"zebrafish,":[62,83],"loss":[63],"Emx2":[65,84],"results":[66,234],"sensory":[68,243],"that":[70,125,158,201,215,239],"only":[72],"are":[78],"not":[79,167,191,228],"innervated":[80],"properly.":[81],"also":[85],"confers":[86],"with":[89,179],"reduced":[90],"mechanosensory":[91],"properties.":[92,146],"Here,":[93],"we":[94],"leverage":[95],"zebrafish":[98,150,176],"models":[99],"lacking":[100],"determine":[103],"how":[104,236],"detecting":[105],"directions":[109],"serves":[110],"vestibular":[111,194],"function,":[112,247],"whether":[114],"has":[116],"roles":[118],"besides":[119],"orienting":[120],"cells.":[122,162],"We":[123,213],"find":[124],"otolith":[126,181,203],"Gpr156":[129,187],"mutants":[131,151],"have":[132],"normal":[133,137,180],"zonal":[134],"organization":[135],"type":[138],"I-II":[139],"distribution":[142],"mechano-electrical":[144],"transduction":[145,222],"contrast,":[148],"gpr156":[149],"lack":[152],"smaller":[154],"mechanically":[155],"evoked":[156],"signals":[157],"characterize":[159],"Emx2-positive":[160],"Loss":[163],"does":[166],"affect":[168],"orientation-selectivity":[169],"afferents":[171],"utricle":[174],"or":[175],"neuromasts.":[177],"Consistent":[178],"organ":[182],"anatomy":[183],"afferent":[185],"selectivity,":[186],"mutant":[188],"mice":[189],"do":[190],"show":[192],"overt":[193],"dysfunction.":[195],"Instead,":[196],"performance":[197],"on":[198],"tests":[200],"engage":[202],"significantly":[206],"altered":[207],"\u2013":[208],"swimming":[209],"off-vertical-axis":[211],"rotation.":[212],"conclude":[214],"relays":[217],"information":[223],"downstream":[224],"EMX2,":[226],"but":[227],"selectivity":[229],"for":[230],"direction-specific":[231],"afferents.":[232],"These":[233],"clarify":[235],"molecular":[237],"mechanisms":[238],"confer":[240],"bi-directionality":[241],"contribute":[245],"from":[248],"single":[249],"physiology":[252],"animal":[254],"behavior.":[255]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-06-02T00:00:00"}