{"id":"https://openalex.org/W7162799208","doi":"https://doi.org/10.1055/s-0044-1797685","title":"AN\u00c1LISE DAEXPRESS\u00c3O DOS RECEPTORES TOLL- LIKE 2 E 9, E DAS VIAS DE SINALIZA\u00c7\u00c3O INTRACELULAR MAPKP38 E NFKBP65 NO CARCINOMA ESCAMOSO DE P\u00caNIS","display_name":"AN\u00c1LISE DAEXPRESS\u00c3O DOS RECEPTORES TOLL- LIKE 2 E 9, E DAS VIAS DE SINALIZA\u00c7\u00c3O INTRACELULAR MAPKP38 E NFKBP65 NO CARCINOMA ESCAMOSO DE P\u00caNIS","publication_year":2019,"publication_date":"2019-11-14","ids":{"openalex":"https://openalex.org/W7162799208","doi":"https://doi.org/10.1055/s-0044-1797685"},"language":"en","primary_location":{"id":"doi:10.1055/s-0044-1797685","doi":"https://doi.org/10.1055/s-0044-1797685","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0044-1797685","pdf_url":null,"source":{"id":"https://openalex.org/S4210193681","display_name":"Brazilian Journal of Oncology","issn_l":"1806-6054","issn":["1806-6054","2526-8732"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","latindex"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1055/s-0044-1797685","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053105597","display_name":"Felipe da Silva Marinho","orcid":"https://orcid.org/0000-0001-7199-7520","observed_orcids":["https://orcid.org/0000-0001-7199-7520"]},"institutions":[{"id":"https://openalex.org/I4210109363","display_name":"Hospital de C\u00e2ncer de Pernambuco","ror":"https://ror.org/01yjd8r15","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210109363"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Felipe da Silva Marinho","raw_affiliation_strings":["Hospital de C\u00e2ncer de Pernambuco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de C\u00e2ncer de Pernambuco","institution_ids":["https://openalex.org/I4210109363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007368180","display_name":"Felipe Dubourcq de Barros","orcid":"https://orcid.org/0000-0002-7881-3322","observed_orcids":["https://orcid.org/0000-0002-7881-3322"]},"institutions":[{"id":"https://openalex.org/I4210109363","display_name":"Hospital de C\u00e2ncer de Pernambuco","ror":"https://ror.org/01yjd8r15","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210109363"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Felipe Dubourcq Barros","raw_affiliation_strings":["Hospital de C\u00e2ncer de Pernambuco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de C\u00e2ncer de Pernambuco","institution_ids":["https://openalex.org/I4210109363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137321915","display_name":"Mauro Marques","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109363","display_name":"Hospital de C\u00e2ncer de Pernambuco","ror":"https://ror.org/01yjd8r15","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210109363"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Mauro Marques","raw_affiliation_strings":["Hospital de C\u00e2ncer de Pernambuco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de C\u00e2ncer de Pernambuco","institution_ids":["https://openalex.org/I4210109363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088033533","display_name":"Leuridan Cavalcante Torres","orcid":"https://orcid.org/0000-0003-3517-6615","observed_orcids":["https://orcid.org/0000-0003-3517-6615"]},"institutions":[{"id":"https://openalex.org/I4210109363","display_name":"Hospital de C\u00e2ncer de Pernambuco","ror":"https://ror.org/01yjd8r15","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210109363"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leuridan Torres","raw_affiliation_strings":["Hospital de C\u00e2ncer de Pernambuco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de C\u00e2ncer de Pernambuco","institution_ids":["https://openalex.org/I4210109363"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5137309199","display_name":"Fernando Augusto Soares","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109363","display_name":"Hospital de C\u00e2ncer de Pernambuco","ror":"https://ror.org/01yjd8r15","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210109363"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernando Augusto Soares","raw_affiliation_strings":["Hospital de C\u00e2ncer de Pernambuco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de C\u00e2ncer de Pernambuco","institution_ids":["https://openalex.org/I4210109363"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210109363"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"CP","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.7006999850273132,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.7006999850273132,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.195700004696846,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/penile-squamous-cell-carcinoma","display_name":"penile squamous cell carcinoma","score":0.9449999928474426},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":1.0},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.7440000176429749},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.9039999842643738},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.6949999928474426},{"id":"https://openalex.org/keywords/peripheral-blood-leukocytes","display_name":"peripheral blood leukocytes","score":0.8659999966621399},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8989999890327454},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.7049999833106995},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.6150000095367432},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.49900001287460327},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4544000029563904},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36169999837875366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33320000767707825},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3158999979496002},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.28600001335144043},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27709999680519104},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.23149999976158142},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2152000069618225},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20839999616146088},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.20550000667572021}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0044-1797685","doi":"https://doi.org/10.1055/s-0044-1797685","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0044-1797685","pdf_url":null,"source":{"id":"https://openalex.org/S4210193681","display_name":"Brazilian Journal of Oncology","issn_l":"1806-6054","issn":["1806-6054","2526-8732"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","latindex"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1055/s-0044-1797685","doi":"https://doi.org/10.1055/s-0044-1797685","is_oa":true,"landing_page_url":"https://doi.org/10.1055/s-0044-1797685","pdf_url":null,"source":{"id":"https://openalex.org/S4210193681","display_name":"Brazilian Journal of Oncology","issn_l":"1806-6054","issn":["1806-6054","2526-8732"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","latindex"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brazilian Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2391158969","https://openalex.org/W994201930","https://openalex.org/W2346455805","https://openalex.org/W2074960477","https://openalex.org/W7113690444","https://openalex.org/W2034277378","https://openalex.org/W2145695910","https://openalex.org/W1961309807","https://openalex.org/W2386056043","https://openalex.org/W4311723523"],"abstract_inverted_index":{"All":[0],"articles":[1],"of":[2,10,36,51,59,72,90,197,218,249,272,276,295,307,331,396,422,453,532],"this":[3],"category":[4],"(opens":[5],"in":[6,21,86,153,177,201,224,335,393],"new":[7],"window)":[8],"Modulation":[9],"the":[11,34,57,70,79,91,120,127,215,346,407,451,454,468],"inflammatory":[12,62],"process":[13],"by":[14,119,448],"TLRs":[15],"may":[16,415],"be":[17],"a":[18,60,106,192,246,269,292,304,328,351,376],"key":[19],"factor":[20,42],"tumor":[22,66,324,347,412],"development":[23,58],"and":[24,29,39,43,49,76,78,84,130,151,163,172,184,199,207,222,233,255,264,278,284,309,318,333,357,365,367,375,382,400,410,419,463],"progression,":[25],"inducing":[26],"both":[27],"pro-tumor":[28,61],"anti-tumor":[30],"responses,":[31],"often":[32],"through":[33],"regulation":[35],"NF-kB":[37],"signaling":[38,81],"subsequent":[40],"growth":[41],"anti-apoptotic":[44],"proteins":[45],"production.":[46],"The":[47,439],"magnitude":[48],"duration":[50],"TLR":[52],"activation":[53],"are":[54,391],"critical":[55],"for":[56,424],"state":[63],"or":[64],"anti-":[65],"response.":[67],"To":[68],"evaluate":[69],"expression":[71,196,275,313,330],"Toll-like":[73],"receptors":[74],"2":[75,513],"9,":[77,515],"intracellular":[80],"pathways":[82],"NF-KBp65":[83],"MAPKp38":[85,152,223,256],"squamous":[87],"cell":[88,408],"carcinoma":[89],"penis.":[92],"38":[93],"male":[94],"patients":[95,225,238,336,425],"with":[96,195,226,239,274,311,337,426],"penile":[97,227,427],"cancer,":[98],"aged":[99],"\u2265":[100],"18":[101],"years,":[102],"were":[103,112,133,146,174,214],"included.":[104,113],"As":[105],"control":[107],"group,":[108],"15":[109],"healthy":[110,157,178],"men":[111],"Serum":[114],"protein":[115],"concentration":[116],"was":[117,136,191,303,327,350],"determined":[118],"flow":[121],"cytometry":[122],"technique.":[123],"For":[124],"statistical":[125],"analysis,":[126],"Mann-Whitney":[128],"tests":[129],"Spearman\u2019s":[131],"correlation":[132,354,379],"used.":[134],"It":[135],"considered":[137],"significant":[138],"p":[139,160,164,181,185,204,208,230,234,258,261,265,281,285,300,315,319,343,362,372,387],"<":[140,165,209,388],"0.05.":[141],"In":[142,188,211,237,323],"peripheral":[143],"blood,":[144],"there":[145,190,213,244,326,349],"more":[147,175],"leukocytes":[148,169,251],"expressing":[149,170,220,252],"TLR2":[150,277,356,381],"patients,":[154],"compared":[155],"to":[156],"controls":[158,179,202],"(":[159,180,203,229,257,280,299,314,342],"=":[161,182,186,205,231,235,259,262,266,282,286,301,316,320,344,360,363,370,373,385],"0.002":[162],"0.0001,":[166],"respectively),":[167,268],"whereas":[168],"TLR9":[171,221,312,332,358,366],"NFkB":[173],"numerous":[176],"0.03":[183],"0.03).":[187],"neutrophils,":[189],"greater":[193,247,329],"number":[194,217,248,306],"NFKBp65":[198,254,279,298,334,368,383,399],"MAPKp38,":[200,401],"0.001":[206],"0.0001).":[210,389],"monocytes,":[212],"highest":[216],"cells":[219],"cancer":[228],"0.003":[232],"0.01).":[236],"tumors":[240,288,338],">":[241],"3.5":[242,290,340],"cm,":[243,291],"is":[245,442,471],"total":[250],"TLR9,":[253,398],"0.01,":[260],"0.008":[263],"0.03,":[267],"higher":[270,293,305],"amount":[271,294],"neutrophils":[273,310],"0.0008":[283],"0.01).In":[287],"\u2264":[289,339],"monocytes":[296,308],"expressed":[297],"0.02).There":[302],"0.009":[317],"0.0003)":[321],".":[322],"tissue,":[325,348],"cm":[341],"0.02).In":[345],"moderate":[352],"positive":[353,378],"between":[355,380],"(r":[359,369,384],"0.65,":[361],"0.0009)":[364],"0.60;":[371],"0.003),":[374],"high":[377],"0.78;":[386],"There":[390],"changes":[392],"blood":[394],"levels":[395],"TLR2,":[397],"at":[402],"different":[403],"levels,":[404],"depending":[405],"on":[406,411],"type,":[409],"tissue":[413],"that":[414],"function":[416],"as":[417,467],"prognostic":[418],"predictive":[420],"factors":[421],"treatment":[423],"SCC.":[428],"Publication":[429],"History":[430],"Article":[431],"published":[432,447],"online:":[433],"23":[434],"October":[435],"2019":[436],"\u00a9":[437],"2019.":[438],"Author(s).":[440],"This":[441],"an":[443],"open":[444],"access":[445],"article":[446],"Thieme":[449,476],"under":[450],"terms":[452],"Creative":[455],"Commons":[456],"Attribution":[457],"4.0":[458],"International":[459],"License,":[460],"permitting":[461],"copying":[462],"reproduction":[464],"so":[465],"long":[466],"original":[469],"work":[470],"given":[472],"appropriate":[473],"credit":[474],"(https://creativecommons.org/licenses/by/4.0/)":[475],"Revinter":[477],"Publica\u00e7\u00f5es":[478],"Ltda.":[479],"Rua":[480],"do":[481],"Matoso":[482],"170,":[483],"Rio":[484],"de":[485],"Janeiro,":[486],"RJ,":[487],"CEP":[488],"20270-135,":[489],"Brazil":[490],"Bibliographical":[491],"Record":[492],"Felipe":[493,497],"da":[494],"Silva":[495],"Marinho,":[496],"Dubourcq":[498],"Barros,":[499],"Mauro":[500],"Marques,":[501],"Leuridan":[502],"Torres,":[503],"Fernando":[504],"Augusto":[505],"Soares.":[506],"AN\u00c1LISE":[507],"DAEXPRESS\u00c3O":[508],"DOS":[509],"RECEPTORES":[510],"TOLL-":[511],"LIKE":[512],"E":[514,516,523],"DAS":[517],"VIAS":[518],"DE":[519,528],"SINALIZA\u00c7\u00c3O":[520],"INTRACELULAR":[521],"MAPKP38":[522],"NFKBP65":[524],"NO":[525],"CARCINOMA":[526],"ESCAMOSO":[527],"P\u00caNIS.":[529],"Brazilian":[530],"Journal":[531],"Oncology":[533],"2019;":[534],"15.":[535],"DOI:":[536],"10.1055/s-0044-1797685":[537]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-05-30T00:00:00"}
