{"id":"https://openalex.org/W7162684635","doi":"https://doi.org/10.1038/s41598-026-54346-x","title":"The SCD inhibitor MTI-301 reduces steatohepatitis and ratio of C18:1/C18:0 levels in diet-induced murine models of MASH","display_name":"The SCD inhibitor MTI-301 reduces steatohepatitis and ratio of C18:1/C18:0 levels in diet-induced murine models of MASH","publication_year":2026,"publication_date":"2026-05-28","ids":{"openalex":"https://openalex.org/W7162684635","doi":"https://doi.org/10.1038/s41598-026-54346-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/42209654"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-54346-x","doi":"https://doi.org/10.1038/s41598-026-54346-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-54346-x","pdf_url":"https://www.nature.com/articles/s41598-026-54346-x_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-026-54346-x_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011997920","display_name":"Santhosh Shanthi Bhupathi","orcid":"https://orcid.org/0000-0003-4423-3546","observed_orcids":["https://orcid.org/0000-0003-4423-3546"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santhosh Shanthi Bhupathi","raw_affiliation_strings":["WVU Cancer Institute, West Virginia University, Morgantown, WV, 26506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WVU Cancer Institute, West Virginia University, Morgantown, WV, 26506, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101150492","display_name":"Karen E. Hayes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136708","display_name":"Modulation Therapeutics (United States)","ror":"https://ror.org/046hxmc98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210136708"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen E. Hayes","raw_affiliation_strings":["Modulation therapeutics, Morgantown, WV, 26505, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modulation therapeutics, Morgantown, WV, 26505, USA","institution_ids":["https://openalex.org/I4210136708"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kusum Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]},{"id":"https://openalex.org/I2802882910","display_name":"West Virginia University Hospitals","ror":"https://ror.org/04fbnx371","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802882910"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kusum Sharma","raw_affiliation_strings":["Department of Pathology, WVU Medicine, Morgantown, WV, 26505, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, WVU Medicine, Morgantown, WV, 26505, USA","institution_ids":["https://openalex.org/I12097938","https://openalex.org/I2802882910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031217037","display_name":"Sridhar Reddy Kaulagari","orcid":"https://orcid.org/0000-0001-9055-2973","observed_orcids":["https://orcid.org/0000-0001-9055-2973"]},"institutions":[{"id":"https://openalex.org/I4210136708","display_name":"Modulation Therapeutics (United States)","ror":"https://ror.org/046hxmc98","country_code":"US","type":"company","lineage":["https://openalex.org/I4210136708"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sridhar Reddy Kaulagari","raw_affiliation_strings":["Modulation therapeutics, Morgantown, WV, 26505, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Modulation therapeutics, Morgantown, WV, 26505, USA","institution_ids":["https://openalex.org/I4210136708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104824768","display_name":"Mark Eminhizer","orcid":"https://orcid.org/0009-0007-2696-0930","observed_orcids":["https://orcid.org/0009-0007-2696-0930"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Eminhizer","raw_affiliation_strings":["Department of Biochemistry & Molecular Medicine, West Virginia University, Morgantown, WV, 26506, USA","Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV, 26506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Medicine, West Virginia University, Morgantown, WV, 26506, USA","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV, 26506, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023795743","display_name":"Vincent M. Wu","orcid":"https://orcid.org/0000-0002-1619-0932","observed_orcids":["https://orcid.org/0000-0002-1619-0932"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent M. Wu","raw_affiliation_strings":["WVU Cancer Institute, West Virginia University, Morgantown, WV, 26506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WVU Cancer Institute, West Virginia University, Morgantown, WV, 26506, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091514582","display_name":"John Alton Copland","orcid":"https://orcid.org/0000-0001-5091-6242","observed_orcids":["https://orcid.org/0000-0001-5091-6242"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]},{"id":"https://openalex.org/I4390039324","display_name":"Mayo Clinic Comprehensive Cancer Center (Florida)","ror":"https://ror.org/007q04248","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Copland","raw_affiliation_strings":["Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA","institution_ids":["https://openalex.org/I4210146710","https://openalex.org/I4390039324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048944005","display_name":"Jianhai Du","orcid":"https://orcid.org/0000-0002-2019-8128","observed_orcids":["https://orcid.org/0000-0002-2019-8128"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianhai Du","raw_affiliation_strings":["Department of Biochemistry & Molecular Medicine, West Virginia University, Morgantown, WV, 26506, USA","Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV, 26506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry & Molecular Medicine, West Virginia University, Morgantown, WV, 26506, USA","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, WV, 26506, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091194969","display_name":"Devanand Sarkar","orcid":"https://orcid.org/0000-0003-0973-2323","observed_orcids":["https://orcid.org/0000-0003-0973-2323"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devanand Sarkar","raw_affiliation_strings":["Department of Cellular, Molecular and Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular, Molecular and Genetic Medicine, Virginia Commonwealth University, Richmond, VA, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040146877","display_name":"Sijin Wen","orcid":"https://orcid.org/0000-0002-6955-2917","observed_orcids":["https://orcid.org/0000-0002-6955-2917"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sijin Wen","raw_affiliation_strings":["WVU Cancer Institute, West Virginia University, Morgantown, WV, 26506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"WVU Cancer Institute, West Virginia University, Morgantown, WV, 26506, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064198776","display_name":"John Maringa Githaka","orcid":"https://orcid.org/0000-0003-1974-0415","observed_orcids":["https://orcid.org/0000-0003-1974-0415"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Maringa Githaka","raw_affiliation_strings":["Department of Medical Oncology, West Virginia University School of Medicine, Morgantown, WV, 26506, USA","WVU Cancer Institute, West Virginia University, Morgantown, WV, 26506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, West Virginia University School of Medicine, Morgantown, WV, 26506, USA","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"WVU Cancer Institute, West Virginia University, Morgantown, WV, 26506, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137264027","display_name":"Werner Geldenhuys","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Werner Geldenhuys","raw_affiliation_strings":["Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054463097","display_name":"Lori Hazlehurst","orcid":"https://orcid.org/0000-0001-7040-4084","observed_orcids":["https://orcid.org/0000-0001-7040-4084"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]},{"id":"https://openalex.org/I2802882910","display_name":"West Virginia University Hospitals","ror":"https://ror.org/04fbnx371","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802882910"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lori A. Hazlehurst","raw_affiliation_strings":["Department of Medical Oncology, West Virginia University School of Medicine, Morgantown, WV, 26506, USA. lahazlehurst@hsc.wvu.edu","Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506, USA. lahazlehurst@hsc.wvu.edu","WVU Cancer Institute, West Virginia University, Morgantown, WV, 26506, USA. lahazlehurst@hsc.wvu.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, West Virginia University School of Medicine, Morgantown, WV, 26506, USA. lahazlehurst@hsc.wvu.edu","institution_ids":["https://openalex.org/I12097938","https://openalex.org/I2802882910"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506, USA. lahazlehurst@hsc.wvu.edu","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"WVU Cancer Institute, West Virginia University, Morgantown, WV, 26506, USA. lahazlehurst@hsc.wvu.edu","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5054463097"],"corresponding_institution_ids":["https://openalex.org/I12097938","https://openalex.org/I2802882910"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37864366,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.906000018119812},{"id":"https://openalex.org/keywords/stearoyl-coa-desaturase","display_name":"stearoyl-CoA desaturase","score":0.9179999828338623},{"id":"https://openalex.org/keywords/monounsaturated-fatty-acids","display_name":"monounsaturated fatty acids","score":0.9409999847412109},{"id":"https://openalex.org/keywords/saturated-fatty-acids","display_name":"saturated fatty acids","score":0.8790000081062317},{"id":"https://openalex.org/keywords/desaturation-index","display_name":"desaturation index","score":0.7630000114440918},{"id":"https://openalex.org/keywords/lipid-droplets","display_name":"lipid droplets","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.8320000171661377},{"id":"https://openalex.org/keywords/diet-induced-liver-disease","display_name":"diet-induced liver disease","score":0.628000020980835},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":0.6240000128746033},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.807200014591217},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.6705999970436096},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.6018000245094299},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5891000032424927},{"id":"https://openalex.org/C2992125399","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Lipid accumulation","level":2,"score":0.5663999915122986},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5291000008583069},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5174000263214111},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.49729999899864197},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.46860000491142273},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4666999876499176},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.4602000117301941},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4442000091075897},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4228000044822693},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.42100000381469727},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.3917999863624573},{"id":"https://openalex.org/C2992518758","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Fat accumulation","level":3,"score":0.31139999628067017},{"id":"https://openalex.org/C3020359197","wikidata":"https://www.wikidata.org/wiki/Q1359801","display_name":"Liver enzyme","level":2,"score":0.29789999127388},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.28870001435279846},{"id":"https://openalex.org/C2908932551","wikidata":"https://www.wikidata.org/wiki/Q14878272","display_name":"Stearoyl-CoA Desaturase","level":4,"score":0.28839999437332153},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.288100004196167},{"id":"https://openalex.org/C2780806160","wikidata":"https://www.wikidata.org/wiki/Q132442","display_name":"Oil Red O","level":4,"score":0.28780001401901245},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.287200003862381},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.28130000829696655},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.27970001101493835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2766000032424927},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27250000834465027},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.2696000039577484},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.2662000060081482},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.25699999928474426},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.25690001249313354},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.25060001015663147}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005234","descriptor_name":"Fatty Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013230","descriptor_name":"Stearoyl-CoA Desaturase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013230","descriptor_name":"Stearoyl-CoA Desaturase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013230","descriptor_name":"Stearoyl-CoA Desaturase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013230","descriptor_name":"Stearoyl-CoA Desaturase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013230","descriptor_name":"Stearoyl-CoA Desaturase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013230","descriptor_name":"Stearoyl-CoA Desaturase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D066292","descriptor_name":"Lipid Droplets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D066292","descriptor_name":"Lipid Droplets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D066292","descriptor_name":"Lipid Droplets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D066292","descriptor_name":"Lipid Droplets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066292","descriptor_name":"Lipid Droplets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066292","descriptor_name":"Lipid Droplets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-026-54346-x","doi":"https://doi.org/10.1038/s41598-026-54346-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-54346-x","pdf_url":"https://www.nature.com/articles/s41598-026-54346-x_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:42209654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42209654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:b8a2ef408ece4df08ff6df1eec4e722f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b8a2ef408ece4df08ff6df1eec4e722f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 16, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13448673","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13448673/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-54346-x","doi":"https://doi.org/10.1038/s41598-026-54346-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-54346-x","pdf_url":"https://www.nature.com/articles/s41598-026-54346-x_reference.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7438406348228455,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7045044369","display_name":null,"funder_award_id":"P20GM121322","funder_id":"https://openalex.org/F4320311274","funder_display_name":"West Virginia University"},{"id":"https://openalex.org/G7656855102","display_name":null,"funder_award_id":"P20GM144230","funder_id":"https://openalex.org/F4320311274","funder_display_name":"West Virginia University"},{"id":"https://openalex.org/G9000088698","display_name":"Tumor Microenvironment-TME CoBRE","funder_award_id":"P20GM121322","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000216164","display_name":null,"funder_award_id":"P20GM144230","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320311274","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334252","display_name":"Cancer Institute, West Virginia University","ror":null},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7162684635.pdf","grobid_xml":"https://content.openalex.org/works/W7162684635.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Metabolic":[0],"dysfunction-associated":[1,6],"steatohepatitis":[2],"(MASH)":[3],"and":[4,16,24,81,145],"metabolic":[5],"steatotic":[7],"liver":[8,72,172],"disease":[9],"(MASLD)":[10],"develop":[11],"because":[12],"of":[13,19,68,77,88,95,108,122,168],"fat":[14],"disposition":[15],"excess":[17],"accumulation":[18],"lipid":[20,60,98,131],"droplets":[21,132],"in":[22,59,63,70,85,97,133,148],"hepatocytes":[23],"hepatic":[25],"stellate":[26],"cells.":[27],"The":[28],"endoplasmic":[29],"reticulum":[30],"enzyme":[31,38],"stearoyl-CoA":[32],"desaturase":[33],"(SCD)":[34],"is":[35,102,158],"the":[36,71,75,86,92,120,123,149,156,166],"rate-limiting":[37],"that":[39,83,138,155],"converts":[40],"saturated":[41],"fatty":[42,47,64,171],"acids":[43,48],"(SFAs)":[44],"to":[45,74,91,118],"monounsaturated":[46],"(MUFAs).":[49],"MUFAs":[50],"are":[51],"an":[52,103,159],"essential":[53],"building":[54],"block":[55],"for":[56,106,162,165],"triglycerides":[57,69],"found":[58],"droplet":[61,99],"deposits":[62],"livers.":[65],"Increased":[66],"deposit":[67],"contributes":[73],"sequelae":[76],"events,":[78],"including":[79],"inflammation":[80],"fibrosis,":[82],"culminates":[84],"development":[87,164],"MASH.":[89],"Due":[90],"key":[93],"role":[94],"SCD":[96,101,125],"formation,":[100],"attractive":[104,160],"target":[105],"management":[107],"MASLD/MASH.":[109],"Two":[110],"independent":[111],"diet":[112],"induced":[113],"MASH":[114],"models":[115],"were":[116],"used":[117],"test":[119],"efficacy":[121],"novel":[124],"inhibitor":[126],"MTI-301.":[127],"MTI-301":[128,157],"treatment":[129,167],"decreased":[130],"both":[134],"models,":[135],"a":[136],"finding":[137],"correlated":[139],"with":[140,170],"reduced":[141],"desaturation":[142],"indices":[143],"(16:1/16:00":[144],"18:1/18:0)":[146],"measured":[147],"liver.":[150],"Collectively":[151],"our":[152],"data":[153],"suggests":[154],"drug":[161],"further":[163],"patients":[169],"disease.":[173]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-05-29T00:00:00"}
