{"id":"https://openalex.org/W7162492490","doi":"https://doi.org/10.1200/jco.2026.44.16_suppl.8631","title":"Prognostic impact of actionable driver alterations and efficacy of targeted therapy in lung squamous cell carcinoma: A large-scale nationwide genomic screening (LC-SCRUM-Asia).","display_name":"Prognostic impact of actionable driver alterations and efficacy of targeted therapy in lung squamous cell carcinoma: A large-scale nationwide genomic screening (LC-SCRUM-Asia).","publication_year":2026,"publication_date":"2026-05-28","ids":{"openalex":"https://openalex.org/W7162492490","doi":"https://doi.org/10.1200/jco.2026.44.16_suppl.8631"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2026.44.16_suppl.8631","doi":"https://doi.org/10.1200/jco.2026.44.16_suppl.8631","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2026.44.16_suppl.8631","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W7162492490"],"child_works_count":0,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5132861833","display_name":"Tetsuya Sakai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuya Sakai","raw_affiliation_strings":["Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137121257","display_name":"Hiroki Izumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Izumi","raw_affiliation_strings":["Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081915644","display_name":"Shingo Matsumoto","orcid":"https://orcid.org/0000-0001-9627-5401","observed_orcids":["https://orcid.org/0000-0001-9627-5401"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shingo Matsumoto","raw_affiliation_strings":["National Cancer Center Hospital East, Kashiwa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center Hospital East, Kashiwa, Japan","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137128787","display_name":"Shuji Murakami","orcid":"https://orcid.org/0000-0001-5104-5493","observed_orcids":["https://orcid.org/0000-0001-5104-5493"]},"institutions":[{"id":"https://openalex.org/I4387152949","display_name":"Kanagawa Cancer Center","ror":"https://ror.org/00aapa202","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4387152949"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuji Murakami","raw_affiliation_strings":["Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan","institution_ids":["https://openalex.org/I4387152949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032960175","display_name":"Kazumi Nishino","orcid":"https://orcid.org/0000-0003-2000-7472","observed_orcids":["https://orcid.org/0000-0003-2000-7472"]},"institutions":[{"id":"https://openalex.org/I4210151107","display_name":"Osaka International Cancer Institute","ror":"https://ror.org/05xvwhv53","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210151107","https://openalex.org/I4405282797"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazumi Nishino","raw_affiliation_strings":["Department of Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, Osaka International Cancer Institute, Osaka, Japan","institution_ids":["https://openalex.org/I4210151107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136424283","display_name":"Daisuke Arai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123464","display_name":"Saiseikai Utsunomiya hospital","ror":"https://ror.org/03a2szg51","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123464"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Arai","raw_affiliation_strings":["Pulmonary Division, Department of Internal Medicine, Saiseikai Utsunomiya Hospital, Utsunomiya, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Division, Department of Internal Medicine, Saiseikai Utsunomiya Hospital, Utsunomiya, Japan","institution_ids":["https://openalex.org/I4210123464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008558946","display_name":"Jun Sugisaka","orcid":"https://orcid.org/0000-0002-1000-0077","observed_orcids":["https://orcid.org/0000-0002-1000-0077"]},"institutions":[{"id":"https://openalex.org/I4210166385","display_name":"Sendai Kousei Hospital","ror":"https://ror.org/05yevkn97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210166385"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Sugisaka","raw_affiliation_strings":["Department of Pulmonary Medicine, Sendai Kousei Hospital, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Medicine, Sendai Kousei Hospital, Sendai, Japan","institution_ids":["https://openalex.org/I4210166385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021644322","display_name":"Saori Takata","orcid":"https://orcid.org/0009-0002-5010-7212","observed_orcids":["https://orcid.org/0009-0002-5010-7212"]},"institutions":[{"id":"https://openalex.org/I190930483","display_name":"Kyorin University","ror":"https://ror.org/0188yz413","country_code":"JP","type":"education","lineage":["https://openalex.org/I190930483"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Saori Takata","raw_affiliation_strings":["Department of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I190930483"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070015883","display_name":"Shoichi Kuyama","orcid":"https://orcid.org/0000-0002-6079-3511","observed_orcids":["https://orcid.org/0000-0002-6079-3511"]},"institutions":[{"id":"https://openalex.org/I4210133339","display_name":"Iwakuni Medical Center","ror":"https://ror.org/03kcxpp45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133339","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoichi Kuyama","raw_affiliation_strings":["Department of Respiratory Medicine, NHO Iwakuni Clinical Center, Iwakuni, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, NHO Iwakuni Clinical Center, Iwakuni, Japan","institution_ids":["https://openalex.org/I4210133339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034149407","display_name":"Jun Sakakibara\u2010Konishi","orcid":"https://orcid.org/0000-0003-4333-8100","observed_orcids":["https://orcid.org/0000-0003-4333-8100"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Sakakibara-Konishi","raw_affiliation_strings":["Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Faculty of Medicine, Hokkaido University, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137088698","display_name":"Ikue Kamei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126715","display_name":"Itami City Hospital","ror":"https://ror.org/02dhn4e70","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210126715"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ikue Kamei","raw_affiliation_strings":["Itami City Hospital, Hyogo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Itami City Hospital, Hyogo, Japan","institution_ids":["https://openalex.org/I4210126715"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070236738","display_name":"Eriko Tabata","orcid":"https://orcid.org/0000-0002-8919-6139","observed_orcids":["https://orcid.org/0000-0002-8919-6139"]},"institutions":[{"id":"https://openalex.org/I4210102296","display_name":"Ikeda Municipal Hospital","ror":"https://ror.org/00qezxe61","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210102296"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eriko Tabata","raw_affiliation_strings":["Department of Respiratory Medicine, Ikeda City Hospital, Ikeda, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Medicine, Ikeda City Hospital, Ikeda, Osaka, Japan","institution_ids":["https://openalex.org/I4210102296"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078647935","display_name":"Naoki Furuya","orcid":"https://orcid.org/0000-0001-7162-5946","observed_orcids":["https://orcid.org/0000-0001-7162-5946"]},"institutions":[{"id":"https://openalex.org/I163917720","display_name":"St. Marianna University School of Medicine","ror":"https://ror.org/043axf581","country_code":"JP","type":"education","lineage":["https://openalex.org/I163917720"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Furuya","raw_affiliation_strings":["St. Marianna University School of Medicine, Kawasaki, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Marianna University School of Medicine, Kawasaki, Japan","institution_ids":["https://openalex.org/I163917720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137105345","display_name":"Shingo Miyamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104057","display_name":"Japanese Red Cross Medical Center","ror":"https://ror.org/01gezbc84","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210104057"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shingo Miyamoto","raw_affiliation_strings":["Japanese Red Cross Medical Center, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Japanese Red Cross Medical Center, Tokyo, Japan","institution_ids":["https://openalex.org/I4210104057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075227198","display_name":"Masahiro Kodani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Kodani","raw_affiliation_strings":["Division of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respiratory Medicine and Rheumatology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080218166","display_name":"Haruko Daga","orcid":"https://orcid.org/0000-0002-5191-6233","observed_orcids":["https://orcid.org/0000-0002-5191-6233"]},"institutions":[{"id":"https://openalex.org/I4210099064","display_name":"Osaka City General Hospital","ror":"https://ror.org/00v053551","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099064","https://openalex.org/I4405284496"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruko Daga","raw_affiliation_strings":["Department of Medical Oncology, Osaka City General Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, Osaka City General Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210099064"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066508513","display_name":"Yuto Motobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802180866","display_name":"Yokohama City University Medical Center","ror":"https://ror.org/03k95ve17","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I2802180866"]},{"id":"https://openalex.org/I4210099218","display_name":"Yokohama City University Hospital","ror":"https://ror.org/010hfy465","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210099218"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuto Motobayashi","raw_affiliation_strings":["Respiratory Disease Center, Yokohama City University Medical Center, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Disease Center, Yokohama City University Medical Center, Yokohama, Japan","institution_ids":["https://openalex.org/I2802180866","https://openalex.org/I4210099218"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037461196","display_name":"K\u014dichi Goto","orcid":"https://orcid.org/0000-0002-3023-2510","observed_orcids":["https://orcid.org/0000-0002-3023-2510"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Goto","raw_affiliation_strings":["Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan","institution_ids":["https://openalex.org/I4210145079"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"44","issue":"16_suppl","first_page":"8631","last_page":"8631"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-squamous-cell-carcinoma","display_name":"lung squamous cell carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7770000100135803},{"id":"https://openalex.org/keywords/prognostic-value","display_name":"prognostic value","score":0.8130000233650208},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8500000238418579},{"id":"https://openalex.org/keywords/alk-inhibitors","display_name":"ALK inhibitors","score":0.828000009059906},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/kras-g12c","display_name":"KRAS G12C","score":0.9549999833106995},{"id":"https://openalex.org/keywords/met-exon-14-skipping","display_name":"MET exon 14 skipping","score":0.9599999785423279},{"id":"https://openalex.org/keywords/alk-fusion","display_name":"ALK fusion","score":0.7149999737739563},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.33500000834465027},{"id":"https://openalex.org/keywords/genomic-screening","display_name":"genomic screening","score":0.5350000262260437},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.5789999961853027},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6100000143051147},{"id":"https://openalex.org/keywords/egfr-exon-20-insertion-mutation","display_name":"EGFR exon 20 insertion","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9271000027656555},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8241999745368958},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.741599977016449},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.7041000127792358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6651999950408936},{"id":"https://openalex.org/C2775999482","wikidata":"https://www.wikidata.org/wiki/Q18031208","display_name":"ROS1","level":4,"score":0.644599974155426},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.527999997138977},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.46650001406669617},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.39079999923706055},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.37310001254081726},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.36959999799728394},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.3328000009059906},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31869998574256897},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.314300000667572},{"id":"https://openalex.org/C2779422266","wikidata":"https://www.wikidata.org/wiki/Q5186964","display_name":"Crizotinib","level":4,"score":0.31279999017715454},{"id":"https://openalex.org/C2779177807","wikidata":"https://www.wikidata.org/wiki/Q3658562","display_name":"non-small cell lung cancer (NSCLC)","level":4,"score":0.29670000076293945},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.27970001101493835},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2791000008583069},{"id":"https://openalex.org/C117643217","wikidata":"https://www.wikidata.org/wiki/Q17824987","display_name":"Anaplastic lymphoma kinase","level":4,"score":0.2754000127315521},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2565999925136566}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2026.44.16_suppl.8631","doi":"https://doi.org/10.1200/jco.2026.44.16_suppl.8631","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2026.44.16_suppl.8631","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310465","display_name":"Takeda Pharmaceutical Company","ror":"https://ror.org/04hjbmv12"},{"id":"https://openalex.org/F4320317302","display_name":"Boehringer Ingelheim Japan","ror":"https://ror.org/02r1d7x68"},{"id":"https://openalex.org/F4320327845","display_name":"Ono Pharmaceutical","ror":"https://ror.org/022jefx64"},{"id":"https://openalex.org/F4320333002","display_name":"Pfizer Japan","ror":"https://ror.org/05pm71w80"},{"id":"https://openalex.org/F4320333376","display_name":"MSD K.K.","ror":"https://ror.org/01kaqxm37"},{"id":"https://openalex.org/F4320333624","display_name":"Eli Lilly Japan","ror":"https://ror.org/01sv7f575"},{"id":"https://openalex.org/F4320334790","display_name":"Daiichi Sankyo Company","ror":"https://ror.org/027y26122"},{"id":"https://openalex.org/F5044247467","display_name":"Novartis Japan","ror":"https://ror.org/01k1ftz35"},{"id":"https://openalex.org/F7575694339","display_name":"Medical and Biological Laboratories","ror":"https://ror.org/033ypzd50"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2947776397","https://openalex.org/W2231879630","https://openalex.org/W2889736104","https://openalex.org/W2762189013","https://openalex.org/W4410822317","https://openalex.org/W2767089261","https://openalex.org/W2991602949","https://openalex.org/W3031537346","https://openalex.org/W2685267987","https://openalex.org/W2477577375"],"abstract_inverted_index":{"8631":[0],"Background:":[1],"Precision":[2],"medicine":[3],"based":[4],"on":[5],"multi-gene":[6,27,391],"analysis":[7,14,28,209,392],"improves":[8],"prognosis":[9],"and":[10,45,64,119,199,264,327,361,373],"has":[11],"established":[12],"multigene":[13],"as":[15],"the":[16,23,39,46,58,65,113,207,387,399,402],"standard":[17],"of":[18,26,41,50,61,67,115,121,135,210,281,359,390,404],"care":[19],"in":[20,29,70,85,91,103,149,221,252,345,356,393],"lung":[21,30,81],"adenocarcinoma.However,":[22],"clinical":[24,101,347,388],"utility":[25,389],"squamous":[31],"cell":[32,80],"carcinoma":[33],"(LUSC)":[34],"remains":[35],"controversial":[36],"due":[37],"to":[38,56,112,128,228,342,375,380,409],"rarity":[40],"actionable":[42,116,144,224,244,351],"driver":[43,62,117,145,225,245,352],"alterations":[44,63,118,146,226,353],"uncertain":[47],"therapeutic":[48,406],"benefits":[49],"targeted":[51,68,122,259,282,368],"therapy.":[52,123],"This":[53],"study":[54],"aimed":[55],"elucidate":[57],"prognostic":[59],"value":[60],"efficacy":[66,280,372],"therapy":[69,369],"LUSC.":[71,139],"Methods:":[72],"We":[73,99],"have":[74],"prospectively":[75],"analyzed":[76],"patients":[77,104,132,151,212,222,242,256],"with":[78,105,213,223,243,364],"non-small":[79],"cancer":[82],"(NSCLC)":[83],"enrolled":[84],"a":[86,365],"nationwide":[87],"genomic":[88],"screening":[89],"project":[90],"Japan":[92],"(LC-SCRUM-Asia)":[93],"using":[94],"NGS":[95],"(Oncomine":[96],"Comprehensive/Precision":[97],"Assay).":[98],"evaluated":[100],"outcomes":[102,338],"LUSC,":[106],"comparing":[107],"overall":[108,377],"survival":[109,208,289,378],"(OS)":[110],"according":[111],"presence":[114],"receipt":[120],"Results:":[124],"From":[125],"March":[126],"2015":[127],"October":[129],"2025,":[130],"19,357":[131],"were":[133,147,339,354,362],"enrolled,":[134],"whom":[136],"2,917":[137],"had":[138],"Among":[140],"these":[141,337],"LUSC":[142,360,394],"patients,":[143],"identified":[148,355],"180":[150],"(6.2%)":[152],"cases,":[153],"including":[154],"EGFR":[155,177,305],"mutations":[156],"(n":[157,162,169,174,181,186,191,196,204,261,269,299,307,316,324,333],"=":[158,163,170,175,182,187,192,197,205,238,262,270,277,300,308,317,325,334],"78),":[159],"KRAS":[160,313],"G12C":[161,314],"33),":[164],"MET":[165,322],"exon":[166,178,201],"14":[167],"skipping":[168],"28),":[171],"ALK":[172,294],"fusions":[173,185,190],"18),":[176],"20":[179,202],"insertions":[180,203],"7),":[183],"RET":[184],"6),":[188],"ROS1":[189,331],"5),":[193],"BRAF":[194],"V600E":[195],"4),":[198],"HER2":[200],"1).In":[206],"2,017":[211],"advanced/recurrent":[214],"disease,":[215],"median":[216,253,287],"OS":[217,254],"was":[218,248,284,290],"significantly":[219],"longer":[220],"compared":[227,379],"those":[229,265,343],"without":[230],"(18.2":[231],"vs.":[232,273],"15.0":[233],"months;":[234],"HR":[235],"0.79,":[236],"p":[237,276],"0.02).":[239],"However,":[240],"among":[241],"alterations,":[246],"there":[247],"no":[249],"significant":[250],"difference":[251],"between":[255],"who":[257,266],"received":[258],"therapies":[260,283],"97)":[263],"did":[267],"not":[268],"45)":[271],"(18.3":[272],"17.0":[274],"months,":[275],"0.94).":[278],"The":[279],"notably":[285],"limited;":[286],"progression-free":[288],"12.4":[291],"months":[292,303,311,320,329],"for":[293,304,312,321,330,401],"tyrosine":[295],"kinase":[296],"inhibitors":[297,315],"(TKIs)":[298],"17),":[301],"8.4":[302],"TKIs":[306,323,332],"46),":[309],"4.5":[310],"10),":[318],"3.6":[319],"15),":[326],"3.4":[328],"5).":[335],"Collectively,":[336],"consistently":[340],"inferior":[341],"reported":[344],"pivotal":[346],"trials.":[348],"Conclusions:":[349],"Although":[350],"approximately":[357],"6%":[358],"associated":[363],"favorable":[366],"prognosis,":[367],"demonstrated":[370],"limited":[371],"failed":[374],"extend":[376],"non-targeted":[381],"approaches.":[382],"These":[383],"findings":[384],"indicate":[385],"that":[386],"is":[395],"currently":[396],"limited,":[397],"highlighting":[398],"need":[400],"development":[403],"novel":[405],"strategies":[407],"specific":[408],"this":[410],"histology.":[411]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2026-05-28T00:00:00"}
