{"id":"https://openalex.org/W7162467477","doi":"https://doi.org/10.1007/s44164-026-00131-z","title":"Converging bioengineering technologies toward predictive, human-relevant in vitro tissue models","display_name":"Converging bioengineering technologies toward predictive, human-relevant in vitro tissue models","publication_year":2026,"publication_date":"2026-05-26","ids":{"openalex":"https://openalex.org/W7162467477","doi":"https://doi.org/10.1007/s44164-026-00131-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/42453624","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13365101"},"language":"en","primary_location":{"id":"doi:10.1007/s44164-026-00131-z","doi":"https://doi.org/10.1007/s44164-026-00131-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s44164-026-00131-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210197991","display_name":"In vitro models","issn_l":"2731-3433","issn":["2731-3433","2731-3441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vitro models","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13365101/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081762891","display_name":"Alp \u00d6zg\u00fcn","orcid":"https://orcid.org/0000-0003-4815-5098","observed_orcids":["https://orcid.org/0000-0003-4815-5098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alp Ozgun","raw_affiliation_strings":["Unaffiliated, Ottawa, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unaffiliated, Ottawa, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067950843","display_name":"Jean\u2010Philippe St\u2010Pierre","orcid":"https://orcid.org/0000-0002-5689-7334","observed_orcids":["https://orcid.org/0000-0002-5689-7334"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jean-Philippe St-Pierre","raw_affiliation_strings":["Department of Chemical and Biological Engineering, Faculty of Engineering, University of Ottawa, Ottawa, ON K1N 6N5 Canada","Ottawa-Carleton Institute for Biomedical Engineering (OCIBME), Ottawa, K1N 6N5 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biological Engineering, Faculty of Engineering, University of Ottawa, Ottawa, ON K1N 6N5 Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Ottawa-Carleton Institute for Biomedical Engineering (OCIBME), Ottawa, K1N 6N5 Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050215240","display_name":"Elena Mart\u00ednez Fraiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210132884","display_name":"Barcelona Institute of Science and Technology","ror":"https://ror.org/03kpps236","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210132884"]},{"id":"https://openalex.org/I4210147769","display_name":"Institute for Bioengineering of Catalonia","ror":"https://ror.org/056h71x09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210147769","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Mart\u00ednez Fraiz","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Av. Monforte de Lemos 3-5, Pabell\u00f3n 11, Planta 0, Madrid, 28029 Spain","Department of Electronics and Biomedical Engineering, University of Barcelona (UB), c/Mart\u00ed i Franqu\u00e8s 1-11, Barcelona, 08028 Spain","Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, 08028 Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red (CIBER), Av. Monforte de Lemos 3-5, Pabell\u00f3n 11, Planta 0, Madrid, 28029 Spain","institution_ids":["https://openalex.org/I4210115082"]},{"raw_affiliation_string":"Department of Electronics and Biomedical Engineering, University of Barcelona (UB), c/Mart\u00ed i Franqu\u00e8s 1-11, Barcelona, 08028 Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, 08028 Spain","institution_ids":["https://openalex.org/I4210132884","https://openalex.org/I4210147769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052523690","display_name":"Fabio Variola","orcid":"https://orcid.org/0000-0002-5519-6915","observed_orcids":["https://orcid.org/0000-0002-5519-6915"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I2799330578","display_name":"Children's Hospital of Eastern Ontario","ror":"https://ror.org/05nsbhw27","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799330578"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Fabio Variola","raw_affiliation_strings":["Children's Hospital of Eastern Ontario (CHEO), Ottawa, K1H 8L1 Canada","Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, K1N6N5 Canada","Department of Mechanical Engineering, Faculty of Engineering, University of Ottawa, Ottawa, K1N 6N5 Canada","Ottawa-Carleton Institute for Biomedical Engineering (OCIBME), Ottawa, K1N 6N5 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital of Eastern Ontario (CHEO), Ottawa, K1H 8L1 Canada","institution_ids":["https://openalex.org/I2799330578"]},{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, K1N6N5 Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Department of Mechanical Engineering, Faculty of Engineering, University of Ottawa, Ottawa, K1N 6N5 Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Ottawa-Carleton Institute for Biomedical Engineering (OCIBME), Ottawa, K1N 6N5 Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5052523690"],"corresponding_institution_ids":["https://openalex.org/I153718931","https://openalex.org/I2799330578"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"2","first_page":"107","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.011599999852478504,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-vitro-tissue-models","display_name":"in vitro tissue models","score":0.9580000042915344},{"id":"https://openalex.org/keywords/human-relevant-models","display_name":"human-relevant models","score":0.7910000085830688},{"id":"https://openalex.org/keywords/predictive-toxicology","display_name":"predictive toxicology","score":0.7670000195503235},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.6420000195503235},{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.44999998807907104},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.7879999876022339}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31929999589920044},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2985999882221222},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2906999886035919},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.27570000290870667},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.27239999175071716},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.26260000467300415},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.23100000619888306},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.2206999957561493},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21070000529289246},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.2087000012397766}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/s44164-026-00131-z","doi":"https://doi.org/10.1007/s44164-026-00131-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s44164-026-00131-z","pdf_url":null,"source":{"id":"https://openalex.org/S4210197991","display_name":"In vitro models","issn_l":"2731-3433","issn":["2731-3433","2731-3441"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","norway-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vitro models","raw_type":"journal-article"},{"id":"pmid:42453624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42453624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In vitro models","raw_type":"Letter"},{"id":"pmh:oai:pubmedcentral.nih.gov:13365101","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13365101/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vitro Model","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13365101","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13365101/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In Vitro Model","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W2913348902","https://openalex.org/W2923099616","https://openalex.org/W3008131683","https://openalex.org/W3042043324","https://openalex.org/W3081739146","https://openalex.org/W3082213210","https://openalex.org/W3091158269","https://openalex.org/W3120981689","https://openalex.org/W3138428755","https://openalex.org/W3163713485","https://openalex.org/W3167503613","https://openalex.org/W3168856962","https://openalex.org/W3171498185","https://openalex.org/W3178628254","https://openalex.org/W3191973919","https://openalex.org/W3215458383","https://openalex.org/W4226056532","https://openalex.org/W4287225820","https://openalex.org/W4292475227","https://openalex.org/W4293385329","https://openalex.org/W4309740738","https://openalex.org/W4312179705","https://openalex.org/W4315864649","https://openalex.org/W4317734005","https://openalex.org/W4321481012","https://openalex.org/W4322493855","https://openalex.org/W4322625728","https://openalex.org/W4360999347","https://openalex.org/W4361291586","https://openalex.org/W4379508290","https://openalex.org/W4379768343","https://openalex.org/W4383187087","https://openalex.org/W4386271217","https://openalex.org/W4386869438","https://openalex.org/W4387095486","https://openalex.org/W4388652864","https://openalex.org/W4388691856","https://openalex.org/W4389298357","https://openalex.org/W4390278712","https://openalex.org/W4390331331","https://openalex.org/W4390485108","https://openalex.org/W4390721421","https://openalex.org/W4391078170","https://openalex.org/W4391749603","https://openalex.org/W4396510509","https://openalex.org/W4396952973","https://openalex.org/W4398207598","https://openalex.org/W4399628691","https://openalex.org/W4399731173","https://openalex.org/W4399878142","https://openalex.org/W4400243741","https://openalex.org/W4402636535","https://openalex.org/W4402692642","https://openalex.org/W4403353437","https://openalex.org/W4403770337","https://openalex.org/W4403819959","https://openalex.org/W4403830738","https://openalex.org/W4403951015","https://openalex.org/W4405494908","https://openalex.org/W4409412635","https://openalex.org/W4409709819","https://openalex.org/W4409723569","https://openalex.org/W4409986818","https://openalex.org/W4411241334","https://openalex.org/W4411918832","https://openalex.org/W4414708591","https://openalex.org/W4415263446","https://openalex.org/W4416025668","https://openalex.org/W4416185381"],"related_works":["https://openalex.org/W3040780738","https://openalex.org/W7058827540","https://openalex.org/W2019596114","https://openalex.org/W7212294415","https://openalex.org/W3215141726","https://openalex.org/W4291152250","https://openalex.org/W6946312983","https://openalex.org/W4210416335","https://openalex.org/W2945473251","https://openalex.org/W3160639522"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2026-05-27T00:00:00"}