{"id":"https://openalex.org/W7162425480","doi":"https://doi.org/10.1073/pnas.2525164123","title":"Epstein\u2013Barr virus (EBV) infection causes human germinal center B cell\u2013derived lymphomas in the absence of EBNA2 expression","display_name":"Epstein\u2013Barr virus (EBV) infection causes human germinal center B cell\u2013derived lymphomas in the absence of EBNA2 expression","publication_year":2026,"publication_date":"2026-05-26","ids":{"openalex":"https://openalex.org/W7162425480","doi":"https://doi.org/10.1073/pnas.2525164123","pmid":"https://pubmed.ncbi.nlm.nih.gov/42189985"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2525164123","doi":"https://doi.org/10.1073/pnas.2525164123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2525164123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2525164123","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Chunyan Wang","orcid":"https://orcid.org/0000-0002-6430-413X","observed_orcids":["https://orcid.org/0000-0002-6430-413X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chunyan Wang","raw_affiliation_strings":["Department of Oncology, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":"https://orcid.org/0000-0002-6430-413X","affiliations":[{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012636364","display_name":"Jillian A. Bristol","orcid":"https://orcid.org/0000-0001-6109-8126","observed_orcids":["https://orcid.org/0000-0001-6109-8126"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jillian A. Bristol","raw_affiliation_strings":["Department of Oncology, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":"https://orcid.org/0000-0001-6109-8126","affiliations":[{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027417625","display_name":"Scott E. Nelson","orcid":"https://orcid.org/0000-0003-0084-1355","observed_orcids":["https://orcid.org/0000-0003-0084-1355"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott E. Nelson","raw_affiliation_strings":["Department of Oncology, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":"https://orcid.org/0000-0003-0084-1355","affiliations":[{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137025041","display_name":"Tony Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tony Chen","raw_affiliation_strings":["Department of Oncology, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137039693","display_name":"Charlotte Hendrickson","orcid":"https://orcid.org/0009-0003-3165-7670","observed_orcids":["https://orcid.org/0009-0003-3165-7670"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlotte Hendrickson","raw_affiliation_strings":["Department of Oncology, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":"https://orcid.org/0009-0003-3165-7670","affiliations":[{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050742922","display_name":"Dana C. Baiu","orcid":"https://orcid.org/0000-0001-7542-5300","observed_orcids":["https://orcid.org/0000-0001-7542-5300"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana C. Baiu","raw_affiliation_strings":["Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062670566","display_name":"Mariah Riel","orcid":"https://orcid.org/0000-0001-9702-4866","observed_orcids":["https://orcid.org/0000-0001-9702-4866"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariah Riel","raw_affiliation_strings":["Department of Oncology, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026213371","display_name":"Mitchell Hayes","orcid":"https://orcid.org/0000-0002-2736-6542","observed_orcids":["https://orcid.org/0000-0002-2736-6542"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitch Hayes","raw_affiliation_strings":["Department of Oncology, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":"https://orcid.org/0000-0002-2736-6542","affiliations":[{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013444784","display_name":"Erik A. Ranheim","orcid":"https://orcid.org/0000-0002-5786-9327","observed_orcids":["https://orcid.org/0000-0002-5786-9327"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik A. Ranheim","raw_affiliation_strings":["Department of Pathology, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079424748","display_name":"Jenny E. Gumperz","orcid":"https://orcid.org/0000-0003-1852-2192","observed_orcids":["https://orcid.org/0000-0003-1852-2192"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny E. Gumperz","raw_affiliation_strings":["Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":"https://orcid.org/0000-0003-1852-2192","affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055987685","display_name":"Eric Johannsen","orcid":"https://orcid.org/0000-0001-5741-9708","observed_orcids":["https://orcid.org/0000-0001-5741-9708"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric C. Johannsen","raw_affiliation_strings":["Department of Medicine, School of Medicine and Public Health, University of Wisconsin","Department of Oncology, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":"https://orcid.org/0000-0001-5741-9708","affiliations":[{"raw_affiliation_string":"Department of Medicine, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028943143","display_name":"Shannon C. Kenney","orcid":"https://orcid.org/0000-0002-9655-6526","observed_orcids":["https://orcid.org/0000-0002-9655-6526"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shannon C. Kenney","raw_affiliation_strings":["Department of Medicine, School of Medicine and Public Health, University of Wisconsin","Department of Oncology, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":"https://orcid.org/0000-0002-9655-6526","affiliations":[{"raw_affiliation_string":"Department of Medicine, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Oncology, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012636364","https://openalex.org/A5028943143"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34544388,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"123","issue":"22","first_page":"e2525164123","last_page":"e2525164123"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.984000027179718},{"id":"https://openalex.org/keywords/ebna2","display_name":"EBNA2","score":0.7089999914169312},{"id":"https://openalex.org/keywords/germinal-center-b-cells","display_name":"germinal center B cells","score":0.9150000214576721},{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.828000009059906},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9449999928474426},{"id":"https://openalex.org/keywords/plasmablastic-lymphoma","display_name":"plasmablastic lymphoma","score":0.9810000061988831},{"id":"https://openalex.org/keywords/lmp2a","display_name":"LMP2A","score":0.9190000295639038},{"id":"https://openalex.org/keywords/lmp1","display_name":"LMP1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ebv-latency","display_name":"EBV latency","score":0.5540000200271606},{"id":"https://openalex.org/keywords/tonsil","display_name":"tonsil","score":0.5429999828338623},{"id":"https://openalex.org/keywords/nsg-mice","display_name":"NSG mice","score":0.6869999766349792},{"id":"https://openalex.org/keywords/plasmablast-differentiation","display_name":"plasmablast differentiation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/lymphocyte-trafficking","display_name":"lymphocyte migration","score":0.828000009059906},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9549999833106995}],"concepts":[{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.8503000140190125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7483999729156494},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.5842000246047974},{"id":"https://openalex.org/C2781375147","wikidata":"https://www.wikidata.org/wiki/Q6900","display_name":"Epstein\u2013Barr virus","level":3,"score":0.5253000259399414},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5033000111579895},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.48890000581741333},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4246000051498413},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41290000081062317},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39500001072883606},{"id":"https://openalex.org/C2781166303","wikidata":"https://www.wikidata.org/wiki/Q17635591","display_name":"Plasmablastic lymphoma","level":3,"score":0.3334999978542328},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32109999656677246},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.3181999921798706},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3156000077724457},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.29980000853538513},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.29249998927116394},{"id":"https://openalex.org/C2779419017","wikidata":"https://www.wikidata.org/wiki/Q180569","display_name":"Tonsil","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C200180986","wikidata":"https://www.wikidata.org/wiki/Q3269473","display_name":"Naive B cell","level":5,"score":0.27570000290870667},{"id":"https://openalex.org/C2778847070","wikidata":"https://www.wikidata.org/wiki/Q389837","display_name":"Gammaherpesvirinae","level":5,"score":0.2718999981880188},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2703000009059906},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.2531999945640564},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.25}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014763","descriptor_name":"Viral Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018858","descriptor_name":"Germinal Center","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D020031","descriptor_name":"Epstein-Barr Virus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.2525164123","doi":"https://doi.org/10.1073/pnas.2525164123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2525164123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:42189985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42189985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13229203","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42189985/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1073/pnas.2525164123","doi":"https://doi.org/10.1073/pnas.2525164123","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2525164123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000102042","display_name":null,"funder_award_id":"R01CA281379","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000223128","display_name":null,"funder_award_id":"P01-CA022443","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000911995","display_name":"Roles of LMP1 and MYC in EBV-induced B-cell tumors","funder_award_id":"U01CA284614","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1896063886","https://openalex.org/W1969998568","https://openalex.org/W1974010997","https://openalex.org/W1976028093","https://openalex.org/W1977620605","https://openalex.org/W1981807499","https://openalex.org/W2001777890","https://openalex.org/W2008994777","https://openalex.org/W2013212354","https://openalex.org/W2018443217","https://openalex.org/W2028943181","https://openalex.org/W2031061362","https://openalex.org/W2035585065","https://openalex.org/W2038295718","https://openalex.org/W2048549194","https://openalex.org/W2050672588","https://openalex.org/W2053644097","https://openalex.org/W2057379398","https://openalex.org/W2060749028","https://openalex.org/W2061905472","https://openalex.org/W2062440665","https://openalex.org/W2066624908","https://openalex.org/W2070255596","https://openalex.org/W2071743218","https://openalex.org/W2073989067","https://openalex.org/W2109848485","https://openalex.org/W2113741025","https://openalex.org/W2127198284","https://openalex.org/W2128715200","https://openalex.org/W2130081467","https://openalex.org/W2133029085","https://openalex.org/W2134517891","https://openalex.org/W2149254717","https://openalex.org/W2150330606","https://openalex.org/W2150644589","https://openalex.org/W2159147754","https://openalex.org/W2164492333","https://openalex.org/W2165371767","https://openalex.org/W2166043441","https://openalex.org/W2166324495","https://openalex.org/W2167681720","https://openalex.org/W2168332137","https://openalex.org/W2172006847","https://openalex.org/W2260507520","https://openalex.org/W2282745969","https://openalex.org/W2346243632","https://openalex.org/W2398456118","https://openalex.org/W2472578965","https://openalex.org/W2603029292","https://openalex.org/W2606869403","https://openalex.org/W2743895040","https://openalex.org/W2748665876","https://openalex.org/W2797584152","https://openalex.org/W2949465756","https://openalex.org/W2952387914","https://openalex.org/W2972436344","https://openalex.org/W3033000546","https://openalex.org/W3089577723","https://openalex.org/W3155878711","https://openalex.org/W3168774436","https://openalex.org/W3195024161","https://openalex.org/W4213258650","https://openalex.org/W4220707597","https://openalex.org/W4284683067","https://openalex.org/W4289886667","https://openalex.org/W4295921243","https://openalex.org/W4313574778","https://openalex.org/W4394727005","https://openalex.org/W4394805756","https://openalex.org/W4400362361","https://openalex.org/W4400745843","https://openalex.org/W4407385420","https://openalex.org/W4410479774"],"related_works":[],"abstract_inverted_index":{"EBV":[0,105,138],"is":[1,85,97],"associated":[2],"with":[3,135],"human":[4,107,128,154,191,238],"B":[5,14,37,74,91,109,131],"cell":[6,15,75],"lymphomas,":[7],"including":[8],"Burkitt":[9],"lymphomas":[10,16,19,23,26,55,112,148,165,240],"(BLs),":[11],"diffuse":[12],"large":[13],"(DLBCLs),":[17],"Hodgkin":[18],"(HLs),":[20],"and":[21,39,67,73,95,146,158,161,177,212,214,233],"Plasmablastic":[22],"(PLs).":[24],"EBV+":[25,54],"in":[27,93,113,115,149,167,182,189,209,218,236],"immunocompetent":[28],"humans":[29],"are":[30,60],"usually":[31],"derived":[32],"from":[33],"germinal":[34],"center":[35],"(GC)-experienced":[36],"cells":[38,92,110,132],"have":[40,174],"stringent":[41],"latency":[42],"forms":[43],"that":[44,56,127,152,199,241],"do":[45,178],"not":[46,179],"express":[47],"the":[48,64,116,168],"viral":[49,65,232],"transforming":[50],"protein,":[51],"EBNA2.":[52],"Human":[53],"lack":[57,242],"EBNA2":[58,84,119,243],"expression":[59,120,205],"largely":[61],"driven":[62],"by":[63,80],"LMP1":[66],"LMP2A":[68,200],"proteins,":[69],"which":[70],"activate":[71],"NF-\u03baB":[72],"receptor-like":[76],"signaling,":[77],"respectively,":[78],"or":[79,121],"Myc":[81,122,171],"translocations.":[82],"However,":[83],"required":[86],"for":[87,102],"EBV-mediated":[88],"transformation":[89],"of":[90,118,170,206,231],"vitro":[94],"there":[96],"currently":[98],"no":[99],"model":[100,195,222],"system":[101,223],"studying":[103],"how":[104],"transforms":[106],"GC-derived":[108],"into":[111],"vivo":[114],"absence":[117,169],"translocation.":[123],"Here,":[124],"we":[125,197],"show":[126,198],"tonsil":[129],"GC":[130],"(GCBs)":[133],"infected":[134],"an":[136],"EBNA2-deleted":[137],"mutant":[139],"proliferate":[140],"on":[141],"a":[142],"CD40L/IL21-expressing":[143],"feeder":[144],"layer":[145],"form":[147],"NSG":[150],"mice":[151],"resemble":[153],"DLBCLs":[155],"(both":[156],"ABC":[157],"GCB":[159],"subtypes)":[160],"PLs.":[162],"These":[163],"EBV-induced":[164,237],"occur":[166],"overexpression,":[172],"often":[173],"normal":[175],"karyotypes,":[176],"contain":[180],"mutations":[181],"cellular":[183,234],"genes":[184,207],"(including":[185],"p53)":[186],"commonly":[187],"mutated":[188],"uninfected":[190],"DLBCLs.":[192],"Using":[193],"this":[194],"system,":[196],"induces":[201],"plasmablast":[202],"differentiation,":[203],"increases":[204],"involved":[208],"lymphocyte":[210],"mobility":[211],"trafficking":[213],"enhances":[215],"tumor":[216],"invasiveness":[217],"vivo.":[219],"This":[220],"new":[221],"can":[224],"thus":[225],"be":[226],"used":[227],"to":[228],"define":[229],"roles":[230],"proteins":[235],"GCB-derived":[239],"expression.":[244]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2026-05-27T00:00:00"}