{"id":"https://openalex.org/W7162268366","doi":null,"title":"Effects of EnXtra\u00ae (Alpinia galanga Extract) and EnXtra\u00ae + Caffeine Combination on Mental Alertness and Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study","display_name":"Effects of EnXtra\u00ae (Alpinia galanga Extract) and EnXtra\u00ae + Caffeine Combination on Mental Alertness and Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study","publication_year":2026,"publication_date":"2026-05-23","ids":{"openalex":"https://openalex.org/W7162268366"},"language":"en","primary_location":{"id":"pmh:oai:dovepress.com/115537","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/effects-of-enxtra-alpinia-galanga-extract-and-enxtra--caffeine-combina-peer-reviewed-fulltext-article-OAJCT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Clinical Trial Report"},"volume":null,"type":"report","is_traditional":false,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.dovepress.com/effects-of-enxtra-alpinia-galanga-extract-and-enxtra--caffeine-combina-peer-reviewed-fulltext-article-OAJCT","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136767140","display_name":"Kiran Pandit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pandit,Kiran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136548918","display_name":"Rajesh R. Patil","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patil,Rajesh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013345758","display_name":"Abhijeet Ashok Morde","orcid":"https://orcid.org/0000-0003-1575-9071","observed_orcids":["https://orcid.org/0000-0003-1575-9071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morde,Abhijeet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044323432","display_name":"Paras Patni","orcid":"https://orcid.org/0000-0003-4648-906X","observed_orcids":["https://orcid.org/0000-0003-4648-906X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patni,Paras","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112620627","display_name":"Sanjay Vaze","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vaze,Sanjay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5136793862","display_name":"Poonam Gotal","orcid":"https://orcid.org/0009-0001-3468-0169","observed_orcids":["https://orcid.org/0009-0001-3468-0169"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gotal,Poonam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.5565999746322632,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12347","display_name":"Ginger and Zingiberaceae research","score":0.19030000269412994,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13651","display_name":"Medicinal Plants and Bioactive Compounds","score":0.1468999981880188,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.9649999737739563},{"id":"https://openalex.org/keywords/mental-alertness","display_name":"mental alertness","score":0.8560000061988831},{"id":"https://openalex.org/keywords/fatigue","display_name":"fatigue","score":0.9729999899864197},{"id":"https://openalex.org/keywords/sleep-restriction","display_name":"sleep restriction","score":0.6729999780654907},{"id":"https://openalex.org/keywords/cognitive-performance","display_name":"cognitive performance","score":0.6039999723434448},{"id":"https://openalex.org/keywords/sustained-attention","display_name":"sustained attention","score":0.8870000243186951},{"id":"https://openalex.org/keywords/psychomotor-function","display_name":"psychomotor performance","score":0.8870000243186951},{"id":"https://openalex.org/keywords/continuous-performance-test","display_name":"continuous performance test","score":0.640999972820282},{"id":"https://openalex.org/keywords/nine-hole-peg-test","display_name":"Nine-Hole Peg Test","score":0.9549999833106995},{"id":"https://openalex.org/keywords/herbal-supplements","display_name":"herbal supplements","score":0.3019999861717224},{"id":"https://openalex.org/keywords/healthy-adults","display_name":"healthy adults","score":0.6579999923706055},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.8048999905586243},{"id":"https://openalex.org/C200678441","wikidata":"https://www.wikidata.org/wiki/Q1423044","display_name":"Alertness","level":2,"score":0.7944999933242798},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6367999911308289},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.6186000108718872},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.5676000118255615},{"id":"https://openalex.org/C164953862","wikidata":"https://www.wikidata.org/wiki/Q7256440","display_name":"Psychomotor learning","level":3,"score":0.5092999935150146},{"id":"https://openalex.org/C2982735371","wikidata":"https://www.wikidata.org/wiki/Q9690","display_name":"Mental fatigue","level":2,"score":0.46970000863075256},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.3734999895095825},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3727000057697296},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.35910001397132874},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3562000095844269},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.3490999937057495},{"id":"https://openalex.org/C134362201","wikidata":"https://www.wikidata.org/wiki/Q317309","display_name":"Mental health","level":2,"score":0.3425999879837036},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.32269999384880066},{"id":"https://openalex.org/C3018541476","wikidata":"https://www.wikidata.org/wiki/Q6206740","display_name":"Work performance","level":2,"score":0.322299987077713},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.30550000071525574},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2766000032424927},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.26510000228881836},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.26109999418258667},{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.2603999972343445}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:dovepress.com/115537","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/effects-of-enxtra-alpinia-galanga-extract-and-enxtra--caffeine-combina-peer-reviewed-fulltext-article-OAJCT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Clinical Trial Report"}],"best_oa_location":{"id":"pmh:oai:dovepress.com/115537","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/effects-of-enxtra-alpinia-galanga-extract-and-enxtra--caffeine-combina-peer-reviewed-fulltext-article-OAJCT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Clinical Trial Report"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388980542","https://openalex.org/W2755450305","https://openalex.org/W4404872381","https://openalex.org/W4380261067","https://openalex.org/W2006260962","https://openalex.org/W3025407911","https://openalex.org/W2904442812","https://openalex.org/W3118871604","https://openalex.org/W2093184001","https://openalex.org/W2403968453"],"abstract_inverted_index":{"Kiran":[0],"Dattatray":[1],"Pandit,1,*":[2],"Rajesh":[3],"Eknath":[4],"Patil,2,*":[5],"Abhijeet":[6,77],"Ashok":[7,78],"Morde,3,*":[8],"Paras":[9],"Pravin":[10],"Patni,3,*":[11],"Sanjay":[12],"Vishnu":[13],"Vaze,4,*":[14],"Poonam":[15],"Shrikant":[16],"Gotal5,*":[17],"1Department":[18],"of":[19,28,49,60,112,149,179],"General":[20,29],"Medicine,":[21,30],"Gurukrupa":[22],"Hospital,":[23,34],"Thane,":[24],"Maharashtra,":[25,37,46,57,69,98],"India;":[26,38,47,58],"2Department":[27],"New":[31],"Manak":[32],"Healthcare":[33],"Navi":[35],"Mumbai,":[36,45,56,68,97],"3Research":[39],"&":[40,81],"Development,":[41,51,82],"OmniActive":[42,83],"Health":[43,84],"Technologies,":[44,85],"4Department":[48],"Clinical":[50],"Vedic":[52,64],"Lifesciences":[53,65],"Pvt.":[54,66],"Ltd.,":[55,67],"5Department":[59],"Science":[61],"and":[62,110,119,127,136,141,157,237,248,265,270,315,338,365,391],"Communication,":[63],"India*These":[70],"authors":[71],"contributed":[72],"equally":[73],"to":[74],"this":[75],"workCorrespondence:":[76],"Morde,":[79],"Research":[80],"Technology":[86],"Center,":[87],"First":[88],"Floor,":[89],"A-10,":[90],"Road":[91],"1,":[92,246],"Wagle":[93],"Estate,":[94],"Thane":[95],"West,":[96],"400604,":[99],"India,":[100],"Tel":[101],"+91":[102],"9594096454,":[103],"Email":[104],"a.morde@omniactives.comPurpose:":[105],"To":[106],"evaluate":[107],"the":[108,166,180,212,357],"efficacy":[109],"safety":[111,238,403],"EnXtra\u00ae":[113],"(Alpinia":[114],"galanga":[115,184,192,274,312,346,380],"extract)":[116],"alone,":[117],"caffeine":[118,123,175,188,197,360,414],"its":[120],"combination":[121,290,317],"with":[122,173,283,298,310,318,320,325,344,372,385,398],"on":[124,255],"mental":[125,208,389,412],"alertness":[126,209,281,296,364,390],"fatigue":[128,222,305,366,393,418],"in":[129,252,280,295,300,304,316,334,363,405],"healthy":[130,406],"sleep-restricted":[131],"adults":[132],"through":[133],"acute":[134,153,269],"single-dose":[135],"sub-acute":[137,159,271,358],"28-day":[138,160],"supplementation":[139],"protocols.Patients":[140],"Methods:":[142],"This":[143],"randomized,":[144],"double-blind,":[145],"placebo-controlled":[146],"study":[147],"consisted":[148],"two":[150],"stages:":[151],"an":[152],"crossover":[154],"design":[155,162],"(n=128)":[156],"a":[158],"parallel":[161],"(n=127).":[163],"In":[164,267,356],"both":[165,268,399],"stages,":[167],"participants":[168],"aged":[169],"18\u2013":[170],"40":[171],"years":[172],"habitual":[174],"intake":[176],"received":[177],"one":[178],"following":[181],"interventions:":[182],"A.":[183,191,273,311,345],"extract":[185,193,275,313],"(300":[186,194,202],"mg),":[187,190,199],"(200":[189,198],"mg)":[195],"+":[196],"or":[200,383],"placebo":[201,284,299,326],"mg).":[203],"The":[204,289],"primary":[205],"outcome":[206],"was":[207],"evaluated":[210],"using":[211],"Jin":[213],"Fan":[214],"Attention":[215],"Network":[216],"Test":[217],"(ANT).":[218],"Secondary":[219],"outcomes":[220],"included":[221],"(Samn-Perelli":[223],"Fatigue":[224],"Scale":[225],"(SPS)),":[226],"psychomotor":[227,335],"performance":[228,336],"(Nine-Hole":[229],"Peg":[230],"Test),":[231,236],"sustained":[232,339],"attention":[233,340],"(Continuous":[234],"Performance":[235],"parameters.":[239],"Cognitive":[240],"assessments":[241],"were":[242,307,342,351],"performed":[243],"at":[244,285,327,368,375],"0,":[245,260],"3,":[247],"5":[249],"hours":[250],"post-dose":[251],"controlled":[253],"environments":[254],"each":[256],"scheduled":[257],"visit":[258],"(Days":[259],"5,":[261],"10,":[262],"15,":[263],"20,":[264],"48).Results:":[266],"phases,":[272],"showed":[276,361],"statistically":[277,321,354],"significant":[278,322],"improvements":[279,294,333,362],"compared":[282,297,324],"selected":[286],"time":[287,329,377],"points.":[288,330],"group":[291],"demonstrated":[292],"greater":[293],"several":[301],"assessments.":[302],"Improvements":[303],"scores":[306],"also":[308],"observed":[309,343],"alone":[314,382],"caffeine,":[319,386,411],"reductions":[323],"certain":[328],"Trends":[331],"toward":[332],"(NHPT)":[337],"(CPT)":[341],"extract,":[347,381],"although":[348],"these":[349],"changes":[350],"not":[352],"consistently":[353],"significant.":[355],"phase,":[359],"primarily":[367],"1":[369],"hour":[370],"post-dose,":[371],"limited":[373],"effects":[374],"later":[376],"points.Conclusion:":[378],"Alpinia":[379,408],"combined":[384],"significantly":[387],"improved":[388],"reduced":[392],"without":[394],"caffeine-associated":[395],"rebound":[396],"effects,":[397],"interventions":[400],"showing":[401],"good":[402],"profiles":[404],"adults.Keywords:":[407],"galanga,":[409],"EnXtra\u00ae,":[410],"alertness,":[413],"crash,":[415],"cognitive":[416],"enhancement,":[417]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-05-25T00:00:00"}