{"id":"https://openalex.org/W7162241981","doi":"https://doi.org/10.32383/appdr/217669","title":"SIRT1 Attenuates Oxyhemoglobin-Induced Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Neuronal Cells","display_name":"SIRT1 Attenuates Oxyhemoglobin-Induced Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Neuronal Cells","publication_year":2026,"publication_date":"2026-05-21","ids":{"openalex":"https://openalex.org/W7162241981","doi":"https://doi.org/10.32383/appdr/217669"},"language":"en","primary_location":{"id":"doi:10.32383/appdr/217669","doi":"https://doi.org/10.32383/appdr/217669","is_oa":true,"landing_page_url":"https://doi.org/10.32383/appdr/217669","pdf_url":"https://doi.org/10.32383/appdr/217669","source":{"id":"https://openalex.org/S157208032","display_name":"Acta Poloniae Pharmaceutica - Drug Research","issn_l":"0001-6837","issn":["0001-6837","2353-5288"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4322807899","host_organization_name":"Polish Pharmaceutical Society","host_organization_lineage":["https://openalex.org/P4322807899"],"host_organization_lineage_names":["Polish Pharmaceutical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Poloniae Pharmaceutica - Drug Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.32383/appdr/217669","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136890162","display_name":"Yuanyuan Shen","orcid":"https://orcid.org/0009-0008-2887-4064","observed_orcids":["https://orcid.org/0009-0008-2887-4064"]},"institutions":[{"id":"https://openalex.org/I4387152107","display_name":"Baoding No.1 Central Hospital","ror":"https://ror.org/022nvaw58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387152107"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Shen","raw_affiliation_strings":["Department of Neurosurgery, Cerebrovascular and Spinal Cord Disease , First Central Hospital of Baoding City , Baoding 071000 , China"],"raw_orcid":"https://orcid.org/0009-0008-2887-4064","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Cerebrovascular and Spinal Cord Disease , First Central Hospital of Baoding City , Baoding 071000 , China","institution_ids":["https://openalex.org/I4387152107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133917366","display_name":"Min Ge","orcid":"https://orcid.org/0009-0003-5390-3975","observed_orcids":["https://orcid.org/0009-0003-5390-3975"]},"institutions":[{"id":"https://openalex.org/I4387152107","display_name":"Baoding No.1 Central Hospital","ror":"https://ror.org/022nvaw58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387152107"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Ge","raw_affiliation_strings":["Department of Neurosurgery, Cerebrovascular and Spinal Cord Disease , First Central Hospital of Baoding City , Baoding 071000 , China"],"raw_orcid":"https://orcid.org/0009-0003-5390-3975","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Cerebrovascular and Spinal Cord Disease , First Central Hospital of Baoding City , Baoding 071000 , China","institution_ids":["https://openalex.org/I4387152107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136876329","display_name":"Meiqi Li","orcid":"https://orcid.org/0009-0007-3155-1891","observed_orcids":["https://orcid.org/0009-0007-3155-1891"]},"institutions":[{"id":"https://openalex.org/I4387152107","display_name":"Baoding No.1 Central Hospital","ror":"https://ror.org/022nvaw58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387152107"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiqi Li","raw_affiliation_strings":["Functional Neurosurgery , First Central Hospital of Baoding City , Baoding 071000 , China"],"raw_orcid":"https://orcid.org/0009-0007-3155-1891","affiliations":[{"raw_affiliation_string":"Functional Neurosurgery , First Central Hospital of Baoding City , Baoding 071000 , China","institution_ids":["https://openalex.org/I4387152107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136883312","display_name":"Fan Wang","orcid":"https://orcid.org/0009-0004-8603-2472","observed_orcids":["https://orcid.org/0009-0004-8603-2472"]},"institutions":[{"id":"https://openalex.org/I4387152107","display_name":"Baoding No.1 Central Hospital","ror":"https://ror.org/022nvaw58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387152107"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Wang","raw_affiliation_strings":["Functional Neurosurgery , First Central Hospital of Baoding City , Baoding 071000 , China","Neurosurgery and Oncology Department , First Central Hospital of Baoding City , Baoding 071000 , China"],"raw_orcid":"https://orcid.org/0009-0004-8603-2472","affiliations":[{"raw_affiliation_string":"Functional Neurosurgery , First Central Hospital of Baoding City , Baoding 071000 , China","institution_ids":["https://openalex.org/I4387152107"]},{"raw_affiliation_string":"Neurosurgery and Oncology Department , First Central Hospital of Baoding City , Baoding 071000 , China","institution_ids":["https://openalex.org/I4387152107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136894503","display_name":"Nan Tian","orcid":"https://orcid.org/0009-0000-8714-1591","observed_orcids":["https://orcid.org/0009-0000-8714-1591"]},"institutions":[{"id":"https://openalex.org/I4387152107","display_name":"Baoding No.1 Central Hospital","ror":"https://ror.org/022nvaw58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387152107"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Tian","raw_affiliation_strings":["Functional Neurosurgery , First Central Hospital of Baoding City , Baoding 071000 , China"],"raw_orcid":"https://orcid.org/0009-0000-8714-1591","affiliations":[{"raw_affiliation_string":"Functional Neurosurgery , First Central Hospital of Baoding City , Baoding 071000 , China","institution_ids":["https://openalex.org/I4387152107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5136875240","display_name":"Ning Gan","orcid":"https://orcid.org/0009-0003-3070-464X","observed_orcids":["https://orcid.org/0009-0003-3070-464X"]},"institutions":[{"id":"https://openalex.org/I4387152107","display_name":"Baoding No.1 Central Hospital","ror":"https://ror.org/022nvaw58","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4387152107"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Gan","raw_affiliation_strings":["Functional Neurosurgery , First Central Hospital of Baoding City , Baoding 071000 , China"],"raw_orcid":"https://orcid.org/0009-0003-3070-464X","affiliations":[{"raw_affiliation_string":"Functional Neurosurgery , First Central Hospital of Baoding City , Baoding 071000 , China","institution_ids":["https://openalex.org/I4387152107"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4387152107"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"82","issue":"6","first_page":"883","last_page":"893"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/oxyhemoglobin","display_name":"oxyhemoglobin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/subarachnoid-hemorrhage","display_name":"subarachnoid hemorrhage","score":0.9210000038146973},{"id":"https://openalex.org/keywords/early-brain-injury","display_name":"early brain injury","score":0.9440000057220459},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9150000214576721},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.925000011920929},{"id":"https://openalex.org/keywords/ex527","display_name":"EX527","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nrf2-ho-1-signaling-pathway","display_name":"Nrf2/HO-1 pathway","score":0.9779999852180481},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9660000205039978},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9520000219345093},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.8029999732971191},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.75},{"id":"https://openalex.org/keywords/bax-bcl-2-ratio","display_name":"Bax/Bcl-2 ratio","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7540000081062317},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.8259999752044678},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6445000171661377},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.6425999999046326},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5964999794960022},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.593999981880188},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5593000054359436},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4864000082015991},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.48489999771118164},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4839000105857849},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47999998927116394},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.47189998626708984},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.427700012922287},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.41929998993873596},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4133000075817108},{"id":"https://openalex.org/C2776536020","wikidata":"https://www.wikidata.org/wiki/Q21113719","display_name":"Sirtuin 1","level":4,"score":0.39480000734329224},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.39169999957084656},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.3797999918460846},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3659000098705292},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.3176000118255615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3068000078201294},{"id":"https://openalex.org/C138488276","wikidata":"https://www.wikidata.org/wiki/Q18037158","display_name":"SIRT3","level":5,"score":0.3001999855041504},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.299699991941452},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.2847999930381775},{"id":"https://openalex.org/C2780369685","wikidata":"https://www.wikidata.org/wiki/Q5058184","display_name":"Cell damage","level":2,"score":0.2809000015258789},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2718999981880188},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.2590000033378601}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.32383/appdr/217669","doi":"https://doi.org/10.32383/appdr/217669","is_oa":true,"landing_page_url":"https://doi.org/10.32383/appdr/217669","pdf_url":"https://doi.org/10.32383/appdr/217669","source":{"id":"https://openalex.org/S157208032","display_name":"Acta Poloniae Pharmaceutica - Drug Research","issn_l":"0001-6837","issn":["0001-6837","2353-5288"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4322807899","host_organization_name":"Polish Pharmaceutical Society","host_organization_lineage":["https://openalex.org/P4322807899"],"host_organization_lineage_names":["Polish Pharmaceutical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Poloniae Pharmaceutica - Drug Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.32383/appdr/217669","doi":"https://doi.org/10.32383/appdr/217669","is_oa":true,"landing_page_url":"https://doi.org/10.32383/appdr/217669","pdf_url":"https://doi.org/10.32383/appdr/217669","source":{"id":"https://openalex.org/S157208032","display_name":"Acta Poloniae Pharmaceutica - Drug Research","issn_l":"0001-6837","issn":["0001-6837","2353-5288"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4322807899","host_organization_name":"Polish Pharmaceutical Society","host_organization_lineage":["https://openalex.org/P4322807899"],"host_organization_lineage_names":["Polish Pharmaceutical Society"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Poloniae Pharmaceutica - Drug Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7162241981.pdf","grobid_xml":"https://content.openalex.org/works/W7162241981.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1541649582","https://openalex.org/W1977334935","https://openalex.org/W2002967368","https://openalex.org/W2046926560","https://openalex.org/W2068005545","https://openalex.org/W2079132836","https://openalex.org/W2173405372","https://openalex.org/W2520731555","https://openalex.org/W2801638873","https://openalex.org/W2941615517","https://openalex.org/W2946491117","https://openalex.org/W2970844985","https://openalex.org/W2987888180","https://openalex.org/W3090668231","https://openalex.org/W3093934852","https://openalex.org/W3103038563","https://openalex.org/W3113272791","https://openalex.org/W4304756319","https://openalex.org/W4311863315","https://openalex.org/W4323035237","https://openalex.org/W4366281541","https://openalex.org/W4411192949"],"related_works":["https://openalex.org/W2531094084","https://openalex.org/W4382405147","https://openalex.org/W4311030974","https://openalex.org/W2921053000","https://openalex.org/W4393269756","https://openalex.org/W3037269854","https://openalex.org/W4283273964","https://openalex.org/W6939778967","https://openalex.org/W4393090371","https://openalex.org/W2560724564"],"abstract_inverted_index":{"Early":[0],"brain":[1,65,227],"injury":[2,57,66,228],"after":[3,229],"aneurysmal":[4],"subarachnoid":[5,24],"hemorrhage":[6],"(SAH)":[7],"is":[8,42,206],"driven":[9],"by":[10,70,165],"exposure":[11,129],"of":[12,99,157,210],"cortical":[13],"neurons":[14],"to":[15,36,75,213],"oxyhemoglobin":[16],"(OxyHb)":[17],"released":[18],"from":[19],"lysed":[20],"blood":[21],"in":[22,54,62,241],"the":[23],"space,":[25],"triggering":[26],"oxidative":[27,138],"stress,":[28,139],"mitochondrial":[29,90,167],"dysfunction,":[30],"inflammation,":[31],"and":[32,48,97,108,126,134,143,146,152,179,197,215],"apoptosis":[33],"that":[34,204,216],"contribute":[35],"poor":[37],"neurological":[38],"outcomes.":[39],"Sirtuin-1":[40],"(SIRT1)":[41],"a":[43,207],"NAD\u207a-dependent":[44],"deacetylase":[45],"with":[46,82,86,159,190],"antioxidant":[47,170],"anti-apoptotic":[49],"properties,":[50],"but":[51],"its":[52,232],"role":[53],"OxyHb-mediated":[55],"neuronal":[56,73,132,211],"remains":[58],"incompletely":[59],"defined.":[60],"An":[61],"vitro":[63],"early":[64,226],"model":[67],"was":[68,79],"established":[69],"exposing":[71],"SH-SY5Y":[72],"cells":[74],"OxyHb.":[76],"SIRT1":[77,151,158,188,205,217],"activity":[78],"pharmacologically":[80],"enhanced":[81],"resveratrol":[83,160],"or":[84],"inhibited":[85],"EX-527.":[87],"Neuronal":[88],"viability,":[89],"ATP":[91,118,135],"content,":[92],"reactive":[93],"oxygen":[94],"species":[95],"generation,":[96],"expression":[98],"SIRT1,":[100],"Nrf2/HO-1,":[101],"NF-\u03baB":[102,141],"p65,":[103],"Bax,":[104],"Bcl-2,":[105],"cleaved":[106],"caspase-3,":[107],"inflammatory":[109],"cytokines":[110],"(TNF-\u03b1,":[111],"IL-6)":[112],"were":[113],"assessed":[114],"using":[115],"MTT":[116],"assay,":[117],"luminescence,":[119],"DCFDA":[120],"fluorescence,":[121],"Western":[122],"blotting,":[123],"quantitative":[124],"PCR,":[125],"microscopy.":[127],"OxyHb":[128,214],"significantly":[130],"reduced":[131],"viability":[133],"levels,":[136],"increased":[137],"activated":[140],"signaling,":[142],"promoted":[144],"pro-inflammatory":[145],"pro-apoptotic":[147],"pathways":[148],"while":[149],"suppressing":[150,175],"Nrf2/HO-1":[153],"expression.":[154],"Pharmacological":[155],"activation":[156,218],"partially":[161],"reversed":[162],"these":[163,201],"effects":[164],"restoring":[166],"bioenergetics,":[168],"enhancing":[169],"defenses,":[171],"reducing":[172],"ROS":[173],"accumulation,":[174],"NF-\u03baB\u2013dependent":[176],"cytokine":[177],"expression,":[178],"shifting":[180],"apoptotic":[181,198],"signaling":[182],"toward":[183],"cell":[184],"survival.":[185],"In":[186],"contrast,":[187],"inhibition":[189],"EX-527":[191],"aggravated":[192],"OxyHb-induced":[193],"oxidative,":[194],"mitochondrial,":[195],"inflammatory,":[196],"injury.":[199],"Overall,":[200],"findings":[202],"demonstrate":[203],"central":[208],"regulator":[209],"responses":[212],"confers":[219],"protection":[220],"against":[221],"key":[222],"pathological":[223],"processes":[224],"underlying":[225],"SAH,":[230],"supporting":[231],"potential":[233],"as":[234],"an":[235],"adjunctive":[236],"therapeutic":[237],"target.":[238],"Further":[239],"validation":[240],"vivo":[242],"may":[243],"clarify":[244],"translational":[245],"relevance":[246],"for":[247],"clinical":[248],"application.":[249]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-05-25T00:00:00"}