{"id":"https://openalex.org/W7162033264","doi":"https://doi.org/10.64898/2026.05.19.726387","title":"Artificial Reactivation of a Cocaine-Associated Ensemble in the Dorsal Dentate Gyrus Attenuates Cocaine Prime-Induced Reinstatement of Conditioned Place Preference","display_name":"Artificial Reactivation of a Cocaine-Associated Ensemble in the Dorsal Dentate Gyrus Attenuates Cocaine Prime-Induced Reinstatement of Conditioned Place Preference","publication_year":2026,"publication_date":"2026-05-21","ids":{"openalex":"https://openalex.org/W7162033264","doi":"https://doi.org/10.64898/2026.05.19.726387"},"language":"en","primary_location":{"id":"doi:10.64898/2026.05.19.726387","doi":"https://doi.org/10.64898/2026.05.19.726387","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.19.726387","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/21/2026.05.19.726387.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/21/2026.05.19.726387.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136627898","display_name":"L Hazel Edwards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LH Edwards","raw_affiliation_strings":["Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136618848","display_name":"Lola Fay Papanikolaou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LF Papanikolaou","raw_affiliation_strings":["Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159986015","display_name":"MR Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MR Wilson","raw_affiliation_strings":["Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136697065","display_name":"Morgan V Brody","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MV Brody","raw_affiliation_strings":["Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136689926","display_name":"William F Wade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"WF Wade","raw_affiliation_strings":["Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135595267","display_name":"Mikayla Cutler","orcid":"https://orcid.org/0009-0008-5439-0856","observed_orcids":["https://orcid.org/0009-0008-5439-0856"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Culter","raw_affiliation_strings":["Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136648726","display_name":"Sonia A Arora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SA Arora","raw_affiliation_strings":["Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136645468","display_name":"Alexander Stratmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Stratmann","raw_affiliation_strings":["Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136702260","display_name":"Sofia Canuelas del Valle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Ca\u00f1uelas del Valle","raw_affiliation_strings":["Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032990821","display_name":"Stephanie L. Grella","orcid":"https://orcid.org/0000-0002-7828-4029","observed_orcids":["https://orcid.org/0000-0002-7828-4029"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"SL Grella","raw_affiliation_strings":["Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA"],"raw_orcid":"https://orcid.org/0000-0002-7828-4029","affiliations":[{"raw_affiliation_string":"Loyola University Chicago, Department of Psychology (Neuroscience Program), Chicago, IL, USA","institution_ids":["https://openalex.org/I1925986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032990821"],"corresponding_institution_ids":["https://openalex.org/I1925986"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.7261000275611877,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.7261000275611877,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.26030001044273376,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10918","display_name":"Memory Processes and Influences","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cocaine","display_name":"cocaine","score":0.753000020980835},{"id":"https://openalex.org/keywords/dorsal-dentate-gyrus","display_name":"dorsal dentate gyrus","score":0.8769999742507935},{"id":"https://openalex.org/keywords/reinstatement","display_name":"reinstatement","score":0.6399999856948853},{"id":"https://openalex.org/keywords/conditioned-place-preference","display_name":"conditioned place preference","score":0.9539999961853027},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.7990000247955322},{"id":"https://openalex.org/keywords/drug-seeking-behavior","display_name":"drug-seeking behavior","score":0.5230000019073486},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5789999961853027},{"id":"https://openalex.org/keywords/cocaine-sensitization","display_name":"cocaine sensitization","score":0.5609999895095825},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.6150000095367432},{"id":"https://openalex.org/keywords/context-memory","display_name":"contextual memory","score":0.6340000033378601},{"id":"https://openalex.org/keywords/extinction","display_name":"extinction","score":0.3479999899864197},{"id":"https://openalex.org/keywords/mice","display_name":"mice","score":0.3840000033378601},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.9589999914169312}],"concepts":[{"id":"https://openalex.org/C28093023","wikidata":"https://www.wikidata.org/wiki/Q175168","display_name":"Engram","level":2,"score":0.8003000020980835},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7554000020027161},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.7095999717712402},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6575000286102295},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.5710999965667725},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5241000056266785},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4921000003814697},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.46070000529289246},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.45910000801086426},{"id":"https://openalex.org/C35124327","wikidata":"https://www.wikidata.org/wiki/Q5159285","display_name":"Conditioned place preference","level":3,"score":0.44040000438690186},{"id":"https://openalex.org/C81444415","wikidata":"https://www.wikidata.org/wiki/Q7243535","display_name":"Priming (agriculture)","level":3,"score":0.41200000047683716},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.33629998564720154},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.31439998745918274},{"id":"https://openalex.org/C2777568134","wikidata":"https://www.wikidata.org/wiki/Q15321582","display_name":"DISC1","level":3,"score":0.3043000102043152},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.2906999886035919},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.26980000734329224},{"id":"https://openalex.org/C2909666625","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Impaired memory","level":3,"score":0.26980000734329224},{"id":"https://openalex.org/C47611674","wikidata":"https://www.wikidata.org/wiki/Q849491","display_name":"Neuroplasticity","level":2,"score":0.265500009059906},{"id":"https://openalex.org/C101991246","wikidata":"https://www.wikidata.org/wiki/Q5422078","display_name":"Extinction (optical mineralogy)","level":2,"score":0.25769999623298645},{"id":"https://openalex.org/C103709681","wikidata":"https://www.wikidata.org/wiki/Q1515727","display_name":"Psychopharmacology","level":2,"score":0.25519999861717224},{"id":"https://openalex.org/C67203356","wikidata":"https://www.wikidata.org/wiki/Q1321905","display_name":"Reinforcement","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C2779369059","wikidata":"https://www.wikidata.org/wiki/Q1758383","display_name":"Gyrus","level":2,"score":0.25220000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.05.19.726387","doi":"https://doi.org/10.64898/2026.05.19.726387","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.19.726387","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/21/2026.05.19.726387.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.05.19.726387","doi":"https://doi.org/10.64898/2026.05.19.726387","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.19.726387","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/21/2026.05.19.726387.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7162033264.pdf","grobid_xml":"https://content.openalex.org/works/W7162033264.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W286924975","https://openalex.org/W1563094024","https://openalex.org/W1847846307","https://openalex.org/W1962727914","https://openalex.org/W1987802538","https://openalex.org/W2026408461","https://openalex.org/W2036431766","https://openalex.org/W2040903782","https://openalex.org/W2044823814","https://openalex.org/W2055949337","https://openalex.org/W2068735847","https://openalex.org/W2072405525","https://openalex.org/W2074615095","https://openalex.org/W2082235945","https://openalex.org/W2093757762","https://openalex.org/W2111968444","https://openalex.org/W2153805137","https://openalex.org/W2248682259","https://openalex.org/W2467084212","https://openalex.org/W2529240153","https://openalex.org/W2614757465","https://openalex.org/W2900696043","https://openalex.org/W2903017345","https://openalex.org/W3090105988","https://openalex.org/W3134120952","https://openalex.org/W3195596417","https://openalex.org/W4213240119","https://openalex.org/W4295350489","https://openalex.org/W4381943580","https://openalex.org/W4391537811","https://openalex.org/W4402955916","https://openalex.org/W4407127398","https://openalex.org/W4414812825","https://openalex.org/W4414868044"],"related_works":["https://openalex.org/W2092921174","https://openalex.org/W1983038420","https://openalex.org/W2949219153","https://openalex.org/W2068735847","https://openalex.org/W2041675118","https://openalex.org/W4416455244","https://openalex.org/W2526703982","https://openalex.org/W2098304576","https://openalex.org/W2022742970","https://openalex.org/W2093084898"],"abstract_inverted_index":{"ABSTRACT":[0],"Relapse-prevention":[1],"strategies":[2],"aimed":[3],"at":[4],"reducing":[5,12],"relapse":[6],"following":[7],"abstinence":[8],"primarily":[9],"focus":[10],"on":[11,118],"cravings":[13],"that":[14,220,229,258,347],"lead":[15],"to":[16,25,104,128,241,283],"drug-seeking":[17],"triggered":[18],"by":[19],"stress,":[20],"drug-related":[21],"cues,":[22],"or":[23,62,204,226,296],"re-exposure":[24],"the":[26,160,172,218,294,325,341],"drug.":[27],"Because":[28],"addictive":[29],"drugs":[30],"form":[31,224],"persistent":[32],"associative":[33],"contextual":[34,222],"memories,":[35],"we":[36,48],"investigated":[37],"how":[38],"reactivation":[39,92,108,129,158,170,183,197,268],"of":[40,93,120,130,148,159,171,184,207,244,269,321],"cocaine-related":[41,95,150],"hippocampal":[42],"memories":[43,260],"influences":[44],"subsequent":[45,357],"drug-seeking.":[46,275],"Here,":[47],"tagged":[49,94,312,323,339],"dorsal":[50,285],"dentate":[51,286],"gyrus":[52,287],"(dDG)":[53,288],"memory":[54,246],"ensembles":[55,96,186,290,313,349],"involved":[56],"in":[57,68,192,300,337],"encoding":[58],"either":[59,293],"a":[60,75,100,149,301],"first":[61,161,295,326],"fourth":[63,173,297,342],"cocaine":[64,80,101,162,245,259,298,302,327,353],"exposure":[65,163,174,299,328],"(15mg/kg,":[66],"i.p)":[67],"male":[69],"and":[70,86,112,140,266,310],"female":[71],"c57BL/6":[72],"mice":[73],"using":[74],"TetTag":[76],"approach.":[77],"Mice":[78],"underwent":[79],"conditioned":[81,303],"place":[82,304],"preference":[83,305],"(CPP),":[84],"extinction,":[85,311],"reinstatement.":[87,167,319],"We":[88,123],"assessed":[89],"whether":[90,107],"optical":[91],"could":[97],"substitute":[98],"for":[99],"priming":[102],"injection":[103],"reinstate":[105,155],"CPP,":[106],"altered":[109],"cocaine-induced":[110,166,189],"reinstatement,":[111,330],"if":[113],"these":[114,126,255],"effects":[115,127,243],"differed":[116],"depending":[117],"stage":[119],"drug":[121,145,264],"exposure.":[122,343],"also":[124,187,237],"compared":[125],"saline-associated":[131,185],"ensembles.":[132],"Cocaine":[133],"produced":[134],"robust":[135],"locomotor":[136],"activation":[137],"during":[138,292,317,324,340,351],"conditioning":[139],"sensitization":[141],"developed":[142],"across":[143,263],"repeated":[144],"exposures.":[146],"Reactivation":[147,320],"engram":[151,164,175],"alone":[152],"did":[153,176],"not":[154,177,335],"CPP.":[156,253],"However,":[157],"attenuated":[165,329],"In":[168],"contrast,":[169],"confer":[178],"this":[179,249,332],"protective":[180],"effect.":[181],"Interestingly,":[182],"reduced":[188],"reinstatement":[190],"specifically":[191],"females,":[193],"suggesting":[194],"dDG":[195,270],"ensemble":[196],"may":[198],"modulate":[199],"relapse-related":[200],"behavior":[201],"through":[202],"interference":[203],"neuromodulatory":[205],"disruption":[206],"cocaine-associated":[208],"representations,":[209],"consistent":[210],"with":[211,231],"our":[212],"prior":[213],"work.":[214],"These":[215,344],"findings":[216,256,345],"raise":[217],"possibility":[219],"early":[221,352],"experiences":[223,354],"competing":[225],"destabilizing":[227],"representations":[228],"interfere":[230],"later":[232],"cocaine-seeking":[233,358],"when":[234],"reactivated.":[235],"Females":[236],"displayed":[238],"greater":[239],"sensitivity":[240],"locomotor-inducing":[242],"reactivation,":[247],"although":[248],"was":[250,281,334],"dissociated":[251],"from":[252],"Together,":[254],"show":[257],"are":[261],"distinct":[262],"experience":[265],"selective":[267],"engrams":[271],"can":[272,355],"differentially":[273],"influence":[274,356],"Graphical":[276],"Abstract":[277],"Text":[278],"Activity-dependent":[279],"tagging":[280],"used":[282],"label":[284],"neuronal":[289,348],"recruited":[291,350],"(CPP)":[306],"task.":[307],"Following":[308],"training":[309],"were":[314],"optogenetically":[315],"reactivated":[316],"cocaine-primed":[318],"neurons":[322],"whereas":[331],"effect":[333],"observed":[336],"animals":[338],"suggest":[346],"behavior.":[359]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-05-22T00:00:00"}
