{"id":"https://openalex.org/W7162017289","doi":"https://doi.org/10.3390/children13050677","title":"Therapeutic Targets for Pediatric Pulmonary Vein Stenosis: Insights from Animal Models","display_name":"Therapeutic Targets for Pediatric Pulmonary Vein Stenosis: Insights from Animal Models","publication_year":2026,"publication_date":"2026-05-14","ids":{"openalex":"https://openalex.org/W7162017289","doi":"https://doi.org/10.3390/children13050677","pmid":"https://pubmed.ncbi.nlm.nih.gov/42194203","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13204097"},"language":"en","primary_location":{"id":"doi:10.3390/children13050677","doi":"https://doi.org/10.3390/children13050677","is_oa":true,"landing_page_url":"https://doi.org/10.3390/children13050677","pdf_url":null,"source":{"id":"https://openalex.org/S2736895435","display_name":"Children","issn_l":"2227-9067","issn":["2227-9067"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Children","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/children13050677","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120569534","display_name":"Siqi She","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siqi She","raw_affiliation_strings":["Shanghai Institute For Pediatric Congenital Heart Disease , Shanghai Children's Medical Center , Shanghai Jiao Tong University School of Medicine , Shanghai , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute For Pediatric Congenital Heart Disease , Shanghai Children's Medical Center , Shanghai Jiao Tong University School of Medicine , Shanghai , China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101690190","display_name":"Debao Li","orcid":"https://orcid.org/0000-0002-1495-0942","observed_orcids":["https://orcid.org/0000-0002-1495-0942"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210159329","display_name":"Children's Hospital of Fudan University","ror":"https://ror.org/05n13be63","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Debao Li","raw_affiliation_strings":["Department of Pediatric Surgery , Children's Hospital of Fudan University , National Children's Medical Center , Shanghai , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Surgery , Children's Hospital of Fudan University , National Children's Medical Center , Shanghai , China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210159329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133986474","display_name":"Qi Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Sun","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery , Shanghai Children's Medical Center , Shanghai Jiao Tong University School of Medicine , Shanghai , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery , Shanghai Children's Medical Center , Shanghai Jiao Tong University School of Medicine , Shanghai , China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078455039","display_name":"Lincai Ye","orcid":"https://orcid.org/0000-0001-8808-2810","observed_orcids":["https://orcid.org/0000-0001-8808-2810"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lincai Ye","raw_affiliation_strings":["Institute of Pediatric Translational Medicine , Shanghai Children's Medical Center , Shanghai Jiao Tong University School of Medicine , Shanghai , China","Shanghai Institute For Pediatric Congenital Heart Disease , Shanghai Children's Medical Center , Shanghai Jiao Tong University School of Medicine , Shanghai , China"],"raw_orcid":"https://orcid.org/0000-0001-8808-2810","affiliations":[{"raw_affiliation_string":"Institute of Pediatric Translational Medicine , Shanghai Children's Medical Center , Shanghai Jiao Tong University School of Medicine , Shanghai , China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]},{"raw_affiliation_string":"Shanghai Institute For Pediatric Congenital Heart Disease , Shanghai Children's Medical Center , Shanghai Jiao Tong University School of Medicine , Shanghai , China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5078455039"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2896},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2896},"fwci":2.281,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.8131677,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"13","issue":"5","first_page":"677","last_page":"677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10300","display_name":"Congenital Heart Disease Studies","score":0.014800000004470348,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-vein-stenosis","display_name":"pulmonary vein stenosis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pediatric-pulmonary-hypertension","display_name":"pediatric pulmonary hypertension","score":0.6840000152587891},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.6650000214576721},{"id":"https://openalex.org/keywords/rodent-models","display_name":"rodent models","score":0.6800000071525574},{"id":"https://openalex.org/keywords/neonatal-rat-model","display_name":"neonatal rat model","score":0.7820000052452087},{"id":"https://openalex.org/keywords/neointimal-hyperplasia","display_name":"intimal hyperplasia","score":0.8870000243186951},{"id":"https://openalex.org/keywords/restenosis","display_name":"restenosis","score":0.7879999876022339},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.9639999866485596},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.8339999914169312},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.8989999890327454},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9629999995231628},{"id":"https://openalex.org/keywords/fibroblast-activation-protein","display_name":"fibroblast activation protein","score":0.906000018119812},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.7720000147819519},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6539999842643738},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7167999744415283},{"id":"https://openalex.org/C2780206163","wikidata":"https://www.wikidata.org/wiki/Q25324124","display_name":"Pulmonary vein stenosis","level":4,"score":0.614300012588501},{"id":"https://openalex.org/C2778283817","wikidata":"https://www.wikidata.org/wiki/Q6590597","display_name":"Restenosis","level":3,"score":0.6018999814987183},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.46219998598098755},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4490000009536743},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.4422000050544739},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4401000142097473},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.43959999084472656},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.43369999527931213},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.42649999260902405},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.40529999136924744},{"id":"https://openalex.org/C2780689522","wikidata":"https://www.wikidata.org/wiki/Q535352","display_name":"Pulmonary vein","level":3,"score":0.39309999346733093},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.39250001311302185},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.3815000057220459},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.37529999017715454},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.3709999918937683},{"id":"https://openalex.org/C207865475","wikidata":"https://www.wikidata.org/wiki/Q1467330","display_name":"Myofibroblast","level":3,"score":0.34709998965263367},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.3149999976158142},{"id":"https://openalex.org/C520753416","wikidata":"https://www.wikidata.org/wiki/Q38344","display_name":"Animal testing","level":2,"score":0.3140999972820282},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.310699999332428},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.30869999527931213},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.30550000071525574},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.30399999022483826},{"id":"https://openalex.org/C162264550","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Translational medicine","level":2,"score":0.30239999294281006},{"id":"https://openalex.org/C2778667336","wikidata":"https://www.wikidata.org/wiki/Q3973118","display_name":"Pulmonic stenosis","level":3,"score":0.28679999709129333},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27959999442100525},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27469998598098755},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.26829999685287476},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C3018605307","wikidata":"https://www.wikidata.org/wiki/Q200779","display_name":"Complex disease","level":3,"score":0.2581999897956848},{"id":"https://openalex.org/C2779751240","wikidata":"https://www.wikidata.org/wiki/Q16909635","display_name":"Intimal hyperplasia","level":3,"score":0.25780001282691956}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/children13050677","doi":"https://doi.org/10.3390/children13050677","is_oa":true,"landing_page_url":"https://doi.org/10.3390/children13050677","pdf_url":null,"source":{"id":"https://openalex.org/S2736895435","display_name":"Children","issn_l":"2227-9067","issn":["2227-9067"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Children","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202604.1016.v1","doi":"https://doi.org/10.20944/preprints202604.1016.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202604.1016.v1","pdf_url":"https://www.preprints.org/frontend/manuscript/92f3dabffa4297eaa411e82402d403de/download_pub","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13204097","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13204097/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13204097/pdf/children-13-00677.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Children (Basel)","raw_type":"Text"},{"id":"pmid:42194203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42194203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Children (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:c86e03170ebc40fb9382f38e1a9a6663","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c86e03170ebc40fb9382f38e1a9a6663","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Children, Vol 13, Iss 5, p 677 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/children13050677","doi":"https://doi.org/10.3390/children13050677","is_oa":true,"landing_page_url":"https://doi.org/10.3390/children13050677","pdf_url":null,"source":{"id":"https://openalex.org/S2736895435","display_name":"Children","issn_l":"2227-9067","issn":["2227-9067"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Children","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G421662722","display_name":null,"funder_award_id":"ZR2025MS1398","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"}],"funders":[{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7162017289.pdf","grobid_xml":"https://content.openalex.org/works/W7162017289.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1598048539","https://openalex.org/W1971605618","https://openalex.org/W1980023540","https://openalex.org/W1992400293","https://openalex.org/W2001271693","https://openalex.org/W2015173256","https://openalex.org/W2019467896","https://openalex.org/W2041831807","https://openalex.org/W2045247659","https://openalex.org/W2049892168","https://openalex.org/W2091780020","https://openalex.org/W2093405242","https://openalex.org/W2093498435","https://openalex.org/W2105592868","https://openalex.org/W2105902710","https://openalex.org/W2115832656","https://openalex.org/W2121203285","https://openalex.org/W2127063807","https://openalex.org/W2152350731","https://openalex.org/W2156467417","https://openalex.org/W2593816418","https://openalex.org/W2626905942","https://openalex.org/W2749477235","https://openalex.org/W2793184763","https://openalex.org/W2797503205","https://openalex.org/W2884608992","https://openalex.org/W2894425317","https://openalex.org/W2901170781","https://openalex.org/W2988126365","https://openalex.org/W3007063746","https://openalex.org/W3036513507","https://openalex.org/W3037654509","https://openalex.org/W3088701469","https://openalex.org/W3110753073","https://openalex.org/W3127014682","https://openalex.org/W3138957508","https://openalex.org/W3153384101","https://openalex.org/W3165333018","https://openalex.org/W3165511298","https://openalex.org/W3179207999","https://openalex.org/W3187678299","https://openalex.org/W3197049036","https://openalex.org/W4210832185","https://openalex.org/W4283729861","https://openalex.org/W4296051123","https://openalex.org/W4309221432","https://openalex.org/W4315568101","https://openalex.org/W4318669972","https://openalex.org/W4320491854","https://openalex.org/W4376136225","https://openalex.org/W4380302872","https://openalex.org/W4381250230","https://openalex.org/W4387230320","https://openalex.org/W4389142529","https://openalex.org/W4391401303","https://openalex.org/W4392294868","https://openalex.org/W4401618509","https://openalex.org/W4402656708","https://openalex.org/W4404214309","https://openalex.org/W4404303039","https://openalex.org/W4404394154","https://openalex.org/W4406535832","https://openalex.org/W4407749120","https://openalex.org/W4409149389","https://openalex.org/W4409776305","https://openalex.org/W4410011578","https://openalex.org/W4412388141","https://openalex.org/W4412704285","https://openalex.org/W4414408997","https://openalex.org/W4415467052","https://openalex.org/W7126261731"],"related_works":["https://openalex.org/W7214379783","https://openalex.org/W4381250230","https://openalex.org/W4409149389","https://openalex.org/W7133122555","https://openalex.org/W3037550884","https://openalex.org/W2049892168","https://openalex.org/W4403388246","https://openalex.org/W4281726891","https://openalex.org/W2626905942","https://openalex.org/W7167397288"],"abstract_inverted_index":{"Pulmonary":[0],"vein":[1],"stenosis":[2],"(PVS)":[3],"is":[4],"a":[5,168],"rare":[6],"and":[7,12,21,29,38,51,70,99,126,133,142,174],"devastating":[8],"condition":[9],"affecting":[10],"infants":[11],"children,":[13],"characterized":[14],"by":[15,158],"progressive":[16],"intimal":[17],"hyperplasia,":[18],"myofibroblast":[19],"proliferation,":[20],"extracellular":[22],"matrix":[23],"deposition,":[24],"leading":[25],"to":[26,46,87],"pulmonary":[27],"hypertension":[28],"right":[30],"heart":[31],"failure.":[32],"Despite":[33],"multimodal":[34],"interventions":[35],"including":[36,136],"surgery":[37],"catheter-based":[39],"approaches,":[40],"long-term":[41],"outcomes":[42],"remain":[43],"poor":[44],"due":[45],"high":[47],"rates":[48],"of":[49,56,68,81,117,149,163],"restenosis":[50],"disease":[52],"progression.":[53],"The":[54,146],"development":[55,148],"representative":[57],"animal":[58,83],"models":[59,153],"has":[60,154],"been":[61],"instrumental":[62],"in":[63,103,108,182],"unraveling":[64],"the":[65,79],"complex":[66],"pathophysiology":[67],"PVS":[69,82,152],"identifying":[71],"potential":[72],"therapeutic":[73,101],"targets.":[74],"This":[75],"review":[76],"comprehensively":[77],"examines":[78],"evolution":[80],"models-from":[84],"large":[85],"animals":[86],"recently":[88],"established":[89],"rodent":[90],"models-and":[91],"synthesizes":[92],"insights":[93],"gained":[94],"regarding":[95],"key":[96],"pathogenic":[97],"pathways":[98,173],"their":[100],"implications":[102],"guiding":[104],"associated":[105],"clinical":[106],"trials":[107],"pediatric":[109],"patients.":[110],"We":[111,166],"discuss":[112,175],"evidence":[113],"supporting":[114],"mammalian":[115],"target":[116],"rapamycin":[118],"(mTOR)":[119],"inhibition,":[120],"TGF-\u03b2,":[121],"platelet-derived":[122],"growth":[123,129],"factor":[124,130],"(PDGF)":[125],"vascular":[127],"endothelial":[128],"(VEGF)":[131],"targeting,":[132],"emerging":[134],"strategies":[135],"fibroblast":[137],"activation":[138],"protein":[139],"(FAP)":[140],"inhibition":[141],"YAP/\u03b2-catenin":[143],"pathway":[144],"modulation.":[145],"recent":[147],"neonatal":[150],"rat":[151],"accelerated":[155],"translational":[156],"research":[157],"enabling":[159],"cost-effective,":[160],"high-throughput":[161],"evaluation":[162],"candidate":[164],"therapies.":[165],"propose":[167],"mechanistic":[169],"framework":[170],"integrating":[171],"these":[172],"future":[176],"directions":[177],"for":[178],"precision":[179],"medicine":[180],"approaches":[181],"PVS.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-05-22T00:00:00"}
