{"id":"https://openalex.org/W7162000653","doi":"https://doi.org/10.3390/biom16050714","title":"Targeting Protein\u2013Protein Interactions (PPIs) to Drive Functional Annotation: An Integrative Methodology to Study Senescence-Associated PPIs Using TMPRSS11a as Model Interactor","display_name":"Targeting Protein\u2013Protein Interactions (PPIs) to Drive Functional Annotation: An Integrative Methodology to Study Senescence-Associated PPIs Using TMPRSS11a as Model Interactor","publication_year":2026,"publication_date":"2026-05-13","ids":{"openalex":"https://openalex.org/W7162000653","doi":"https://doi.org/10.3390/biom16050714","pmid":"https://pubmed.ncbi.nlm.nih.gov/42194062","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13204010"},"language":"en","primary_location":{"id":"doi:10.3390/biom16050714","doi":"https://doi.org/10.3390/biom16050714","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom16050714","pdf_url":null,"source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biom16050714","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056547385","display_name":"Roberto Rosales\u2010Rojas","orcid":"https://orcid.org/0000-0002-3735-7818","observed_orcids":["https://orcid.org/0000-0002-3735-7818"]},"institutions":[{"id":"https://openalex.org/I134695357","display_name":"Universidad de Talca","ror":"https://ror.org/01s4gpq44","country_code":"CL","type":"education","lineage":["https://openalex.org/I134695357"]},{"id":"https://openalex.org/I4210163394","display_name":"Millennium Institute on Immunology and Immunotherapy","ror":"https://ror.org/05j6ybs54","country_code":"CL","type":"facility","lineage":["https://openalex.org/I4210163394"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Roberto Rosales-Rojas","raw_affiliation_strings":["Center for Bioinformatics, Simulation and Modeling, Faculty of Engineering, Universidad de Talca, Talca 3460000, Chile","Millennium Institute on Immunology and Immunotherapy, Instituto de Ciencias Biom\u00e9dicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile"],"raw_orcid":"https://orcid.org/0000-0002-3735-7818","affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Simulation and Modeling, Faculty of Engineering, Universidad de Talca, Talca 3460000, Chile","institution_ids":["https://openalex.org/I134695357"]},{"raw_affiliation_string":"Millennium Institute on Immunology and Immunotherapy, Instituto de Ciencias Biom\u00e9dicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile","institution_ids":["https://openalex.org/I4210163394","https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052176222","display_name":"Christian Fern\u00e1ndez","orcid":"https://orcid.org/0000-0001-8157-5997","observed_orcids":["https://orcid.org/0000-0001-8157-5997"]},"institutions":[{"id":"https://openalex.org/I4210163394","display_name":"Millennium Institute on Immunology and Immunotherapy","ror":"https://ror.org/05j6ybs54","country_code":"CL","type":"facility","lineage":["https://openalex.org/I4210163394"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Christian Fern\u00e1ndez","raw_affiliation_strings":["Instituo de Ciencias Biomedicas (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile","Millennium Institute on Immunology and Immunotherapy, Instituto de Ciencias Biom\u00e9dicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile"],"raw_orcid":"https://orcid.org/0000-0001-8157-5997","affiliations":[{"raw_affiliation_string":"Instituo de Ciencias Biomedicas (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Millennium Institute on Immunology and Immunotherapy, Instituto de Ciencias Biom\u00e9dicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile","institution_ids":["https://openalex.org/I4210163394","https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002777511","display_name":"Mariela Gonz\u00e1lez\u2010Avenda\u00f1o","orcid":"https://orcid.org/0009-0004-8113-6758","observed_orcids":["https://orcid.org/0009-0004-8113-6758"]},"institutions":[{"id":"https://openalex.org/I134695357","display_name":"Universidad de Talca","ror":"https://ror.org/01s4gpq44","country_code":"CL","type":"education","lineage":["https://openalex.org/I134695357"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Mariela Gonz\u00e1lez-Avenda\u00f1o","raw_affiliation_strings":["Center for Bioinformatics, Simulation and Modeling, Faculty of Engineering, Universidad de Talca, Talca 3460000, Chile"],"raw_orcid":"https://orcid.org/0009-0004-8113-6758","affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Simulation and Modeling, Faculty of Engineering, Universidad de Talca, Talca 3460000, Chile","institution_ids":["https://openalex.org/I134695357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008454570","display_name":"Ariela Vergara\u2010Jaque","orcid":"https://orcid.org/0000-0002-1236-013X","observed_orcids":["https://orcid.org/0000-0002-1236-013X"]},"institutions":[{"id":"https://openalex.org/I134695357","display_name":"Universidad de Talca","ror":"https://ror.org/01s4gpq44","country_code":"CL","type":"education","lineage":["https://openalex.org/I134695357"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Ariela Vergara-Jaque","raw_affiliation_strings":["Center for Bioinformatics, Simulation and Modeling, Faculty of Engineering, Universidad de Talca, Talca 3460000, Chile"],"raw_orcid":"https://orcid.org/0000-0002-1236-013X","affiliations":[{"raw_affiliation_string":"Center for Bioinformatics, Simulation and Modeling, Faculty of Engineering, Universidad de Talca, Talca 3460000, Chile","institution_ids":["https://openalex.org/I134695357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006914781","display_name":"M\u00f3nica C\u00e1ceres","orcid":"https://orcid.org/0000-0002-0456-0721","observed_orcids":["https://orcid.org/0000-0002-0456-0721"]},"institutions":[{"id":"https://openalex.org/I4210163394","display_name":"Millennium Institute on Immunology and Immunotherapy","ror":"https://ror.org/05j6ybs54","country_code":"CL","type":"facility","lineage":["https://openalex.org/I4210163394"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"M\u00f3nica C\u00e1ceres","raw_affiliation_strings":["Instituo de Ciencias Biomedicas (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile","Millennium Institute on Immunology and Immunotherapy, Instituto de Ciencias Biom\u00e9dicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile"],"raw_orcid":"https://orcid.org/0000-0002-0456-0721","affiliations":[{"raw_affiliation_string":"Instituo de Ciencias Biomedicas (ICBM), Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Millennium Institute on Immunology and Immunotherapy, Instituto de Ciencias Biom\u00e9dicas (ICBM), Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 8380453, Chile","institution_ids":["https://openalex.org/I4210163394","https://openalex.org/I69737025"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006914781","https://openalex.org/A5008454570"],"corresponding_institution_ids":["https://openalex.org/I134695357","https://openalex.org/I4210163394","https://openalex.org/I69737025"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":1.2774,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.70314506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"16","issue":"5","first_page":"714","last_page":"714"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.38960000872612,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.38960000872612,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.19099999964237213,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.13950000703334808,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":1.0},{"id":"https://openalex.org/keywords/hsc70","display_name":"Hsc70","score":0.984000027179718},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.7139999866485596},{"id":"https://openalex.org/keywords/co-immunoprecipitation","display_name":"co-immunoprecipitation","score":0.921999990940094},{"id":"https://openalex.org/keywords/interaction-interfaces","display_name":"interaction interfaces","score":0.5569999814033508},{"id":"https://openalex.org/keywords/proximity-ligation-assay","display_name":"proximity ligation assay","score":0.8840000033378601},{"id":"https://openalex.org/keywords/integrated-approach","display_name":"integrated approach","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C166998942","wikidata":"https://www.wikidata.org/wiki/Q16969238","display_name":"Interactor","level":2,"score":0.6761000156402588},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6561999917030334},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.5141000151634216},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.5019999742507935},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.48170000314712524},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.45820000767707825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45080000162124634},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.4424999952316284},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4065999984741211},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.35019999742507935},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.3472999930381775},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3249000012874603},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31369999051094055},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.3133000135421753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30880001187324524},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3059000074863434},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.2985999882221222},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2930000126361847},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.2858000099658966},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.2705000042915344},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C39743133","wikidata":"https://www.wikidata.org/wiki/Q3262595","display_name":"Signalling","level":2,"score":0.26750001311302185},{"id":"https://openalex.org/C2994130171","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Signaling proteins","level":3,"score":0.2639999985694885},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.26170000433921814},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.25780001282691956},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.25369998812675476},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.25049999356269836}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050883","descriptor_name":"HSC70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050883","descriptor_name":"HSC70 Heat-Shock Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/biom16050714","doi":"https://doi.org/10.3390/biom16050714","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom16050714","pdf_url":null,"source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13204010","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13204010/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13204010/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Text"},{"id":"pmid:42194062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42194062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d5e2cf975553472789ef3527a5df0644","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d5e2cf975553472789ef3527a5df0644","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomolecules, Vol 16, Iss 5, p 714 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biom16050714","doi":"https://doi.org/10.3390/biom16050714","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biom16050714","pdf_url":null,"source":{"id":"https://openalex.org/S4210236520","display_name":"Biomolecules","issn_l":"2218-273X","issn":["2218-273X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomolecules","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3430018896","display_name":null,"funder_award_id":"#1220110","funder_id":"https://openalex.org/F4320319253","funder_display_name":"Agen\u021bia Na\u021bional\u0103 pentru Cercetare \u0219i Dezvoltare"},{"id":"https://openalex.org/G6481653303","display_name":null,"funder_award_id":"ICN 2021_045","funder_id":"https://openalex.org/F4320328212","funder_display_name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia"},{"id":"https://openalex.org/G6898337182","display_name":"STRUCTURAL AND FUNCTIONAL PROPERTIES REGULATING THE ASSOCIATION OF TRP CHANNELS AND 14-3-3 PROTEINS NEW INSIGHTS INTO PROTEIN-PROTEIN INTERACTIONS FOR DRUG DISCOVERY.","funder_award_id":"1220110","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G7628373921","display_name":"MILLENNIUM INSTITUTE ON IMMUNOLOGY AND IMMUNOTHERAPY","funder_award_id":"ICN2021_045","funder_id":"https://openalex.org/F4320331146","funder_display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo"},{"id":"https://openalex.org/G8468503119","display_name":null,"funder_award_id":"PROGRAMA ICM\u2014ANID, ICN2021_045","funder_id":"https://openalex.org/F4320328212","funder_display_name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia"}],"funders":[{"id":"https://openalex.org/F4320319253","display_name":"Agen\u021bia Na\u021bional\u0103 pentru Cercetare \u0219i Dezvoltare","ror":"https://ror.org/04kp6rb84"},{"id":"https://openalex.org/F4320328212","display_name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia","ror":"https://ror.org/05j6ybs54"},{"id":"https://openalex.org/F4320331146","display_name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","ror":"https://ror.org/05btm5233"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7162000653.pdf","grobid_xml":"https://content.openalex.org/works/W7162000653.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1965754110","https://openalex.org/W1969189143","https://openalex.org/W1991008573","https://openalex.org/W1993188029","https://openalex.org/W2029667189","https://openalex.org/W2038758364","https://openalex.org/W2041449172","https://openalex.org/W2043816461","https://openalex.org/W2047647552","https://openalex.org/W2058971275","https://openalex.org/W2067174909","https://openalex.org/W2070753604","https://openalex.org/W2074713036","https://openalex.org/W2077450385","https://openalex.org/W2087689873","https://openalex.org/W2093398011","https://openalex.org/W2103017472","https://openalex.org/W2109936231","https://openalex.org/W2118957830","https://openalex.org/W2126525177","https://openalex.org/W2133790733","https://openalex.org/W2146134187","https://openalex.org/W2150981663","https://openalex.org/W2152231829","https://openalex.org/W2152811165","https://openalex.org/W2156576736","https://openalex.org/W2159675211","https://openalex.org/W2169589032","https://openalex.org/W2194304382","https://openalex.org/W2211041313","https://openalex.org/W2296911202","https://openalex.org/W2427214953","https://openalex.org/W2481244956","https://openalex.org/W2511687775","https://openalex.org/W2560115833","https://openalex.org/W2578020568","https://openalex.org/W2602739620","https://openalex.org/W2620914886","https://openalex.org/W2742876579","https://openalex.org/W2900569176","https://openalex.org/W2917101543","https://openalex.org/W2950954328","https://openalex.org/W2970416468","https://openalex.org/W2988310131","https://openalex.org/W3000364256","https://openalex.org/W3009927904","https://openalex.org/W3047318639","https://openalex.org/W3048953874","https://openalex.org/W3087769169","https://openalex.org/W3111207111","https://openalex.org/W3159278417","https://openalex.org/W3178166327","https://openalex.org/W3182826320","https://openalex.org/W3186565777","https://openalex.org/W4220821501","https://openalex.org/W4281790889","https://openalex.org/W4289545008","https://openalex.org/W4294921042","https://openalex.org/W4309306035","https://openalex.org/W4309506674","https://openalex.org/W4313531093","https://openalex.org/W4375862051","https://openalex.org/W4385550946","https://openalex.org/W4385805455","https://openalex.org/W4389868846","https://openalex.org/W4390581987","https://openalex.org/W4400767145","https://openalex.org/W4404511387","https://openalex.org/W4407843345","https://openalex.org/W4407956796","https://openalex.org/W4413342662"],"related_works":["https://openalex.org/W4415059025","https://openalex.org/W6926561502","https://openalex.org/W3186565777","https://openalex.org/W6902521488","https://openalex.org/W4391843691","https://openalex.org/W2954879720","https://openalex.org/W4403953579","https://openalex.org/W1998751928","https://openalex.org/W4408129837","https://openalex.org/W2003015662"],"abstract_inverted_index":{"Protein-protein":[0],"interactions":[1],"(PPIs)":[2],"play":[3],"a":[4,67,148],"central":[5],"role":[6],"in":[7,104,119],"regulating":[8],"cellular":[9,40],"processes.":[10],"However,":[11],"the":[12,82,85,91,105,109,112],"identification":[13],"and":[14,26,54,74,90,108,133,135],"characterization":[15],"of":[16,111],"senescence-associated":[17,152],"PPIs":[18,37,153],"remain":[19],"challenging.":[20],"In":[21],"this":[22,63,78,145],"study,":[23],"we":[24,65,80],"developed":[25],"evaluated":[27,116],"an":[28,118,129,140],"integrative":[29],"methodology":[30],"based":[31],"on":[32,62],"selective":[33,70],"proteomics":[34],"to":[35,99,150],"identify":[36,100],"associated":[38],"with":[39,52,139],"senescence":[41,142],"induced":[42],"by":[43,58],"TMPRSS11a.":[44],"We":[45],"started":[46],"from":[47,154],"isolated":[48],"proteins":[49],"that":[50],"co-immunoprecipitated":[51],"TMPRSS11a":[53,89,132],"were":[55,97],"subsequently":[56],"identified":[57],"mass":[59],"spectrometry.":[60],"Building":[61],"dataset,":[64],"implemented":[66],"workflow":[68,149],"combining":[69],"proteomics,":[71],"structural":[72],"bioinformatics,":[73],"experimental":[75],"validation.":[76],"Using":[77],"approach,":[79],"investigated":[81],"interaction":[83,106,130],"between":[84,131],"transmembrane":[86],"serine":[87],"protease":[88],"chaperone":[92],"HSPA8.":[93],"Structural":[94],"bioinformatics":[95],"analyses":[96],"performed":[98],"potential":[101],"residues":[102],"involved":[103],"interface,":[107],"proximity":[110,121],"TMPRSS11a-HSPA8":[113],"complex":[114],"was":[115],"using":[117],"vitro":[120],"ligation":[122],"assay.":[123],"Our":[124],"results":[125],"provide":[126],"evidence":[127],"for":[128],"HSPA8":[134],"suggest":[136],"its":[137],"association":[138],"enhanced":[141],"response.":[143],"Overall,":[144],"study":[146],"presents":[147],"investigate":[151],"proteomics-derived":[155],"candidate":[156],"proteins.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-05-22T00:00:00"}