{"id":"https://openalex.org/W7161970362","doi":"https://doi.org/10.1007/s00109-026-02686-6","title":"The mechanism of the JNK signaling pathway in drug addiction","display_name":"The mechanism of the JNK signaling pathway in drug addiction","publication_year":2026,"publication_date":"2026-05-21","ids":{"openalex":"https://openalex.org/W7161970362","doi":"https://doi.org/10.1007/s00109-026-02686-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/42168396"},"language":"en","primary_location":{"id":"doi:10.1007/s00109-026-02686-6","doi":"https://doi.org/10.1007/s00109-026-02686-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00109-026-02686-6","pdf_url":null,"source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5136700491","display_name":"Shuang Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161350542","display_name":"China Three Gorges University","ror":"https://ror.org/0419nfc77","country_code":"CN","type":"education","lineage":["https://openalex.org/I161350542"]},{"id":"https://openalex.org/I4210152080","display_name":"Yichang Central People's Hospital","ror":"https://ror.org/04cr34a11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152080"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Han","raw_affiliation_strings":["Hubei Province Clinical Medical Research Center for Rare Diseases of Nervous System, Yichang, 443000, China","The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, 443000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Province Clinical Medical Research Center for Rare Diseases of Nervous System, Yichang, 443000, China","institution_ids":[]},{"raw_affiliation_string":"The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, 443000, China","institution_ids":["https://openalex.org/I161350542","https://openalex.org/I4210152080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136706220","display_name":"Hongming Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128608","display_name":"Hubei Polytechnic Institute","ror":"https://ror.org/0353dhs61","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210128608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongming Ye","raw_affiliation_strings":["Hubei Polytechnic Institute, Xiaogan, 432000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Polytechnic Institute, Xiaogan, 432000, China","institution_ids":["https://openalex.org/I4210128608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159880856","display_name":"Min Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161350542","display_name":"China Three Gorges University","ror":"https://ror.org/0419nfc77","country_code":"CN","type":"education","lineage":["https://openalex.org/I161350542"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443000, China","Hubei Province Clinical Medical Research Center for Rare Diseases of Nervous System, Yichang, 443000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443000, China","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Hubei Province Clinical Medical Research Center for Rare Diseases of Nervous System, Yichang, 443000, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136637324","display_name":"Yuzhu Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161350542","display_name":"China Three Gorges University","ror":"https://ror.org/0419nfc77","country_code":"CN","type":"education","lineage":["https://openalex.org/I161350542"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuzhu Wang","raw_affiliation_strings":["College of Basic Medical Sciences, China Three Gorges University, Yichang, China","Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medical Sciences, China Three Gorges University, Yichang, China","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443000, China","institution_ids":["https://openalex.org/I161350542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136650330","display_name":"Yue Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Chen","raw_affiliation_strings":["College of Medicine, Jiaxing University, Jiaxing, 314001, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, Jiaxing University, Jiaxing, 314001, People's Republic of China","institution_ids":["https://openalex.org/I4210092870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100566514","display_name":"Xiaohong Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161350542","display_name":"China Three Gorges University","ror":"https://ror.org/0419nfc77","country_code":"CN","type":"education","lineage":["https://openalex.org/I161350542"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohong Zhou","raw_affiliation_strings":["College of Basic Medical Sciences, China Three Gorges University, Yichang, China","Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Basic Medical Sciences, China Three Gorges University, Yichang, China","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443000, China","institution_ids":["https://openalex.org/I161350542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090903603","display_name":"Zicheng Li","orcid":"https://orcid.org/0000-0001-8533-5325","observed_orcids":["https://orcid.org/0000-0001-8533-5325"]},"institutions":[{"id":"https://openalex.org/I161350542","display_name":"China Three Gorges University","ror":"https://ror.org/0419nfc77","country_code":"CN","type":"education","lineage":["https://openalex.org/I161350542"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zicheng Li","raw_affiliation_strings":["College of Basic Medical Sciences, China Three Gorges University, Yichang, China. zichengli@ctgu.edu.cn","Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443000, China. zichengli@ctgu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0001-8533-5325","affiliations":[{"raw_affiliation_string":"College of Basic Medical Sciences, China Three Gorges University, Yichang, China. zichengli@ctgu.edu.cn","institution_ids":["https://openalex.org/I161350542"]},{"raw_affiliation_string":"Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443000, China. zichengli@ctgu.edu.cn","institution_ids":["https://openalex.org/I161350542"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5090903603"],"corresponding_institution_ids":["https://openalex.org/I161350542"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12235563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"104","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jnk-signaling","display_name":"JNK signaling","score":0.9259999990463257},{"id":"https://openalex.org/keywords/drug-addiction","display_name":"drug addiction","score":0.8640000224113464},{"id":"https://openalex.org/keywords/c-jun-n-terminal-kinase","display_name":"c-Jun N-terminal kinase","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mapk-family","display_name":"MAPK family","score":0.8370000123977661},{"id":"https://openalex.org/keywords/neuronal-homeostasis","display_name":"neuronal homeostasis","score":0.7990000247955322},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":1.0},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/neural-stem-progenitor-cells","display_name":"neural stem/progenitor cells","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7113000154495239},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6504999995231628},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5475999712944031},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5331000089645386},{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.4747999906539917},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4449999928474426},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.43320000171661377},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.3952000141143799},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3614000082015991},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33469998836517334},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3294000029563904},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.32850000262260437},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.250900000333786}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D019966","descriptor_name":"Substance-Related Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00109-026-02686-6","doi":"https://doi.org/10.1007/s00109-026-02686-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00109-026-02686-6","pdf_url":null,"source":{"id":"https://openalex.org/S114689480","display_name":"Journal of Molecular Medicine","issn_l":"0946-2716","issn":["0946-2716","1432-1440"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:42168396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42168396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular medicine (Berlin, Germany)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1555852983","https://openalex.org/W1998770173","https://openalex.org/W2007311189","https://openalex.org/W2010909357","https://openalex.org/W2038112013","https://openalex.org/W2043885237","https://openalex.org/W2059010085","https://openalex.org/W2071399511","https://openalex.org/W2074073259","https://openalex.org/W2075486656","https://openalex.org/W2079153927","https://openalex.org/W2123868590","https://openalex.org/W2125784520","https://openalex.org/W2128533924","https://openalex.org/W2146965545","https://openalex.org/W2168069435","https://openalex.org/W2394496903","https://openalex.org/W2407228423","https://openalex.org/W2436149313","https://openalex.org/W2532640523","https://openalex.org/W2555461573","https://openalex.org/W2562416289","https://openalex.org/W2598774184","https://openalex.org/W2601417349","https://openalex.org/W2610467888","https://openalex.org/W2773542203","https://openalex.org/W2794307136","https://openalex.org/W2899293777","https://openalex.org/W2901250283","https://openalex.org/W2915298192","https://openalex.org/W2951053873","https://openalex.org/W2956671755","https://openalex.org/W2977791257","https://openalex.org/W2981184261","https://openalex.org/W2985632750","https://openalex.org/W2993119708","https://openalex.org/W3007303177","https://openalex.org/W3007326088","https://openalex.org/W3012781453","https://openalex.org/W3014808271","https://openalex.org/W3042329401","https://openalex.org/W3081863423","https://openalex.org/W3087975979","https://openalex.org/W3107395714","https://openalex.org/W3112134478","https://openalex.org/W3133762545","https://openalex.org/W3135610688","https://openalex.org/W3138548238","https://openalex.org/W3196422625","https://openalex.org/W4221061854","https://openalex.org/W4223526151","https://openalex.org/W4225129690","https://openalex.org/W4282923268","https://openalex.org/W4283735127","https://openalex.org/W4283794465","https://openalex.org/W4290790569","https://openalex.org/W4327624542","https://openalex.org/W4365444207","https://openalex.org/W4367052992","https://openalex.org/W4384405535","https://openalex.org/W4391946279","https://openalex.org/W4392858933","https://openalex.org/W4394692170","https://openalex.org/W4398765852","https://openalex.org/W4399007204","https://openalex.org/W4400019692","https://openalex.org/W4400723295","https://openalex.org/W4405201360","https://openalex.org/W4405433780","https://openalex.org/W4406642315","https://openalex.org/W4409199043","https://openalex.org/W4409342969","https://openalex.org/W4411058051","https://openalex.org/W4411604829","https://openalex.org/W4411617404","https://openalex.org/W4411735839","https://openalex.org/W4413297473","https://openalex.org/W4413740631","https://openalex.org/W4414868044"],"related_works":["https://openalex.org/W2342443645","https://openalex.org/W4404802524","https://openalex.org/W1977081170","https://openalex.org/W4297841239","https://openalex.org/W2514160263","https://openalex.org/W2050157822","https://openalex.org/W4404296317","https://openalex.org/W2052814828","https://openalex.org/W2068341427","https://openalex.org/W2116504386"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-05-22T00:00:00"}