{"id":"https://openalex.org/W7161838457","doi":"https://doi.org/10.64898/2026.05.16.725651","title":"Transforming off-the-shelf personal glucose meter into a sustainable and decentralized label-free nucleic acid and NAAT detection platform","display_name":"Transforming off-the-shelf personal glucose meter into a sustainable and decentralized label-free nucleic acid and NAAT detection platform","publication_year":2026,"publication_date":"2026-05-20","ids":{"openalex":"https://openalex.org/W7161838457","doi":"https://doi.org/10.64898/2026.05.16.725651"},"language":"en","primary_location":{"id":"doi:10.64898/2026.05.16.725651","doi":"https://doi.org/10.64898/2026.05.16.725651","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.16.725651","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/20/2026.05.16.725651.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/20/2026.05.16.725651.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059194142","display_name":"Aditya Chourasia","orcid":"https://orcid.org/0009-0003-3653-8144","observed_orcids":["https://orcid.org/0009-0003-3653-8144"]},"institutions":[{"id":"https://openalex.org/I4210164565","display_name":"Mahindra University","ror":"https://ror.org/05751b994","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210164565"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Aditya Chourasia","raw_affiliation_strings":["Centre for Life Sciences, Mahindra University, Hyderabad, Telangana, India","Interdisciplinary Centre for Nanosensors and Nanomedicine, Mahindra University, Hyderabad, Telangana, India"],"raw_orcid":"https://orcid.org/0009-0003-3653-8144","affiliations":[{"raw_affiliation_string":"Centre for Life Sciences, Mahindra University, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I4210164565"]},{"raw_affiliation_string":"Interdisciplinary Centre for Nanosensors and Nanomedicine, Mahindra University, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I4210164565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157931456","display_name":"Saba Parveen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164565","display_name":"Mahindra University","ror":"https://ror.org/05751b994","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210164565"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saba Parveen","raw_affiliation_strings":["Centre for Life Sciences, Mahindra University, Hyderabad, Telangana, India","Interdisciplinary Centre for Nanosensors and Nanomedicine, Mahindra University, Hyderabad, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Life Sciences, Mahindra University, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I4210164565"]},{"raw_affiliation_string":"Interdisciplinary Centre for Nanosensors and Nanomedicine, Mahindra University, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I4210164565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136521768","display_name":"Shrawan Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164565","display_name":"Mahindra University","ror":"https://ror.org/05751b994","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210164565"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shrawan Kumar","raw_affiliation_strings":["Centre for Life Sciences, Mahindra University, Hyderabad, Telangana, India","Interdisciplinary Centre for Nanosensors and Nanomedicine, Mahindra University, Hyderabad, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Life Sciences, Mahindra University, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I4210164565"]},{"raw_affiliation_string":"Interdisciplinary Centre for Nanosensors and Nanomedicine, Mahindra University, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I4210164565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057532533","display_name":"Arunansu Talukdar","orcid":"https://orcid.org/0000-0002-0407-4969","observed_orcids":["https://orcid.org/0000-0002-0407-4969"]},"institutions":[{"id":"https://openalex.org/I68428275","display_name":"Medical College and Hospital, Kolkata","ror":"https://ror.org/021nb2v44","country_code":"IN","type":"education","lineage":["https://openalex.org/I226431899","https://openalex.org/I68428275"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arunansu Talukdar","raw_affiliation_strings":["Department of Geriatric Medicine, Medical College and Hospital Kolkata, Kolkata"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine, Medical College and Hospital Kolkata, Kolkata","institution_ids":["https://openalex.org/I68428275"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041081791","display_name":"Mrittika Sengupta","orcid":"https://orcid.org/0000-0001-9438-1606","observed_orcids":["https://orcid.org/0000-0001-9438-1606"]},"institutions":[{"id":"https://openalex.org/I4210164565","display_name":"Mahindra University","ror":"https://ror.org/05751b994","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210164565"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mrittika Sengupta","raw_affiliation_strings":["Centre for Life Sciences, Mahindra University, Hyderabad, Telangana, India","Interdisciplinary Centre for Nanosensors and Nanomedicine, Mahindra University, Hyderabad, Telangana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Life Sciences, Mahindra University, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I4210164565"]},{"raw_affiliation_string":"Interdisciplinary Centre for Nanosensors and Nanomedicine, Mahindra University, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I4210164565"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074601587","display_name":"Souradyuti Ghosh","orcid":"https://orcid.org/0000-0002-8510-1171","observed_orcids":["https://orcid.org/0000-0002-8510-1171"]},"institutions":[{"id":"https://openalex.org/I4210164565","display_name":"Mahindra University","ror":"https://ror.org/05751b994","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210164565"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Souradyuti Ghosh","raw_affiliation_strings":["Centre for Life Sciences, Mahindra University, Hyderabad, Telangana, India","Interdisciplinary Centre for Nanosensors and Nanomedicine, Mahindra University, Hyderabad, Telangana, India"],"raw_orcid":"https://orcid.org/0000-0002-8510-1171","affiliations":[{"raw_affiliation_string":"Centre for Life Sciences, Mahindra University, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I4210164565"]},{"raw_affiliation_string":"Interdisciplinary Centre for Nanosensors and Nanomedicine, Mahindra University, Hyderabad, Telangana, India","institution_ids":["https://openalex.org/I4210164565"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074601587"],"corresponding_institution_ids":["https://openalex.org/I4210164565"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.5619999766349792,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.288100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10212","display_name":"Electrochemical sensors and biosensors","score":0.1387999951839447,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleic-acid-amplification-testing","display_name":"nucleic acid amplification tests","score":0.8240000009536743},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.7300000190734863},{"id":"https://openalex.org/keywords/methylene-blue","display_name":"methylene blue","score":0.5440000295639038},{"id":"https://openalex.org/keywords/ferricyanide-ferrocyanide-redox-system","display_name":"ferricyanide/ferrocyanide redox system","score":0.9079999923706055},{"id":"https://openalex.org/keywords/electrochemical-biosensing","display_name":"electrochemical biosensing","score":0.6959999799728394},{"id":"https://openalex.org/keywords/loop-mediated-isothermal-amplification","display_name":"loop-mediated isothermal amplification","score":0.8949999809265137},{"id":"https://openalex.org/keywords/rolling-circle-amplification","display_name":"rolling circle amplification","score":0.9940000176429749},{"id":"https://openalex.org/keywords/single-stranded-dna-detection","display_name":"single-stranded DNA detection","score":0.6269999742507935},{"id":"https://openalex.org/keywords/resource-limited-settings","display_name":"resource-limited settings","score":0.75}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.9164999723434448},{"id":"https://openalex.org/C60635243","wikidata":"https://www.wikidata.org/wiki/Q6675780","display_name":"Loop-mediated isothermal amplification","level":3,"score":0.6466000080108643},{"id":"https://openalex.org/C2777661988","wikidata":"https://www.wikidata.org/wiki/Q422017","display_name":"Potassium ferrocyanide","level":2,"score":0.6053000092506409},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5127000212669373},{"id":"https://openalex.org/C2781307518","wikidata":"https://www.wikidata.org/wiki/Q408810","display_name":"Potassium ferricyanide","level":2,"score":0.48829999566078186},{"id":"https://openalex.org/C2910367586","wikidata":"https://www.wikidata.org/wiki/Q348667","display_name":"Nucleic acid detection","level":3,"score":0.47600001096725464},{"id":"https://openalex.org/C2909633786","wikidata":"https://www.wikidata.org/wiki/Q348667","display_name":"Nucleic Acid Amplification Tests","level":3,"score":0.3939000070095062},{"id":"https://openalex.org/C2777411777","wikidata":"https://www.wikidata.org/wiki/Q2259447","display_name":"Ferricyanide","level":2,"score":0.38920000195503235},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3797999918460846},{"id":"https://openalex.org/C2776043530","wikidata":"https://www.wikidata.org/wiki/Q1963663","display_name":"Ferrocyanide","level":3,"score":0.376800000667572},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.3465999960899353},{"id":"https://openalex.org/C7452308","wikidata":"https://www.wikidata.org/wiki/Q3112822","display_name":"Rolling circle replication","level":4,"score":0.34389999508857727},{"id":"https://openalex.org/C153289436","wikidata":"https://www.wikidata.org/wiki/Q3826844","display_name":"Nucleic acid methods","level":3,"score":0.3431999981403351},{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.3379000127315521},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2978000044822693},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.29750001430511475},{"id":"https://openalex.org/C126307556","wikidata":"https://www.wikidata.org/wiki/Q4227909","display_name":"Nucleic acid quantitation","level":3,"score":0.2930999994277954},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.2833000123500824},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.2824999988079071},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.26820001006126404},{"id":"https://openalex.org/C126142528","wikidata":"https://www.wikidata.org/wiki/Q3771876","display_name":"Nucleic acid structure","level":4,"score":0.2639000117778778},{"id":"https://openalex.org/C2779191827","wikidata":"https://www.wikidata.org/wiki/Q422134","display_name":"Methylene blue","level":4,"score":0.2639000117778778},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26350000500679016}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.05.16.725651","doi":"https://doi.org/10.64898/2026.05.16.725651","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.16.725651","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/20/2026.05.16.725651.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.05.16.725651","doi":"https://doi.org/10.64898/2026.05.16.725651","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.16.725651","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/20/2026.05.16.725651.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320321027","display_name":"Indo-French Centre for the Promotion of Advanced Research","ror":"https://ror.org/017aem598"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7161838457.pdf","grobid_xml":"https://content.openalex.org/works/W7161838457.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1565247711","https://openalex.org/W1995401918","https://openalex.org/W2098985451","https://openalex.org/W2111939469","https://openalex.org/W2413854093","https://openalex.org/W2741120152","https://openalex.org/W2789098290","https://openalex.org/W3009021919","https://openalex.org/W3151631725","https://openalex.org/W3164129271","https://openalex.org/W3197325821","https://openalex.org/W4206424404","https://openalex.org/W4290830035","https://openalex.org/W4401907838","https://openalex.org/W4406586462","https://openalex.org/W4407423578","https://openalex.org/W4409510185","https://openalex.org/W4411758934","https://openalex.org/W4412006948","https://openalex.org/W4412084796","https://openalex.org/W4416867198"],"related_works":["https://openalex.org/W4412746353","https://openalex.org/W3128641117","https://openalex.org/W4223905951","https://openalex.org/W2999132098","https://openalex.org/W2141042991","https://openalex.org/W4406586462","https://openalex.org/W4400865019","https://openalex.org/W3161687323","https://openalex.org/W2937562408","https://openalex.org/W2173383310"],"abstract_inverted_index":{"Abstract":[0],"In":[1],"today\u2019s":[2],"world,":[3],"point-of-care":[4,201],"nucleic":[5,39,43,86,94,121,168,190],"acid":[6,44,122,169,191],"detection":[7,37,115],"still":[8],"remains":[9],"extensively":[10],"constrained":[11],"and":[12,23,41,85,109,133,141,151,182,186,198,207,213],"limited":[13],"by":[14],"the":[15,42,55,113,147,173],"heavy":[16],"dependence":[17],"on":[18],"centralized":[19],"urban":[20],"instrumentation":[21],"facilities":[22],"complex":[24],"assay":[25,155],"workflows.":[26],"Here,":[27],"we":[28],"elucidate":[29],"a":[30,48,165,184],"glucometer-based":[31],"analytical":[32],"platform":[33,194],"that":[34],"enables":[35],"label-free":[36],"of":[38,138,146],"acids":[40,95],"amplification":[45,123],"products":[46],"through":[47],"simple":[49],"redox-mediated":[50],"mechanism.":[51],"The":[52,193],"approach":[53],"leverages":[54],"potassium":[56,63],"ferricyanide":[57],"(K":[58,65],"3":[59],"[Fe(CN)":[60,67],"6":[61,68],"])/":[62],"ferrocyanide":[64],"4":[66],"]),":[69],"redox":[70],"system,":[71],"which":[72],"is":[73],"intrinsic":[74],"to":[75,144],"commercial":[76],"glucometers,":[77],"complementing":[78],"with":[79,120],"interactions":[80,89],"between":[81,107],"methylene":[82],"blue":[83],"(MB)":[84],"acids.":[87],"These":[88],"transduce":[90],"concentration":[91],"differences":[92],"in":[93],"into":[96],"quantifiable":[97],"electrochemical":[98],"signal":[99,103,149],"readouts.":[100],"Distinct":[101],"varied":[102],"outputs":[104],"are":[105],"observed":[106],"single-stranded":[108],"double-stranded":[110],"DNA,":[111],"enabling":[112,204],"direct":[114],"as":[116,118,164],"well":[117],"integration":[119],"tests":[124],"(NAATs),":[125],"including":[126],"polymerase":[127],"chain":[128],"reaction,":[129],"rolling":[130],"circle":[131],"amplification,":[132],"loop-mediated":[134],"isothermal":[135],"amplification.":[136],"Optimization":[137],"reaction":[139],"parameters":[140],"conditions":[142],"leads":[143],"enhancement":[145],"overall":[148],"discrimination":[150],"sensitivity":[152],"across":[153],"various":[154],"formats.":[156],"This":[157],"innovation":[158],"repurposes":[159],"widely":[160],"available":[161],"off-the-shelf":[162],"glucometers":[163],"low-cost,":[166],"portable":[167],"detectors,":[170],"thus":[171,195],"eliminating":[172],"need":[174],"for":[175,189],"any":[176],"specialized":[177],"instrumentation.":[178],"Our":[179],"results":[180],"enumerate":[181],"establish":[183],"generalized":[185],"scalable":[187],"strategy":[188],"sensing.":[192],"supports":[196],"sustainable":[197],"environmentally":[199],"responsible":[200],"testing,":[202],"thereby":[203],"improved":[205],"accessibility":[206],"public":[208],"health":[209],"monitoring":[210],"at":[211],"resource-limited":[212],"remote":[214],"settings.":[215]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-05-21T00:00:00"}
