{"id":"https://openalex.org/W7161813643","doi":"https://doi.org/10.1021/acs.bioconjchem.6c00154","title":"Peptide Tag-nology for Preparation of Site-Specific Antibody\u2013Drug Conjugates","display_name":"Peptide Tag-nology for Preparation of Site-Specific Antibody\u2013Drug Conjugates","publication_year":2026,"publication_date":"2026-05-20","ids":{"openalex":"https://openalex.org/W7161813643","doi":"https://doi.org/10.1021/acs.bioconjchem.6c00154","pmid":"https://pubmed.ncbi.nlm.nih.gov/42159256","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13576668"},"language":"en","primary_location":{"id":"doi:10.1021/acs.bioconjchem.6c00154","doi":"https://doi.org/10.1021/acs.bioconjchem.6c00154","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.bioconjchem.6c00154","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.6c00154?ref=article_openPDF","source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.6c00154?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060030863","display_name":"Alina Ringaci","orcid":"https://orcid.org/0000-0001-6951-4032","observed_orcids":["https://orcid.org/0000-0001-6951-4032"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alina Ringaci","raw_affiliation_strings":["Boston University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University , , , ,","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001975624","display_name":"Mark W. Grinstaff","orcid":"https://orcid.org/0000-0002-5453-3668","observed_orcids":["https://orcid.org/0000-0002-5453-3668"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark W. Grinstaff","raw_affiliation_strings":["Boston University , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-5453-3668","affiliations":[{"raw_affiliation_string":"Boston University , , , ,","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001975624"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"6","first_page":"1108","last_page":"1114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0731000006198883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.9929999709129333},{"id":"https://openalex.org/keywords/peptide-tags","display_name":"peptide tags","score":0.8059999942779541},{"id":"https://openalex.org/keywords/site-specific-conjugation","display_name":"site-specific conjugation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/bioconjugation","display_name":"bioconjugation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/drug-to-antibody-ratio","display_name":"drug-to-antibody ratio","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cytotoxic-payloads","display_name":"cytotoxic payloads","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cancer-therapeutics","display_name":"cancer therapeutics","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C23963754","wikidata":"https://www.wikidata.org/wiki/Q4914729","display_name":"Bioconjugation","level":2,"score":0.9474999904632568},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9225000143051147},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.7991999983787537},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6931999921798706},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.6158000230789185},{"id":"https://openalex.org/C66882249","wikidata":"https://www.wikidata.org/wiki/Q169336","display_name":"Homogeneous","level":2,"score":0.5861999988555908},{"id":"https://openalex.org/C3020495827","wikidata":"https://www.wikidata.org/wiki/Q426141","display_name":"Bispecific antibody","level":4,"score":0.45980000495910645},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4300999939441681},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4250999987125397},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.40119999647140503},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3797000050544739},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3605000078678131},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.33640000224113464},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.32109999656677246},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C3018146709","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Anticancer drug","level":3,"score":0.3125999867916107},{"id":"https://openalex.org/C112613896","wikidata":"https://www.wikidata.org/wiki/Q898370","display_name":"Conjugated system","level":3,"score":0.3111000061035156},{"id":"https://openalex.org/C2779809887","wikidata":"https://www.wikidata.org/wiki/Q14864278","display_name":"Peptide synthesis","level":3,"score":0.30320000648498535},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2906000018119812},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.2847000062465668},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.2752000093460083},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.2718000113964081},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.2712000012397766},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26899999380111694},{"id":"https://openalex.org/C60984968","wikidata":"https://www.wikidata.org/wiki/Q389172","display_name":"Cyclic peptide","level":3,"score":0.26409998536109924},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.26170000433921814},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.26010000705718994}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.bioconjchem.6c00154","doi":"https://doi.org/10.1021/acs.bioconjchem.6c00154","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.bioconjchem.6c00154","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.6c00154?ref=article_openPDF","source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:42159256","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42159256","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13576668","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13576668/pdf/nihms-2202487.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjug Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.bioconjchem.6c00154","doi":"https://doi.org/10.1021/acs.bioconjchem.6c00154","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.bioconjchem.6c00154","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.bioconjchem.6c00154?ref=article_openPDF","source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7334384660","display_name":"R21: A novel antibody-drug conjugate for treatment of squamous cell lung carcinoma","funder_award_id":"R21CA273645","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306799","display_name":"Pharmaceutical Research and Manufacturers of America Foundation","ror":"https://ror.org/01z88k350"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7161813643.pdf","grobid_xml":"https://content.openalex.org/works/W7161813643.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1521126454","https://openalex.org/W1915856409","https://openalex.org/W1976672416","https://openalex.org/W1977241343","https://openalex.org/W1979108979","https://openalex.org/W1979491356","https://openalex.org/W1982251004","https://openalex.org/W1992175481","https://openalex.org/W2011697808","https://openalex.org/W2055973049","https://openalex.org/W2056405796","https://openalex.org/W2064839484","https://openalex.org/W2116150122","https://openalex.org/W2258806502","https://openalex.org/W2272134016","https://openalex.org/W2327630133","https://openalex.org/W2496850373","https://openalex.org/W2510878575","https://openalex.org/W2597045666","https://openalex.org/W2605310352","https://openalex.org/W2743892428","https://openalex.org/W2744157341","https://openalex.org/W2785471015","https://openalex.org/W2808989639","https://openalex.org/W2892934299","https://openalex.org/W2921407524","https://openalex.org/W2938537124","https://openalex.org/W2946734999","https://openalex.org/W2948212452","https://openalex.org/W2963417472","https://openalex.org/W2979907769","https://openalex.org/W3029754491","https://openalex.org/W3096107020","https://openalex.org/W3116908771","https://openalex.org/W3191940842","https://openalex.org/W4220847494","https://openalex.org/W4229035306","https://openalex.org/W4233964747","https://openalex.org/W4283392950","https://openalex.org/W4306155108","https://openalex.org/W4310371237","https://openalex.org/W4317035097","https://openalex.org/W4323654562","https://openalex.org/W4378349018","https://openalex.org/W4379986466","https://openalex.org/W4380997179","https://openalex.org/W4387019376","https://openalex.org/W4387520499","https://openalex.org/W4387811431","https://openalex.org/W4390673654","https://openalex.org/W4393115738","https://openalex.org/W4403694618","https://openalex.org/W4409117425","https://openalex.org/W4409527847","https://openalex.org/W4412726029","https://openalex.org/W4414695861","https://openalex.org/W4415789276","https://openalex.org/W7133238120"],"related_works":["https://openalex.org/W2272264121","https://openalex.org/W2939244675","https://openalex.org/W4409527847","https://openalex.org/W2767336874","https://openalex.org/W2309076462","https://openalex.org/W1984111577","https://openalex.org/W2414183324","https://openalex.org/W7168694915","https://openalex.org/W2344731741","https://openalex.org/W7172529392"],"abstract_inverted_index":{"Antibody-drug":[0],"conjugates":[1],"(ADC)":[2],"are":[3,57],"a":[4],"rapidly":[5],"growing":[6],"therapeutic":[7],"class":[8],"that":[9,43],"leverages":[10],"the":[11,94,100],"specificity":[12],"of":[13,70,102],"antibodies":[14],"to":[15,19,36,59,87,107],"deliver":[16],"cytotoxic":[17],"payloads":[18],"cells.":[20],"While":[21],"ADCs":[22],"have":[23],"demonstrated":[24],"significant":[25],"clinical":[26],"success":[27],"in":[28,53,105],"cancer":[29],"treatment,":[30],"substantial":[31],"challenges":[32,62],"remain":[33],"with":[34,67],"regard":[35],"stability,":[37],"low":[38],"drug-antibody":[39],"ratios,":[40],"and":[41,48,63,75,90,98],"heterogeneity":[42],"negatively":[44],"impact":[45],"pharmacokinetics,":[46],"efficacy,":[47],"safety":[49],"profiles.":[50],"Bioconjugation":[51],"and,":[52],"particular,":[54],"peptide":[55],"tag-nologies":[56],"key":[58],"overcoming":[60],"these":[61,103],"enabling":[64],"future":[65],"designs":[66],"diverse":[68],"types":[69],"antibody":[71],"formats,":[72],"multiple":[73],"payloads,":[74],"high":[76],"drug":[77],"loadings.":[78],"This":[79],"Viewpoint":[80],"explores":[81],"novel,":[82],"facile":[83],"peptide-based":[84],"conjugation":[85,96],"strategies":[86],"synthesize":[88],"homogeneous":[89],"site-specific":[91],"ADCs,":[92],"describes":[93],"underlying":[95],"reactions,":[97],"highlights":[99],"advantages":[101],"technologies":[104],"comparison":[106],"classically":[108],"used":[109],"approaches.":[110]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2026-05-21T00:00:00"}
