{"id":"https://openalex.org/W7161521256","doi":null,"title":"POTENTIAL BIOMARKER FOR EPILEPSY: HIGH-MOBILITY GROUP BOX 1 PROTEIN (HMGB1)","display_name":"POTENTIAL BIOMARKER FOR EPILEPSY: HIGH-MOBILITY GROUP BOX 1 PROTEIN (HMGB1)","publication_year":2023,"publication_date":"2023-06-08","ids":{"openalex":"https://openalex.org/W7161521256"},"language":"en","primary_location":{"id":"pmh:oai:journal.univerpublishing.org:article/1932","doi":null,"is_oa":true,"landing_page_url":"https://journal.univerpublishing.org/index.php/horizon/article/view/1932","pdf_url":"https://journal.univerpublishing.org/index.php/horizon/article/download/1932/1683","source":{"id":"https://openalex.org/S7407063665","display_name":"Horizon Journal of Humanity and Artificial Intelligence","issn_l":"2835-3064","issn":["2835-3064"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"10.31150/jhai.v2i6","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journal.univerpublishing.org/index.php/horizon/article/download/1932/1683","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078757329","display_name":"Sultonova Dilbar Azamat qizi.","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164592","display_name":"Tashkent Medical Academy","ror":"https://ror.org/05sgw3s08","country_code":"UZ","type":"education","lineage":["https://openalex.org/I4210164592","https://openalex.org/I4405267534"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"Azamat qizi, Sultonova Dilbar","raw_affiliation_strings":["student, assistant of Tashkent Medical Academy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"student, assistant of Tashkent Medical Academy","institution_ids":["https://openalex.org/I4210164592"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5136325672","display_name":"A. M. (Abdujapparova) B","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164592","display_name":"Tashkent Medical Academy","ror":"https://ror.org/05sgw3s08","country_code":"UZ","type":"education","lineage":["https://openalex.org/I4210164592","https://openalex.org/I4405267534"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"R. B., Azizova","raw_affiliation_strings":["Assosiate professor of Tashkent Medical Academy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assosiate professor of Tashkent Medical Academy","institution_ids":["https://openalex.org/I4210164592"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210164592"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.35415787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.8544999957084656,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.12950000166893005,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hmgb1","display_name":"HMGB1","score":0.953000009059906},{"id":"https://openalex.org/keywords/high-mobility-group-box-1-protein","display_name":"high mobility group box 1 protein","score":0.8830000162124634},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8610000014305115},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.8930000066757202},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.7829999923706055},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9340000152587891},{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.9549999833106995},{"id":"https://openalex.org/keywords/epileptogenesis","display_name":"epileptogenesis","score":0.859000027179718},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2780545709","wikidata":"https://www.wikidata.org/wiki/Q21130552","display_name":"HMGB1","level":3,"score":0.961899995803833},{"id":"https://openalex.org/C2778857457","wikidata":"https://www.wikidata.org/wiki/Q153641","display_name":"Rage (emotion)","level":2,"score":0.8463000059127808},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8216000199317932},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7775999903678894},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.6949999928474426},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.6236000061035156},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.5916000008583069},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5767999887466431},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5449000000953674},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.444599986076355},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.41499999165534973},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38830000162124634},{"id":"https://openalex.org/C30683889","wikidata":"https://www.wikidata.org/wiki/Q926211","display_name":"High-mobility group","level":3,"score":0.3864000141620636},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3840999901294708},{"id":"https://openalex.org/C29512474","wikidata":"https://www.wikidata.org/wiki/Q16860021","display_name":"Nuclear protein","level":4,"score":0.3598000109195709},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.3578000068664551},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.32280001044273376},{"id":"https://openalex.org/C3020196126","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammatory response","level":3,"score":0.32190001010894775},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3156000077724457},{"id":"https://openalex.org/C111289621","wikidata":"https://www.wikidata.org/wiki/Q418772","display_name":"Pattern recognition receptor","level":4,"score":0.3043999969959259},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3001999855041504},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.29319998621940613},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.2897999882698059},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.2797999978065491},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27970001101493835},{"id":"https://openalex.org/C2780851604","wikidata":"https://www.wikidata.org/wiki/Q596366","display_name":"S100 protein","level":3,"score":0.27570000290870667},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.27149999141693115},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.26589998602867126},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.26440000534057617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26429998874664307},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.26429998874664307},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.25949999690055847},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.2535000145435333}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:journal.univerpublishing.org:article/1932","doi":null,"is_oa":true,"landing_page_url":"https://journal.univerpublishing.org/index.php/horizon/article/view/1932","pdf_url":"https://journal.univerpublishing.org/index.php/horizon/article/download/1932/1683","source":{"id":"https://openalex.org/S7407063665","display_name":"Horizon Journal of Humanity and Artificial Intelligence","issn_l":"2835-3064","issn":["2835-3064"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"10.31150/jhai.v2i6","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:neliti.com:721873","doi":null,"is_oa":true,"landing_page_url":"https://www.neliti.com/publications/721873/potential-biomarker-for-epilepsy-high-mobility-group-box-1-protein-hmgb1","pdf_url":"https://media.neliti.com/media/publications/721873-potential-biomarker-for-epilepsy-high-mo-630807c8.pdf","source":{"id":"https://openalex.org/S7407055263","display_name":"Neliti","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Repository Antis Publisher","raw_type":"Journal:eArticle"}],"best_oa_location":{"id":"pmh:oai:journal.univerpublishing.org:article/1932","doi":null,"is_oa":true,"landing_page_url":"https://journal.univerpublishing.org/index.php/horizon/article/view/1932","pdf_url":"https://journal.univerpublishing.org/index.php/horizon/article/download/1932/1683","source":{"id":"https://openalex.org/S7407063665","display_name":"Horizon Journal of Humanity and Artificial Intelligence","issn_l":"2835-3064","issn":["2835-3064"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"10.31150/jhai.v2i6","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7161521256.pdf","grobid_xml":"https://content.openalex.org/works/W7161521256.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1503384439","https://openalex.org/W1539795210","https://openalex.org/W1970571456","https://openalex.org/W1972204333","https://openalex.org/W1999881215","https://openalex.org/W2000441131","https://openalex.org/W2022981588","https://openalex.org/W2039813398","https://openalex.org/W2043846490","https://openalex.org/W2081689918","https://openalex.org/W2099157718","https://openalex.org/W2127587930","https://openalex.org/W2166742500","https://openalex.org/W2490839939","https://openalex.org/W2764134495","https://openalex.org/W2767110902","https://openalex.org/W2803019757"],"related_works":["https://openalex.org/W2889849480","https://openalex.org/W4307871430","https://openalex.org/W3004438850","https://openalex.org/W7000801992","https://openalex.org/W2761267249","https://openalex.org/W4353081103","https://openalex.org/W3037900192","https://openalex.org/W7218502183","https://openalex.org/W2909985059","https://openalex.org/W2556505330"],"abstract_inverted_index":{"High":[0],"mobility":[1],"group":[2],"box":[3],"protein":[4,11],"1":[5],"(HMGB1)":[6],"is":[7,13,43],"a":[8,72,85],"ubiquitous":[9],"nuclear":[10],"that":[12,92],"generated":[14],"by":[15,95],"glia":[16],"and":[17,29,59,68],"neurons":[18],"in":[19,51],"response":[20],"to":[21,48],"inflammasome":[22],"activation,":[23],"activating":[24],"the":[25,38,44],"target":[26,74],"cells'":[27],"RAGE":[28],"TLR4":[30],"receptors":[31],"for":[32,75,89],"advanced":[33],"glycation":[34],"end":[35],"products.One":[36],"of":[37,41],"main":[39],"triggers":[40],"neuroinflammation":[42],"HMGB1/TLR4":[45],"axis.":[46],"Due":[47],"its":[49],"role":[50],"traumatic":[52],"brain":[53],"injury":[54],"(TBI),":[55],"neuroinflammatory":[56],"diseases,":[57],"epileptogenesis,":[58],"cognitive":[60],"deficits,":[61],"HMGB1":[62,79],"has":[63,69,80],"received":[64],"increased":[65],"attention":[66],"recently":[67],"emerged":[70],"as":[71,84],"novel":[73],"those":[76],"diseases.":[77],"But":[78],"not":[81],"been":[82],"portrayed":[83],"typical":[86],"predictive":[87],"biomarker":[88],"these":[90],"illnesses":[91],"are":[93],"mediated":[94],"HMGB1.":[96]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-05-18T00:00:00"}