{"id":"https://openalex.org/W7161472864","doi":"https://doi.org/10.1038/s42004-026-02260-8","title":"Rapid peptide mapping of monoclonal antibodies with direct infusion mass spectrometry","display_name":"Rapid peptide mapping of monoclonal antibodies with direct infusion mass spectrometry","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7161472864","doi":"https://doi.org/10.1038/s42004-026-02260-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/42182118","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13192854"},"language":"en","primary_location":{"id":"doi:10.1038/s42004-026-02260-8","doi":"https://doi.org/10.1038/s42004-026-02260-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42004-026-02260-8","pdf_url":"https://www.nature.com/articles/s42004-026-02260-8_reference.pdf","source":{"id":"https://openalex.org/S4210191625","display_name":"Communications Chemistry","issn_l":"2399-3669","issn":["2399-3669"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s42004-026-02260-8_reference.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061801549","display_name":"Austin Z. Salome","orcid":"https://orcid.org/0000-0001-7360-3759","observed_orcids":["https://orcid.org/0000-0001-7360-3759"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Austin Z. Salome","raw_affiliation_strings":["Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","Department of Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":"https://orcid.org/0000-0001-7360-3759","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027724470","display_name":"Marcel Morgenstern","orcid":"https://orcid.org/0000-0001-6880-4839","observed_orcids":["https://orcid.org/0000-0001-6880-4839"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcel Morgenstern","raw_affiliation_strings":["Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":"https://orcid.org/0000-0001-6880-4839","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051218655","display_name":"Alexander S. Hebert","orcid":"https://orcid.org/0000-0003-4882-2241","observed_orcids":["https://orcid.org/0000-0003-4882-2241"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander S. Hebert","raw_affiliation_strings":["Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083665081","display_name":"Craig D. Wenger","orcid":"https://orcid.org/0000-0002-7361-8456","observed_orcids":["https://orcid.org/0000-0002-7361-8456"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig D. Wenger","raw_affiliation_strings":["Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":"https://orcid.org/0000-0002-7361-8456","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015711923","display_name":"Pavel G. Sinitcyn","orcid":"https://orcid.org/0000-0002-2653-1702","observed_orcids":["https://orcid.org/0000-0002-2653-1702"]},"institutions":[{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavel Sinitcyn","raw_affiliation_strings":["Morgridge Institute for Research, Madison, WI, USA"],"raw_orcid":"https://orcid.org/0000-0002-2653-1702","affiliations":[{"raw_affiliation_string":"Morgridge Institute for Research, Madison, WI, USA","institution_ids":["https://openalex.org/I29680605"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008047821","display_name":"Benton J. Anderson","orcid":"https://orcid.org/0000-0001-6156-342X","observed_orcids":["https://orcid.org/0000-0001-6156-342X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benton J. Anderson","raw_affiliation_strings":["Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":"https://orcid.org/0000-0001-6156-342X","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001208748","display_name":"John S. Chlystek","orcid":"https://orcid.org/0000-0002-4647-889X","observed_orcids":["https://orcid.org/0000-0002-4647-889X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John S. Chlystek","raw_affiliation_strings":["Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037217891","display_name":"Lia R. Serrano","orcid":"https://orcid.org/0000-0001-5662-5884","observed_orcids":["https://orcid.org/0000-0001-5662-5884"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lia R. Serrano","raw_affiliation_strings":["Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","Department of Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062416234","display_name":"Keaton L. Mertz","orcid":"https://orcid.org/0000-0001-9858-5331","observed_orcids":["https://orcid.org/0000-0001-9858-5331"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keaton L. Mertz","raw_affiliation_strings":["Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","Department of Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065527623","display_name":"Ian J. Miller","orcid":"https://orcid.org/0000-0001-5084-9035","observed_orcids":["https://orcid.org/0000-0001-5084-9035"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian J. Miller","raw_affiliation_strings":["Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136332928","display_name":"Erik Miller-Galow","orcid":"https://orcid.org/0009-0004-4637-163X","observed_orcids":["https://orcid.org/0009-0004-4637-163X"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik Miller-Galow","raw_affiliation_strings":["Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":"https://orcid.org/0009-0004-4637-163X","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069030612","display_name":"Malika P. Godamudunage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malika P. Godamudunage","raw_affiliation_strings":["AbbVie, Inc., Biologics CMC Developability, North Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie, Inc., Biologics CMC Developability, North Chicago, IL, USA","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136336278","display_name":"Michael Batt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Batt","raw_affiliation_strings":["Eli Lilly and Company, Mass Spec Analytical-BioTDR, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company, Mass Spec Analytical-BioTDR, San Diego, CA, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054826871","display_name":"Bhavin R. Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330063522","display_name":"Johnson & Johnson (United States)","ror":"https://ror.org/03qd7mz70","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhavin R. Patel","raw_affiliation_strings":["Johnson & Johnson Innovative Medicine, Johnson & Johnson, Spring House, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson Innovative Medicine, Johnson & Johnson, Spring House, PA, USA","institution_ids":["https://openalex.org/I1330063522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005832805","display_name":"Gihoon Lee","orcid":"https://orcid.org/0000-0003-0783-9899","observed_orcids":["https://orcid.org/0000-0003-0783-9899"]},"institutions":[{"id":"https://openalex.org/I1330063522","display_name":"Johnson & Johnson (United States)","ror":"https://ror.org/03qd7mz70","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gihoon Lee","raw_affiliation_strings":["Johnson & Johnson Innovative Medicine, Johnson & Johnson, Spring House, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson Innovative Medicine, Johnson & Johnson, Spring House, PA, USA","institution_ids":["https://openalex.org/I1330063522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022080753","display_name":"Lloyd M. Smith","orcid":"https://orcid.org/0000-0002-6652-8639","observed_orcids":["https://orcid.org/0000-0002-6652-8639"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lloyd M. Smith","raw_affiliation_strings":["Department of Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA"],"raw_orcid":"https://orcid.org/0000-0002-6652-8639","affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061220286","display_name":"Scott T. Quarmby","orcid":"https://orcid.org/0000-0003-2991-5637","observed_orcids":["https://orcid.org/0000-0003-2991-5637"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott T. Quarmby","raw_affiliation_strings":["Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","National Center for Quantitative Biology of Complex Systems, Madison, WI, USA"],"raw_orcid":"https://orcid.org/0000-0003-2991-5637","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"National Center for Quantitative Biology of Complex Systems, Madison, WI, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016185612","display_name":"Alayna M. George Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2948539688","display_name":"AbbVie (United States)","ror":"https://ror.org/02g5p4n58","country_code":"US","type":"company","lineage":["https://openalex.org/I2948539688"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alayna M. George Thompson","raw_affiliation_strings":["AbbVie, Inc., Biologics CMC Developability, North Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie, Inc., Biologics CMC Developability, North Chicago, IL, USA","institution_ids":["https://openalex.org/I2948539688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012244435","display_name":"Joomi Ahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joomi Ahn","raw_affiliation_strings":["Eli Lilly and Company, Mass Spec Analytical-BioTDR, San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company, Mass Spec Analytical-BioTDR, San Diego, CA, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018067681","display_name":"Harsha P. Gunawardena","orcid":"https://orcid.org/0000-0003-3245-3293","observed_orcids":["https://orcid.org/0000-0003-3245-3293"]},"institutions":[{"id":"https://openalex.org/I1330063522","display_name":"Johnson & Johnson (United States)","ror":"https://ror.org/03qd7mz70","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harsha P. Gunawardena","raw_affiliation_strings":["Johnson & Johnson Innovative Medicine, Johnson & Johnson, Spring House, PA, USA"],"raw_orcid":"https://orcid.org/0000-0003-3245-3293","affiliations":[{"raw_affiliation_string":"Johnson & Johnson Innovative Medicine, Johnson & Johnson, Spring House, PA, USA","institution_ids":["https://openalex.org/I1330063522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086840789","display_name":"Joshua J. Coon","orcid":"https://orcid.org/0000-0002-0004-8253","observed_orcids":["https://orcid.org/0000-0002-0004-8253"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I29680605","display_name":"Morgridge Institute for Research","ror":"https://ror.org/05cb4rb43","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I135310074","https://openalex.org/I29680605"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua J. Coon","raw_affiliation_strings":["Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","Department of Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","Morgridge Institute for Research, Madison, WI, USA","National Center for Quantitative Biology of Complex Systems, Madison, WI, USA"],"raw_orcid":"https://orcid.org/0000-0002-0004-8253","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Chemistry, University of Wisconsin\u2013Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Morgridge Institute for Research, Madison, WI, USA","institution_ids":["https://openalex.org/I29680605"]},{"raw_affiliation_string":"National Center for Quantitative Biology of Complex Systems, Madison, WI, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5086840789"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I29680605"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":1.2774,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.70314506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peptide-mapping","display_name":"peptide mapping","score":0.7839999794960022},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":1.0},{"id":"https://openalex.org/keywords/direct-infusion-mass-spectrometry","display_name":"direct infusion mass spectrometry","score":0.9860000014305115},{"id":"https://openalex.org/keywords/therapeutic-proteins","display_name":"therapeutic proteins","score":0.6970000267028809},{"id":"https://openalex.org/keywords/high-throughput-sample-processing","display_name":"high-throughput sample preparation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/antibody-characterization","display_name":"antibody characterization","score":0.4490000009536743},{"id":"https://openalex.org/keywords/oxidation","display_name":"oxidation","score":0.6000000238418579},{"id":"https://openalex.org/keywords/deamidation","display_name":"deamidation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/isomerization","display_name":"isomerization","score":0.9089999794960022},{"id":"https://openalex.org/keywords/glycosylation","display_name":"glycosylation","score":0.9940000176429749},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.9549999833106995},{"id":"https://openalex.org/keywords/antibody-drug-development","display_name":"antibody drug development","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2910669755","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide mapping","level":4,"score":0.7037000060081482},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6345000267028809},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6216999888420105},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5564000010490417},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5354999899864197},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4684999883174896},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.4674000144004822},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3959999978542328},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.3662000000476837},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.35260000824928284},{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.3215000033378601},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.30079999566078186},{"id":"https://openalex.org/C149629883","wikidata":"https://www.wikidata.org/wiki/Q660926","display_name":"Fraction (chemistry)","level":2,"score":0.29589998722076416},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.29330000281333923},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.2827000021934509},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.2825999855995178},{"id":"https://openalex.org/C2781241564","wikidata":"https://www.wikidata.org/wiki/Q1347450","display_name":"Epitope mapping","level":4,"score":0.27090001106262207},{"id":"https://openalex.org/C61053724","wikidata":"https://www.wikidata.org/wiki/Q1154615","display_name":"Sequence analysis","level":3,"score":0.26739999651908875},{"id":"https://openalex.org/C3017395165","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide fragment","level":3,"score":0.262800008058548}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1038/s42004-026-02260-8","doi":"https://doi.org/10.1038/s42004-026-02260-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42004-026-02260-8","pdf_url":"https://www.nature.com/articles/s42004-026-02260-8_reference.pdf","source":{"id":"https://openalex.org/S4210191625","display_name":"Communications Chemistry","issn_l":"2399-3669","issn":["2399-3669"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Chemistry","raw_type":"journal-article"},{"id":"doi:10.64898/2026.05.14.725248","doi":"https://doi.org/10.64898/2026.05.14.725248","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.14.725248","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/16/2026.05.14.725248.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42182118","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42182118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/487982","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/487982","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"/dk/atira/pure/researchoutput/researchoutputtypes/workingpaper/preprint"},{"id":"pmh:oai:pubmedcentral.nih.gov:13192854","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13192854/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/s42004-026-02260-8","doi":"https://doi.org/10.1038/s42004-026-02260-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s42004-026-02260-8","pdf_url":"https://www.nature.com/articles/s42004-026-02260-8_reference.pdf","source":{"id":"https://openalex.org/S4210191625","display_name":"Communications Chemistry","issn_l":"2399-3669","issn":["2399-3669"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000880556","display_name":"Structure, Function and Regulation of the Proteome","funder_award_id":"R35GM118110","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000895787","display_name":"National Center for Quantitative Biology of Complex Systems","funder_award_id":"P41GM108538","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000902734","display_name":"Revealing Proteoforms: The Primary Effectors of Biological Function","funder_award_id":"R35GM126914","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309434","display_name":"University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332178","display_name":"National Institute of Standards and Technology","ror":"https://ror.org/05xpvk416"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7161472864.pdf","grobid_xml":"https://content.openalex.org/works/W7161472864.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1865824976","https://openalex.org/W1891660574","https://openalex.org/W1967931040","https://openalex.org/W1984007340","https://openalex.org/W1984670732","https://openalex.org/W2006395654","https://openalex.org/W2010399703","https://openalex.org/W2018740072","https://openalex.org/W2019417245","https://openalex.org/W2032975690","https://openalex.org/W2102169331","https://openalex.org/W2117811575","https://openalex.org/W2131793758","https://openalex.org/W2150812437","https://openalex.org/W2170426247","https://openalex.org/W2412156741","https://openalex.org/W2513720654","https://openalex.org/W2555577306","https://openalex.org/W2593373253","https://openalex.org/W2751949649","https://openalex.org/W2787783783","https://openalex.org/W2799800134","https://openalex.org/W2805746983","https://openalex.org/W2807443486","https://openalex.org/W2886098280","https://openalex.org/W2890820905","https://openalex.org/W2901520359","https://openalex.org/W2981266307","https://openalex.org/W2992897232","https://openalex.org/W2999061498","https://openalex.org/W2999958881","https://openalex.org/W3036783606","https://openalex.org/W3044195134","https://openalex.org/W3081638084","https://openalex.org/W3087044605","https://openalex.org/W3119965917","https://openalex.org/W3131091842","https://openalex.org/W3131380995","https://openalex.org/W3145233098","https://openalex.org/W3149626385","https://openalex.org/W3159844184","https://openalex.org/W3177828909","https://openalex.org/W3186432004","https://openalex.org/W3214877553","https://openalex.org/W4200134357","https://openalex.org/W4206693961","https://openalex.org/W4225263758","https://openalex.org/W4280603584","https://openalex.org/W4292112379","https://openalex.org/W4309737076","https://openalex.org/W4311685820","https://openalex.org/W4317475285","https://openalex.org/W4320728841","https://openalex.org/W4321599838","https://openalex.org/W4324143928","https://openalex.org/W4365148338","https://openalex.org/W4376604031","https://openalex.org/W4387107694","https://openalex.org/W4388412887","https://openalex.org/W4390613013","https://openalex.org/W4390796639","https://openalex.org/W4396623853","https://openalex.org/W4401014778","https://openalex.org/W4401358418","https://openalex.org/W4402442892","https://openalex.org/W4402758368","https://openalex.org/W4405656845","https://openalex.org/W7128961518"],"related_works":["https://openalex.org/W1967931040","https://openalex.org/W4412828447","https://openalex.org/W4414816604","https://openalex.org/W3005419894","https://openalex.org/W2473914370","https://openalex.org/W3109405798","https://openalex.org/W3177896618","https://openalex.org/W3194797923","https://openalex.org/W7099304678","https://openalex.org/W2070541143"],"abstract_inverted_index":{"Peptide":[0],"mapping":[1,31],"is":[2,11,125,143],"a":[3,23,114],"critical":[4],"tool":[5],"for":[6,13,132,159],"characterizing":[7],"biotherapeutic":[8],"proteins":[9],"and":[10,34,77,86,96,102,128,155,174],"essential":[12],"the":[14,37,117,133,157],"development":[15,154],"of":[16,63,116,135,149,161,170],"monoclonal":[17],"antibody":[18,172],"drugs.":[19],"Here":[20,90],"we":[21,46,91],"describe":[22],"new":[24],"direct":[25,55],"infusion":[26,56],"technology":[27],"that":[28,93,164],"streamlines":[29],"peptide":[30,138],"data":[32,123],"collection":[33,134,160],"analysis,":[35],"accelerating":[36],"method":[38],"by":[39,120],"up":[40],"to":[41,69,82,108,145],"100-fold.":[42],"This":[43],"method,":[44],"which":[45],"term":[47],"RaPiD-mAb-MS,":[48],"combines":[49],"high-throughput":[50],"plate-based":[51],"sample":[52],"preparation":[53],"with":[54,105],"mass":[57],"spectrometry":[58],"analysis.":[59],"RaPiD-mAb-MS":[60,94,142],"allows":[61],"analysis":[62,124],"96":[64],"samples":[65],"within":[66],"~":[67,136],"1.5":[68],"2":[70],"hours,":[71],"routinely":[72],"achieves":[73],">95%":[74],"sequence":[75,103],"coverage,":[76],"has":[78],"been":[79],"successfully":[80],"applied":[81],"28":[83],"unique":[84],"antibodies":[85],"over":[87],"2000":[88],"samples.":[89],"demonstrate":[92],"detects":[95],"quantifies":[97],"oxidation,":[98],"deamidation,":[99],"isomerization,":[100],"glycosylation,":[101],"variants":[104,173],"results":[106],"comparable":[107],"conventional":[109],"LC-MS":[110],"based":[111],"methods":[112],"in":[113],"fraction":[115],"time.":[118],"Further,":[119],"eliminating":[121],"chromatography,":[122],"greatly":[126],"streamlined":[127],"simplified.":[129],"By":[130],"allowing":[131],"1000":[137],"maps":[139],"per":[140],"day,":[141],"positioned":[144],"accelerate":[146],"all":[147],"phases":[148],"antibody-based":[150],"drug":[151],"discovery":[152],"&":[153],"sets":[156],"stage":[158],"massive":[162],"datasets":[163],"would":[165],"allow":[166],"artificial":[167],"intelligent":[168],"prediction":[169],"optimal":[171],"formulations.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-05-18T00:00:00"}