{"id":"https://openalex.org/W71614571","doi":"https://doi.org/10.1007/978-3-0348-8225-5_16","title":"\u03b1-Synuclein/NACP and neurodegeneration","display_name":"\u03b1-Synuclein/NACP and neurodegeneration","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W71614571","doi":"https://doi.org/10.1007/978-3-0348-8225-5_16","mag":"71614571"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-0348-8225-5_16","doi":"https://doi.org/10.1007/978-3-0348-8225-5_16","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-0348-8225-5_16","pdf_url":null,"source":{"id":"https://openalex.org/S4306462920","display_name":"Birkh\u00e4user Basel eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscientific Basis of Dementia","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W563906519","display_name":"Neuroscientific Basis of Dementia"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079206027","display_name":"Seigo Tanaka","orcid":"https://orcid.org/0000-0002-4304-202X","observed_orcids":["https://orcid.org/0000-0002-4304-202X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seigo Tanaka","raw_affiliation_strings":["Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009286968","display_name":"Masanori Takehashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanori Takehashi","raw_affiliation_strings":["Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085872433","display_name":"Naomi Matoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naomi Matoh","raw_affiliation_strings":["Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105989049","display_name":"Kunihiro Ueda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4399598384","display_name":"Kyoto University Institute for Chemical Research","ror":"https://ror.org/0349bbg69","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunihiro Ueda","raw_affiliation_strings":["Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4399598384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4409,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.76400299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"137","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7484999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.24539999663829803,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9430000185966492},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.8500000238418579},{"id":"https://openalex.org/keywords/amyloid-deposition","display_name":"amyloid deposition","score":0.8889999985694885},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.9449999928474426},{"id":"https://openalex.org/keywords/protein-precursors","display_name":"precursor protein","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C68026918","wikidata":"https://www.wikidata.org/wiki/Q1970256","display_name":"Senile plaques","level":4,"score":0.6252350211143494},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.6219640970230103},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5920505523681641},{"id":"https://openalex.org/C2777916540","wikidata":"https://www.wikidata.org/wiki/Q24767155","display_name":"Synuclein","level":5,"score":0.4735637903213501},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.44945022463798523},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44933199882507324},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3500075340270996},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3042322099208832},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2859065532684326},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28070148825645447},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.2633662223815918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22633028030395508},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.22446724772453308},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.22044306993484497},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.13926059007644653},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-0348-8225-5_16","doi":"https://doi.org/10.1007/978-3-0348-8225-5_16","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-0348-8225-5_16","pdf_url":null,"source":{"id":"https://openalex.org/S4306462920","display_name":"Birkh\u00e4user Basel eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscientific Basis of Dementia","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1595422166","https://openalex.org/W1792681624","https://openalex.org/W1935894920","https://openalex.org/W1970673084","https://openalex.org/W1972409470","https://openalex.org/W1986042913","https://openalex.org/W2013313629","https://openalex.org/W2016816471","https://openalex.org/W2028652101","https://openalex.org/W2046444180","https://openalex.org/W2059261643","https://openalex.org/W2068602144","https://openalex.org/W2086857730","https://openalex.org/W2091265794","https://openalex.org/W2108410348","https://openalex.org/W2116597539","https://openalex.org/W2148568069","https://openalex.org/W2150656456","https://openalex.org/W2158748165","https://openalex.org/W2161334375","https://openalex.org/W2162010804"],"related_works":["https://openalex.org/W2059261643","https://openalex.org/W1595422166","https://openalex.org/W2078172830","https://openalex.org/W2008695023","https://openalex.org/W164931211","https://openalex.org/W2040526078","https://openalex.org/W2092099974","https://openalex.org/W103502886","https://openalex.org/W2074710446","https://openalex.org/W2025399871"],"abstract_inverted_index":{"Amyloid":[0],"deposition":[1],"in":[2,14,31,95],"the":[3,10,15,72,86,96,101,132,139,145],"senile":[4,32],"plaque":[5],"cores":[6],"is":[7,49,65,93,136],"one":[8],"of":[9,25,43,100],"major":[11],"neuropathological":[12],"features":[13],"brain":[16],"with":[17,67],"Alzheimer\u2019s":[18],"disease":[19],"(AD).":[20],"A":[21],"non-A\u03b2":[22],"component":[23],"(NAC)":[24],"AD":[26],"amyloid":[27],"was":[28],"originally":[29],"identified":[30],"plaques":[33],"as":[34,144],"a":[35,55,89],"protein":[36],"other":[37],"than":[38],"A\u03b2":[39],"[1].":[40],"NAC,":[41],"consisting":[42],"at":[44],"least":[45],"35":[46],"amino":[47],"acids,":[48],"supposed":[50],"to":[51,71],"be":[52,142],"produced":[53],"from":[54],"precursor":[56],"protein,":[57],"termed":[58],"NACP,":[59],"by":[60,127,131],"an":[61],"unkown":[62],"mechanism.":[63],"NACP":[64],"identical":[66],"\u03b1-synuclein":[68,87,102,107],"that":[69],"belongs":[70],"synuclein":[73],"family.":[74],"This":[75,134],"family":[76],"comprises":[77],"\u03b1-,":[78],"\u03b2-":[79],"and":[80,114,129,138],"\u03b3-synucleins":[81],"[2\u20134],":[82],"among":[83],"which":[84],"only":[85],"has":[88,108],"NAC":[90,92],"domain.":[91],"located":[94],"most":[97],"hydrophobic":[98],"portion":[99],"molecule":[103],"(Fig.":[104],"1).":[105],"The":[106],"seven":[109],"incompletely":[110],"repeated":[111],"KTKEGV":[112],"motifs":[113],"no":[115],"signal":[116],"peptide":[117],"sequence":[118],"or":[119],"N-linked":[120],"glycosylation":[121],"sites.":[122],"These":[123],"keywords":[124,140],"were":[125],"added":[126],"machine":[128],"not":[130],"authors.":[133],"process":[135],"experimental":[137],"may":[141],"updated":[143],"learning":[146],"algorithm":[147],"improves.":[148]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}