{"id":"https://openalex.org/W7161424828","doi":"https://doi.org/10.1016/j.clnu.2026.106690","title":"Does \u03b2-hydroxy-\u03b2-methylbutyrate (HMB) have an anti-inflammatory impact in critically ill patients? A secondary post hoc analysis of an RCT","display_name":"Does \u03b2-hydroxy-\u03b2-methylbutyrate (HMB) have an anti-inflammatory impact in critically ill patients? A secondary post hoc analysis of an RCT","publication_year":2026,"publication_date":"2026-05-16","ids":{"openalex":"https://openalex.org/W7161424828","doi":"https://doi.org/10.1016/j.clnu.2026.106690","pmid":"https://pubmed.ncbi.nlm.nih.gov/42202485"},"language":"en","primary_location":{"id":"doi:10.1016/j.clnu.2026.106690","doi":"https://doi.org/10.1016/j.clnu.2026.106690","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.clnu.2026.106690","pdf_url":null,"source":{"id":"https://openalex.org/S102860386","display_name":"Clinical Nutrition","issn_l":"0261-5614","issn":["0261-5614","1532-1983"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.clnu.2026.106690","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031660292","display_name":"Mette M. Berger","orcid":"https://orcid.org/0000-0001-5427-1648","observed_orcids":["https://orcid.org/0000-0001-5427-1648"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Mette M. Berger","raw_affiliation_strings":["Faculty of Biology and Medicine, Lausanne University, Lausanne, Switzerland; Dept of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland. Electronic address: Mette.Berger@unil.ch"],"raw_orcid":"https://orcid.org/0000-0001-5427-1648","affiliations":[{"raw_affiliation_string":"Faculty of Biology and Medicine, Lausanne University, Lausanne, Switzerland; Dept of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland. Electronic address: Mette.Berger@unil.ch","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035556085","display_name":"Marina Ver\u00e7oza Viana","orcid":"https://orcid.org/0000-0001-9564-4885","observed_orcids":["https://orcid.org/0000-0001-9564-4885"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Marina V. Viana","raw_affiliation_strings":["Dept of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland. Electronic address: marivv1981@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Adult Intensive Care, Lausanne University Hospital (CHUV), Lausanne, Switzerland. Electronic address: marivv1981@gmail.com","institution_ids":["https://openalex.org/I2802229882"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003725112","display_name":"MARI\u00cbLLE P. K. J. ENGELEN","orcid":"https://orcid.org/0000-0001-9884-2553","observed_orcids":["https://orcid.org/0000-0001-9884-2553"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mari\u00eblle P.K.J. Engelen","raw_affiliation_strings":["Center for Translational Research in Aging & Longevity, Texas A&M University, United States. Electronic address: mpkj.engelen@ctral.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Research in Aging & Longevity, Texas A&M University, United States. Electronic address: mpkj.engelen@ctral.org","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073459667","display_name":"Nicolaas E.P. Deutz","orcid":"https://orcid.org/0000-0001-5845-6447","observed_orcids":["https://orcid.org/0000-0001-5845-6447"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicolaas E.P. Deutz","raw_affiliation_strings":["Center for Translational Research in Aging & Longevity, Texas A&M University, United States. Electronic address: nep.deutz@ctral.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational Research in Aging & Longevity, Texas A&M University, United States. Electronic address: nep.deutz@ctral.org","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5003725112","https://openalex.org/A5031660292","https://openalex.org/A5035556085","https://openalex.org/A5073459667"],"corresponding_institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I91045830","https://openalex.org/I97565354"],"apc_list":{"value":3320,"currency":"USD","value_usd":3320},"apc_paid":{"value":3320,"currency":"USD","value_usd":3320},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28225521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"62","issue":null,"first_page":"106690","last_page":"106690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.1973000019788742,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-hydroxy-beta-methylbutyrate","display_name":"beta-hydroxy-beta-methylbutyrate","score":0.9399999976158142},{"id":"https://openalex.org/keywords/leucine-metabolites","display_name":"leucine metabolites","score":0.7540000081062317},{"id":"https://openalex.org/keywords/critically-ill-patients","display_name":"critically ill patients","score":0.8040000200271606},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6230000257492065},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8240000009536743},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.6110000014305115},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.7009999752044678},{"id":"https://openalex.org/keywords/intracellular-amino-acid-pool","display_name":"intracellular amino acid pool","score":0.7979999780654907},{"id":"https://openalex.org/keywords/taurine","display_name":"taurine","score":0.7609999775886536},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.9629999995231628},{"id":"https://openalex.org/keywords/urea-creatinine-ratio","display_name":"urea/creatinine ratio","score":0.8619999885559082},{"id":"https://openalex.org/keywords/muscle-protein-degradation","display_name":"muscle protein degradation","score":0.3490000069141388},{"id":"https://openalex.org/keywords/postabsorptive-state","display_name":"postabsorptive state","score":0.6299999952316284},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9672999978065491},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.8147000074386597},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.7793999910354614},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6190999746322632},{"id":"https://openalex.org/C2992886853","wikidata":"https://www.wikidata.org/wiki/Q18381816","display_name":"Post hoc","level":2,"score":0.558899998664856},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4975000023841858},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.3190000057220459},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2793999910354614},{"id":"https://openalex.org/C2993568657","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critical illness","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.25850000977516174},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.25529998540878296}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014631","descriptor_name":"Valerates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014631","descriptor_name":"Valerates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.clnu.2026.106690","doi":"https://doi.org/10.1016/j.clnu.2026.106690","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.clnu.2026.106690","pdf_url":null,"source":{"id":"https://openalex.org/S102860386","display_name":"Clinical Nutrition","issn_l":"0261-5614","issn":["0261-5614","1532-1983"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Nutrition","raw_type":"journal-article"},{"id":"pmid:42202485","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42202485","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical nutrition (Edinburgh, Scotland)","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/282323","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/282323","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.1016/j.clnu.2026.106690","doi":"https://doi.org/10.1016/j.clnu.2026.106690","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.clnu.2026.106690","pdf_url":null,"source":{"id":"https://openalex.org/S102860386","display_name":"Clinical Nutrition","issn_l":"0261-5614","issn":["0261-5614","1532-1983"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333012","display_name":"Texas A and M-Texarkana","ror":"https://ror.org/01x3z9745"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1972458687","https://openalex.org/W2082243216","https://openalex.org/W2153058083","https://openalex.org/W2164863345","https://openalex.org/W2346464498","https://openalex.org/W2346723591","https://openalex.org/W2612068365","https://openalex.org/W2790947187","https://openalex.org/W2946968686","https://openalex.org/W2973799290","https://openalex.org/W3139047201","https://openalex.org/W3186749525","https://openalex.org/W4206620445","https://openalex.org/W4307336590","https://openalex.org/W4309962995","https://openalex.org/W4393398521","https://openalex.org/W4402580817","https://openalex.org/W4405574942","https://openalex.org/W4406777840","https://openalex.org/W4409247835","https://openalex.org/W4412672915","https://openalex.org/W4415427778","https://openalex.org/W7128377134","https://openalex.org/W7140311009"],"related_works":["https://openalex.org/W3104979345","https://openalex.org/W7214887065","https://openalex.org/W2346464498","https://openalex.org/W2618564522","https://openalex.org/W2467778097","https://openalex.org/W2790947187","https://openalex.org/W2153058083","https://openalex.org/W2084705395","https://openalex.org/W2896506790","https://openalex.org/W362549335"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"Beta-hydroxy-beta-methylbutyrate":[3],"(HMB),":[4],"a":[5,28,35,326,331,339],"natural":[6],"breakdown":[7,41],"product":[8],"of":[9,38,92,146,230,253,345],"the":[10,52,67,78,107,188,191,244,249,290,295,312],"amino":[11,127],"acid":[12,134],"leucine,":[13],"has":[14,338],"been":[15],"shown":[16],"to":[17,50,297],"increase":[18],"protein":[19,40,57,125],"synthesis":[20,58,344],"in":[21,27,42,106,217,275,289,311],"human":[22],"skeletal":[23],"muscle.":[24],"After":[25],"demonstrating":[26],"randomised":[29],"10-day":[30],"supplementation":[31,322],"trial":[32],"using":[33],"isotopes,":[34],"significant":[36,340],"reduction":[37],"net":[39],"critically":[43,84],"ill":[44,85],"patients,":[45],"this":[46],"post-hoc":[47,73],"study":[48,102,318],"aimed":[49],"investigate":[51],"global,":[53],"extra-,":[54],"and":[55,63,113,131,138,177,232,261,264,273,283],"intracellular":[56,250,343],"pathways":[59],"impacted":[60],"by":[61,197,240,308],"HMB,":[62,256],"its":[64],"influence":[65],"on":[66,110,342],"inflammatory":[68,328],"response.":[69,335],"METHODS:":[70],"This":[71],"secondary":[72],"analysis":[74,119],"used":[75],"data":[76],"from":[77],"previously":[79],"published":[80],"randomized":[81],"trial,":[82],"where":[83],"patients":[86,165],"were":[87,104,141,166,265],"supplied":[88],"with":[89,213,325],"3":[90],"g":[91],"HMB/day":[93],"or":[94],"placebo":[95],"for":[96,201],"at":[97],"least":[98],"10":[99],"days.":[100],"The":[101,316],"procedures":[103],"conducted":[105],"postabsorptive":[108],"state":[109],"days":[111],"4":[112],"15":[114,310],"after":[115,143],"ICU":[116],"admission.":[117],"Blood":[118],"included":[120,167],"cytokines":[121,207],"(by":[122],"Luminex),":[123],"C-reactive":[124],"(CRP),":[126],"acids":[128],"(AA),":[129],"urea":[130,296],"creatinine.":[132],"Amino":[133],"whole":[135],"body":[136,228],"productions":[137],"plasma":[139],"concentrations":[140],"measured":[142,193],"pulse":[144],"administrations":[145],"an":[147],"8":[148],"mL":[149],"solution":[150],"containing":[151],"18":[152],"stable":[153],"AA":[154,231],"tracers.":[155],"Data":[156],"are":[157],"presented":[158],"as":[159],"means":[160],"[95%CI].":[161],"RESULTS:":[162],"Altogether":[163],"37":[164,192],"(aged":[168],"65":[169],"[56,":[170],"74]":[171],"years,":[172],"SAPS2":[173],"48":[174],"[40,":[175],"52],":[176],"APACHEII":[178],"23":[179],"[19,":[180],"26]):":[181],"baseline":[182],"characteristics":[183],"did":[184,236],"not":[185,237],"differ":[186,238],"between":[187,210],"groups.":[189],"Among":[190],"cytokines,":[194],"most":[195],"declined":[196],"day":[198,241,309],"15,":[199],"except":[200],"some":[202],"specific":[203],"growth":[204],"factors.":[205],"Twelve":[206],"differed":[208],"significantly":[209,239,266,272,287,301],"groups":[211,277],"post-intervention,":[212],"levels":[214],"being":[215],"higher":[216,267],"HMB":[218,245,284,291,313,321,337],"group":[219,246],"(including":[220],"7":[221],"proinflammatory":[222],"cytokines)":[223],"(p":[224,278],"<":[225,279],"0.05).":[226],"Whole":[227],"production":[229,270,285],"extracellular":[233],"pool":[234,251],"sizes":[235,252],"15.":[242],"In":[243,293],"(vs.":[247],"placebo),":[248],"citrulline,":[254],"glutamine,":[255],"KMV":[257],"(\u03b1-keto-\u03b2-methylvaleric":[258],"acid),":[259],"taurine,":[260],"tau-methyhistidine":[262],"increased":[263,271,286],"post-intervention.":[268],"Taurine":[269],"similarly":[274],"both":[276],"0.05)":[280],"but":[281],"glutamine":[282],"more":[288,332],"group.":[292,314],"parallel,":[294],"creatinine":[298],"ratio":[299],"decreased":[300],"(125":[302],"vs":[303],"181,":[304],"p":[305],"=":[306],"0.002)":[307],"CONCLUSION:":[315],"present":[317],"shows":[319],"that":[320],"is":[323],"associated":[324],"different":[327],"pattern,":[329],"suggesting":[330],"efficient":[333],"immune":[334],"Furthermore,":[336],"impact":[341],"selected":[346],"AA,":[347],"particularly":[348],"glutamine.":[349],"(NCT03628365:":[350],"https://clinicaltrials.gov/ct2/show/NCT03628365).":[351]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-05-17T00:00:00"}