{"id":"https://openalex.org/W7161296548","doi":"https://doi.org/10.64898/2026.05.14.725289","title":"Obligate multicellularity circumvents population genetic barriers to collective-level adaptation","display_name":"Obligate multicellularity circumvents population genetic barriers to collective-level adaptation","publication_year":2026,"publication_date":"2026-05-15","ids":{"openalex":"https://openalex.org/W7161296548","doi":"https://doi.org/10.64898/2026.05.14.725289"},"language":"en","primary_location":{"id":"doi:10.64898/2026.05.14.725289","doi":"https://doi.org/10.64898/2026.05.14.725289","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.14.725289","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.05.14.725289","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081385495","display_name":"Autumn Peterson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Autumn Peterson","raw_affiliation_strings":["Georgia Institute of Technology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology;","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010603147","display_name":"Eric Libby","orcid":"https://orcid.org/0000-0002-6569-5793","observed_orcids":["https://orcid.org/0000-0002-6569-5793"]},"institutions":[{"id":"https://openalex.org/I90267481","display_name":"Ume\u00e5 University","ror":"https://ror.org/05kb8h459","country_code":"SE","type":"education","lineage":["https://openalex.org/I90267481"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Eric Libby","raw_affiliation_strings":["Umea University"],"raw_orcid":"https://orcid.org/0000-0002-6569-5793","affiliations":[{"raw_affiliation_string":"Umea University","institution_ids":["https://openalex.org/I90267481"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041720512","display_name":"Anthony Burnetti","orcid":"https://orcid.org/0000-0003-3856-8251","observed_orcids":["https://orcid.org/0000-0003-3856-8251"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony J Burnetti","raw_affiliation_strings":["Georgia Institute of Technology;"],"raw_orcid":"https://orcid.org/0000-0003-3856-8251","affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology;","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136236749","display_name":"Jenasis Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenasis Campbell","raw_affiliation_strings":["Georgia Institute of Technology;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology;","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032185000","display_name":"William C. Ratcliff","orcid":"https://orcid.org/0000-0002-6837-8355","observed_orcids":["https://orcid.org/0000-0002-6837-8355"]},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William Ratcliff","raw_affiliation_strings":["Georgia Institute of Technology;"],"raw_orcid":"https://orcid.org/0000-0002-6837-8355","affiliations":[{"raw_affiliation_string":"Georgia Institute of Technology;","institution_ids":["https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032185000"],"corresponding_institution_ids":["https://openalex.org/I130701444"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonality","display_name":"clonality","score":0.8539999723434448},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9819999933242798},{"id":"https://openalex.org/keywords/whole-genome-doubling","display_name":"whole-genome duplication","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tetraploidy","display_name":"tetraploidy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/within-group-conflict","display_name":"within-group conflict","score":0.796999990940094},{"id":"https://openalex.org/keywords/life-cycle-evolution","display_name":"life cycle evolution","score":0.6290000081062317},{"id":"https://openalex.org/keywords/mathematical-modeling-of-evolution","display_name":"mathematical modeling of evolution","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.951200008392334},{"id":"https://openalex.org/C24990904","wikidata":"https://www.wikidata.org/wiki/Q7075144","display_name":"Obligate","level":2,"score":0.925000011920929},{"id":"https://openalex.org/C53144768","wikidata":"https://www.wikidata.org/wiki/Q5428855","display_name":"Facultative","level":2,"score":0.9235000014305115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8679999709129333},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.7297999858856201},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6044999957084656},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5389999747276306},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.5389000177383423},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.4058000147342682},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.373199999332428},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.35420000553131104},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.3370000123977661},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3077000081539154},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.2930999994277954},{"id":"https://openalex.org/C197583594","wikidata":"https://www.wikidata.org/wiki/Q1052390","display_name":"Most recent common ancestor","level":4,"score":0.2800000011920929},{"id":"https://openalex.org/C2988562018","wikidata":"https://www.wikidata.org/wiki/Q1063","display_name":"Biological evolution","level":2,"score":0.2728999853134155},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.25619998574256897},{"id":"https://openalex.org/C167683757","wikidata":"https://www.wikidata.org/wiki/Q5937774","display_name":"Human evolutionary genetics","level":4,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.05.14.725289","doi":"https://doi.org/10.64898/2026.05.14.725289","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.14.725289","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.05.14.725289","doi":"https://doi.org/10.64898/2026.05.14.725289","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.14.725289","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W20375342","https://openalex.org/W1573821798","https://openalex.org/W1894082217","https://openalex.org/W1926814242","https://openalex.org/W1967390196","https://openalex.org/W1974102091","https://openalex.org/W1977832160","https://openalex.org/W1978320850","https://openalex.org/W1988714210","https://openalex.org/W2009625348","https://openalex.org/W2018643684","https://openalex.org/W2020402841","https://openalex.org/W2021498612","https://openalex.org/W2023850342","https://openalex.org/W2028929689","https://openalex.org/W2030121195","https://openalex.org/W2038227545","https://openalex.org/W2042694314","https://openalex.org/W2046724325","https://openalex.org/W2092604303","https://openalex.org/W2096405172","https://openalex.org/W2102829950","https://openalex.org/W2104287464","https://openalex.org/W2112743201","https://openalex.org/W2114416030","https://openalex.org/W2119266425","https://openalex.org/W2122139514","https://openalex.org/W2125310261","https://openalex.org/W2138670394","https://openalex.org/W2150727896","https://openalex.org/W2157679469","https://openalex.org/W2160332754","https://openalex.org/W2166053865","https://openalex.org/W2166410860","https://openalex.org/W2166797439","https://openalex.org/W2167474377","https://openalex.org/W2171501215","https://openalex.org/W2175209904","https://openalex.org/W2602840959","https://openalex.org/W2763577959","https://openalex.org/W2765832106","https://openalex.org/W2789928729","https://openalex.org/W2790556376","https://openalex.org/W2940082836","https://openalex.org/W3045069371","https://openalex.org/W3081224153","https://openalex.org/W3162428610","https://openalex.org/W3166713748","https://openalex.org/W3190638530","https://openalex.org/W3201357410","https://openalex.org/W3215604651","https://openalex.org/W4200065527","https://openalex.org/W4200407540","https://openalex.org/W4211239758","https://openalex.org/W4245354300","https://openalex.org/W4254519174","https://openalex.org/W4280651628","https://openalex.org/W4286494030","https://openalex.org/W4293716244","https://openalex.org/W4294373694","https://openalex.org/W4296553204","https://openalex.org/W4362635228","https://openalex.org/W4366590364","https://openalex.org/W4366603691","https://openalex.org/W4376113416","https://openalex.org/W4384922592","https://openalex.org/W4385955064","https://openalex.org/W4387965835","https://openalex.org/W4390702889","https://openalex.org/W4391543707","https://openalex.org/W4392581170","https://openalex.org/W4404376545","https://openalex.org/W4408244280"],"related_works":["https://openalex.org/W4387965835","https://openalex.org/W4296794283","https://openalex.org/W2112743201","https://openalex.org/W7000441333","https://openalex.org/W2138670394","https://openalex.org/W2314242364","https://openalex.org/W2623104563","https://openalex.org/W3040919035","https://openalex.org/W2150727896","https://openalex.org/W4391543707"],"abstract_inverted_index":{"'Complex'":[0],"multicellularity":[1,48,55,171,178],"has":[2],"evolved":[3,88,102],"in":[4,119],"five":[5,97],"eukaryotic":[6],"lineages,":[7],"all":[8],"of":[9,46,68,76],"which":[10],"develop":[11],"clonally":[12],"and":[13,87,140,169],"are":[14,159],"obligately":[15,78,83,98],"multicellular":[16,32,99],"(i.e.,":[17],"lack":[18],"a":[19,28,65],"reproductive":[20],"unicellular":[21,84],"phase).":[22],"Clonal":[23],"development":[24],"is":[25,40],"well-established":[26],"as":[27],"critical":[29],"factor":[30],"promoting":[31],"adaptation":[33],"by":[34,182,188],"limiting":[35],"within-group":[36,184],"conflict,":[37,185],"but":[38],"little":[39],"known":[41],"about":[42],"the":[43,130,149,155,174,186],"evolutionary":[44],"consequences":[45],"obligate":[47,54,170],"itself.":[49],"Here,":[50],"we":[51],"show":[52],"that":[53,137,151,167],"alleviates":[56],"an":[57],"establishment":[58],"barrier":[59],"to":[60,179,193],"collective-level":[61,194],"adaptation.":[62,195],"We":[63],"engineered":[64],"single":[66],"strain":[67],"snowflake":[69],"yeast":[70],"(":[71],"Saccharomyces":[72],"cerevisiae":[73],")":[74],"capable":[75],"exhibiting":[77],"multicellular,":[79,81],"facultatively":[80],"or":[82],"life":[85,132,144,157],"cycles,":[86],"them":[89],"under":[90],"selection":[91,142],"for":[92,176],"larger":[93,103],"group":[94,138],"size.":[95],"All":[96],"populations":[100,111],"rapidly":[101],"groups,":[104],"primarily":[105],"through":[106],"whole":[107],"genome":[108],"duplication.":[109],"Facultative":[110],"were":[112],"far":[113],"more":[114],"constrained,":[115],"with":[116],"tetraploidy":[117],"evolving":[118],"only":[120],"2/10":[121],"populations,":[122],"despite":[123],"this":[124],"trait":[125],"being":[126],"strongly":[127],"beneficial":[128,153],"across":[129,143,154],"full":[131,156],"cycle.":[133],"Mathematical":[134],"modeling":[135],"suggests":[136],"formation":[139],"opposing":[141],"cycle":[145,158],"phases":[146],"interact,":[147],"increasing":[148],"chance":[150],"mutations":[152],"lost":[160],"before":[161],"they":[162],"establish.":[163],"These":[164],"results":[165],"suggest":[166],"clonality":[168],"jointly":[172],"create":[173],"conditions":[175],"complex":[177],"evolve,":[180],"one":[181],"suppressing":[183],"other":[187],"removing":[189],"population":[190],"genetic":[191],"barriers":[192]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-05-16T00:00:00"}
