{"id":"https://openalex.org/W7161237652","doi":"https://doi.org/10.64898/2026.05.14.722739","title":"Actin disassembly triggers CNS myelin compaction and wrapping","display_name":"Actin disassembly triggers CNS myelin compaction and wrapping","publication_year":2026,"publication_date":"2026-05-15","ids":{"openalex":"https://openalex.org/W7161237652","doi":"https://doi.org/10.64898/2026.05.14.722739","pmid":"https://pubmed.ncbi.nlm.nih.gov/42182328"},"language":"en","primary_location":{"id":"doi:10.64898/2026.05.14.722739","doi":"https://doi.org/10.64898/2026.05.14.722739","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.14.722739","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/15/2026.05.14.722739.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/15/2026.05.14.722739.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075032645","display_name":"Husniye Kantarci","orcid":"https://orcid.org/0000-0002-3667-8003","observed_orcids":["https://orcid.org/0000-0002-3667-8003"]},"institutions":[{"id":"https://openalex.org/I1338920048","display_name":"Marine Biological Laboratory","ror":"https://ror.org/046dg4z72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1338920048"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Husniye Kantarci","raw_affiliation_strings":["Department of Neuroscience, The University of Texas at Austin, Austin, TX, 78712, USA","Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA","Neurobiology Course, The Marine Biological Laboratory, Woods Hole, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-3667-8003","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, The University of Texas at Austin, Austin, TX, 78712, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Neurobiology Course, The Marine Biological Laboratory, Woods Hole, MA, USA","institution_ids":["https://openalex.org/I1338920048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018124957","display_name":"Kathryn Wu","orcid":"https://orcid.org/0000-0002-1570-7143","observed_orcids":["https://orcid.org/0000-0002-1570-7143"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn Wu","raw_affiliation_strings":["Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-1570-7143","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048302905","display_name":"Nicholas Ambiel","orcid":"https://orcid.org/0000-0002-0415-9823","observed_orcids":["https://orcid.org/0000-0002-0415-9823"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Ambiel","raw_affiliation_strings":["Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-0415-9823","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136198682","display_name":"Eduardo Chaparro Barriera","orcid":"https://orcid.org/0009-0001-4982-4663","observed_orcids":["https://orcid.org/0009-0001-4982-4663"]},"institutions":[{"id":"https://openalex.org/I1338920048","display_name":"Marine Biological Laboratory","ror":"https://ror.org/046dg4z72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1338920048"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eduardo Chaparro Barriera","raw_affiliation_strings":["Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA","Neurobiology Course, The Marine Biological Laboratory, Woods Hole, MA, USA"],"raw_orcid":"https://orcid.org/0009-0001-4982-4663","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Neurobiology Course, The Marine Biological Laboratory, Woods Hole, MA, USA","institution_ids":["https://openalex.org/I1338920048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015673854","display_name":"Madeline H. Cooper","orcid":"https://orcid.org/0000-0001-5698-5150","observed_orcids":["https://orcid.org/0000-0001-5698-5150"]},"institutions":[{"id":"https://openalex.org/I1338920048","display_name":"Marine Biological Laboratory","ror":"https://ror.org/046dg4z72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1338920048"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madeline H. Cooper","raw_affiliation_strings":["Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA","Neurobiology Course, The Marine Biological Laboratory, Woods Hole, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-5698-5150","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Neurobiology Course, The Marine Biological Laboratory, Woods Hole, MA, USA","institution_ids":["https://openalex.org/I1338920048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066812423","display_name":"Alexandra E. M\u00fcnch","orcid":"https://orcid.org/0000-0002-9609-3277","observed_orcids":["https://orcid.org/0000-0002-9609-3277"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra M\u00fcnch","raw_affiliation_strings":["Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-9609-3277","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000571249","display_name":"Yaron M. Sigal","orcid":"https://orcid.org/0000-0001-9636-4164","observed_orcids":["https://orcid.org/0000-0001-9636-4164"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yari M. Sigal","raw_affiliation_strings":["Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA","Department of Physics, Harvard University, Cambridge, MA, USA","Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Physics, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100690752","display_name":"Miguel \u00c1ngel Garc\u00eda","orcid":"https://orcid.org/0000-0003-4181-5372","observed_orcids":["https://orcid.org/0000-0003-4181-5372"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel A. Garcia","raw_affiliation_strings":["Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4181-5372","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082716310","display_name":"Manasi Iyer","orcid":"https://orcid.org/0000-0002-6376-3633","observed_orcids":["https://orcid.org/0000-0002-6376-3633"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manasi Iyer","raw_affiliation_strings":["Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-6376-3633","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072470315","display_name":"Danielle M. Jorgens","orcid":"https://orcid.org/0000-0002-7143-0118","observed_orcids":["https://orcid.org/0000-0002-7143-0118"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle M. Jorgens","raw_affiliation_strings":["Electron Microscope Laboratory, University of California, Berkeley, CA, USA"],"raw_orcid":"https://orcid.org/0000-0002-7143-0118","affiliations":[{"raw_affiliation_string":"Electron Microscope Laboratory, University of California, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044494389","display_name":"J. Bradley Zuchero","orcid":"https://orcid.org/0000-0002-4706-2538","observed_orcids":["https://orcid.org/0000-0002-4706-2538"]},"institutions":[{"id":"https://openalex.org/I1338920048","display_name":"Marine Biological Laboratory","ror":"https://ror.org/046dg4z72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1338920048"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Bradley Zuchero","raw_affiliation_strings":["Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA","Neurobiology Course, The Marine Biological Laboratory, Woods Hole, MA, USA"],"raw_orcid":"https://orcid.org/0000-0002-4706-2538","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Neurobiology Course, The Marine Biological Laboratory, Woods Hole, MA, USA","institution_ids":["https://openalex.org/I1338920048"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5044494389"],"corresponding_institution_ids":["https://openalex.org/I1338920048","https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/actin-filament-disassembly","display_name":"actin filament disassembly","score":0.9670000076293945},{"id":"https://openalex.org/keywords/myelin-compaction","display_name":"myelin compaction","score":0.8769999742507935},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cytoskeletal-remodeling","display_name":"cytoskeletal remodeling","score":0.7540000081062317},{"id":"https://openalex.org/keywords/membrane-compaction","display_name":"membrane compaction","score":0.7059999704360962},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.652999997138977},{"id":"https://openalex.org/keywords/central-nervous-system-development","display_name":"central nervous system development","score":0.6890000104904175},{"id":"https://openalex.org/keywords/actin-filaments","display_name":"F-actin","score":0.7250000238418579},{"id":"https://openalex.org/keywords/myelin-sheath","display_name":"myelin sheath","score":0.5680000185966492},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"live-cell imaging","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.7738999724388123},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6930000185966492},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.6152999997138977},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5386999845504761},{"id":"https://openalex.org/C3620293","wikidata":"https://www.wikidata.org/wiki/Q14908027","display_name":"Actin remodeling","level":5,"score":0.5264999866485596},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4993000030517578},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.4510999917984009},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.4185999929904938},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38100001215934753},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.36640000343322754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35030001401901245},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.313400000333786},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C151000934","wikidata":"https://www.wikidata.org/wiki/Q4676834","display_name":"Actin remodeling of neurons","level":5,"score":0.2994999885559082},{"id":"https://openalex.org/C196715460","wikidata":"https://www.wikidata.org/wiki/Q1414356","display_name":"Compaction","level":2,"score":0.29919999837875366},{"id":"https://openalex.org/C2776190535","wikidata":"https://www.wikidata.org/wiki/Q4676836","display_name":"Actina","level":4,"score":0.2614000141620636},{"id":"https://openalex.org/C189040839","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Microfilament","level":4,"score":0.26100000739097595},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2606000006198883}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.05.14.722739","doi":"https://doi.org/10.64898/2026.05.14.722739","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.14.722739","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/15/2026.05.14.722739.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42182328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42182328","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13192955","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13192955/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.64898/2026.05.14.722739","doi":"https://doi.org/10.64898/2026.05.14.722739","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.05.14.722739","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/05/15/2026.05.14.722739.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1002601351","display_name":null,"funder_award_id":"SCR_017787","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1207615942","display_name":"NeuroNex: Enabling Identification and Impact of Synaptic Weight in Functional Networks","funder_award_id":"2014862","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G1402008077","display_name":null,"funder_award_id":"R01 NS119823","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G2921824517","display_name":"Bio-AFM for combined light and atomic force imaging","funder_award_id":"1s10od021514-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3150481158","display_name":null,"funder_award_id":"1S10RR02678001","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3456662724","display_name":"NeuroNex Technology Hub: Enhanced resolution for 3DEM analysis of synapses across brain regions and taxa","funder_award_id":"1707356","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4324392417","display_name":null,"funder_award_id":"SCR_017787","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4896855234","display_name":null,"funder_award_id":"1S10RR026780","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6103662825","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007365","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7755990828","display_name":null,"funder_award_id":"NSF 2014862","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8571311407","display_name":"Transmission Electron Microscope","funder_award_id":"1s10rr026780-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000042590","display_name":null,"funder_award_id":"R01NS119823","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306144","display_name":"McKnight Endowment Fund for Neuroscience","ror":"https://ror.org/003ghvj67"},{"id":"https://openalex.org/F4320308324","display_name":"McKnight Foundation","ror":"https://ror.org/003ghvj67"},{"id":"https://openalex.org/F4320320084","display_name":"Multiple Sclerosis Society","ror":"https://ror.org/043fwdk81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333063","display_name":"Stanford Bio-X","ror":"https://ror.org/00f54p054"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337901","display_name":"Office of Research Infrastructure Programs, National Institutes of Health","ror":"https://ror.org/01jdyfj45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7161237652.pdf","grobid_xml":"https://content.openalex.org/works/W7161237652.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Compact":[0],"myelin":[1,81,149,164],"enables":[2],"rapid":[3],"and":[4,68,118,128,170,182],"precise":[5],"impulse":[6],"conduction":[7],"in":[8,69,115,142,151,159,180],"the":[9,145],"vertebrate":[10],"nervous":[11],"system.":[12],"During":[13],"CNS":[14],"development,":[15],"oligodendrocytes":[16,117],"wrap":[17],"spirally":[18],"around":[19],"axons":[20],"while":[21],"compacting":[22],"membranes,":[23],"yet":[24],"how":[25,75,176],"cytoskeletal":[26],"remodeling":[27],"is":[28,37,44,57,78,133,178],"coupled":[29,79],"to":[30,54,73,80,174],"these":[31],"events":[32],"remains":[33],"unclear.":[34],"Actin":[35],"disassembly":[36,77,91,132,141,162],"required":[38],"for":[39,99],"wrapping,":[40],"but":[41],"whether":[42],"wrapping":[43,94,165],"driven":[45],"by":[46,166],"iterative":[47],"actin-based":[48],"protrusion":[49],"or":[50],"follows":[51],"a":[52,108,157,172],"transition":[53],"actin-independent":[55],"mechanisms":[56],"unresolved.":[58],"Here":[59],"we":[60],"integrate":[61],"tract-resolved":[62],"developmental":[63],"profiling,":[64],"live-cell":[65,109],"compaction":[66,114,121,177],"mapping,":[67],"vivo":[70,143],"genetic":[71],"perturbation":[72],"define":[74],"actin":[76,86,101,126,131,140,161],"wrapping.":[82,105],"We":[83,106],"find":[84],"that":[85,111,120],"filaments":[87,127],"undergo":[88],"pronounced,":[89],"sustained":[90],"before":[92],"active":[93],"begins,":[95],"with":[96,136],"little":[97],"evidence":[98],"persistent":[100],"within":[102],"sheaths":[103],"during":[104],"develop":[107],"assay":[110],"maps":[112],"membrane":[113,168],"cultured":[116],"show":[119],"zones":[122],"are":[123],"depleted":[124],"of":[125,147],"expand":[129],"when":[130],"promoted.":[134],"Consistent":[135],"this":[137],"model,":[138],"oligodendrocyte-specific":[139],"accelerates":[144],"appearance":[146],"thicker":[148],"early":[150],"development.":[152],"Together,":[153],"our":[154],"results":[155],"support":[156],"model":[158],"which":[160],"promotes":[163],"enabling":[167],"compaction,":[169],"provide":[171],"platform":[173],"dissect":[175],"regulated":[179],"development":[181],"disease.":[183]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-05-16T00:00:00"}
