{"id":"https://openalex.org/W7161069199","doi":"https://doi.org/10.47475/2409-4102-2026-33-1-84-97","title":"GLYCOPROTEIN-P (ABCB1): STRUCTURAL-FUNCTIONAL ORGANIZATION, MOLECULAR-GENETIC MECHANISMS OF ACTIVITY REGULATION, MOLECULAR MECHANISM OF ACTION AND CLINICAL SIGNI CANCE IN MULTIPLE-DRUG RESISTANCE","display_name":"GLYCOPROTEIN-P (ABCB1): STRUCTURAL-FUNCTIONAL ORGANIZATION, MOLECULAR-GENETIC MECHANISMS OF ACTIVITY REGULATION, MOLECULAR MECHANISM OF ACTION AND CLINICAL SIGNI CANCE IN MULTIPLE-DRUG RESISTANCE","publication_year":2026,"publication_date":"2026-03-31","ids":{"openalex":"https://openalex.org/W7161069199","doi":"https://doi.org/10.47475/2409-4102-2026-33-1-84-97"},"language":"en","primary_location":{"id":"doi:10.47475/2409-4102-2026-33-1-84-97","doi":"https://doi.org/10.47475/2409-4102-2026-33-1-84-97","is_oa":false,"landing_page_url":"https://doi.org/10.47475/2409-4102-2026-33-1-84-97","pdf_url":null,"source":{"id":"https://openalex.org/S4387283947","display_name":"\u0412\u0435\u0441\u0442\u043d\u0438\u043a \u0427\u0435\u043b\u044f\u0431\u0438\u043d\u0441\u043a\u043e\u0433\u043e \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0430 \u041e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435 \u0438 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435","issn_l":"2409-4102","issn":["2409-4102"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u0412\u0435\u0441\u0442\u043d\u0438\u043a \u0427\u0435\u043b\u044f\u0431\u0438\u043d\u0441\u043a\u043e\u0433\u043e \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0430 \u041e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435 \u0438 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://cyberleninka.ru/article/n/glikoprotein-p-abcb1-strukturno-funktsionalnaya-organizatsiya-molekulyarno-geneticheskie-mehanizmy-regulyatsii-aktivnosti/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002434862","display_name":"\u0412. \u042d. \u0426\u0435\u0439\u043b\u0438\u043a\u043c\u0430\u043d","orcid":"https://orcid.org/0000-0001-6430-030X","observed_orcids":["https://orcid.org/0000-0001-6430-030X"]},"institutions":[{"id":"https://openalex.org/I137211346","display_name":"Chelyabinsk State University","ror":"https://ror.org/04s36qm86","country_code":"RU","type":"education","lineage":["https://openalex.org/I137211346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V.E. TSEILIKMAN","raw_affiliation_strings":["Chelyabinsk State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chelyabinsk State University","institution_ids":["https://openalex.org/I137211346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069935277","display_name":"Vladislav A. Shatilov","orcid":"https://orcid.org/0000-0001-9405-0348","observed_orcids":["https://orcid.org/0000-0001-9405-0348"]},"institutions":[{"id":"https://openalex.org/I137211346","display_name":"Chelyabinsk State University","ror":"https://ror.org/04s36qm86","country_code":"RU","type":"education","lineage":["https://openalex.org/I137211346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V.A. SHATILOV","raw_affiliation_strings":["Chelyabinsk State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chelyabinsk State University","institution_ids":["https://openalex.org/I137211346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136023299","display_name":"M.S. ZHUKOV","orcid":"https://orcid.org/0009-0000-6347-6370","observed_orcids":["https://orcid.org/0009-0000-6347-6370"]},"institutions":[{"id":"https://openalex.org/I137211346","display_name":"Chelyabinsk State University","ror":"https://ror.org/04s36qm86","country_code":"RU","type":"education","lineage":["https://openalex.org/I137211346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M.S. ZHUKOV","raw_affiliation_strings":["Chelyabinsk State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chelyabinsk State University","institution_ids":["https://openalex.org/I137211346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117542947","display_name":"Georgiy N. Patrikyan","orcid":"https://orcid.org/0009-0009-9059-3156","observed_orcids":["https://orcid.org/0009-0009-9059-3156"]},"institutions":[{"id":"https://openalex.org/I137211346","display_name":"Chelyabinsk State University","ror":"https://ror.org/04s36qm86","country_code":"RU","type":"education","lineage":["https://openalex.org/I137211346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G.N. PATRIKYAN","raw_affiliation_strings":["Chelyabinsk State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chelyabinsk State University","institution_ids":["https://openalex.org/I137211346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5118276189","display_name":"Timur Dinarovich Khaibullin","orcid":"https://orcid.org/0009-0006-4851-1813","observed_orcids":["https://orcid.org/0009-0006-4851-1813"]},"institutions":[{"id":"https://openalex.org/I137211346","display_name":"Chelyabinsk State University","ror":"https://ror.org/04s36qm86","country_code":"RU","type":"education","lineage":["https://openalex.org/I137211346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T.L. KHAIBULIN","raw_affiliation_strings":["Chelyabinsk State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chelyabinsk State University","institution_ids":["https://openalex.org/I137211346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I137211346"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"1","first_page":"84","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9959999918937683},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.8450000286102295},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.578000009059906},{"id":"https://openalex.org/keywords/xenobiotic-transport","display_name":"xenobiotic transport","score":0.824999988079071},{"id":"https://openalex.org/keywords/nuclear-receptors","display_name":"nuclear receptors","score":0.753000020980835},{"id":"https://openalex.org/keywords/pregnane-x-receptor","display_name":"pregnane X receptor","score":0.7879999876022339},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.984000027179718},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9800000190734863},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6236000061035156},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.607699990272522},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5587000250816345},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.5354999899864197},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5170000195503235},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43860000371932983},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.4361000061035156},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43290001153945923},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.40400001406669617},{"id":"https://openalex.org/C2780791683","wikidata":"https://www.wikidata.org/wiki/Q846785","display_name":"Action (physics)","level":2,"score":0.40299999713897705},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.4011000096797943},{"id":"https://openalex.org/C86380466","wikidata":"https://www.wikidata.org/wiki/Q5308872","display_name":"Drug action","level":3,"score":0.3901999890804291},{"id":"https://openalex.org/C2778545548","wikidata":"https://www.wikidata.org/wiki/Q4914739","display_name":"Biodefense","level":2,"score":0.3763999938964844},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3756999969482422},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35569998621940613},{"id":"https://openalex.org/C2910769707","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multidrug Resistance-Associated Proteins","level":5,"score":0.3465999960899353},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.3441999852657318},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.3379000127315521},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.3330000042915344},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.32269999384880066},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31369999051094055},{"id":"https://openalex.org/C115335371","wikidata":"https://www.wikidata.org/wiki/Q142943","display_name":"Membrane transport protein","level":4,"score":0.3098999857902527},{"id":"https://openalex.org/C115448650","wikidata":"https://www.wikidata.org/wiki/Q409205","display_name":"Xenobiotic","level":3,"score":0.30379998683929443},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.2847000062465668},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2827000021934509},{"id":"https://openalex.org/C168167062","wikidata":"https://www.wikidata.org/wiki/Q1117970","display_name":"Component (thermodynamics)","level":2,"score":0.28200000524520874},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27880001068115234},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2782000005245209},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.27309998869895935},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.27300000190734863},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26829999685287476},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.26339998841285706},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C2225953","wikidata":"https://www.wikidata.org/wiki/Q1661899","display_name":"Inducer","level":3,"score":0.2581999897956848},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.25699999928474426},{"id":"https://openalex.org/C57947595","wikidata":"https://www.wikidata.org/wiki/Q7886088","display_name":"Membrane transport","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2513999938964844}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.47475/2409-4102-2026-33-1-84-97","doi":"https://doi.org/10.47475/2409-4102-2026-33-1-84-97","is_oa":false,"landing_page_url":"https://doi.org/10.47475/2409-4102-2026-33-1-84-97","pdf_url":null,"source":{"id":"https://openalex.org/S4387283947","display_name":"\u0412\u0435\u0441\u0442\u043d\u0438\u043a \u0427\u0435\u043b\u044f\u0431\u0438\u043d\u0441\u043a\u043e\u0433\u043e \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0430 \u041e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435 \u0438 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435","issn_l":"2409-4102","issn":["2409-4102"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u0412\u0435\u0441\u0442\u043d\u0438\u043a \u0427\u0435\u043b\u044f\u0431\u0438\u043d\u0441\u043a\u043e\u0433\u043e \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0430 \u041e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435 \u0438 \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u0435","raw_type":"journal-article"},{"id":"pmh:https://cyberleninka.ru/article/n/glikoprotein-p-abcb1-strukturno-funktsionalnaya-organizatsiya-molekulyarno-geneticheskie-mehanizmy-regulyatsii-aktivnosti","doi":null,"is_oa":true,"landing_page_url":"https://cyberleninka.ru/article/n/glikoprotein-p-abcb1-strukturno-funktsionalnaya-organizatsiya-molekulyarno-geneticheskie-mehanizmy-regulyatsii-aktivnosti","pdf_url":"https://cyberleninka.ru/article/n/glikoprotein-p-abcb1-strukturno-funktsionalnaya-organizatsiya-molekulyarno-geneticheskie-mehanizmy-regulyatsii-aktivnosti/pdf","source":{"id":"https://openalex.org/S4306401404","display_name":"CyberLeninK (CyberLeninka)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":{"id":"pmh:https://cyberleninka.ru/article/n/glikoprotein-p-abcb1-strukturno-funktsionalnaya-organizatsiya-molekulyarno-geneticheskie-mehanizmy-regulyatsii-aktivnosti","doi":null,"is_oa":true,"landing_page_url":"https://cyberleninka.ru/article/n/glikoprotein-p-abcb1-strukturno-funktsionalnaya-organizatsiya-molekulyarno-geneticheskie-mehanizmy-regulyatsii-aktivnosti","pdf_url":"https://cyberleninka.ru/article/n/glikoprotein-p-abcb1-strukturno-funktsionalnaya-organizatsiya-molekulyarno-geneticheskie-mehanizmy-regulyatsii-aktivnosti/pdf","source":{"id":"https://openalex.org/S4306401404","display_name":"CyberLeninK (CyberLeninka)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7161069199.pdf","grobid_xml":"https://content.openalex.org/works/W7161069199.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1499112972","https://openalex.org/W1983491589","https://openalex.org/W1991205228","https://openalex.org/W2002345475","https://openalex.org/W2006434892","https://openalex.org/W2021242983","https://openalex.org/W2023350482","https://openalex.org/W2028533496","https://openalex.org/W2051793369","https://openalex.org/W2062982487","https://openalex.org/W2083522771","https://openalex.org/W2090841445","https://openalex.org/W2092825895","https://openalex.org/W2095518518","https://openalex.org/W2106941934","https://openalex.org/W2119468178","https://openalex.org/W2129137680","https://openalex.org/W2142373414","https://openalex.org/W2157393167","https://openalex.org/W2465912477","https://openalex.org/W2544147855","https://openalex.org/W2767950945","https://openalex.org/W2784697242","https://openalex.org/W2789199387","https://openalex.org/W2889943713","https://openalex.org/W2899085656","https://openalex.org/W2913248782","https://openalex.org/W2932289624","https://openalex.org/W2953674468","https://openalex.org/W2955962371","https://openalex.org/W3090016913","https://openalex.org/W3147395413","https://openalex.org/W3162623872","https://openalex.org/W4283273621","https://openalex.org/W4323348565","https://openalex.org/W4394723000","https://openalex.org/W4402335050","https://openalex.org/W4410269716"],"related_works":["https://openalex.org/W4253789696","https://openalex.org/W2070440937","https://openalex.org/W2887349375","https://openalex.org/W2102110565","https://openalex.org/W1982542571","https://openalex.org/W2090814277","https://openalex.org/W2157635452","https://openalex.org/W2009938237","https://openalex.org/W2083808039","https://openalex.org/W4233641679"],"abstract_inverted_index":{"P-glycoprotein":[0,43,83],"(ABCB1)":[1],"is":[2,44],"a":[3,15],"key":[4],"component":[5],"of":[6,14,18,30,34,42,48,51,82,87,102],"the":[7,25,35,64,85,98],"body\u2019s":[8],"biodefense":[9],"system,":[10],"mediating":[11],"ATP-dependent":[12],"transport":[13],"wide":[16],"range":[17],"xenobiotics":[19],"and":[20,27,72,76,100],"drugs.":[21],"This":[22],"review":[23],"analyzes":[24],"structural":[26],"functional":[28],"characteristics":[29],"this":[31],"transmembrane":[32],"protein":[33,52],"ABC":[36],"transporter":[37],"family.":[38],"The":[39,46,78],"molecular":[40],"architecture":[41],"described.":[45],"mechanisms":[47],"transcriptional":[49],"regulation":[50],"expression":[53],"via":[54],"nuclear":[55],"receptors":[56],"(PXR,":[57],"CAR)":[58],"are":[59,105],"discussed,":[60],"as":[61,63,92,94],"well":[62,93],"post-translational":[65],"modi":[66],"cations":[67],"that":[68],"determine":[69],"its":[70,95],"activity":[71],"sensitivity":[73],"to":[74],"inducers":[75],"inhibitors.":[77],"clinical":[79],"signi":[80],"cance":[81],"in":[84,90,97],"context":[86],"multidrug":[88],"resistance":[89],"cancer,":[91],"role":[96],"pharmacokinetics":[99],"bioavailability":[101],"therapeutic":[103],"drugs,":[104],"analyzed.":[106]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-05-14T00:00:00"}
