{"id":"https://openalex.org/W7161008655","doi":"https://doi.org/10.1002/ece3.74524","title":"Selection on PER2 Phosphorylation Regulation Underlies Atypical Mammalian Circadian Rhythms","display_name":"Selection on PER2 Phosphorylation Regulation Underlies Atypical Mammalian Circadian Rhythms","publication_year":2026,"publication_date":"2026-10-01","ids":{"openalex":"https://openalex.org/W7161008655","doi":"https://doi.org/10.1002/ece3.74524","pmid":"https://pubmed.ncbi.nlm.nih.gov/42890498","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13671881"},"language":"en","primary_location":{"id":"doi:10.1002/ece3.74524","doi":"https://doi.org/10.1002/ece3.74524","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ece3.74524","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ece3.74524","source":{"id":"https://openalex.org/S2482021738","display_name":"Ecology and Evolution","issn_l":"2045-7758","issn":["2045-7758"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ece3.74524","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101298635","display_name":"Yujie Chong","orcid":"https://orcid.org/0009-0003-9696-2940","observed_orcids":["https://orcid.org/0009-0003-9696-2940"]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujie Chong","raw_affiliation_strings":["Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I152031979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133571556","display_name":"Qingqing Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingqing Liu","raw_affiliation_strings":["Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I152031979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133583026","display_name":"Haojia Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haojia Jiang","raw_affiliation_strings":["Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I152031979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133581597","display_name":"Linxue Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linxue Tan","raw_affiliation_strings":["Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I152031979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133570043","display_name":"Huan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Chen","raw_affiliation_strings":["Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I152031979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159053606","display_name":"Wenhua Ren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhua Ren","raw_affiliation_strings":["Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I152031979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088061006","display_name":"Shixia Xu","orcid":"https://orcid.org/0000-0002-0283-0986","observed_orcids":["https://orcid.org/0000-0002-0283-0986"]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shixia Xu","raw_affiliation_strings":["Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China"],"raw_orcid":"https://orcid.org/0000-0002-0283-0986","affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I152031979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136080810","display_name":"Guang Yang","orcid":"https://orcid.org/0000-0001-6285-6937","observed_orcids":["https://orcid.org/0000-0001-6285-6937"]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]},{"id":"https://openalex.org/I4210106122","display_name":"Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)","ror":"https://ror.org/00y7mag53","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106122"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guang Yang","raw_affiliation_strings":["Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China","Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)  Guangzhou Guangdong China"],"raw_orcid":"https://orcid.org/0000-0001-6285-6937","affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I152031979"]},{"raw_affiliation_string":"Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)  Guangzhou Guangdong China","institution_ids":["https://openalex.org/I4210106122"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062441777","display_name":"Daiqing Yin","orcid":"https://orcid.org/0009-0007-6682-5864","observed_orcids":["https://orcid.org/0009-0007-6682-5864"]},"institutions":[{"id":"https://openalex.org/I152031979","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74","country_code":"CN","type":"education","lineage":["https://openalex.org/I152031979"]},{"id":"https://openalex.org/I4210106122","display_name":"Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)","ror":"https://ror.org/00y7mag53","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210106122"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Daiqing Yin","raw_affiliation_strings":["Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China","Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)  Guangzhou Guangdong China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences Nanjing Normal University  Nanjing Jiangsu China","institution_ids":["https://openalex.org/I152031979"]},{"raw_affiliation_string":"Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)  Guangzhou Guangdong China","institution_ids":["https://openalex.org/I4210106122"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062441777"],"corresponding_institution_ids":["https://openalex.org/I152031979","https://openalex.org/I4210106122"],"apc_list":{"value":2570,"currency":"USD","value_usd":2570},"apc_paid":{"value":2570,"currency":"USD","value_usd":2570},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30480968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"10","first_page":"e74524","last_page":"e74524"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.8299999833106995},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.7710000276565552},{"id":"https://openalex.org/keywords/molecular-evolution","display_name":"molecular evolution","score":0.800000011920929},{"id":"https://openalex.org/keywords/ck1epsilon","display_name":"CK1\u03b5","score":0.953000009059906},{"id":"https://openalex.org/keywords/cdk5","display_name":"cyclin-dependent kinase 5","score":0.9399999976158142},{"id":"https://openalex.org/keywords/gsk3b","display_name":"GSK3B","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cetaceans","display_name":"cetaceans","score":0.8759999871253967},{"id":"https://openalex.org/keywords/protein-half-life","display_name":"protein half-life","score":0.671999990940094},{"id":"https://openalex.org/keywords/circadian-plasticity","display_name":"circadian plasticity","score":0.871999979019165},{"id":"https://openalex.org/keywords/sleep-regulation","display_name":"sleep regulation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C2779064383","wikidata":"https://www.wikidata.org/wiki/Q15323251","display_name":"PER2","level":5,"score":0.9316999912261963},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8485000133514404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8432999849319458},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.6284000277519226},{"id":"https://openalex.org/C130679736","wikidata":"https://www.wikidata.org/wiki/Q3454009","display_name":"Bacterial circadian rhythms","level":4,"score":0.4781999886035919},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44769999384880066},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4255000054836273},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.39489999413490295},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.3560999929904938},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.35030001401901245},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.34040001034736633},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.33169999718666077},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3190000057220459},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.29910001158714294},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.28999999165534973},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.28940001130104065},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.28769999742507935},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.2822999954223633},{"id":"https://openalex.org/C33507282","wikidata":"https://www.wikidata.org/wiki/Q4680759","display_name":"Adaptive response","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C187765855","wikidata":"https://www.wikidata.org/wiki/Q506874","display_name":"Chronobiology","level":3,"score":0.2678999900817871},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2581999897956848}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1002/ece3.74524","doi":"https://doi.org/10.1002/ece3.74524","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ece3.74524","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ece3.74524","source":{"id":"https://openalex.org/S2482021738","display_name":"Ecology and Evolution","issn_l":"2045-7758","issn":["2045-7758"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecology and Evolution","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.6578345","doi":"https://doi.org/10.2139/ssrn.6578345","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.6578345","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.22541/authorea.15003238/v1","doi":"https://doi.org/10.22541/authorea.15003238/v1","is_oa":false,"landing_page_url":"https://doi.org/10.22541/authorea.15003238/v1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13671881","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13671881/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13671881/pdf/ECE3-16-e74524.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecol Evol","raw_type":"Text"},{"id":"pmid:42890498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42890498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecology and evolution","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:bf3ade3602a44668ab2c70665e637860","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bf3ade3602a44668ab2c70665e637860","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ecology and Evolution, Vol 16, Iss 10, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/ece3.74524","doi":"https://doi.org/10.1002/ece3.74524","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ece3.74524","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ece3.74524","source":{"id":"https://openalex.org/S2482021738","display_name":"Ecology and Evolution","issn_l":"2045-7758","issn":["2045-7758"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecology and Evolution","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1123855201","display_name":null,"funder_award_id":"32030011","funder_id":"https://openalex.org/F4320327518","funder_display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions"},{"id":"https://openalex.org/G3142972076","display_name":null,"funder_award_id":"U24A20362","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7005880918","display_name":null,"funder_award_id":"32030011","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8506773787","display_name":null,"funder_award_id":"32200348","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320310902","display_name":"Nanjing Normal University","ror":"https://ror.org/036trcv74"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320327518","display_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7161008655.pdf","grobid_xml":"https://content.openalex.org/works/W7161008655.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1979742015","https://openalex.org/W1981388992","https://openalex.org/W1990192893","https://openalex.org/W1992726958","https://openalex.org/W2006961929","https://openalex.org/W2009724101","https://openalex.org/W2023325911","https://openalex.org/W2029605093","https://openalex.org/W2036873071","https://openalex.org/W2039931639","https://openalex.org/W2042500733","https://openalex.org/W2046412128","https://openalex.org/W2057456873","https://openalex.org/W2059145105","https://openalex.org/W2072000404","https://openalex.org/W2078086032","https://openalex.org/W2091242424","https://openalex.org/W2101704044","https://openalex.org/W2110335151","https://openalex.org/W2119034148","https://openalex.org/W2124659015","https://openalex.org/W2124659072","https://openalex.org/W2124967403","https://openalex.org/W2129805026","https://openalex.org/W2136847298","https://openalex.org/W2138199676","https://openalex.org/W2143238378","https://openalex.org/W2143499154","https://openalex.org/W2165688051","https://openalex.org/W2470204196","https://openalex.org/W2549026759","https://openalex.org/W2792475317","https://openalex.org/W2803948731","https://openalex.org/W3022723204","https://openalex.org/W3045087719","https://openalex.org/W3108679364","https://openalex.org/W3177828909","https://openalex.org/W4200284708","https://openalex.org/W4360804719","https://openalex.org/W4366982553","https://openalex.org/W4410547009"],"related_works":["https://openalex.org/W4408560995","https://openalex.org/W4391363081","https://openalex.org/W4400808908","https://openalex.org/W4405624909","https://openalex.org/W2099472001","https://openalex.org/W4249228539","https://openalex.org/W2765707161","https://openalex.org/W2147751154","https://openalex.org/W2048466060","https://openalex.org/W4225819662"],"abstract_inverted_index":{"ABSTRACT":[0],"Circadian":[1],"rhythms":[2,27],"are":[3,28,96,227],"fundamental":[4],"biological":[5],"processes":[6],"that":[7,106,144,220],"enhance":[8],"survival":[9],"and":[10,16,93,129,157,174,185,199,211,233],"reproductive":[11],"fitness":[12],"by":[13,196],"coordinating":[14],"physiology":[15],"behavior":[17],"with":[18,189,229],"predictable":[19],"environmental":[20],"cycles.":[21],"However,":[22],"in":[23,78,98,132,223,244],"some":[24],"species,":[25],"circadian":[26,83,114,171,231,242],"weakened,":[29],"irregular,":[30],"or":[31,41],"even":[32],"undetectable,":[33],"likely":[34],"reflecting":[35],"evolutionary":[36,221],"responses":[37],"to":[38,112,170,182],"extreme":[39],"environments":[40],"specialized":[42],"ecological":[43],"niches.":[44],"Nevertheless,":[45],"the":[46,59,99,150,159,162,238],"genetic":[47,239],"basis":[48],"of":[49,62,86,102,126,155,161],"these":[50],"atypical":[51,82,230],"phenotypes":[52,232],"remains":[53],"incompletely":[54],"understood.":[55],"Here,":[56],"we":[57],"investigated":[58],"molecular":[60,166],"evolution":[61,131],"20":[63],"PER2\u2010associated":[64],"genes":[65,74],"across":[66],"71":[67],"representative":[68],"mammalian":[69,79],"species.":[70],"We":[71],"identified":[72],"four":[73],"under":[75],"positive":[76,127],"selection":[77,128],"lineages":[80],"exhibiting":[81],"phenotypes,":[84],"three":[85],"which":[87,134],"(":[88],"CDK5":[89],",":[90,92],"CSNK1E":[91,146,206],"GSK3B":[94],")":[95],"involved":[97],"post\u2010translational":[100],"regulation":[101,226],"PER2":[103,107,122,156,163,178,224],"phosphorylation,":[104,123],"suggesting":[105],"phosphorylation":[108,148,179,225],"regulators":[109],"may":[110,180],"contribute":[111,181],"lineage\u2010specific":[113],"variation.":[115],"Notably,":[116],"CSNK1E,":[117],"a":[118,165],"key":[119],"kinase":[120],"regulating":[121],"showed":[124,143],"signatures":[125],"accelerated":[130],"cetaceans,":[133],"exhibit":[135],"unihemispheric":[136],"slow\u2010wave":[137],"sleep":[138,175,184,213],"(USWS).":[139],"In":[140],"vitro":[141],"assays":[142],"dolphin":[145,205],"increased":[147],"at":[149],"stabilizing":[151],"FASP":[152],"site":[153],"S662":[154],"extended":[158],"half\u2010life":[160],"protein,":[164],"feature":[167],"closely":[168],"linked":[169],"oscillator":[172],"amplitude":[173],"regulation.":[176],"Increased":[177],"altered":[183],"locomotor":[186,209],"activity":[187,210],"associated":[188,228],"sustained":[190],"wakefulness":[191],"during":[192],"USWS,":[193],"as":[194],"supported":[195],"our":[197,216],"cellular":[198],"whole\u2010animal":[200],"assays.":[201],"Consistently,":[202],"zebrafish":[203],"overexpressing":[204],"exhibited":[207],"elevated":[208],"reduced":[212],"duration.":[214],"Overall,":[215],"findings":[217],"provide":[218],"evidence":[219],"changes":[222],"offer":[234],"novel":[235],"insights":[236],"into":[237],"mechanisms":[240],"underlying":[241],"plasticity":[243],"mammals.":[245]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2026-05-14T00:00:00"}
