{"id":"https://openalex.org/W7160930200","doi":"https://doi.org/10.1172/jci.insight.203997","title":"Protective role of complement signaling in Kawasaki disease vasculitis","display_name":"Protective role of complement signaling in Kawasaki disease vasculitis","publication_year":2026,"publication_date":"2026-05-12","ids":{"openalex":"https://openalex.org/W7160930200","doi":"https://doi.org/10.1172/jci.insight.203997","pmid":"https://pubmed.ncbi.nlm.nih.gov/42118583"},"language":"en","primary_location":{"id":"doi:10.1172/jci.insight.203997","doi":"https://doi.org/10.1172/jci.insight.203997","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.203997","pdf_url":"http://insight.jci.org/articles/view/203997/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://insight.jci.org/articles/view/203997/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082523649","display_name":"Asli E. Atici","orcid":"https://orcid.org/0000-0003-1546-7191","observed_orcids":["https://orcid.org/0000-0003-1546-7191"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asli E. Atici","raw_affiliation_strings":["Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002855882","display_name":"Beg\u00fcm Kocat\u00fcrk","orcid":"https://orcid.org/0000-0003-3657-6055","observed_orcids":["https://orcid.org/0000-0003-3657-6055"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beg\u00fcm Kocat\u00fcrk","raw_affiliation_strings":["Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and"],"raw_orcid":"https://orcid.org/0000-0003-3657-6055","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058843347","display_name":"B. Evan Ross","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin L. Ross","raw_affiliation_strings":["Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093060507","display_name":"Emily A. Aubuchon","orcid":"https://orcid.org/0009-0009-5044-5722","observed_orcids":["https://orcid.org/0009-0009-5044-5722"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily A. Aubuchon","raw_affiliation_strings":["Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071174652","display_name":"Rebecca A. Porritt","orcid":"https://orcid.org/0000-0002-0973-5092","observed_orcids":["https://orcid.org/0000-0002-0973-5092"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca A. Porritt","raw_affiliation_strings":["Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and"],"raw_orcid":"https://orcid.org/0000-0002-0973-5092","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122499865","display_name":"Thacyana Teixeira de Carvalho","orcid":"https://orcid.org/0000-0002-8580-6200","observed_orcids":["https://orcid.org/0000-0002-8580-6200"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thacyana T. Carvalho","raw_affiliation_strings":["Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and"],"raw_orcid":"https://orcid.org/0000-0002-8580-6200","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048669983","display_name":"Takahiro Namba","orcid":"https://orcid.org/0000-0003-2025-1379","observed_orcids":["https://orcid.org/0000-0003-2025-1379"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takahiro Namba","raw_affiliation_strings":["Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100647021","display_name":"Youngho Lee","orcid":"https://orcid.org/0000-0002-5227-683X","observed_orcids":["https://orcid.org/0000-0002-5227-683X"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youngho Lee","raw_affiliation_strings":["Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and"],"raw_orcid":"https://orcid.org/0000-0002-5227-683X","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069728836","display_name":"Magali Noval Rivas","orcid":"https://orcid.org/0000-0001-5570-8928","observed_orcids":["https://orcid.org/0000-0001-5570-8928"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Magali Noval Rivas","raw_affiliation_strings":["Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040035646","display_name":"Moshe Arditi","orcid":"https://orcid.org/0000-0001-9042-2909","observed_orcids":["https://orcid.org/0000-0001-9042-2909"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I4210141674","display_name":"Cedars-Sinai Smidt Heart Institute","ror":"https://ror.org/041vn2102","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834","https://openalex.org/I4210141674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moshe Arditi","raw_affiliation_strings":["Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and","Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California, USA"],"raw_orcid":"https://orcid.org/0000-0001-9042-2909","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Cedars-Sinai Guerin Children\u2019s,","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Infectious and Immunologic Diseases Research Center (IIDRC) and Department of Biomedical Sciences, and","institution_ids":[]},{"raw_affiliation_string":"Smidt Heart Institute, Cedars-Sinai Health Sciences University, Los Angeles, California, USA","institution_ids":["https://openalex.org/I4210141674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":{"value":4100,"currency":"USD","value_usd":4100},"fwci":6.5134,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.95507981,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"11","issue":"14","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kawasaki-disease","display_name":"Kawasaki disease","score":1.0},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/vasculitis","display_name":"vasculitis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/complement-c3","display_name":"complement C3","score":0.7070000171661377},{"id":"https://openalex.org/keywords/c5a-receptor-1","display_name":"C5a receptor 1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/lactobacillus-casei-cell-wall-extract","display_name":"Lactobacillus casei cell wall extract","score":0.9309999942779541},{"id":"https://openalex.org/keywords/opsonization","display_name":"opsonization","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cardiovascular-lesions","display_name":"cardiovascular lesions","score":0.6340000033378601},{"id":"https://openalex.org/keywords/complement-inhibition","display_name":"complement inhibition","score":0.48899999260902405},{"id":"https://openalex.org/keywords/pediatric-vasculitis","display_name":"pediatric vasculitis","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2781423770","wikidata":"https://www.wikidata.org/wiki/Q265936","display_name":"Kawasaki disease","level":3,"score":0.8810999989509583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7631999850273132},{"id":"https://openalex.org/C112313634","wikidata":"https://www.wikidata.org/wiki/Q7886648","display_name":"Complement (music)","level":5,"score":0.6862000226974487},{"id":"https://openalex.org/C2776015282","wikidata":"https://www.wikidata.org/wiki/Q644318","display_name":"Vasculitis","level":3,"score":0.67330002784729},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6190000176429749},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5609999895095825},{"id":"https://openalex.org/C2777374719","wikidata":"https://www.wikidata.org/wiki/Q7663822","display_name":"Systemic vasculitis","level":4,"score":0.45980000495910645},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.40950000286102295},{"id":"https://openalex.org/C175773311","wikidata":"https://www.wikidata.org/wiki/Q5156412","display_name":"Complement receptor","level":4,"score":0.375900000333786},{"id":"https://openalex.org/C171279029","wikidata":"https://www.wikidata.org/wiki/Q5128320","display_name":"Classical complement pathway","level":4,"score":0.35580000281333923},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.33500000834465027},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.3021000027656555},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2883000075817108},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.2849000096321106},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.2728999853134155},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.25929999351501465},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.2574999928474426}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003176","descriptor_name":"Complement C3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007780","descriptor_name":"Lacticaseibacillus casei","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007780","descriptor_name":"Lacticaseibacillus casei","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007780","descriptor_name":"Lacticaseibacillus casei","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007780","descriptor_name":"Lacticaseibacillus casei","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007780","descriptor_name":"Lacticaseibacillus casei","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044087","descriptor_name":"Receptor, Anaphylatoxin C5a","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D044087","descriptor_name":"Receptor, Anaphylatoxin C5a","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D044087","descriptor_name":"Receptor, Anaphylatoxin C5a","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D044087","descriptor_name":"Receptor, Anaphylatoxin C5a","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D044087","descriptor_name":"Receptor, Anaphylatoxin C5a","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci.insight.203997","doi":"https://doi.org/10.1172/jci.insight.203997","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.203997","pdf_url":"http://insight.jci.org/articles/view/203997/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},{"id":"pmid:42118583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42118583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI insight","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f0b145a01b0e483892ce283150802570","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f0b145a01b0e483892ce283150802570","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JCI Insight, Vol 11, Iss 14 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13461170","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13461170/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JCI Insight","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1172/jci.insight.203997","doi":"https://doi.org/10.1172/jci.insight.203997","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci.insight.203997","pdf_url":"http://insight.jci.org/articles/view/203997/files/pdf","source":{"id":"https://openalex.org/S2764964142","display_name":"JCI Insight","issn_l":"2379-3708","issn":["2379-3708"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCI Insight","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G539934162","display_name":"Role of complement system in the experimental murine model of Kawasaki Disease vasculitis","funder_award_id":"24POST1196203","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7160930200.pdf","grobid_xml":"https://content.openalex.org/works/W7160930200.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Kawasaki":[0],"disease":[1,19,37],"(KD)":[2],"is":[3],"an":[4,133],"acute":[5,31,51],"febrile":[6],"systemic":[7],"vasculitis":[8],"of":[9,16,56,66,81,88,95,97,177,197,204],"unknown":[10],"etiology":[11],"and":[12,122,142],"the":[13,64,67,72,98,108,146,164,183],"leading":[14],"cause":[15],"acquired":[17],"heart":[18],"among":[20],"children.":[21],"Complement":[22],"activation":[23,65,96],"has":[24],"long":[25],"been":[26],"observed":[27,126],"in":[28,59,71,91,145,151,191],"patients":[29,49],"with":[30,50,63,107,155],"KD;":[32],"however,":[33],"its":[34],"contribution":[35],"to":[36,130],"development":[38],"remains":[39],"unknown.":[40],"Here,":[41],"using":[42],"publicly":[43],"available":[44],"datasets,":[45],"we":[46,125],"showed":[47],"that":[48,127,136,162,182],"KD":[52,170,192],"exhibited":[53],"higher":[54,150],"expression":[55,87],"complement":[57,68,89,99,109,165,184],"products":[58,90],"whole":[60],"blood,":[61],"consistent":[62],"pathway.":[69],"Similarly,":[70],"Lactobacillus":[73],"casei":[74],"cell":[75],"wall":[76],"extract":[77],"(LCWE)":[78],"murine":[79],"model":[80],"KD,":[82],"LCWE":[83,128,143],"injection":[84],"induced":[85],"increased":[86],"cardiovascular":[92,120],"tissues,":[93],"suggestive":[94],"pathways.":[100],"C3-deficient":[101,152],"mice":[102,105,153],"or":[103,201],"WT":[104,156],"treated":[106],"C5a":[110],"receptor":[111],"1":[112],"(C5ar1)":[113],"antagonist":[114],"developed":[115],"significantly":[116,149,167],"more":[117],"severe":[118],"LCWE-induced":[119,169],"lesions":[121],"vasculitis.":[123],"Furthermore,":[124],"binds":[129],"serum":[131],"C3,":[132],"opsonizing":[134],"factor":[135],"labels":[137],"microbial":[138],"targets":[139],"for":[140],"clearance,":[141],"deposition":[144],"liver":[147],"was":[148],"compared":[154],"mice.":[157],"Overall,":[158],"our":[159],"data":[160,180],"indicate":[161],"blocking":[163],"system":[166],"exacerbates":[168],"vasculitis,":[171],"likely":[172],"by":[173,194],"impairing":[174],"C3-mediated":[175],"clearance":[176,196],"LCWE.":[178],"These":[179],"suggest":[181],"pathway":[185],"may":[186],"play":[187],"a":[188,198],"protective":[189],"role":[190],"pathogenesis":[193],"promoting":[195],"potential":[199],"bacterial":[200],"viral":[202],"trigger":[203],"KD.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2026-05-13T00:00:00"}