{"id":"https://openalex.org/W7160925752","doi":"https://doi.org/10.1152/physiol.2026.41.s1.2290924","title":"Metabolic Remodeling\u2013Driven Dicarbonyl Stress Impairs Mitochondrial Function in Angiotensin II/Phenylephrine-induced Heart Failure with Preserved Ejection Fraction Phenotype","display_name":"Metabolic Remodeling\u2013Driven Dicarbonyl Stress Impairs Mitochondrial Function in Angiotensin II/Phenylephrine-induced Heart Failure with Preserved Ejection Fraction Phenotype","publication_year":2026,"publication_date":"2026-05-01","ids":{"openalex":"https://openalex.org/W7160925752","doi":"https://doi.org/10.1152/physiol.2026.41.s1.2290924"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2026.41.s1.2290924","doi":"https://doi.org/10.1152/physiol.2026.41.s1.2290924","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2026.41.s1.2290924","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051530408","display_name":"Ankit Aryal","orcid":"https://orcid.org/0000-0002-1691-5112","observed_orcids":["https://orcid.org/0000-0002-1691-5112"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ankit Aryal","raw_affiliation_strings":["Louisiana State University-Health Sciences Center (LSUHSC), New Orleans, Louisiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University-Health Sciences Center (LSUHSC), New Orleans, Louisiana, United States","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134152240","display_name":"Luther Bishop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]},{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luther Bishop","raw_affiliation_strings":["Louisiana State University Health Science Center-New Orleans, Baton Rouge, Louisiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University Health Science Center-New Orleans, Baton Rouge, Louisiana, United States","institution_ids":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081922390","display_name":"Parnia Mobasheran","orcid":"https://orcid.org/0009-0003-3582-1669","observed_orcids":["https://orcid.org/0009-0003-3582-1669"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parnia Mobasheran","raw_affiliation_strings":["Louisiana State University Health Science Center- New Orleans, New Orleans, Louisiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University Health Science Center- New Orleans, New Orleans, Louisiana, United States","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047209818","display_name":"Chatterjee Sabyasachi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chatterjee Sabyasachi","raw_affiliation_strings":["Louisiana State University Health Science Center-New Orleans, New Orleans, Louisiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University Health Science Center-New Orleans, New Orleans, Louisiana, United States","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125540185","display_name":"Scott Jennings","orcid":"https://orcid.org/0009-0003-0018-6909","observed_orcids":["https://orcid.org/0009-0003-0018-6909"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Jennings","raw_affiliation_strings":["Louisiana State University Health Science Center-New Orleans, New Orleans, Louisiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University Health Science Center-New Orleans, New Orleans, Louisiana, United States","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103543948","display_name":"Huijing Xia","orcid":"https://orcid.org/0000-0001-7024-5693","observed_orcids":["https://orcid.org/0000-0001-7024-5693"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huijing Xia","raw_affiliation_strings":["Louisiana State University Health Science Center- New Orleans, New Orleans, Louisiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University Health Science Center- New Orleans, New Orleans, Louisiana, United States","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050387959","display_name":"Eric D. Lazartigues","orcid":"https://orcid.org/0000-0001-7290-0786","observed_orcids":["https://orcid.org/0000-0001-7290-0786"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Lazartigues","raw_affiliation_strings":["Louisiana State University Health Science Center-New Orleans, New Orleans, Louisiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University Health Science Center-New Orleans, New Orleans, Louisiana, United States","institution_ids":["https://openalex.org/I75420490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101884781","display_name":"Qinglin Yang","orcid":"https://orcid.org/0000-0002-6024-2517","observed_orcids":["https://orcid.org/0000-0002-6024-2517"]},"institutions":[{"id":"https://openalex.org/I75420490","display_name":"Louisiana State University Health Sciences Center New Orleans","ror":"https://ror.org/01qv8fp92","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I75420490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinglin Yang","raw_affiliation_strings":["Louisiana State University Health Science Center-New Orleans, New Orleans, Louisiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louisiana State University Health Science Center-New Orleans, New Orleans, Louisiana, United States","institution_ids":["https://openalex.org/I75420490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.26136514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6205999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.3188000023365021,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9800000190734863},{"id":"https://openalex.org/keywords/metabolic-remodeling","display_name":"metabolic remodeling","score":0.7950000166893005},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.7950000166893005},{"id":"https://openalex.org/keywords/dicarbonyl-stress","display_name":"dicarbonyl stress","score":0.953000009059906},{"id":"https://openalex.org/keywords/glycative-stress","display_name":"glycative stress","score":0.8410000205039978},{"id":"https://openalex.org/keywords/methylglyoxal","display_name":"methylglyoxal","score":0.8980000019073486},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-respiration","display_name":"mitochondrial respiration","score":0.906000018119812},{"id":"https://openalex.org/keywords/mitochondrial-calcium-retention-capacity","display_name":"mitochondrial calcium retention capacity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.7839999794960022},{"id":"https://openalex.org/keywords/phenylephrine","display_name":"phenylephrine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/myocardial-metabolism","display_name":"myocardial metabolism","score":0.5540000200271606},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7418000102043152},{"id":"https://openalex.org/C2777099384","wikidata":"https://www.wikidata.org/wiki/Q3799239","display_name":"Heart failure with preserved ejection fraction","level":4,"score":0.6877999901771545},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6786999702453613},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6748999953269958},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5767999887466431},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.5584999918937683},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5026000142097473},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.49470001459121704},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.484499990940094},{"id":"https://openalex.org/C147990577","wikidata":"https://www.wikidata.org/wiki/Q25790","display_name":"Glycation","level":3,"score":0.4772000014781952},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.45210000872612},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4438999891281128},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.42480000853538513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38929998874664307},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3781999945640564},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.36959999799728394},{"id":"https://openalex.org/C2775946041","wikidata":"https://www.wikidata.org/wiki/Q14875321","display_name":"Angiotensin-converting enzyme 2","level":5,"score":0.36800000071525574},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.3659000098705292},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.3580000102519989},{"id":"https://openalex.org/C17093226","wikidata":"https://www.wikidata.org/wiki/Q2734081","display_name":"Carbohydrate metabolism","level":2,"score":0.33629998564720154},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.3310000002384186},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30399999022483826},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.302700012922287},{"id":"https://openalex.org/C2778592357","wikidata":"https://www.wikidata.org/wiki/Q903881","display_name":"Methylglyoxal","level":3,"score":0.3009999990463257},{"id":"https://openalex.org/C2777092462","wikidata":"https://www.wikidata.org/wiki/Q15334407","display_name":"MFN2","level":5,"score":0.2870999872684479},{"id":"https://openalex.org/C2778271984","wikidata":"https://www.wikidata.org/wiki/Q17126794","display_name":"Pressure overload","level":4,"score":0.28690001368522644},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.26249998807907104},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2615000009536743},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.26010000705718994},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.2563000023365021}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2026.41.s1.2290924","doi":"https://doi.org/10.1152/physiol.2026.41.s1.2290924","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2026.41.s1.2290924","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7155097677","https://openalex.org/W4387620955","https://openalex.org/W4402928763","https://openalex.org/W7117463484","https://openalex.org/W4281775316","https://openalex.org/W2484301708","https://openalex.org/W4413269992","https://openalex.org/W4396959305","https://openalex.org/W4403794180","https://openalex.org/W7220932570"],"abstract_inverted_index":{"Heart":[0],"failure":[1,16],"(HF)":[2],"is":[3,339,346],"a":[4,145,159,211],"highly":[5],"morbid":[6],"condition":[7],"affecting":[8],"over":[9],"60":[10],"million":[11],"people":[12],"worldwide.":[13],"Notably,":[14],"heart":[15,60],"with":[17,29,97,229],"preserved":[18,160],"ejection":[19,161],"fraction":[20,162],"(HFpEF)":[21],"comprises":[22],"nearly":[23],"50%":[24],"of":[25,37,68,108,156,195,200,282],"all":[26],"HF":[27],"cases,":[28],"increasing":[30],"prevalence":[31],"in":[32,58,95,119,249,298,322,342,360],"young":[33],"populations.":[34],"The":[35,302,353],"pathophysiology":[36],"HFpEF":[38,102,300,323],"remains":[39,81],"incompletely":[40],"understood,":[41],"limiting":[42],"early":[43],"diagnosis":[44],"and":[45,55,78,92,114,133,163,187,205,232,266,289,315,338],"effective":[46],"treatment":[47],"strategies.":[48],"Emerging":[49],"evidence":[50],"indicates":[51],"that":[52,245,258,274],"metabolic":[53,90,212,275],"remodeling":[54,91,276],"mitochondrial":[56,79,93,176,184,189,243,286,294,316],"dysfunction":[57],"the":[59,65,71,105,151,280,299,333,361],"are":[61],"central":[62],"contributors":[63],"to":[64,128,169,253,279,318],"pathophysiological":[66],"progression":[67],"HFpEF.":[69],"However,":[70],"mechanistic":[72],"relationship":[73],"between":[74],"altered":[75],"cardiac":[76,154],"metabolism":[77,223],"impairment":[80],"poorly":[82],"defined.":[83],"In":[84],"this":[85],"study,":[86],"we":[87],"comprehensively":[88],"analyzed":[89],"health":[94],"mice":[96,121,142,149,172,251],"Angiotensin":[98],"II":[99,180],"(AngII)/phenylephrine":[100],"(PE)-induced":[101],"phenotype,":[103],"without":[104],"confounding":[106],"effects":[107],"multiple":[109],"stressors,":[110],"such":[111],"as":[112,291,293],"obesity":[113],"aging.":[115],"HFpEF-phenotype":[116],"was":[117,330,357],"induced":[118],"8\u201310-week-old":[120],"(n=12-15/group)":[122],"by":[123],"subcutaneously":[124],"implanting":[125],"osmotic":[126],"pumps":[127],"infuse":[129],"AngII":[130],"(1.5":[131],"\u03bcg/g/day)":[132,136],"PE":[134],"(50":[135],"for":[137],"28":[138],"days,":[139],"while":[140],"Control":[141],"received":[143],"only":[144,340],"saline":[146],"infusion.":[147],"AngII/PE-infused":[148,171,250],"recapitulate":[150],"characteristic":[152],"clinical":[153],"parameters":[155],"HFpEF,":[157],"including":[158],"an":[164],"elevated":[165,226],"E/E\u2032":[166],"ratio.":[167],"Compared":[168],"Control,":[170],"showed":[173],"significantly":[174,247],"reduced":[175,206],"respiration,":[177,290],"diminished":[178],"complex":[179],"protein":[181,260],"levels,":[182],"impaired":[183],"supercomplex":[185],"formation,":[186],"decreased":[188],"calcium":[190,295],"retention":[191,296],"capacity.":[192],"Metabolomic":[193],"analysis":[194,240,256],"mitochondria":[196],"revealed":[197],"increased":[198,230],"metabolites":[199],"alternative":[201,221],"glucose":[202,222],"utilization":[203,265],"pathways,":[204],"fatty":[207,215],"acid":[208,216],"metabolites,":[209],"suggesting":[210],"shift":[213],"from":[214],"oxidation":[217],"toward":[218],"reliance":[219],"on":[220],"pathways.":[224],"AngII/PE":[225],"dicarbonyl/glycative":[227,283],"stress":[228,314],"methylglyoxal":[231],"advanced":[233],"glycation":[234],"end":[235],"products":[236],"(AGEs).":[237],"Mass":[238],"spectral":[239],"identified":[241],"17":[242],"proteins":[244],"were":[246],"glycated":[248,259],"compared":[252],"controls.":[254],"Pathway":[255],"suggests":[257],"can":[261],"potentially":[262],"affect":[263],"substrate":[264],"impair":[267],"oxidative":[268],"phosphorylation.":[269],"Collectively,":[270],"our":[271],"findings":[272,304],"indicate":[273],"critically":[277],"contributes":[278],"increase":[281],"stress,":[284],"impairing":[285],"supercomplexes":[287],"formation":[288],"well":[292],"capacity":[297],"heart.":[301],"present":[303],"yield":[305],"novel":[306],"insights":[307],"into":[308],"future":[309],"promising":[310],"therapies":[311],"targeting":[312],"anti-dicarbonyl/glycation":[313],"function":[317],"improve":[319],"disease":[320],"prognosis":[321],"patients.":[324],"Fund:":[325],"NIH":[326],"R01HL160969)":[327],"This":[328],"abstract":[329],"presented":[331],"at":[332],"American":[334],"Physiology":[335,354],"Summit":[336],"2026":[337],"available":[341],"HTML":[343],"format.":[344],"There":[345],"no":[347],"downloadable":[348],"file":[349],"or":[350],"PDF":[351],"version.":[352],"editorial":[355],"board":[356],"not":[358],"involved":[359],"peer":[362],"review":[363],"process.":[364]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2026-05-13T00:00:00"}
