{"id":"https://openalex.org/W7160898015","doi":"https://doi.org/10.1507/endocrj.ej25-0663","title":"\u03b3-Secretase inhibitor ameliorates thyroid autoimmune damage via blocking Notch1 signaling and reducing \u03b3\u03b4T17 cells in EAT mice","display_name":"\u03b3-Secretase inhibitor ameliorates thyroid autoimmune damage via blocking Notch1 signaling and reducing \u03b3\u03b4T17 cells in EAT mice","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7160898015","doi":"https://doi.org/10.1507/endocrj.ej25-0663","pmid":"https://pubmed.ncbi.nlm.nih.gov/42128874","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13478689"},"language":"en","primary_location":{"id":"doi:10.1507/endocrj.ej25-0663","doi":"https://doi.org/10.1507/endocrj.ej25-0663","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.ej25-0663","pdf_url":null,"source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1507/endocrj.ej25-0663","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5132859141","display_name":"Jue Wang","orcid":"https://orcid.org/0009-0002-2008-9033","observed_orcids":["https://orcid.org/0009-0002-2008-9033"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jue Wang","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China"],"raw_orcid":"https://orcid.org/0009-0002-2008-9033","affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126209568","display_name":"Longfei Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Longfei Ding","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106467752","display_name":"Chengyan He","orcid":"https://orcid.org/0000-0001-9640-4867","observed_orcids":["https://orcid.org/0000-0001-9640-4867"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengyan He","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135965779","display_name":"Hao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Liu","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100367694","display_name":"Yiwen Helen Li","orcid":"https://orcid.org/0000-0002-9688-0393","observed_orcids":["https://orcid.org/0000-0002-9688-0393"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwen Li","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108289820","display_name":"Yujiao Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujiao Zhu","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387744","display_name":"Yue Li","orcid":"https://orcid.org/0000-0001-8198-9911","observed_orcids":["https://orcid.org/0000-0001-8198-9911"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Li","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121992885","display_name":"Haibo Xue","orcid":"https://orcid.org/0000-0002-0495-3349","observed_orcids":["https://orcid.org/0000-0002-0495-3349"]},"institutions":[{"id":"https://openalex.org/I134841294","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37","country_code":"CN","type":"education","lineage":["https://openalex.org/I134841294"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haibo Xue","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China"],"raw_orcid":"https://orcid.org/0000-0002-0495-3349","affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, Binzhou 256603, China","institution_ids":["https://openalex.org/I134841294"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5121992885"],"corresponding_institution_ids":["https://openalex.org/I134841294"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24019146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8","first_page":"951","last_page":"961"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5009999871253967,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5009999871253967,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.4032999873161316,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.041600000113248825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-secretase-inhibitors","display_name":"gamma-secretase inhibitors","score":0.968999981880188},{"id":"https://openalex.org/keywords/dapt","display_name":"DAPT","score":0.8420000076293945},{"id":"https://openalex.org/keywords/experimental-autoimmune-thyroiditis","display_name":"experimental autoimmune thyroiditis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/gammadeltat17-cells","display_name":"\u03b3\u03b4T17 cells","score":0.8989999890327454},{"id":"https://openalex.org/keywords/notch1-signaling","display_name":"Notch1 signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/il-17a","display_name":"IL-17A","score":0.9810000061988831},{"id":"https://openalex.org/keywords/thyroid-autoimmunity","display_name":"thyroid autoimmunity","score":0.8960000276565552},{"id":"https://openalex.org/keywords/anti-thyroglobulin-antibodies","display_name":"thyroglobulin antibodies","score":0.9580000042915344},{"id":"https://openalex.org/keywords/notch-intracellular-domain","display_name":"Notch intracellular domain","score":0.8029999732971191},{"id":"https://openalex.org/keywords/lymphocytic-infiltration","display_name":"lymphocyte infiltration","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C144745244","wikidata":"https://www.wikidata.org/wiki/Q4927286","display_name":"Blocking (statistics)","level":2,"score":0.8288000226020813},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5928000211715698},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4934999942779541},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42419999837875366},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4162999987602234},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39480000734329224},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.38100001215934753},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.328900009393692},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.32339999079704285},{"id":"https://openalex.org/C23186085","wikidata":"https://www.wikidata.org/wiki/Q22906809","display_name":"Blocking effect","level":2,"score":0.30160000920295715},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.296999990940094},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.28630000352859497},{"id":"https://openalex.org/C2909320318","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Self Tolerance","level":4,"score":0.25130000710487366}],"mesh":[{"descriptor_ui":"D000072056","descriptor_name":"Transcription Factor HES-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000072056","descriptor_name":"Transcription Factor HES-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013967","descriptor_name":"Thyroiditis, Autoimmune","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013967","descriptor_name":"Thyroiditis, Autoimmune","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013967","descriptor_name":"Thyroiditis, Autoimmune","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013967","descriptor_name":"Thyroiditis, Autoimmune","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020381","descriptor_name":"Interleukin-17","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053829","descriptor_name":"Amyloid Precursor Protein Secretases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D058504","descriptor_name":"Th17 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D058504","descriptor_name":"Th17 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D058504","descriptor_name":"Th17 Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1507/endocrj.ej25-0663","doi":"https://doi.org/10.1507/endocrj.ej25-0663","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.ej25-0663","pdf_url":null,"source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},{"id":"pmid:42128874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42128874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13478689","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13478689/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocr J","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c5be53161b0c4c51971ad787ec0c2371","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c5be53161b0c4c51971ad787ec0c2371","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Endocrine Journal, Vol 73, Iss 8, Pp 951-961 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1507/endocrj.ej25-0663","doi":"https://doi.org/10.1507/endocrj.ej25-0663","is_oa":true,"landing_page_url":"https://doi.org/10.1507/endocrj.ej25-0663","pdf_url":null,"source":{"id":"https://openalex.org/S191387813","display_name":"Endocrine Journal","issn_l":"0918-8959","issn":["0918-8959","1348-4540"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310313267","host_organization_name":"Japan Endocrine Society","host_organization_lineage":["https://openalex.org/P4310313267"],"host_organization_lineage_names":["Japan Endocrine Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1689374887","display_name":null,"funder_award_id":"J16LL01","funder_id":"https://openalex.org/F4320329039","funder_display_name":"Project of Shandong Province Higher Educational Science and Technology Program"},{"id":"https://openalex.org/G1820939504","display_name":null,"funder_award_id":"ZR2022MH175","funder_id":"https://openalex.org/F4320324174","funder_display_name":"Natural Science Foundation of Shandong Province"},{"id":"https://openalex.org/G5769288817","display_name":null,"funder_award_id":"JC2019-03","funder_id":"https://openalex.org/F4320324321","funder_display_name":"Binzhou Medical University"},{"id":"https://openalex.org/G5804913988","display_name":null,"funder_award_id":"202031","funder_id":"https://openalex.org/F4320324321","funder_display_name":"Binzhou Medical University"},{"id":"https://openalex.org/G7411812300","display_name":null,"funder_award_id":"2016GSF201021","funder_id":"https://openalex.org/F4320333596","funder_display_name":"Key Technology Research and Development Program of Shandong"}],"funders":[{"id":"https://openalex.org/F4320324174","display_name":"Natural Science Foundation of Shandong Province","ror":null},{"id":"https://openalex.org/F4320324321","display_name":"Binzhou Medical University","ror":"https://ror.org/008w1vb37"},{"id":"https://openalex.org/F4320329039","display_name":"Project of Shandong Province Higher Educational Science and Technology Program","ror":null},{"id":"https://openalex.org/F4320333596","display_name":"Key Technology Research and Development Program of Shandong","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4313650724","https://openalex.org/W4391322629","https://openalex.org/W2299395186","https://openalex.org/W4306930553","https://openalex.org/W193378259","https://openalex.org/W4321429568","https://openalex.org/W275435757","https://openalex.org/W3034496247","https://openalex.org/W2386323867","https://openalex.org/W2002937734"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,33,62,73,236],"explore":[3],"if":[4],"\u03b3-secretase":[5,232],"inhibitor":[6,233],"can":[7],"regulate":[8],"\u03b3\u03b4T17":[9,90,141,214,245],"cells":[10,91,142,146,151,215,246],"by":[11,94,111,127,243],"blockading":[12],"Notch1":[13,229],"signaling":[14,252],"pathway":[15],"and":[16,40,43,50,81,103,107,113,123,134,148,158,228],"then":[17],"affect":[18],"thyroid":[19,68,149,205,238],"autoimmune":[20,24,239],"damage":[21],"in":[22,85,136,143,161,177,189,204,241],"experimental":[23],"thyroiditis":[25],"(EAT)":[26],"mice.":[27],"Twenty-four":[28],"female":[29],"C57BL/6":[30],"mice,":[31],"6":[32],"8-week-old,":[34],"were":[35,92,109,125,164,183,206,220],"randomly":[36],"divided":[37],"into":[38],"NC":[39,170],"EAT":[41,44,218,242],"groups,":[42],"group":[45,171,191],"included":[46],"EAT-A":[47,162,190,211],"(pTg":[48],"treated)":[49],"EAT-B":[51,178],"(treated":[52],"with":[53,169,210,223],"DAPT":[54],"before":[55],"pTg)":[56],"subgroups.":[57],"HE":[58],"staining":[59],"was":[60,71],"conducted":[61],"observe":[63],"the":[64,75,114,138,153,180,199,250],"pathological":[65],"changes":[66],"of":[67,77,89,100,117,132,140,201,217,249],"tissue.":[69],"ELISA":[70],"adopted":[72],"measure":[74],"concentrations":[76,227],"thyroglobulin":[78],"antibody":[79],"(TgAb)":[80],"interleukin":[82],"17A":[83],"(IL-17A)":[84],"serum.":[86],"The":[87,97,130],"proportions":[88,139],"analysed":[93],"flow":[95],"cytometry.":[96],"mRNA":[98,157,230],"expressions":[99,160],"Notch1,":[101,154],"hairy":[102],"split":[104],"1":[105],"(Hes1)":[106],"IL-17A":[108,124,135,156,226],"measured":[110],"RT-qPCR":[112],"protein":[115,159],"levels":[116],"Notch":[118],"intracellular":[119],"domain":[120],"(NICD),":[121],"Hes1":[122],"examined":[126],"Western":[128],"Blot.":[129],"titers":[131],"TgAb":[133,224],"serum,":[137],"spleen":[144],"mononuclear":[145,150],"(SMCs)":[147],"(TMCs),":[152],"Hes1,":[155],"mice":[163,219],"all":[165,184],"increased":[166],"significantly":[167,186],"compared":[168,209],"(all":[172,192],"p":[173,193],"<":[174,194],"0.001).":[175],"However,":[176],"group,":[179],"above":[181],"indexes":[182],"reduced":[185],"than":[187],"those":[188],"0.05),":[195],"as":[196,198],"well":[197],"degrees":[200],"lymphocyte":[202],"infiltration":[203],"alleviated":[207],"remarkably":[208],"group.":[212],"Additionally,":[213],"percentages":[216],"positively":[221],"correlated":[222],"titers,":[225],"expressions.":[231],"is":[234],"speculated":[235],"alleviate":[237],"injury":[240],"downregulating":[244],"via":[247],"inhibition":[248],"Notch1/Hes1":[251],"pathway.":[253]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2026-05-13T00:00:00"}
