{"id":"https://openalex.org/W7160832110","doi":"https://doi.org/10.2147/dddt.s587510","title":"Intravenous Tranexamic Acid Reduces the Incidence of Postoperative Delirium in Elderly Patients Undergoing Hip Arthroplasty: A Retrospective Cohort Study","display_name":"Intravenous Tranexamic Acid Reduces the Incidence of Postoperative Delirium in Elderly Patients Undergoing Hip Arthroplasty: A Retrospective Cohort Study","publication_year":2026,"publication_date":"2026-05-01","ids":{"openalex":"https://openalex.org/W7160832110","doi":"https://doi.org/10.2147/dddt.s587510","pmid":"https://pubmed.ncbi.nlm.nih.gov/42148364"},"language":"en","primary_location":{"id":"doi:10.2147/dddt.s587510","doi":"https://doi.org/10.2147/dddt.s587510","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s587510","pdf_url":null,"source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2147/dddt.s587510","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126608443","display_name":"Junyang Chu","orcid":"https://orcid.org/0009-0001-9438-6316","observed_orcids":["https://orcid.org/0009-0001-9438-6316"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junyang Chu","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China","Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, 310053, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0001-9438-6316","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China","institution_ids":["https://openalex.org/I4210092870"]},{"raw_affiliation_string":"Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, 310053, People's Republic of China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135876041","display_name":"Yushun Liu","orcid":"https://orcid.org/0009-0003-2879-5714","observed_orcids":["https://orcid.org/0009-0003-2879-5714"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]},{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yushun Liu","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China","Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, 310053, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0003-2879-5714","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China","institution_ids":["https://openalex.org/I4210092870"]},{"raw_affiliation_string":"Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, 310053, People's Republic of China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135895264","display_name":"Lei Xie","orcid":"https://orcid.org/0009-0005-4173-2042","observed_orcids":["https://orcid.org/0009-0005-4173-2042"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Xie","raw_affiliation_strings":["Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, 310053, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0005-4173-2042","affiliations":[{"raw_affiliation_string":"Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, 310053, People's Republic of China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126635331","display_name":"Hanqi Zhang","orcid":"https://orcid.org/0009-0009-5922-3413","observed_orcids":["https://orcid.org/0009-0009-5922-3413"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanqi Zhang","raw_affiliation_strings":["School of Medicine, Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0009-5922-3413","affiliations":[{"raw_affiliation_string":"School of Medicine, Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China","institution_ids":["https://openalex.org/I4210092870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028458552","display_name":"Yixuan Chen","orcid":"https://orcid.org/0009-0000-2533-8081","observed_orcids":["https://orcid.org/0009-0000-2533-8081"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yixuan Chen","raw_affiliation_strings":["School of Medicine, Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China"],"raw_orcid":"https://orcid.org/0009-0000-2533-8081","affiliations":[{"raw_affiliation_string":"School of Medicine, Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China","institution_ids":["https://openalex.org/I4210092870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135875748","display_name":"Zhuo Li","orcid":"https://orcid.org/0009-0008-2602-6491","observed_orcids":["https://orcid.org/0009-0008-2602-6491"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuo Li","raw_affiliation_strings":["School of Medicine, Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China","institution_ids":["https://openalex.org/I4210092870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085403973","display_name":"Kang Deng","orcid":"https://orcid.org/0009-0002-2205-2023","observed_orcids":["https://orcid.org/0009-0002-2205-2023"]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kang Deng","raw_affiliation_strings":["Department of Anesthesiology and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology and Pain Medicine, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, 314001, People's Republic of China","institution_ids":["https://openalex.org/I4210092870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27867448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"Volume 20","issue":null,"first_page":"1","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.9092000126838684,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.07150000333786011,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tranexamic-acid","display_name":"tranexamic acid","score":0.8100000023841858},{"id":"https://openalex.org/keywords/postoperative-delirium","display_name":"postoperative delirium","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hip-arthroplasty","display_name":"total hip arthroplasty","score":0.9980000257492065},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.996999979019165},{"id":"https://openalex.org/keywords/intraoperative-blood-loss","display_name":"intraoperative blood loss","score":0.8180000185966492},{"id":"https://openalex.org/keywords/blood-transfusion","display_name":"blood transfusion","score":0.8529999852180481},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.871999979019165},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.6840000152587891},{"id":"https://openalex.org/keywords/thromboembolic-events","display_name":"thromboembolic events","score":0.9399999976158142},{"id":"https://openalex.org/keywords/opioid-consumption","display_name":"opioid consumption","score":0.45100000500679016},{"id":"https://openalex.org/keywords/intraoperative-hypotension","display_name":"intraoperative hypotension","score":0.7990000247955322},{"id":"https://openalex.org/keywords/d-dimer","display_name":"D-dimer","score":0.6399999856948853},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9480000138282776},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9380000233650208},{"id":"https://openalex.org/keywords/prothrombin-time","display_name":"prothrombin time","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9146000146865845},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.784600019454956},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.7664999961853027},{"id":"https://openalex.org/C2779637338","wikidata":"https://www.wikidata.org/wiki/Q418666","display_name":"Tranexamic acid","level":3,"score":0.7414000034332275},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5314000248908997},{"id":"https://openalex.org/C2779753318","wikidata":"https://www.wikidata.org/wiki/Q160796","display_name":"Delirium","level":2,"score":0.5034999847412109},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.49970000982284546},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4348999857902527},{"id":"https://openalex.org/C2778885795","wikidata":"https://www.wikidata.org/wiki/Q240856","display_name":"Hip fracture","level":3,"score":0.3181000053882599},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.31619998812675476},{"id":"https://openalex.org/C2992051495","wikidata":"https://www.wikidata.org/wiki/Q32333487","display_name":"Hip surgery","level":3,"score":0.2718000113964081},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2685999870300293},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.2531000077724457}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000933","descriptor_name":"Antifibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000933","descriptor_name":"Antifibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000933","descriptor_name":"Antifibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000933","descriptor_name":"Antifibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003693","descriptor_name":"Delirium","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003693","descriptor_name":"Delirium","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003693","descriptor_name":"Delirium","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003693","descriptor_name":"Delirium","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003693","descriptor_name":"Delirium","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003693","descriptor_name":"Delirium","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003693","descriptor_name":"Delirium","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003693","descriptor_name":"Delirium","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019644","descriptor_name":"Arthroplasty, Replacement, Hip","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019644","descriptor_name":"Arthroplasty, Replacement, Hip","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019644","descriptor_name":"Arthroplasty, Replacement, Hip","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019644","descriptor_name":"Arthroplasty, Replacement, Hip","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D061605","descriptor_name":"Administration, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061605","descriptor_name":"Administration, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061605","descriptor_name":"Administration, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061605","descriptor_name":"Administration, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2147/dddt.s587510","doi":"https://doi.org/10.2147/dddt.s587510","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s587510","pdf_url":null,"source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},{"id":"pmid:42148364","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42148364","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug design, development and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:dovepress.com/115034","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/intravenous-tranexamic-acid-reduces-the-incidence-of-postoperative-del-peer-reviewed-fulltext-article-DDDT","pdf_url":"https://www.dovepress.com/article/download/115034","source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13179762","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42148364/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Des Devel Ther","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.2147/dddt.s587510","doi":"https://doi.org/10.2147/dddt.s587510","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s587510","pdf_url":null,"source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W2061021079","https://openalex.org/W2437295384","https://openalex.org/W2735141479","https://openalex.org/W2770650766","https://openalex.org/W2789189490","https://openalex.org/W2791409209","https://openalex.org/W2899288620","https://openalex.org/W2901139787","https://openalex.org/W2905308560","https://openalex.org/W2907554752","https://openalex.org/W2911447021","https://openalex.org/W2979907718","https://openalex.org/W2990312696","https://openalex.org/W3009164479","https://openalex.org/W3121856353","https://openalex.org/W3127599822","https://openalex.org/W3131764736","https://openalex.org/W3132817925","https://openalex.org/W3136197702","https://openalex.org/W3152983776","https://openalex.org/W3159112409","https://openalex.org/W3170114533","https://openalex.org/W3193867662","https://openalex.org/W3196443520","https://openalex.org/W3204607528","https://openalex.org/W3206779268","https://openalex.org/W4200063526","https://openalex.org/W4211145358","https://openalex.org/W4221075441","https://openalex.org/W4233741605","https://openalex.org/W4241672734","https://openalex.org/W4280590548","https://openalex.org/W4281617131","https://openalex.org/W4300960613","https://openalex.org/W4306793222","https://openalex.org/W4313644840","https://openalex.org/W4319437629","https://openalex.org/W4321748400","https://openalex.org/W4360861742","https://openalex.org/W4364352439","https://openalex.org/W4385738864","https://openalex.org/W4386379528","https://openalex.org/W4390224497","https://openalex.org/W4390918582","https://openalex.org/W4392661589","https://openalex.org/W4396545911","https://openalex.org/W4400198307","https://openalex.org/W4402581753","https://openalex.org/W4402604366","https://openalex.org/W4403286195","https://openalex.org/W4406385486","https://openalex.org/W4408846429","https://openalex.org/W4409049807","https://openalex.org/W4411919729","https://openalex.org/W4412923972","https://openalex.org/W4414628381"],"related_works":[],"abstract_inverted_index":{"Purpose:":[0],"This":[1],"study":[2],"aimed":[3],"to":[4,130],"investigate":[5],"the":[6,14,43,60,65,73,109,120,126,131,174,211,230,251],"effect":[7],"of":[8,16,31,62,114,176,190,232,274,280,298],"intravenous":[9,258,278],"Tranexamic":[10],"acid":[11],"(TXA)":[12],"on":[13,52],"incidence":[15,61,121,175,231,297],"postoperative":[17,68,186,225,243,311],"delirium":[18,312],"(POD)":[19],"in":[20,125,169,210,224,229,242,300],"elderly":[21,33,301],"patients":[22,34,116,302],"undergoing":[23,35,303],"hip":[24,36,304],"arthroplasty.":[25,305],"Patients":[26],"and":[27,40,93,100,149,204,245,261,294],"Methods:":[28],"A":[29,112],"total":[30,113],"627":[32],"arthroplasty":[37],"were":[38,106,167,207,222,248],"enrolled":[39],"stratified":[41],"into":[42],"TXA":[44,54,127,141,212,259,281],"group":[45,49,128,133,142,213],"(n=336)":[46],"or":[47,173,228,235],"control":[48,132],"(n=291)":[50],"based":[51],"intraoperative":[53,146,177,257],"administration.":[55],"The":[56,140],"primary":[57],"outcome":[58],"was":[59,282],"POD":[63,299],"within":[64],"first":[66],"7":[67],"days,":[69],"assessed":[70],"daily":[71],"using":[72],"Confusion":[74],"Assessment":[75],"Method":[76],"(CAM).":[77],"Secondary":[78],"outcomes":[79],"included":[80],"blood":[81,147,289],"loss,":[82,290],"transfusion":[83,150,156],"volume,":[84],"Numeric":[85],"Rating":[86],"Scale":[87],"(NRS)":[88],"pain":[89,292],"scores,":[90,293],"thromboembolic":[91,236],"events,":[92],"perioperative":[94],"laboratory":[95],"parameters":[96],"(coagulation,":[97],"inflammatory":[98],"markers,":[99],"liver/kidney":[101],"function).":[102],"Results:":[103],"Baseline":[104],"characteristics":[105],"comparable":[107],"between":[108,179,250],"two":[110,252],"groups.":[111,253],"193":[115],"developed":[117],"POD,":[118],"with":[119,153,284],"being":[122],"significantly":[123,144,208],"lower":[124,155,209,291],"compared":[129],"(22.6%":[134],"vs":[135,159],"40.2%,":[136],"P":[137,161,182,215],"<":[138,162,216],"0.001).":[139],"exhibited":[143],"reduced":[145,285],"loss":[148],"volumes,":[151],"along":[152],"a":[154,295],"rate":[157],"(9.2%":[158],"17.5%,":[160],"0.05).":[163,184,217],"No":[164],"significant":[165,220,240,271],"differences":[166,221,241],"observed":[168,223,249],"anesthetic":[170],"opioid":[171],"doses":[172],"hypotension":[178],"groups":[180],"(":[181,214],">":[183],"On":[185],"day":[187],"2,":[188],"levels":[189],"prothrombin":[191],"time":[192,197],"(PT),":[193],"activated":[194],"partial":[195],"thromboplastin":[196],"(APTT),":[198],"D-dimer,":[199],"high-sensitivity":[200],"C-reactive":[201],"protein":[202],"(hs-CRP),":[203],"interleukin-6":[205],"(IL-6)":[206],"Conversely,":[218],"no":[219,239],"sufentanil":[226],"consumption,":[227],"coagulation":[233],"abnormalities":[234],"events.":[237],"Furthermore,":[238],"liver":[244],"renal":[246],"function":[247],"Multivariate":[254],"analysis":[255],"identified":[256],"administration":[260,279],"preoperative":[262],"comorbid":[263],"chronic":[264],"obstructive":[265],"pulmonary":[266],"disease":[267],"(COPD)":[268],"scores":[269],"as":[270],"independent":[272],"predictors":[273],"POD.":[275],"Conclusion:":[276],"Intraoperative":[277],"associated":[283],"systemic":[286],"inflammation,":[287],"less":[288],"decreased":[296],"Keywords:":[306],"tranexamic":[307],"acid,":[308],"aged,":[309],"arthroplasty,":[310]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-05-12T00:00:00"}