{"id":"https://openalex.org/W7160794","doi":null,"title":"Wound repair-induced expression of a stromelysins is associated with the acquisition of a mesenchymal phenotype in human respiratory epithelial cells.","display_name":"Wound repair-induced expression of a stromelysins is associated with the acquisition of a mesenchymal phenotype in human respiratory epithelial cells.","publication_year":1996,"publication_date":"1996-03-01","ids":{"openalex":"https://openalex.org/W7160794","mag":"7160794","pmid":"https://pubmed.ncbi.nlm.nih.gov/8600317"},"language":"en","primary_location":{"id":"pmid:8600317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8600317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087615343","display_name":"Anne\u2010C\u00e9cile Buisson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I96226040","display_name":"Universit\u00e9 de Reims Champagne-Ardenne","ror":"https://ror.org/03hypw319","country_code":"FR","type":"education","lineage":["https://openalex.org/I96226040"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A C Buisson","raw_affiliation_strings":["INSERM Unit\u00e9 314, Universit\u00e9 de Reims, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM Unit\u00e9 314, Universit\u00e9 de Reims, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I96226040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102969515","display_name":"Christine Gilles","orcid":"https://orcid.org/0000-0002-6891-4920","observed_orcids":["https://orcid.org/0000-0002-6891-4920","https://orcid.org/0000-0003-4738-5924"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"C Gilles","raw_affiliation_strings":["Universit\u00e9 de Li\u00e8ge - ULi\u00e8ge > D\u00e9partement des sciences cliniques > Labo de biologie des tumeurs et du d\u00e9veloppement >  >"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Li\u00e8ge - ULi\u00e8ge > D\u00e9partement des sciences cliniques > Labo de biologie des tumeurs et du d\u00e9veloppement >  >","institution_ids":["https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047035945","display_name":"Myriam Polette","orcid":"https://orcid.org/0000-0001-8173-3246","observed_orcids":["https://orcid.org/0000-0001-8173-3246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Polette","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111779809","display_name":"Jean\u2010Marie Zahm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Zahm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105839491","display_name":"Philippe L. Birembaut","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Birembaut","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110234522","display_name":"J.M. Tournier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Tournier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2076,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.95237444,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"74","issue":"3","first_page":"658","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0803999975323677,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stromelysin-3","display_name":"stromelysin-3","score":0.8790000081062317},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8119999766349792},{"id":"https://openalex.org/keywords/mesenchymal-phenotype","display_name":"mesenchymal phenotype","score":0.8349999785423279},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7459999918937683},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.8320000171661377},{"id":"https://openalex.org/keywords/keratin-14","display_name":"keratin 14","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bronchial-mucosa","display_name":"bronchial mucosa","score":0.921999990940094},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7190616130828857},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.7051947116851807},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.6809592247009277},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6008509397506714},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5998919606208801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5356793999671936},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5031597018241882},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.47182804346084595},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4548512101173401},{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.4435950219631195},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.4217492938041687},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3501385748386383},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34889230132102966},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3465747833251953},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26935434341430664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1354953944683075},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11290723085403442},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.08900168538093567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008648","descriptor_name":"Mesoderm","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012137","descriptor_name":"Respiratory System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012137","descriptor_name":"Respiratory System","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012137","descriptor_name":"Respiratory System","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:8600317","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8600317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"},{"id":"pmh:oai:orbi.ulg.ac.be:2268/63224","doi":null,"is_oa":false,"landing_page_url":"https://orbi.uliege.be/handle/2268/63224","pdf_url":null,"source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Laboratory Investigation, 74 (3), 658-69 (1996)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"mag:7160794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8600317","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2954757532","https://openalex.org/W2024580059","https://openalex.org/W2141880708","https://openalex.org/W1970425207","https://openalex.org/W2023721177","https://openalex.org/W2087239912","https://openalex.org/W1996645270","https://openalex.org/W2041860756","https://openalex.org/W1921977789","https://openalex.org/W7140239733"],"abstract_inverted_index":{"Wound":[0],"repair":[1,160],"involves":[2],"many":[3,47],"processes":[4,16],"including":[5],"cell":[6,81,116,122,224,250],"migration,":[7],"provisional":[8],"matrix":[9,28,37,41,228],"deposition,":[10],"and":[11,83,109,123,128,134,155,206,226],"remodeling.":[12],"All":[13],"of":[14,26,34,49,113,245],"these":[15],"are":[17,31,217],"likely":[18],"to":[19,193,211,219,242,262],"be":[20,61,220,254],"affected":[21],"by":[22,63,98,143,236],"matrix-modifying":[23],"enzymes.":[24],"Members":[25],"the":[27,35,50,56,144,158,163,188,203,243,257],"metalloproteinases":[29,42],"family":[30],"physiologic":[32],"mediators":[33],"extracellular":[36,51,227],"degradation.":[38],"Within":[39],"this":[40],"family,":[43],"stromelysins":[44,59,139,152,194,216],"can":[45],"degrade":[46],"components":[48],"matrix.":[52],"We":[53],"therefore":[54],"tested":[55],"hypothesis":[57],"that":[58,138,151],"could":[60],"produced":[62,141],"human":[64,87],"surface":[65],"respiratory":[66],"epithelial":[67,181,261],"(HSRE)":[68],"cells":[69,112,119,178,186,198,239],"repairing":[70,107,237],"a":[71,246,263],"wound.":[72],"Experimental":[73],"wounds":[74],"were":[75,126,140,153,199,208],"created":[76],"in":[77,79,84,86,91,101,121,202,222],"vitro":[78],"HSRE":[80,115,146,197,223,238,249],"cultures":[82,125],"situ":[85],"bronchial":[88],"mucosa":[89],"maintained":[90],"organ":[92],"culture.":[93],"Stromelysin":[94],"production":[95,165,235],"was":[96],"measured":[97],"casein-gel":[99],"zymography":[100],"cellular":[102],"protein":[103],"extracts":[104],"derived":[105],"from":[106,259],"migratory":[108,145],"nonrepairing":[110],"stationary":[111],"wounded":[114,204],"cultures.":[117],"Stromelysin-producing":[118],"present":[120],"tissue":[124],"localized":[127],"characterized":[129],"using":[130],"immunofluorescence":[131,135],"techniques.":[132],"Zymographic":[133],"techniques":[136],"showed":[137,150],"exclusively":[142,200],"cells.":[147,182],"Zymogram":[148],"analysis":[149],"overexpressed":[154],"overactivated":[156],"during":[157,230],"wound":[159,168,231],"process,":[161],"with":[162,256],"maximal":[164],"observed":[166],"at":[167],"closure.":[169],"Using":[170],"an":[171,260],"anti-cytokeratin":[172],"14":[173],"antibody,":[174],"we":[175],"identified":[176],"stromelysin-3-producing":[177,185],"as":[179],"basal":[180],"Moreover,":[183],"most":[184],"expressed":[187],"mesenchymal":[189,247,264],"marker":[190],"vimentin.":[191],"Similar":[192],"localization,":[195],"vimentin-positive":[196],"located":[201],"area,":[205],"they":[207],"also":[209],"positive":[210],"cytokeratin":[212],"14.":[213],"In":[214],"conclusion,":[215],"suggested":[218],"involved":[221],"migration":[225,251],"remodeling":[229],"repair.":[232],"Furthermore,":[233],"stromelysin":[234],"is":[240],"linked":[241],"acquisition":[244],"phenotype.":[248,265],"may":[252],"then":[253],"associated":[255],"shift":[258]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
