{"id":"https://openalex.org/W7160765","doi":"https://doi.org/10.1007/978-3-642-16861-1_7","title":"The Role of Matrix Metalloproteinases in Cellular Invasion and Metastasis","display_name":"The Role of Matrix Metalloproteinases in Cellular Invasion and Metastasis","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W7160765","doi":"https://doi.org/10.1007/978-3-642-16861-1_7","mag":"7160765"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-16861-1_7","doi":"https://doi.org/10.1007/978-3-642-16861-1_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-16861-1_7","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Extracellular Matrix Degradation","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W336244373","display_name":"Extracellular Matrix Degradation"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073815757","display_name":"Elena I. Deryugina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elena I. Deryugina","raw_affiliation_strings":["The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109423483","display_name":"James P. Quigley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Quigley","raw_affiliation_strings":["The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073815757"],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":null,"apc_paid":null,"fwci":1.0115,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.76056338,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"145","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":1.0},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7490000128746033},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7440000176429749},{"id":"https://openalex.org/keywords/extracellular-matrix-remodeling","display_name":"extracellular matrix remodeling","score":0.9079999923706055},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mt1-mmp","display_name":"MT1-MMP","score":0.9660000205039978},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9580000042915344},{"id":"https://openalex.org/keywords/basement-membrane-invasion","display_name":"basement membrane invasion","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.7789999842643738},{"id":"https://openalex.org/keywords/pre-metastatic-niche","display_name":"pre-metastatic niche","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.6470000147819519},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.8337374925613403},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6687900424003601},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6019297242164612},{"id":"https://openalex.org/C3019223276","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Proteolytic enzymes","level":3,"score":0.5970114469528198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5412617921829224},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4992091655731201},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48448941111564636},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.46552368998527527},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.45618736743927},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.4536428451538086},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.4439057409763336},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4322819709777832},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4215153157711029},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4081553518772125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33634108304977417},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09922084212303162},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09604942798614502},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09428426623344421}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-642-16861-1_7","doi":"https://doi.org/10.1007/978-3-642-16861-1_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-16861-1_7","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Extracellular Matrix Degradation","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6800000071525574,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":263,"referenced_works":["https://openalex.org/W52256561","https://openalex.org/W78406546","https://openalex.org/W84181780","https://openalex.org/W89180169","https://openalex.org/W174176163","https://openalex.org/W284164312","https://openalex.org/W1480357432","https://openalex.org/W1486740674","https://openalex.org/W1501988955","https://openalex.org/W1531661260","https://openalex.org/W1536370890","https://openalex.org/W1555806697","https://openalex.org/W1574172480","https://openalex.org/W1575243854","https://openalex.org/W1605223584","https://openalex.org/W1606352234","https://openalex.org/W1764557127","https://openalex.org/W1767515115","https://openalex.org/W1815115486","https://openalex.org/W1919303367","https://openalex.org/W1922516116","https://openalex.org/W1964081206","https://openalex.org/W1964396019","https://openalex.org/W1964548308","https://openalex.org/W1965037168","https://openalex.org/W1966706677","https://openalex.org/W1967690338","https://openalex.org/W1968084778","https://openalex.org/W1968206020","https://openalex.org/W1968680922","https://openalex.org/W1968820371","https://openalex.org/W1969204556","https://openalex.org/W1971797342","https://openalex.org/W1971964548","https://openalex.org/W1972039621","https://openalex.org/W1972332991","https://openalex.org/W1973620761","https://openalex.org/W1976736011","https://openalex.org/W1976870661","https://openalex.org/W1976906421","https://openalex.org/W1977381126","https://openalex.org/W1978591675","https://openalex.org/W1978846041","https://openalex.org/W1979390430","https://openalex.org/W1979988883","https://openalex.org/W1981332876","https://openalex.org/W1984086503","https://openalex.org/W1985136204","https://openalex.org/W1985462222","https://openalex.org/W1985614501","https://openalex.org/W1985760249","https://openalex.org/W1986471913","https://openalex.org/W1987245481","https://openalex.org/W1990858735","https://openalex.org/W1991031388","https://openalex.org/W1991693796","https://openalex.org/W1991944021","https://openalex.org/W1992171419","https://openalex.org/W1992588954","https://openalex.org/W1992885568","https://openalex.org/W1993645457","https://openalex.org/W1997991194","https://openalex.org/W1998972215","https://openalex.org/W1999650405","https://openalex.org/W2000292756","https://openalex.org/W2001009247","https://openalex.org/W2002157461","https://openalex.org/W2002277974","https://openalex.org/W2003177515","https://openalex.org/W2003500892","https://openalex.org/W2009887475","https://openalex.org/W2010254599","https://openalex.org/W2010715204","https://openalex.org/W2011502034","https://openalex.org/W2011980209","https://openalex.org/W2012063336","https://openalex.org/W2012124753","https://openalex.org/W2012247886","https://openalex.org/W2013214765","https://openalex.org/W2013483737","https://openalex.org/W2014990538","https://openalex.org/W2016484384","https://openalex.org/W2017586839","https://openalex.org/W2019522696","https://openalex.org/W2021153529","https://openalex.org/W2022363275","https://openalex.org/W2022380333","https://openalex.org/W2022391934","https://openalex.org/W2023101194","https://openalex.org/W2023164440","https://openalex.org/W2024331903","https://openalex.org/W2027892036","https://openalex.org/W2028768078","https://openalex.org/W2029033880","https://openalex.org/W2030201335","https://openalex.org/W2030326855","https://openalex.org/W2030615739","https://openalex.org/W2031856001","https://openalex.org/W2032050847","https://openalex.org/W2032263001","https://openalex.org/W2034855589","https://openalex.org/W2036008499","https://openalex.org/W2037099316","https://openalex.org/W2037489902","https://openalex.org/W2039168259","https://openalex.org/W2040166170","https://openalex.org/W2040401976","https://openalex.org/W2041764146","https://openalex.org/W2042082129","https://openalex.org/W2042198997","https://openalex.org/W2042419096","https://openalex.org/W2043436438","https://openalex.org/W2045024397","https://openalex.org/W2047039315","https://openalex.org/W2048270768","https://openalex.org/W2049016944","https://openalex.org/W2049220062","https://openalex.org/W2050039508","https://openalex.org/W2050834003","https://openalex.org/W2052109094","https://openalex.org/W2053043355","https://openalex.org/W2053559643","https://openalex.org/W2056037928","https://openalex.org/W2056447026","https://openalex.org/W2056802402","https://openalex.org/W2057151160","https://openalex.org/W2057580337","https://openalex.org/W2058015990","https://openalex.org/W2058239698","https://openalex.org/W2058554403","https://openalex.org/W2062249523","https://openalex.org/W2062570896","https://openalex.org/W2063482106","https://openalex.org/W2064231568","https://openalex.org/W2065226637","https://openalex.org/W2066801055","https://openalex.org/W2068561276","https://openalex.org/W2070058781","https://openalex.org/W2070291618","https://openalex.org/W2070312129","https://openalex.org/W2072855151","https://openalex.org/W2074187493","https://openalex.org/W2074826273","https://openalex.org/W2076415360","https://openalex.org/W2076782790","https://openalex.org/W2076942176","https://openalex.org/W2078344536","https://openalex.org/W2078502914","https://openalex.org/W2079118949","https://openalex.org/W2079152631","https://openalex.org/W2080264320","https://openalex.org/W2080433269","https://openalex.org/W2081147459","https://openalex.org/W2081743768","https://openalex.org/W2082833890","https://openalex.org/W2083365605","https://openalex.org/W2083423010","https://openalex.org/W2083796876","https://openalex.org/W2084284395","https://openalex.org/W2084306763","https://openalex.org/W2084616372","https://openalex.org/W2085776836","https://openalex.org/W2085815730","https://openalex.org/W2086337788","https://openalex.org/W2087561530","https://openalex.org/W2089370460","https://openalex.org/W2089666322","https://openalex.org/W2090399120","https://openalex.org/W2092868756","https://openalex.org/W2093979559","https://openalex.org/W2096353669","https://openalex.org/W2097308038","https://openalex.org/W2098203510","https://openalex.org/W2099054255","https://openalex.org/W2101037339","https://openalex.org/W2102944450","https://openalex.org/W2105241495","https://openalex.org/W2107561601","https://openalex.org/W2108296770","https://openalex.org/W2110088809","https://openalex.org/W2110108339","https://openalex.org/W2110792223","https://openalex.org/W2111957505","https://openalex.org/W2112327424","https://openalex.org/W2113275925","https://openalex.org/W2114736117","https://openalex.org/W2115062156","https://openalex.org/W2115810495","https://openalex.org/W2117116688","https://openalex.org/W2117402284","https://openalex.org/W2117539984","https://openalex.org/W2118102354","https://openalex.org/W2122561971","https://openalex.org/W2123114542","https://openalex.org/W2123257343","https://openalex.org/W2123754736","https://openalex.org/W2124138369","https://openalex.org/W2125053924","https://openalex.org/W2125743967","https://openalex.org/W2126527231","https://openalex.org/W2127094853","https://openalex.org/W2128609469","https://openalex.org/W2131464730","https://openalex.org/W2132152127","https://openalex.org/W2132495434","https://openalex.org/W2133054656","https://openalex.org/W2133569303","https://openalex.org/W2134765094","https://openalex.org/W2134987819","https://openalex.org/W2135423586","https://openalex.org/W2136124678","https://openalex.org/W2136166312","https://openalex.org/W2139810515","https://openalex.org/W2140338369","https://openalex.org/W2140441306","https://openalex.org/W2140551998","https://openalex.org/W2140563259","https://openalex.org/W2141127028","https://openalex.org/W2141592196","https://openalex.org/W2141815918","https://openalex.org/W2142345281","https://openalex.org/W2142376052","https://openalex.org/W2142416414","https://openalex.org/W2142739240","https://openalex.org/W2143141633","https://openalex.org/W2143717394","https://openalex.org/W2144191486","https://openalex.org/W2144498589","https://openalex.org/W2144648444","https://openalex.org/W2146406291","https://openalex.org/W2146530991","https://openalex.org/W2147104337","https://openalex.org/W2147336841","https://openalex.org/W2148682310","https://openalex.org/W2149479154","https://openalex.org/W2149927639","https://openalex.org/W2152393981","https://openalex.org/W2152877944","https://openalex.org/W2153256423","https://openalex.org/W2153863159","https://openalex.org/W2155555524","https://openalex.org/W2155879201","https://openalex.org/W2156043911","https://openalex.org/W2156234950","https://openalex.org/W2157215186","https://openalex.org/W2157293287","https://openalex.org/W2158739925","https://openalex.org/W2159141617","https://openalex.org/W2159744630","https://openalex.org/W2159999899","https://openalex.org/W2161680142","https://openalex.org/W2161889463","https://openalex.org/W2162317646","https://openalex.org/W2163502506","https://openalex.org/W2166419546","https://openalex.org/W2166470775","https://openalex.org/W2167189514","https://openalex.org/W2169281418","https://openalex.org/W2170164215","https://openalex.org/W2171154252","https://openalex.org/W2803499602","https://openalex.org/W2804842145","https://openalex.org/W2912349604"],"related_works":["https://openalex.org/W146600679","https://openalex.org/W2214297241","https://openalex.org/W93858324","https://openalex.org/W2027275036","https://openalex.org/W2411160598","https://openalex.org/W2755526861","https://openalex.org/W1481557757","https://openalex.org/W2150417542","https://openalex.org/W2024569350","https://openalex.org/W8691493"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}