{"id":"https://openalex.org/W7160637064","doi":"https://doi.org/10.7759/cureus.c430","title":"Nonasthmatic Eosinophilic Bronchitis: An Overlooked Cause of Chronic Cough in Children","display_name":"Nonasthmatic Eosinophilic Bronchitis: An Overlooked Cause of Chronic Cough in Children","publication_year":2026,"publication_date":"2026-05-08","ids":{"openalex":"https://openalex.org/W7160637064","doi":"https://doi.org/10.7759/cureus.c430","pmid":"https://pubmed.ncbi.nlm.nih.gov/42112425"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.c430","doi":"https://doi.org/10.7759/cureus.c430","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.c430","pdf_url":null,"source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.7759/cureus.c430","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100041668","display_name":"Badar Al Dhouyani","orcid":"https://orcid.org/0009-0009-8327-4261","observed_orcids":["https://orcid.org/0009-0009-8327-4261"]},"institutions":[{"id":"https://openalex.org/I4210130525","display_name":"Sidra Medical and Research Center","ror":"https://ror.org/03acdk243","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210130525"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Badar Al Dhouyani","raw_affiliation_strings":["Pediatric Pulmonology, Sidra Medicine, Doha, QAT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Pulmonology, Sidra Medicine, Doha, QAT","institution_ids":["https://openalex.org/I4210130525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069466651","display_name":"Ahmed Abushahin","orcid":"https://orcid.org/0000-0002-9980-3780","observed_orcids":["https://orcid.org/0000-0002-9980-3780","https://orcid.org/0000-0001-6021-2142"]},"institutions":[{"id":"https://openalex.org/I4210130525","display_name":"Sidra Medical and Research Center","ror":"https://ror.org/03acdk243","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210130525"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Ahmed Abushahin","raw_affiliation_strings":["Pediatric Pulmonology, Sidra Medicine, Doha, QAT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Pulmonology, Sidra Medicine, Doha, QAT","institution_ids":["https://openalex.org/I4210130525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049147905","display_name":"Mutasim Abu\u2010Hasan","orcid":"https://orcid.org/0000-0002-0470-334X","observed_orcids":["https://orcid.org/0000-0002-0470-334X"]},"institutions":[{"id":"https://openalex.org/I4210130525","display_name":"Sidra Medical and Research Center","ror":"https://ror.org/03acdk243","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210130525"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Mutasim Abu-Hasan","raw_affiliation_strings":["Pediatric Pulmonology, Sidra Medicine, Doha, QAT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Pulmonology, Sidra Medicine, Doha, QAT","institution_ids":["https://openalex.org/I4210130525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210130525"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.30767561,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"5","first_page":"c430","last_page":"c430"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.82669997215271,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.147599995136261,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12538","display_name":"Eosinophilic Esophagitis","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-cough","display_name":"chronic cough","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pediatric-airway-disorders","display_name":"pediatric airway disease","score":0.6859999895095825},{"id":"https://openalex.org/keywords/eosinophilic-airway-inflammation","display_name":"eosinophilic airway inflammation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/misdiagnosis-as-asthma","display_name":"misdiagnosis as asthma","score":0.8640000224113464},{"id":"https://openalex.org/keywords/methacholine-challenge","display_name":"methacholine challenge","score":0.796999990940094},{"id":"https://openalex.org/keywords/airway-hyperresponsiveness","display_name":"airway hyperresponsiveness","score":0.9750000238418579},{"id":"https://openalex.org/keywords/inhaled-corticosteroids","display_name":"inhaled corticosteroids","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.800000011920929},{"id":"https://openalex.org/keywords/airway-wall-thickening","display_name":"airway wall thickening","score":0.6449999809265137},{"id":"https://openalex.org/keywords/exertional-dyspnea","display_name":"exertional dyspnea","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9940999746322632},{"id":"https://openalex.org/C2777707825","wikidata":"https://www.wikidata.org/wiki/Q60791486","display_name":"Chronic cough","level":3,"score":0.9179999828338623},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5892999768257141},{"id":"https://openalex.org/C2779758542","wikidata":"https://www.wikidata.org/wiki/Q2106364","display_name":"Eosinophilic","level":2,"score":0.47749999165534973},{"id":"https://openalex.org/C2987552334","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic disease","level":2,"score":0.41190001368522644},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3244999945163727},{"id":"https://openalex.org/C2910901110","wikidata":"https://www.wikidata.org/wiki/Q35805","display_name":"Productive Cough","level":3,"score":0.28439998626708984},{"id":"https://openalex.org/C3017571381","wikidata":"https://www.wikidata.org/wiki/Q35805","display_name":"Dry cough","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.24279999732971191},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.23919999599456787}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.c430","doi":"https://doi.org/10.7759/cureus.c430","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.c430","pdf_url":null,"source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmid:42112425","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42112425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Published Erratum"},{"id":"pmh:oai:pubmedcentral.nih.gov:13156925","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13156925/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cureus","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7759/cureus.c430","doi":"https://doi.org/10.7759/cureus.c430","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.c430","pdf_url":null,"source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","score":0.5790625810623169,"display_name":"Zero hunger"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Non-asthmatic":[0],"eosinophilic":[1,56],"bronchitis":[2],"(NAEB)":[3],"is":[4,32,287],"an":[5],"inflammatory":[6,251],"airway":[7,36,57,163,185,212,229,284],"disease":[8],"that":[9,296],"causes":[10],"chronic":[11,54,86,292],"cough,":[12,55],"responds":[13],"well":[14],"to":[15,96],"inhaled":[16,103,219,238,277],"steroids,":[17,239,278],"and":[18,59,89,125,132,147,166,211,279,301],"can":[19,297],"be":[20,307],"misdiagnosed":[21],"as":[22],"asthma":[23],"because":[24,226],"of":[25,50,67,70,85,174,197,227,235,258,291],"the":[26,228,240,259],"pathophysiologic":[27],"overlap.":[28],"Unlike":[29],"asthma,":[30],"NAEB":[31,38,286],"not":[33,40,94],"associated":[34],"with":[35,53,81,99,110,150,171,208,237],"hyperresponsiveness.":[37,285],"has":[39],"been":[41],"previously":[42],"described":[43],"in":[44,294],"children.":[45],"We":[46],"report":[47],"a":[48,51,60,68,75,82,144,193,232,288,302],"case":[49],"child":[52],"inflammation,":[58],"negative":[61],"methacholine":[62,303],"challenge":[63,270,304],"test,":[64],"strongly":[65],"suggestive":[66],"diagnosis":[69],"NAEB.":[71],"The":[72,203,250],"patient":[73,204],"was":[74,79,158,205,215,246,267,272],"10-year-old":[76],"boy":[77],"who":[78],"hospitalized":[80],"2-year":[83],"history":[84],"productive":[87],"cough":[88,293],"exertional":[90],"dyspnea,":[91],"which":[92],"did":[93],"respond":[95],"repeated":[97],"treatment":[98,236],"oral":[100],"antibiotics":[101,210],"or":[102,176],"bronchodilators.":[104],"On":[105],"examination,":[106],"he":[107],"appeared":[108],"tachypneic":[109],"low":[111],"O2":[112],"saturation":[113],"(89%)":[114],"on":[115,218],"room":[116],"air.":[117],"Chest":[118,160,254],"auscultation":[119],"revealed":[120,182],"bilateral":[121,167],"crackles.":[122],"WBC,":[123],"ESR,":[124],"CRP":[126],"were":[127,137,201],"elevated.":[128],"Peripheral":[129],"eosinophil":[130,195],"count":[131,196],"Immunoglobulin":[133],"E":[134],"(IgE)":[135],"level":[136],"normal.":[138,159,268],"Pulmonary":[139],"function":[140],"testing":[141,271],"(PFT)":[142],"demonstrated":[143],"combined":[145],"obstructive":[146],"restrictive":[148],"pattern":[149],"air":[151],"trapping.":[152],"Fractional":[153],"exhaled":[154],"nitric":[155],"oxide":[156],"(FeNO)":[157],"CT":[161,255],"showed":[162,192,256,282],"wall":[164],"thickening":[165],"small":[168],"centrilobular":[169],"nodules,":[170],"no":[172,283],"evidence":[173],"bronchiectasis":[175],"interstitial":[177],"lung":[178],"infiltrates.":[179,261],"Flexible":[180],"bronchoscopy":[181],"diffuse":[183],"thick":[184],"secretions.":[186],"Bronchoalveolar":[187],"lavage":[188],"(BAL)":[189],"fluid":[190],"analysis":[191],"high":[194],"40%.":[198],"BAL":[199],"cultures":[200],"negative.":[202],"initially":[206],"treated":[207],"IV":[209],"clearance.":[213],"He":[214,245],"then":[216],"started":[217],"steroids":[220],"using":[221],"budesonide/salmeterol":[222],"MDI":[223],"(160/25":[224],"mcg)":[225],"eosinophilia.":[230],"Within":[231],"few":[233],"days":[234],"patient\u2019s":[241],"symptoms":[242],"improved":[243],"significantly.":[244],"weaned":[247],"off":[248],"O2.":[249],"markers":[252],"normalized.":[253],"resolution":[257],"abnormal":[260],"Repeat":[262],"PFT":[263],"4":[264],"months":[265],"later":[266],"Methacholine":[269],"performed":[273],"twice":[274],"after":[275],"discontinuing":[276],"both":[280],"tests":[281],"possible":[289],"cause":[290],"children":[295],"mimic":[298],"asthma.":[299],"Bronchoscopy":[300],"test":[305],"may":[306],"needed":[308],"for":[309],"diagnosis.":[310]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-05-09T00:00:00"}