{"id":"https://openalex.org/W7160621718","doi":"https://doi.org/10.1021/acs.jnatprod.6c00411","title":"Prenylated Isoflavones Originating from East African Medicinal Plants Selectively Modulate the \u03b1-Glucosidase from Saccharomyces cerevisiae","display_name":"Prenylated Isoflavones Originating from East African Medicinal Plants Selectively Modulate the \u03b1-Glucosidase from Saccharomyces cerevisiae","publication_year":2026,"publication_date":"2026-05-08","ids":{"openalex":"https://openalex.org/W7160621718","doi":"https://doi.org/10.1021/acs.jnatprod.6c00411","pmid":"https://pubmed.ncbi.nlm.nih.gov/42101363"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jnatprod.6c00411","doi":"https://doi.org/10.1021/acs.jnatprod.6c00411","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.6c00411","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.6c00411?ref=article_openPDF","source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.6c00411?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039597324","display_name":"Kai L\u00fcersen","orcid":"https://orcid.org/0000-0001-5812-1196","observed_orcids":["https://orcid.org/0000-0001-5812-1196"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Kai L\u00fcersen","raw_affiliation_strings":["Institute of Human Nutrition and Food Science","University of Kiel"],"raw_orcid":"https://orcid.org/0000-0001-5812-1196","affiliations":[{"raw_affiliation_string":"Institute of Human Nutrition and Food Science","institution_ids":[]},{"raw_affiliation_string":"University of Kiel","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135711282","display_name":"Friederike Neuber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Friederike Neuber","raw_affiliation_strings":["Institute of Human Nutrition and Food Science","University of Kiel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Nutrition and Food Science","institution_ids":[]},{"raw_affiliation_string":"University of Kiel","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042121750","display_name":"Eric Sperlich","orcid":"https://orcid.org/0000-0002-3118-9518","observed_orcids":["https://orcid.org/0000-0002-3118-9518"]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eric Sperlich","raw_affiliation_strings":["University of Potsdam, Institut f\u00fcr Chemie, Karl-Liebknecht-Strasse 24-25, Potsdam-Golm, Potsdam D-14476, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Potsdam, Institut f\u00fcr Chemie, Karl-Liebknecht-Strasse 24-25, Potsdam-Golm, Potsdam D-14476, Germany","institution_ids":["https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045271104","display_name":"Alexandra Kelling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexandra Kelling","raw_affiliation_strings":["University of Potsdam, Institut f\u00fcr Chemie, Karl-Liebknecht-Strasse 24-25, Potsdam-Golm, Potsdam D-14476, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Potsdam, Institut f\u00fcr Chemie, Karl-Liebknecht-Strasse 24-25, Potsdam-Golm, Potsdam D-14476, Germany","institution_ids":["https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115411232","display_name":"Sarah von Chamier Gliszczinski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sarah von Chamier-Gliszczinski","raw_affiliation_strings":["University of Potsdam, Institut f\u00fcr Chemie, Karl-Liebknecht-Strasse 24-25, Potsdam-Golm, Potsdam D-14476, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Potsdam, Institut f\u00fcr Chemie, Karl-Liebknecht-Strasse 24-25, Potsdam-Golm, Potsdam D-14476, Germany","institution_ids":["https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014543128","display_name":"Julia Greese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Greese","raw_affiliation_strings":["University of Potsdam, Institut f\u00fcr Chemie, Karl-Liebknecht-Strasse 24-25, Potsdam-Golm, Potsdam D-14476, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Potsdam, Institut f\u00fcr Chemie, Karl-Liebknecht-Strasse 24-25, Potsdam-Golm, Potsdam D-14476, Germany","institution_ids":["https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034826426","display_name":"Taye Beyene Demissie","orcid":"https://orcid.org/0000-0001-8735-4933","observed_orcids":["https://orcid.org/0000-0001-8735-4933"]},"institutions":[{"id":"https://openalex.org/I157273133","display_name":"University of Botswana","ror":"https://ror.org/01encsj80","country_code":"BW","type":"education","lineage":["https://openalex.org/I157273133"]}],"countries":["BW"],"is_corresponding":false,"raw_author_name":"Taye B. Demissie","raw_affiliation_strings":["Department of Chemistry, Faculty of Science","University of Botswana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science","institution_ids":[]},{"raw_affiliation_string":"University of Botswana","institution_ids":["https://openalex.org/I157273133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026951945","display_name":"Bernd Schmidt","orcid":"https://orcid.org/0000-0002-0224-6069","observed_orcids":["https://orcid.org/0000-0002-0224-6069"]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Schmidt","raw_affiliation_strings":["University of Potsdam, Institut f\u00fcr Chemie, Karl-Liebknecht-Strasse 24-25, Potsdam-Golm, Potsdam D-14476, Germany"],"raw_orcid":"https://orcid.org/0000-0002-0224-6069","affiliations":[{"raw_affiliation_string":"University of Potsdam, Institut f\u00fcr Chemie, Karl-Liebknecht-Strasse 24-25, Potsdam-Golm, Potsdam D-14476, Germany","institution_ids":["https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054741610","display_name":"Gerald H Rimbach","orcid":"https://orcid.org/0000-0001-7888-4684","observed_orcids":["https://orcid.org/0000-0001-7888-4684"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerald Rimbach","raw_affiliation_strings":["Institute of Human Nutrition and Food Science","University of Kiel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Nutrition and Food Science","institution_ids":[]},{"raw_affiliation_string":"University of Kiel","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023256353","display_name":"Vaderament\u2010A. Nchiozem\u2010Ngnitedem","orcid":"https://orcid.org/0000-0001-8337-9260","observed_orcids":["https://orcid.org/0000-0001-8337-9260"]},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Vaderament-Alexe Nchiozem-Ngnitedem","raw_affiliation_strings":["University of Potsdam, Institut f\u00fcr Chemie, Karl-Liebknecht-Strasse 24-25, Potsdam-Golm, Potsdam D-14476, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8337-9260","affiliations":[{"raw_affiliation_string":"University of Potsdam, Institut f\u00fcr Chemie, Karl-Liebknecht-Strasse 24-25, Potsdam-Golm, Potsdam D-14476, Germany","institution_ids":["https://openalex.org/I176453806"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023256353","https://openalex.org/A5039597324"],"corresponding_institution_ids":["https://openalex.org/I176453806","https://openalex.org/I32021983"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.2600087,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"89","issue":"5","first_page":"1610","last_page":"1624"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.05730000138282776,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.01679999940097332,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prenylated-isoflavones","display_name":"prenylated isoflavones","score":1.0},{"id":"https://openalex.org/keywords/alpha-glucosidase","display_name":"alpha-glucosidase","score":0.8629999756813049},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9539999961853027},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.8029999732971191},{"id":"https://openalex.org/keywords/enzyme-activation","display_name":"enzyme activation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.7789999842643738},{"id":"https://openalex.org/keywords/uncompetitive-inhibition","display_name":"uncompetitive inhibition","score":0.9679999947547913},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.5249999761581421},{"id":"https://openalex.org/keywords/psoralea-corylifolia","display_name":"Psoralea corylifolia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/plant-secondary-metabolites","display_name":"plant secondary metabolites","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.694100022315979},{"id":"https://openalex.org/C57790582","wikidata":"https://www.wikidata.org/wiki/Q901141","display_name":"Prenylation","level":3,"score":0.6557999849319458},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5712000131607056},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.49410000443458557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48730000853538513},{"id":"https://openalex.org/C2779705811","wikidata":"https://www.wikidata.org/wiki/Q412519","display_name":"Isoflavones","level":2,"score":0.4666000008583069},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.337799996137619},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3366999924182892},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.2809000015258789},{"id":"https://openalex.org/C2781380062","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Folk medicine","level":2,"score":0.2797999978065491},{"id":"https://openalex.org/C206103511","wikidata":"https://www.wikidata.org/wiki/Q426694","display_name":"Terpenoid","level":2,"score":0.271699994802475},{"id":"https://openalex.org/C202216756","wikidata":"https://www.wikidata.org/wiki/Q841408","display_name":"Ethnobotany","level":3,"score":0.26350000500679016}],"mesh":[{"descriptor_ui":"D000094846","descriptor_name":"East African People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000094846","descriptor_name":"East African People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000351","descriptor_name":"Africa, Eastern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000351","descriptor_name":"Africa, Eastern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000520","descriptor_name":"alpha-Glucosidases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000520","descriptor_name":"alpha-Glucosidases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000520","descriptor_name":"alpha-Glucosidases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000520","descriptor_name":"alpha-Glucosidases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000520","descriptor_name":"alpha-Glucosidases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000520","descriptor_name":"alpha-Glucosidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000520","descriptor_name":"alpha-Glucosidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000520","descriptor_name":"alpha-Glucosidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000520","descriptor_name":"alpha-Glucosidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000520","descriptor_name":"alpha-Glucosidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007529","descriptor_name":"Isoflavones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054876","descriptor_name":"Prenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054876","descriptor_name":"Prenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054876","descriptor_name":"Prenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054876","descriptor_name":"Prenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054876","descriptor_name":"Prenylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.jnatprod.6c00411","doi":"https://doi.org/10.1021/acs.jnatprod.6c00411","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.6c00411","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.6c00411?ref=article_openPDF","source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"pmid:42101363","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42101363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13200251","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42101363/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Nat Prod","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.jnatprod.6c00411","doi":"https://doi.org/10.1021/acs.jnatprod.6c00411","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jnatprod.6c00411","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.6c00411?ref=article_openPDF","source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.40450000762939453}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6738007664680481}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320875","display_name":"Deutscher Akademischer Austauschdienst","ror":"https://ror.org/039djdh30"},{"id":"https://openalex.org/F4320322480","display_name":"Universit\u00e4t Potsdam","ror":"https://ror.org/03bnmw459"},{"id":"https://openalex.org/F4320322871","display_name":"Organisation for the Prohibition of Chemical Weapons","ror":"https://ror.org/02rqftv84"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7160621718.pdf","grobid_xml":"https://content.openalex.org/works/W7160621718.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W44929223","https://openalex.org/W61666677","https://openalex.org/W1969335186","https://openalex.org/W1969360633","https://openalex.org/W1978890358","https://openalex.org/W1984165251","https://openalex.org/W1985328966","https://openalex.org/W2001714417","https://openalex.org/W2018406341","https://openalex.org/W2029145802","https://openalex.org/W2032206999","https://openalex.org/W2033032354","https://openalex.org/W2036276021","https://openalex.org/W2046229956","https://openalex.org/W2049075991","https://openalex.org/W2067338816","https://openalex.org/W2071025291","https://openalex.org/W2071419109","https://openalex.org/W2072721238","https://openalex.org/W2073348133","https://openalex.org/W2081138839","https://openalex.org/W2103915214","https://openalex.org/W2105277692","https://openalex.org/W2106441572","https://openalex.org/W2127442518","https://openalex.org/W2131350133","https://openalex.org/W2153663490","https://openalex.org/W2157818323","https://openalex.org/W2164306929","https://openalex.org/W2165666776","https://openalex.org/W2202210344","https://openalex.org/W2470498898","https://openalex.org/W2586745316","https://openalex.org/W2601948086","https://openalex.org/W2725689741","https://openalex.org/W2801458406","https://openalex.org/W2804653108","https://openalex.org/W2809941338","https://openalex.org/W2811039398","https://openalex.org/W2908841689","https://openalex.org/W2909753093","https://openalex.org/W2913917892","https://openalex.org/W2935656641","https://openalex.org/W2950462108","https://openalex.org/W2972093359","https://openalex.org/W2974358682","https://openalex.org/W2991188715","https://openalex.org/W3011008204","https://openalex.org/W3019662048","https://openalex.org/W3029189015","https://openalex.org/W3033045996","https://openalex.org/W3035846281","https://openalex.org/W3097447225","https://openalex.org/W3101071117","https://openalex.org/W3105087002","https://openalex.org/W3152055274","https://openalex.org/W3171946840","https://openalex.org/W3176541466","https://openalex.org/W3185053804","https://openalex.org/W3193722096","https://openalex.org/W3206056148","https://openalex.org/W3213723185","https://openalex.org/W4200225733","https://openalex.org/W4200291910","https://openalex.org/W4200410668","https://openalex.org/W4224284715","https://openalex.org/W4244805546","https://openalex.org/W4283834209","https://openalex.org/W4285794432","https://openalex.org/W4291669663","https://openalex.org/W4295206819","https://openalex.org/W4308494679","https://openalex.org/W4308553947","https://openalex.org/W4315702921","https://openalex.org/W4324148911","https://openalex.org/W4378783556","https://openalex.org/W4386347531","https://openalex.org/W4386371889","https://openalex.org/W4386973510","https://openalex.org/W4390475881","https://openalex.org/W4392111202","https://openalex.org/W4393997313","https://openalex.org/W4401272681","https://openalex.org/W4402919324","https://openalex.org/W4405310761","https://openalex.org/W4407372709","https://openalex.org/W4409449709","https://openalex.org/W4409833977","https://openalex.org/W4412653665"],"related_works":[],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Nine":[7],"naturally":[8],"occurring":[9],"prenylated":[10,46],"isoflavones":[11,30,47,123],"and":[12,26,55,90,106,127,163,190],"three":[13],"nonnatural":[14,165],"analogues":[15],"were":[16,31,69,131,147],"synthesized":[17,25,29],"for":[18,33,149],"the":[19,44,73,118,180,196,203],"first":[20,204],"time.":[21],"The":[22,140],"12":[23],"newly":[24],"11":[27],"previously":[28],"tested":[32,48],"their":[34],"activity":[35,181],"as":[36],"modulators":[37],"of":[38,43,77,85,112,117,136,174,182,198,206,210],"Saccharomyces":[39],"cerevisiae":[40,79,138,184],"\u03b1-glucosidase.":[41,139],"Out":[42],"23":[45],"in":[49,121,144],"total,":[50],"4\u2032,7-dihydroxy-3\u2032,5\u2032-diprenylisoflavone":[51],"(":[52,57,151,168],"26":[53,100],")":[54],"8-prenyldaidzein":[56],"28":[58,107],"),":[59,153],"both":[60,177],"secondary":[61,155],"plant":[62,156],"metabolites":[63],"originally":[64,158],"isolated":[65,159],"from":[66,160],"Psoralea":[67],"corylifolia,":[68],"found":[70,132],"to":[71,133],"be":[72,134],"most":[74,141],"potent":[75],"inhibitors":[76],"S.":[78,137,183],"\u03b1-glucosidase,":[80],"with":[81,124],"IC":[82],"50":[83,175],"values":[84],"7.8":[86],"\u00b1":[87,92,188,192],"2.3":[88],"\u03bcM":[89],"14.6":[91],"5.1":[93],"\u03bcM,":[94,176],"respectively.":[95,194],"Kinetic":[96],"analysis":[97],"revealed":[98],"that":[99],"acts":[101],"through":[102,108],"a":[103,115,125,154,172],"noncompetitive":[104],"mechanism":[105,111],"an":[109],"uncompetitive":[110],"inhibition.":[113],"Surprisingly,":[114],"few":[116],"compounds":[119,178],"tested,":[120],"particular":[122],"6,7-":[126],"3\u2032,4\u2032-dioxy":[128],"substitution":[129],"pattern,":[130],"activators":[135,209],"notable":[142],"effects":[143],"this":[145,211],"regard":[146],"observed":[148],"predurallone":[150],"21c":[152],"metabolite":[157],"Millettia":[161],"dura,":[162],"its":[164],"analogue":[166],"7-methylpredurallone":[167],"22c":[169],").":[170],"At":[171],"concentration":[173],"enhanced":[179],"\u03b1-glucosidase":[185],"by":[186],"53.7":[187],"8.8%":[189],"41.5":[191],"8.2%,":[193],"To":[195],"best":[197],"our":[199],"knowledge,":[200],"these":[201],"are":[202],"examples":[205],"small":[207],"molecule":[208],"enzyme.":[212]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-05-09T00:00:00"}