{"id":"https://openalex.org/W7160408317","doi":"https://doi.org/10.1056/nejmoa2505783","title":"Daraxonrasib in Previously Treated Advanced RAS -Mutated Pancreatic Cancer","display_name":"Daraxonrasib in Previously Treated Advanced RAS -Mutated Pancreatic Cancer","publication_year":2026,"publication_date":"2026-05-06","ids":{"openalex":"https://openalex.org/W7160408317","doi":"https://doi.org/10.1056/nejmoa2505783","pmid":"https://pubmed.ncbi.nlm.nih.gov/42090791"},"language":"en","primary_location":{"id":"doi:10.1056/nejmoa2505783","doi":"https://doi.org/10.1056/nejmoa2505783","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmoa2505783","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047496278","display_name":"Brian Matthew Wolpin","orcid":"https://orcid.org/0000-0002-0455-1032","observed_orcids":["https://orcid.org/0000-0002-0455-1032"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian M. Wolpin","raw_affiliation_strings":["Dana\u2013Farber Cancer Institute, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana\u2013Farber Cancer Institute, Boston","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033315908","display_name":"Wungki Park","orcid":"https://orcid.org/0000-0002-8006-3102","observed_orcids":["https://orcid.org/0000-0002-8006-3102"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wungki Park","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York"],"raw_orcid":"https://orcid.org/0000-0002-8006-3102","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029563022","display_name":"Ignacio Garrido\u2010Laguna","orcid":"https://orcid.org/0000-0003-2273-9028","observed_orcids":["https://orcid.org/0000-0003-2273-9028"]},"institutions":[{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ignacio Garrido-Laguna","raw_affiliation_strings":["Huntsman Cancer Institute, University of Utah, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Cancer Institute, University of Utah, Salt Lake City","institution_ids":["https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044613951","display_name":"Alexander I. Spira","orcid":"https://orcid.org/0000-0003-1303-0447","observed_orcids":["https://orcid.org/0000-0003-1303-0447"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Spira","raw_affiliation_strings":["NEXT Oncology Virgina, Virgina Cancer Specialists Research Institute, Fairfax"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NEXT Oncology Virgina, Virgina Cancer Specialists Research Institute, Fairfax","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110147506","display_name":"Alexander Starodub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134025","display_name":"Christ Hospital","ror":"https://ror.org/03dm2se39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210134025"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Starodub","raw_affiliation_strings":["Christ Hospital, Cincinnati"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christ Hospital, Cincinnati","institution_ids":["https://openalex.org/I4210134025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063897579","display_name":"David Sommerhalder","orcid":"https://orcid.org/0000-0002-7033-9064","observed_orcids":["https://orcid.org/0000-0002-7033-9064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Sommerhalder","raw_affiliation_strings":["NEXT Oncology, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NEXT Oncology, San Antonio, TX","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066766559","display_name":"Salman Rafi Punekar","orcid":"https://orcid.org/0000-0002-7613-6305","observed_orcids":["https://orcid.org/0000-0002-7613-6305"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salman R. Punekar","raw_affiliation_strings":["NYU Langone Health, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NYU Langone Health, New York","institution_ids":["https://openalex.org/I4210086933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015591858","display_name":"Minal A. Barve","orcid":"https://orcid.org/0009-0007-4259-7457","observed_orcids":["https://orcid.org/0009-0007-4259-7457"]},"institutions":[{"id":"https://openalex.org/I4210087725","display_name":"Mary Crowley Cancer Research Center","ror":"https://ror.org/002ksg449","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087725"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minal Barve","raw_affiliation_strings":["Mary Crowley Cancer Research, Dallas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary Crowley Cancer Research, Dallas","institution_ids":["https://openalex.org/I4210087725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082164882","display_name":"Meredith S. Pelster","orcid":"https://orcid.org/0009-0005-2448-3478","observed_orcids":["https://orcid.org/0009-0005-2448-3478"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meredith Pelster","raw_affiliation_strings":["Sarah Cannon Research Institute, Nashville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarah Cannon Research Institute, Nashville","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070121613","display_name":"Benjamin Herzberg","orcid":"https://orcid.org/0000-0002-3253-3106","observed_orcids":["https://orcid.org/0000-0002-3253-3106"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Herzberg","raw_affiliation_strings":["Columbia University, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Columbia University, New York","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060219345","display_name":"Nilofer Saba Azad","orcid":"https://orcid.org/0000-0002-9613-3988","observed_orcids":["https://orcid.org/0000-0002-9613-3988"]},"institutions":[{"id":"https://openalex.org/I4210164401","display_name":"Sidney Kimmel Comprehensive Cancer Center","ror":"https://ror.org/05m5b8x20","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210164401"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nilofer S. Azad","raw_affiliation_strings":["Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore","institution_ids":["https://openalex.org/I4210164401"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001020016","display_name":"Joel Randolph Hecht","orcid":"https://orcid.org/0000-0003-2277-4157","observed_orcids":["https://orcid.org/0000-0003-2277-4157"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel Randolph Hecht","raw_affiliation_strings":["David Geffen School of Medicine at UCLA, Los Angeles"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David Geffen School of Medicine at UCLA, Los Angeles","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087923582","display_name":"Sai\u2010Hong Ignatius Ou","orcid":"https://orcid.org/0000-0002-1764-4975","observed_orcids":["https://orcid.org/0000-0002-1764-4975"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sai Hong Ignatius Ou","raw_affiliation_strings":["University of California, Irvine, Irvine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Irvine, Irvine","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100769666","display_name":"Tong Lin","orcid":"https://orcid.org/0000-0003-1181-3763","observed_orcids":["https://orcid.org/0000-0003-1181-3763"]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tong Lin","raw_affiliation_strings":["Revolution Medicines, Redwood City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Redwood City, CA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062601988","display_name":"Sumit Kar","orcid":"https://orcid.org/0000-0002-8213-8497","observed_orcids":["https://orcid.org/0000-0002-8213-8497"]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumit Kar","raw_affiliation_strings":["Revolution Medicines, Redwood City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Redwood City, CA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126968678","display_name":"Lin Tao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Tao","raw_affiliation_strings":["Revolution Medicines, Redwood City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Redwood City, CA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002513596","display_name":"Rashmi Vora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rashmi Vora","raw_affiliation_strings":["Revolution Medicines, Redwood City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Redwood City, CA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133902441","display_name":"Aparna Hegde","orcid":"https://orcid.org/0000-0001-6616-4882","observed_orcids":["https://orcid.org/0000-0001-6616-4882"]},"institutions":[{"id":"https://openalex.org/I4210100604","display_name":"Revolution Medicines (United States)","ror":"https://ror.org/00mny1y94","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100604"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aparna Hegde","raw_affiliation_strings":["Revolution Medicines, Redwood City, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Revolution Medicines, Redwood City, CA","institution_ids":["https://openalex.org/I4210100604"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066902945","display_name":"Kyaw Lwin Aung","orcid":"https://orcid.org/0000-0001-9889-0379","observed_orcids":["https://orcid.org/0000-0001-9889-0379","https://orcid.org/0000-0003-2910-2847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyaw Aung","raw_affiliation_strings":["Miami Cancer Institute, Miami"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miami Cancer Institute, Miami","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026095888","display_name":"David S. Hong","orcid":"https://orcid.org/0000-0001-8721-1609","observed_orcids":["https://orcid.org/0000-0001-8721-1609"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Hong","raw_affiliation_strings":["M.D. Anderson Cancer Center, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M.D. Anderson Cancer Center, Houston","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":214.9843,"has_fulltext":false,"cited_by_count":86,"citation_normalized_percentile":{"value":0.99991395,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"394","issue":"18","first_page":"1790","last_page":"1802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/daraxonrasib","display_name":"daraxonrasib","score":0.9679999947547913},{"id":"https://openalex.org/keywords/rmc-6236","display_name":"RMC-6236","score":0.9789999723434448},{"id":"https://openalex.org/keywords/objective-response-rate","display_name":"objective response rate","score":0.8080000281333923},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9750000238418579},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9570000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.789900004863739},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6092000007629395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48820000886917114},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4081000089645386},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34630000591278076},{"id":"https://openalex.org/C2776737053","wikidata":"https://www.wikidata.org/wiki/Q7130407","display_name":"Pancreatic disease","level":3,"score":0.3133000135421753},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2904999852180481},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2872999906539917},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.25929999351501465},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.257099986076355},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.25519999861717224}],"mesh":[{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejmoa2505783","doi":"https://doi.org/10.1056/nejmoa2505783","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmoa2505783","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:42090791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42090791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.4556187391281128},{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4300883412361145}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320318921","display_name":"Revolution Medicines","ror":"https://ror.org/00mny1y94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1992995822","https://openalex.org/W2018159884","https://openalex.org/W2080719056","https://openalex.org/W2081990599","https://openalex.org/W2158798157","https://openalex.org/W2165480504","https://openalex.org/W2282990014","https://openalex.org/W2285093314","https://openalex.org/W2518765238","https://openalex.org/W2748710555","https://openalex.org/W2909729333","https://openalex.org/W3042568371","https://openalex.org/W3093242429","https://openalex.org/W3132199378","https://openalex.org/W3142010099","https://openalex.org/W3172081492","https://openalex.org/W3174662367","https://openalex.org/W3197559541","https://openalex.org/W3204487449","https://openalex.org/W4281650778","https://openalex.org/W4311292692","https://openalex.org/W4312094134","https://openalex.org/W4313546483","https://openalex.org/W4378901135","https://openalex.org/W4386529421","https://openalex.org/W4386614978","https://openalex.org/W4387378648","https://openalex.org/W4387811516","https://openalex.org/W4390936597","https://openalex.org/W4390946922","https://openalex.org/W4394580100","https://openalex.org/W4394580205","https://openalex.org/W4394595642","https://openalex.org/W4406869918","https://openalex.org/W4408247136"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"mutations":[1],"occur":[2],"in":[3],"more":[4],"than":[5],"90%":[6],"of":[7,48,61],"PDAC":[8],"tumors.":[9],"Daraxonrasib":[10],"(RMC-6236)":[11],"is":[12],"an":[13,42],"oral":[14],"RAS(ON)":[15],"multiselective":[16],"inhibitor":[17],"that":[18],"targets":[19],"guanosine":[20],"triphosphate-bound":[21],"mutant":[22],"and":[23,67],"wild-type":[24],"RAS.":[25],"METHODS:":[26],"-mutated":[27,74],"PDAC.":[28],"RESULTS:":[29],"G12,":[30],"G13,":[31],"or":[32],"Q61":[33],"mutations,":[34],"29%":[35],"(95%":[36,53],"CI,":[37,54],"15":[38],"to":[39,56],"46)":[40],"had":[41],"objective":[43],"response.":[44],"The":[45],"median":[46,59],"duration":[47],"response":[49],"was":[50,78],"8.2":[51],"months":[52,63,69],"3.8":[55],"8.8),":[57],"with":[58],"values":[60],"8.1":[62],"for":[64,70],"progression-free":[65],"survival":[66],"15.6":[68],"overall":[71],"survival.":[72],"CONCLUSIONS:":[73],"PDAC;":[75],"antitumor":[76],"activity":[77],"also":[79],"reported.":[80],"(Funded":[81],"by":[82],"Revolution":[83],"Medicines;":[84],"RMC-6236-001":[85],"ClinicalTrials.gov":[86],"number,":[87],"NCT05379985.).":[88]},"counts_by_year":[{"year":2026,"cited_by_count":85},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2026-05-07T00:00:00"}