{"id":"https://openalex.org/W7160335249","doi":"https://doi.org/10.1038/s41375-026-02976-5","title":"A novel CRLF2-targeted antibody-drug conjugate exhibits potent anti-leukemic activity against Ph-like acute lymphoblastic leukemia","display_name":"A novel CRLF2-targeted antibody-drug conjugate exhibits potent anti-leukemic activity against Ph-like acute lymphoblastic leukemia","publication_year":2026,"publication_date":"2026-05-05","ids":{"openalex":"https://openalex.org/W7160335249","doi":"https://doi.org/10.1038/s41375-026-02976-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/42086931"},"language":"en","primary_location":{"id":"doi:10.1038/s41375-026-02976-5","doi":"https://doi.org/10.1038/s41375-026-02976-5","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41375-026-02976-5","pdf_url":null,"source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017822055","display_name":"Sara M. A. Mohamed","orcid":"https://orcid.org/0000-0001-9948-7979","observed_orcids":["https://orcid.org/0000-0001-9948-7979"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU","EG"],"is_corresponding":false,"raw_author_name":"Sara M. A. Mohamed","raw_affiliation_strings":["Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia","Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0001-9948-7979","affiliations":[{"raw_affiliation_string":"Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103577894","display_name":"PR Schofield","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136750679","display_name":"Garvan Institute of Medical Research","ror":"https://ror.org/01b3dvp57","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I136750679","https://openalex.org/I4210087284"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter Schofield","raw_affiliation_strings":["Garvan Institute of Medical Research, Sydney, NSW, Australia","St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garvan Institute of Medical Research, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I136750679"]},{"raw_affiliation_string":"St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102933279","display_name":"Kathryn Evans","orcid":"https://orcid.org/0000-0001-8737-6358","observed_orcids":["https://orcid.org/0000-0001-8737-6358"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Kathryn Evans","raw_affiliation_strings":["Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110287674","display_name":"Karlheinz Friedrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl-Heinz Friedrich","raw_affiliation_strings":["Institute of Biochemistry II, Jena University Hospital, Jena, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry II, Jena University Hospital, Jena, Germany","institution_ids":["https://openalex.org/I4210134900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008710503","display_name":"Daniel Christ","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136750679","display_name":"Garvan Institute of Medical Research","ror":"https://ror.org/01b3dvp57","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I136750679","https://openalex.org/I4210087284"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Daniel Christ","raw_affiliation_strings":["Garvan Institute of Medical Research, Sydney, NSW, Australia","St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Garvan Institute of Medical Research, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I136750679"]},{"raw_affiliation_string":"St. Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000806228","display_name":"Narges Bayat","orcid":"https://orcid.org/0000-0002-1986-2845","observed_orcids":["https://orcid.org/0000-0002-1986-2845"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Narges Bayat","raw_affiliation_strings":["Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia"],"raw_orcid":"https://orcid.org/0000-0002-1986-2845","affiliations":[{"raw_affiliation_string":"Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028049853","display_name":"Richard B. Lock","orcid":"https://orcid.org/0000-0002-3436-9071","observed_orcids":["https://orcid.org/0000-0002-3436-9071"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210112315","display_name":"Children's Cancer Institute Australia","ror":"https://ror.org/01x784220","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210112315"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Richard B. Lock","raw_affiliation_strings":["Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia. rlock@ccia.org.au"],"raw_orcid":"https://orcid.org/0000-0002-3436-9071","affiliations":[{"raw_affiliation_string":"Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health, UNSW Centre for Childhood Cancer Research, UNSW Sydney, Sydney, NSW, Australia. rlock@ccia.org.au","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210112315"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5028049853"],"corresponding_institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210112315"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28301176,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"7","first_page":"1569","last_page":"1573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crlf2","display_name":"CRLF2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/philadelphia-chromosome-like-acute-lymphoblastic-leukemia","display_name":"Philadelphia chromosome-like acute lymphoblastic leukemia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/b-cell-acute-lymphoblastic-leukemia","display_name":"B-cell acute lymphoblastic leukemia","score":0.6769999861717224},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.45100000500679016},{"id":"https://openalex.org/keywords/relapsed-refractory-leukemia","display_name":"relapsed/refractory leukemia","score":0.7039999961853027},{"id":"https://openalex.org/keywords/cd19-negative-relapse","display_name":"CD19-negative relapse","score":0.5709999799728394},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.6110000014305115},{"id":"https://openalex.org/keywords/tslpr","display_name":"TSLPR","score":0.4869999885559082},{"id":"https://openalex.org/keywords/janus-kinase-signaling","display_name":"Janus kinase signaling","score":0.6050000190734863},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.4390000104904175},{"id":"https://openalex.org/keywords/inotuzumab-ozogamicin","display_name":"inotuzumab ozogamicin","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5953999757766724},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.5594000220298767},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.4512999951839447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4453999996185303},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.435699999332428},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.42910000681877136},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.37560001015663147},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.33250001072883606},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32199999690055847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29159998893737793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28790000081062317},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2703999876976013},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.26579999923706055},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26260000467300415},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.25859999656677246},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.25850000977516174},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2574000060558319},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.25690001249313354}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1038/s41375-026-02976-5","doi":"https://doi.org/10.1038/s41375-026-02976-5","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41375-026-02976-5","pdf_url":null,"source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"pmid:42086931","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42086931","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Letter"},{"id":"pmh:oai:unsworks.library.unsw.edu.au:1959.4/107836","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1959.4/107836","pdf_url":null,"source":{"id":"https://openalex.org/S4306401737","display_name":"UNSWorks (University of New South Wales, Sydney, Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40053085","host_organization_name":"Australian Defence Force Academy","host_organization_lineage":["https://openalex.org/I40053085"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Leukemia, 40, 7, 1-5","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1766561546","https://openalex.org/W1973864734","https://openalex.org/W2016833582","https://openalex.org/W2762869808","https://openalex.org/W2765201398","https://openalex.org/W2771668512","https://openalex.org/W2916249195","https://openalex.org/W2920230491","https://openalex.org/W2994610571","https://openalex.org/W3080735623","https://openalex.org/W3198233413","https://openalex.org/W4311679896","https://openalex.org/W4388007326","https://openalex.org/W4395068276","https://openalex.org/W4403694618"],"related_works":["https://openalex.org/W4389242295","https://openalex.org/W6964740632","https://openalex.org/W3097208648","https://openalex.org/W3198233413","https://openalex.org/W4388007326","https://openalex.org/W3211478118","https://openalex.org/W6927437027","https://openalex.org/W4417004270","https://openalex.org/W4296528842","https://openalex.org/W4409630714"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2026-05-06T00:00:00"}
