{"id":"https://openalex.org/W7160332009","doi":"https://doi.org/10.1113/ep093516","title":"Inflammation, mechanical allodynia and an exaggerated exercise pressor reflex during disease progression in UCD\u2010type 2 diabetes mellitus rats","display_name":"Inflammation, mechanical allodynia and an exaggerated exercise pressor reflex during disease progression in UCD\u2010type 2 diabetes mellitus rats","publication_year":2026,"publication_date":"2026-05-05","ids":{"openalex":"https://openalex.org/W7160332009","doi":"https://doi.org/10.1113/ep093516","pmid":"https://pubmed.ncbi.nlm.nih.gov/42086336","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13394175"},"language":"en","primary_location":{"id":"doi:10.1113/ep093516","doi":"https://doi.org/10.1113/ep093516","is_oa":true,"landing_page_url":"https://doi.org/10.1113/ep093516","pdf_url":null,"source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1113/ep093516","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006927014","display_name":"Michelle Harrison","orcid":"https://orcid.org/0000-0001-9205-1961","observed_orcids":["https://orcid.org/0000-0001-9205-1961"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle L. Harrison","raw_affiliation_strings":["Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002845846","display_name":"Richard K. McCuller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard K. McCuller","raw_affiliation_strings":["Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003673237","display_name":"Yu Huo","orcid":"https://orcid.org/0000-0002-9504-0018","observed_orcids":["https://orcid.org/0000-0002-9504-0018"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Huo","raw_affiliation_strings":["Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota USA","Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135402908","display_name":"Amshula N. Gajula","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amshula N. Gajula","raw_affiliation_strings":["Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014783803","display_name":"Kai M. Ybarbo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Ybarbo","raw_affiliation_strings":["Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003402833","display_name":"Mark J. Van Ryzin","orcid":"https://orcid.org/0000-0003-2034-1585","observed_orcids":["https://orcid.org/0000-0003-2034-1585"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark J. Van Ryzin","raw_affiliation_strings":["Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056635157","display_name":"Kimber L. Stanhope","orcid":"https://orcid.org/0000-0002-2474-0914","observed_orcids":["https://orcid.org/0000-0002-2474-0914"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimber L. Stanhope","raw_affiliation_strings":["Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition University of California  Davis California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition University of California  Davis California USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034829692","display_name":"Peter Joseph Havel","orcid":"https://orcid.org/0000-0003-3652-8301","observed_orcids":["https://orcid.org/0000-0003-3652-8301"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Peter J. Havel","raw_affiliation_strings":["Department of Cellular and Physiological Sciences School of Medicine University of British Columbia  Vancouver British Columbia Canada","Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition University of California  Davis California USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Physiological Sciences School of Medicine University of British Columbia  Vancouver British Columbia Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Molecular Biosciences, School of Veterinary Medicine and Department of Nutrition University of California  Davis California USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091881806","display_name":"Audrey J. Stone","orcid":"https://orcid.org/0000-0002-0081-0244","observed_orcids":["https://orcid.org/0000-0002-0081-0244"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Audrey J. Stone","raw_affiliation_strings":["Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA"],"raw_orcid":"https://orcid.org/0000-0002-0081-0244","affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Health Education The University of Texas at Austin  Austin Texas USA","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5091881806"],"corresponding_institution_ids":["https://openalex.org/I86519309"],"apc_list":{"value":2940,"currency":"USD","value_usd":2940},"apc_paid":{"value":2940,"currency":"USD","value_usd":2940},"fwci":3.2613,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.83764404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.996999979019165},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":0.8790000081062317},{"id":"https://openalex.org/keywords/exercise-pressor-reflex","display_name":"exercise pressor reflex","score":0.9580000042915344},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.7609999775886536},{"id":"https://openalex.org/keywords/chronic-low-grade-inflammation","display_name":"low-grade inflammation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7900000214576721},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9160000085830688},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7059999704360962},{"id":"https://openalex.org/keywords/diabetic-pain","display_name":"diabetic pain","score":0.4869999885559082},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9081000089645386},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.7336999773979187},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.6722999811172485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6110000014305115},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.5109999775886536},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.49050000309944153},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4652000069618225},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43880000710487366},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42890000343322754},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.39750000834465027},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.37279999256134033},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.36809998750686646},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32690000534057617},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.320499986410141},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C3673659","wikidata":"https://www.wikidata.org/wiki/Q1098125","display_name":"Threshold of pain","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.28049999475479126},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.27880001068115234},{"id":"https://openalex.org/C181588539","wikidata":"https://www.wikidata.org/wiki/Q219067","display_name":"Physical exercise","level":2,"score":0.25369998812675476}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1113/ep093516","doi":"https://doi.org/10.1113/ep093516","is_oa":true,"landing_page_url":"https://doi.org/10.1113/ep093516","pdf_url":null,"source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},{"id":"pmid:42086336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42086336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13394175","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13394175/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Physiol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1113/ep093516","doi":"https://doi.org/10.1113/ep093516","is_oa":true,"landing_page_url":"https://doi.org/10.1113/ep093516","pdf_url":null,"source":{"id":"https://openalex.org/S65894173","display_name":"Experimental Physiology","issn_l":"0958-0670","issn":["0958-0670","1469-445X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Physiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2118984387","display_name":"Temporal effects of inflammation on the autonomic control of circulation during exercise in type 2 diabetic rats","funder_award_id":"R01HL144723","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000911018","display_name":"Neuropathology and inflammation in a nonhuman primate model of insulin resistance/metabolic syndrome","funder_award_id":"R01AG085572","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1988209540","https://openalex.org/W2003604699","https://openalex.org/W2011525584","https://openalex.org/W2029360289","https://openalex.org/W2034721936","https://openalex.org/W2036198864","https://openalex.org/W2049972637","https://openalex.org/W2056453954","https://openalex.org/W2063307212","https://openalex.org/W2083483148","https://openalex.org/W2084928699","https://openalex.org/W2087421621","https://openalex.org/W2091015977","https://openalex.org/W2097930427","https://openalex.org/W2100974457","https://openalex.org/W2150367899","https://openalex.org/W2153113977","https://openalex.org/W2154661835","https://openalex.org/W2180851509","https://openalex.org/W2266945844","https://openalex.org/W2403854759","https://openalex.org/W2409813268","https://openalex.org/W2783611475","https://openalex.org/W2790400225","https://openalex.org/W2892932086","https://openalex.org/W2946606555","https://openalex.org/W2954153234","https://openalex.org/W2997584489","https://openalex.org/W3045697406","https://openalex.org/W3081655479","https://openalex.org/W4313250793","https://openalex.org/W4315489820","https://openalex.org/W4386102671","https://openalex.org/W4387357057","https://openalex.org/W4390796037","https://openalex.org/W4401729373","https://openalex.org/W4404493522","https://openalex.org/W4409742382"],"related_works":["https://openalex.org/W3177273644","https://openalex.org/W4387062431","https://openalex.org/W3016278214","https://openalex.org/W6927201849","https://openalex.org/W2954153234","https://openalex.org/W4225403937","https://openalex.org/W3170282517","https://openalex.org/W4404493522","https://openalex.org/W6946101657","https://openalex.org/W4378649260"],"abstract_inverted_index":{"Chronic":[0],"low-grade":[1],"inflammation":[2,206],"characterizes":[3],"type":[4],"2":[5],"diabetes":[6,61,114,134,147,159],"mellitus":[7],"(T2DM)":[8],"and":[9,22,96,101,170,172,205],"underlies":[10],"the":[11,47,143,151,200],"development":[12],"of":[13,17,30,42,49,68,168,202],"peripheral":[14],"neuropathy,":[15],"symptoms":[16],"which":[18,136],"include":[19],"mechanical":[20,37,89,203],"allodynia":[21,38,90,204],"an":[23,50,215],"exaggerated":[24,51],"exercise":[25,52,152],"pressor":[26,53,153],"reflex.":[27,54],"The":[28],"purpose":[29],"this":[31],"study":[32],"was":[33,57,107],"to":[34,59,113,131,158,207],"determine":[35,208],"whether":[36],"and/or":[39],"specific":[40],"concentrations":[41],"inflammatory":[43,97],"mediators":[44,98],"coincide":[45],"with":[46,179,211],"presence":[48],"Haemoglobin":[55],"A1c":[56],"assessed":[58,88],"detect":[60],"onset":[62],"(threshold":[63],"\u22655.6%)":[64],"in":[65,127,146],"male":[66],"University":[67],"California":[69],"Davis":[70],"(UCD)-T2DM":[71],"rats":[72,79,122,162],"(n":[73,80],"=":[74,81],"18).":[75],"Age-matched,":[76],"healthy":[77],"Sprague-Dawley":[78],"18)":[82],"served":[83],"as":[84,149],"controls.":[85],"Monthly":[86],"measurements":[87],"(via":[91,99],"paw":[92],"withdrawal":[93,105],"threshold),":[94],"insulin":[95],"ELISA":[100],"multiplex":[102],"kits).":[103],"Paw":[104],"threshold":[106,129],"not":[108],"different":[109],"between":[110],"groups":[111],"prior":[112],"onset.":[115],"However,":[116],"by":[117],"8":[118,139,187],"weeks":[119,188],"post-onset,":[120],"T2DM":[121,212],"demonstrated":[123],"a":[124,183,193],"significant":[125,184],"decrease":[126],"pain":[128],"compared":[130],"that":[132],"before":[133],"onset,":[135,160],"persisted":[137,175],"for":[138,196,218],"weeks.":[140],"This":[141],"is":[142,155],"same":[144],"period":[145],"progression":[148],"when":[150,209],"reflex":[154],"exaggerated.":[156],"Prior":[157],"UCD\u2011T2DM":[161],"had":[163],"significantly":[164],"higher":[165],"circulating":[166],"levels":[167],"IL\u20116":[169],"IL\u20111\u03b2,":[171],"these":[173],"elevations":[174],"throughout":[176],"disease":[177],"progression,":[178],"only":[180],"CRP":[181],"showing":[182],"increase":[185],"at":[186,214],"post\u2011onset.":[189],"These":[190],"findings":[191],"offer":[192],"useful":[194],"foundation":[195],"further":[197],"exploration":[198],"into":[199],"assessments":[201],"those":[210],"are":[213],"increased":[216],"risk":[217],"experiencing":[219],"adverse":[220],"cardiovascular":[221],"events.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-05-06T00:00:00"}