{"id":"https://openalex.org/W7160200723","doi":"https://doi.org/10.7759/cureus.108100","title":"Isolated Solar Angioedema: A Rare Case Successfully Treated With Dapsone","display_name":"Isolated Solar Angioedema: A Rare Case Successfully Treated With Dapsone","publication_year":2026,"publication_date":"2026-05-01","ids":{"openalex":"https://openalex.org/W7160200723","doi":"https://doi.org/10.7759/cureus.108100","pmid":"https://pubmed.ncbi.nlm.nih.gov/42226854","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13222562"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.108100","doi":"https://doi.org/10.7759/cureus.108100","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.108100","pdf_url":"https://www.cureus.com/articles/483032-isolated-solar-angioedema-a-rare-case-successfully-treated-with-dapsone.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/483032-isolated-solar-angioedema-a-rare-case-successfully-treated-with-dapsone.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107058321","display_name":"Mary Grace Hash","orcid":"https://orcid.org/0000-0002-1675-9404","observed_orcids":["https://orcid.org/0000-0002-1675-9404"]},"institutions":[{"id":"https://openalex.org/I896114043","display_name":"Edward Via College of Osteopathic Medicine","ror":"https://ror.org/00sda2672","country_code":"US","type":"education","lineage":["https://openalex.org/I896114043"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary Grace H London","raw_affiliation_strings":["Medicine, Edward Via College of Osteopathic Medicine, Auburn, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Edward Via College of Osteopathic Medicine, Auburn, USA","institution_ids":["https://openalex.org/I896114043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111336530","display_name":"Bret-Ashleigh Coleman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I896114043","display_name":"Edward Via College of Osteopathic Medicine","ror":"https://ror.org/00sda2672","country_code":"US","type":"education","lineage":["https://openalex.org/I896114043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bret-Ashleigh Coleman","raw_affiliation_strings":["Medicine, Edward Via College of Osteopathic Medicine, Auburn, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, Edward Via College of Osteopathic Medicine, Auburn, USA","institution_ids":["https://openalex.org/I896114043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107136787","display_name":"Grace Herrick","orcid":"https://orcid.org/0009-0009-2087-3005","observed_orcids":["https://orcid.org/0009-0009-2087-3005"]},"institutions":[{"id":"https://openalex.org/I2799524434","display_name":"Alabama College of Osteopathic Medicine","ror":"https://ror.org/02rzdts70","country_code":"US","type":"education","lineage":["https://openalex.org/I2799524434"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace Herrick","raw_affiliation_strings":["Dermatology, Alabama College of Osteopathic Medicine, Dothan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, Alabama College of Osteopathic Medicine, Dothan, USA","institution_ids":["https://openalex.org/I2799524434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5159936650","display_name":"John Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Evans","raw_affiliation_strings":["Dermatology, Alabama Dermatology and Skin Specialists, Huntsville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dermatology, Alabama Dermatology and Skin Specialists, Huntsville, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5107058321"],"corresponding_institution_ids":["https://openalex.org/I896114043"],"apc_list":null,"apc_paid":null,"fwci":3.8809,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.86583757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"18","issue":"5","first_page":"e108100","last_page":"e108100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.11299999803304672,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12438","display_name":"Urticaria and Related Conditions","score":0.07029999792575836,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dapsone","display_name":"dapsone","score":0.8209999799728394},{"id":"https://openalex.org/keywords/photodermatoses","display_name":"photodermatosis","score":0.9739999771118164},{"id":"https://openalex.org/keywords/facial-swelling","display_name":"facial swelling","score":0.847000002861023},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.8130000233650208},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.6389999985694885},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9767000079154968},{"id":"https://openalex.org/C2777640609","wikidata":"https://www.wikidata.org/wiki/Q422226","display_name":"Dapsone","level":2,"score":0.7631999850273132},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5685999989509583},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3725999891757965},{"id":"https://openalex.org/C2779701055","wikidata":"https://www.wikidata.org/wiki/Q929833","display_name":"Rare disease","level":3,"score":0.2475000023841858},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.24169999361038208},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.2363000065088272},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.2079000025987625},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.1964000016450882},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.18889999389648438}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.108100","doi":"https://doi.org/10.7759/cureus.108100","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.108100","pdf_url":"https://www.cureus.com/articles/483032-isolated-solar-angioedema-a-rare-case-successfully-treated-with-dapsone.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmid:42226854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42226854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:13222562","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13222562/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7759/cureus.108100","doi":"https://doi.org/10.7759/cureus.108100","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.108100","pdf_url":"https://www.cureus.com/articles/483032-isolated-solar-angioedema-a-rare-case-successfully-treated-with-dapsone.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7160200723.pdf","grobid_xml":"https://content.openalex.org/works/W7160200723.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W2069724741","https://openalex.org/W2073541488","https://openalex.org/W2130834234","https://openalex.org/W2157856855","https://openalex.org/W2553841091","https://openalex.org/W2555697673","https://openalex.org/W2727587197","https://openalex.org/W2810385606","https://openalex.org/W2900664494","https://openalex.org/W2905510695","https://openalex.org/W2999356769","https://openalex.org/W3138305683"],"related_works":["https://openalex.org/W3138305683","https://openalex.org/W2073541488","https://openalex.org/W2124280995","https://openalex.org/W2098901568","https://openalex.org/W4234756564","https://openalex.org/W2809849381","https://openalex.org/W2169262300","https://openalex.org/W2135945806","https://openalex.org/W4400125670","https://openalex.org/W2951168145"],"abstract_inverted_index":{"Isolated":[0],"solar":[1],"angioedema":[2,13,187],"(ISA)":[3],"is":[4],"an":[5],"exceptionally":[6],"rare":[7,289],"photodermatosis":[8],"characterized":[9],"by":[10,15,195],"transient,":[11],"painless":[12],"triggered":[14],"ultraviolet":[16],"(UV)":[17],"or":[18,26,90,100,279],"visible":[19],"light":[20],"exposure,":[21,156],"typically":[22],"presenting":[23,303],"without":[24,87],"urticaria":[25,89],"pruritus,":[27,97],"which":[28],"complicates":[29],"diagnosis":[30,143],"and":[31,47,76,108,129,161,188,201,204,218,251,291],"treatment.":[32],"To":[33],"date,":[34],"fewer":[35],"than":[36],"10":[37],"cases":[38],"of":[39,59,144,159,164,185,233,240,253,287,295],"ISA":[40,145,274],"have":[41],"been":[42],"documented":[43],"in":[44,182,227,248,301],"the":[45,48,57,150,157,162,168,215,242,249,292],"literature,":[46],"most":[49],"effective":[50],"management":[51],"strategies":[52],"remain":[53],"unclear.":[54],"We":[55],"describe":[56],"case":[58,229,264],"a":[60,114,138,245,269],"31-year-old":[61],"woman":[62],"who":[63],"presented":[64],"with":[65,121,137,154,304],"recurrent,":[66],"asymptomatic":[67],"facial":[68],"edema":[69],"affecting":[70],"her":[71],"left":[72],"cheek,":[73],"perioral":[74],"region,":[75],"eyelids":[77],"after":[78],"sun":[79,155,261],"exposure.":[80,262],"Each":[81],"episode":[82],"resolved":[83],"within":[84],"24":[85],"hours":[86],"residual":[88],"systemic":[91],"symptoms.":[92],"The":[93],"patient":[94,243],"denied":[95],"urticaria,":[96,160],"tongue":[98],"swelling,":[99],"respiratory":[101],"difficulties.":[102],"Initial":[103],"treatments,":[104],"including":[105],"cetirizine,":[106],"montelukast,":[107],"prednisone,":[109],"provided":[110],"minimal":[111],"relief,":[112],"suggesting":[113],"mechanism":[115],"beyond":[116],"histamine-mediated":[117],"pathways.":[118,236],"Laboratory":[119],"workup":[120],"normal":[122],"complement":[123],"C4":[124],"helped":[125],"exclude":[126],"hereditary":[127],"angioedema,":[128],"C-reactive":[130],"protein":[131],"(CRP)":[132],"was":[133,146,176],"mildly":[134],"elevated,":[135],"consistent":[136,151],"nonspecific":[139],"inflammatory":[140,190,221,235],"process.":[141],"A":[142],"made":[147],"based":[148],"on":[149],"temporal":[152],"relationship":[153],"absence":[158],"exclusion":[163],"alternative":[165,234],"diagnoses.":[166],"Given":[167],"patient's":[169],"poor":[170],"response":[171],"to":[172,179,260,276],"conventional":[173,277],"therapies,":[174],"dapsone":[175,210,266,296],"initiated":[177],"due":[178],"its":[180,223],"efficacy":[181],"other":[183],"forms":[184],"idiopathic":[186],"chronic":[189],"dermatoses.":[191],"Dapsone":[192],"modulates":[193,220],"inflammation":[194],"inhibiting":[196],"neutrophil":[197],"recruitment,":[198],"suppressing":[199],"prostaglandin":[200],"leukotriene":[202],"activity,":[203],"scavenging":[205],"reactive":[206],"oxygen":[207],"species.":[208],"Since":[209],"does":[211],"not":[212],"directly":[213],"target":[214],"bradykinin":[216],"pathway":[217],"primarily":[219],"processes,":[222],"observed":[224],"clinical":[225],"benefit":[226],"this":[228,288],"may":[230,267,297],"suggest":[231],"involvement":[232],"After":[237],"three":[238],"months":[239],"therapy,":[241],"reported":[244],"notable":[246],"decrease":[247],"frequency":[250],"severity":[252],"flare-ups,":[254],"as":[255,257],"well":[256],"enhanced":[258],"tolerance":[259],"This":[263],"suggests":[265],"represent":[268],"potential":[270,293],"therapeutic":[271],"option":[272],"for":[273],"refractory":[275,305],"antihistamines":[278],"corticosteroids,":[280],"although":[281],"further":[282],"studies":[283],"are":[284],"needed.":[285],"Awareness":[286],"entity":[290],"benefits":[294],"help":[298],"improve":[299],"outcomes":[300],"patients":[302],"ISA.":[306]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-05-05T00:00:00"}
