{"id":"https://openalex.org/W7160064582","doi":"https://doi.org/10.1016/j.dmd.2026.100312","title":"Advances in organ-on-chip for drug transporter study: Key insights and hurdles","display_name":"Advances in organ-on-chip for drug transporter study: Key insights and hurdles","publication_year":2026,"publication_date":"2026-04-30","ids":{"openalex":"https://openalex.org/W7160064582","doi":"https://doi.org/10.1016/j.dmd.2026.100312","pmid":"https://pubmed.ncbi.nlm.nih.gov/42285028"},"language":"en","primary_location":{"id":"doi:10.1016/j.dmd.2026.100312","doi":"https://doi.org/10.1016/j.dmd.2026.100312","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dmd.2026.100312","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.dmd.2026.100312","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105990525","display_name":"Isy Petit","orcid":"https://orcid.org/0009-0000-1707-3976","observed_orcids":["https://orcid.org/0009-0000-1707-3976"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387153263","display_name":"Pharmacologie & Transplantation","ror":"https://ror.org/013dngs07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387153263","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isy Petit","raw_affiliation_strings":["U1248 Pharmacology & Transplantation, Inserm, Universit\u00e9 de Limoges, Limoges, France"],"raw_orcid":"https://orcid.org/0009-0000-1707-3976","affiliations":[{"raw_affiliation_string":"U1248 Pharmacology & Transplantation, Inserm, Universit\u00e9 de Limoges, Limoges, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387153263","https://openalex.org/I65806277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108994001","display_name":"Jean-S\u00e9bastien Bernard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387153263","display_name":"Pharmacologie & Transplantation","ror":"https://ror.org/013dngs07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387153263","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-S\u00e9bastien Bernard","raw_affiliation_strings":["U1248 Pharmacology & Transplantation, Inserm, Universit\u00e9 de Limoges, Limoges, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U1248 Pharmacology & Transplantation, Inserm, Universit\u00e9 de Limoges, Limoges, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387153263","https://openalex.org/I65806277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011605143","display_name":"Quentin Faucher","orcid":"https://orcid.org/0000-0003-0983-8996","observed_orcids":["https://orcid.org/0000-0003-0983-8996"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Quentin Faucher","raw_affiliation_strings":["Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-0983-8996","affiliations":[{"raw_affiliation_string":"Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116454795","display_name":"Dorian Chastagner","orcid":"https://orcid.org/0009-0003-1764-1007","observed_orcids":["https://orcid.org/0009-0003-1764-1007"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387153263","display_name":"Pharmacologie & Transplantation","ror":"https://ror.org/013dngs07","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387153263","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dorian Chastagner","raw_affiliation_strings":["U1248 Pharmacology & Transplantation, Inserm, Universit\u00e9 de Limoges, Limoges, France"],"raw_orcid":"https://orcid.org/0009-0003-1764-1007","affiliations":[{"raw_affiliation_string":"U1248 Pharmacology & Transplantation, Inserm, Universit\u00e9 de Limoges, Limoges, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4387153263","https://openalex.org/I65806277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073480980","display_name":"H\u00e9l\u00e8ne Arnion","orcid":"https://orcid.org/0000-0003-1244-3629","observed_orcids":["https://orcid.org/0000-0003-1244-3629"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387152534","display_name":"BISCEm - Biologie Int\u00e9grative Sant\u00e9 Chimie Environnement","ror":"https://ror.org/04kbqb151","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387152534","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"H\u00e9l\u00e8ne Arnion","raw_affiliation_strings":["UAR2015/US42 Integrative Biology Health Chemistry and Environment BISCEm, CNRS, Inserm, CHU Limoges, Universit\u00e9 de Limoges, Limoges, France"],"raw_orcid":"https://orcid.org/0000-0003-1244-3629","affiliations":[{"raw_affiliation_string":"UAR2015/US42 Integrative Biology Health Chemistry and Environment BISCEm, CNRS, Inserm, CHU Limoges, Universit\u00e9 de Limoges, Limoges, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4387152534","https://openalex.org/I65806277"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031067410","display_name":"Florent Di Meo","orcid":"https://orcid.org/0000-0001-6279-1272","observed_orcids":["https://orcid.org/0000-0001-6279-1272"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210118469","display_name":"Centre Hospitalier Universitaire de Limoges","ror":"https://ror.org/01tc2d264","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210118469"]},{"id":"https://openalex.org/I4387152534","display_name":"BISCEm - Biologie Int\u00e9grative Sant\u00e9 Chimie Environnement","ror":"https://ror.org/04kbqb151","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387152534","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Florent Di Meo","raw_affiliation_strings":["U1248 Pharmacology & Transplantation, Inserm, Universit\u00e9 de Limoges, Limoges, France; UAR2015/US42 Integrative Biology Health Chemistry and Environment BISCEm, CNRS, Inserm, CHU Limoges, Universit\u00e9 de Limoges, Limoges, France"],"raw_orcid":"https://orcid.org/0000-0001-6279-1272","affiliations":[{"raw_affiliation_string":"U1248 Pharmacology & Transplantation, Inserm, Universit\u00e9 de Limoges, Limoges, France; UAR2015/US42 Integrative Biology Health Chemistry and Environment BISCEm, CNRS, Inserm, CHU Limoges, Universit\u00e9 de Limoges, Limoges, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210118469","https://openalex.org/I4387152534","https://openalex.org/I65806277"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014701585","display_name":"Nicolas V\u00e9drenne","orcid":"https://orcid.org/0000-0001-6210-2254","observed_orcids":["https://orcid.org/0000-0001-6210-2254"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Nicolas V\u00e9drenne","raw_affiliation_strings":["U1248 Pharmacology & Transplantation, Inserm, Universit\u00e9 de Limoges, Limoges, France. Electronic address: nicolas.vedrenne@unilim.fr"],"raw_orcid":"https://orcid.org/0000-0001-6210-2254","affiliations":[{"raw_affiliation_string":"U1248 Pharmacology & Transplantation, Inserm, Universit\u00e9 de Limoges, Limoges, France. Electronic address: nicolas.vedrenne@unilim.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I65806277"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5014701585"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I65806277"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.4891,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.81894671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"54","issue":"6","first_page":"100312","last_page":"100312"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.19619999825954437,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/organ-on-a-chip","display_name":"organ-on-a-chip","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.8579999804496765},{"id":"https://openalex.org/keywords/membrane-transporters","display_name":"membrane transporters","score":0.9620000123977661},{"id":"https://openalex.org/keywords/inter-organ-communication","display_name":"inter-organ communication","score":0.8610000014305115},{"id":"https://openalex.org/keywords/microphysiological-systems","display_name":"microphysiological systems","score":0.8050000071525574},{"id":"https://openalex.org/keywords/transporter-regulation","display_name":"transporter regulation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7300000190734863},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.7960000038146973},{"id":"https://openalex.org/keywords/organ-crosstalk","display_name":"organ crosstalk","score":0.5680000185966492},{"id":"https://openalex.org/keywords/drug-disposition","display_name":"drug disposition","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.7347000241279602},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5343000292778015},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5077999830245972},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5059999823570251},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.43070000410079956},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37369999289512634},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.37299999594688416},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3528999984264374},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3131999969482422},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.27149999141693115},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.2637999951839447},{"id":"https://openalex.org/C178855305","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmaceutical sciences","level":2,"score":0.2614000141620636}],"mesh":[{"descriptor_ui":"D000094182","descriptor_name":"Microphysiological Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.dmd.2026.100312","doi":"https://doi.org/10.1016/j.dmd.2026.100312","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dmd.2026.100312","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},{"id":"pmid:42285028","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42285028","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug metabolism and disposition: the biological fate of chemicals","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05793487v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05793487","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Metabolism and Disposition, 2026, 54 (6), pp.100312. &#x27E8;10.1016/j.dmd.2026.100312&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/486320","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/486320","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1016/j.dmd.2026.100312","doi":"https://doi.org/10.1016/j.dmd.2026.100312","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.dmd.2026.100312","pdf_url":null,"source":{"id":"https://openalex.org/S145039780","display_name":"Drug Metabolism and Disposition","issn_l":"0090-9556","issn":["0090-9556","1521-009X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Metabolism and Disposition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.428600013256073,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1392644413","display_name":null,"funder_award_id":"25OKv2209","funder_id":"https://openalex.org/F4320321643","funder_display_name":"Nierstichting"},{"id":"https://openalex.org/G4331405924","display_name":null,"funder_award_id":"101107439","funder_id":"https://openalex.org/F4320338337","funder_display_name":"H2020 Marie Sk\u0142odowska-Curie Actions"},{"id":"https://openalex.org/G5139742475","display_name":"In silico models of drug transport to enhance personalized medicine","funder_award_id":"ANR-19-CE17-0020","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G5510842890","display_name":null,"funder_award_id":"AAP-NA- ESR 2019","funder_id":"https://openalex.org/F4320325796","funder_display_name":"Conseil R\u00e9gional Aquitaine"},{"id":"https://openalex.org/G576549424","display_name":"Roscovitine analogues as targeted pharmacotherapies for rare cholestatic liver diseases","funder_award_id":"ANR-21-CE18-0030","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G6295295268","display_name":null,"funder_award_id":"2023 MUSYPHA","funder_id":"https://openalex.org/F4320325796","funder_display_name":"Conseil R\u00e9gional Aquitaine"},{"id":"https://openalex.org/G7199756500","display_name":"Multi-scale and longitudinal data modeling in pharmacology: toward digital pharmacological twins","funder_award_id":"ANR-22-PESN-0017","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320309327","display_name":"Google","ror":"https://ror.org/00njsd438"},{"id":"https://openalex.org/F4320319947","display_name":"Kidney Foundation of Canada","ror":"https://ror.org/019a0gk53"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320321643","display_name":"Nierstichting","ror":"https://ror.org/020k6v967"},{"id":"https://openalex.org/F4320325796","display_name":"Conseil R\u00e9gional Aquitaine","ror":"https://ror.org/01wjxf448"},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null},{"id":"https://openalex.org/F4320338337","display_name":"H2020 Marie Sk\u0142odowska-Curie Actions","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":112,"referenced_works":["https://openalex.org/W94592376","https://openalex.org/W1822042631","https://openalex.org/W1963587340","https://openalex.org/W1964530424","https://openalex.org/W1972604432","https://openalex.org/W1973792425","https://openalex.org/W1983508148","https://openalex.org/W1991520741","https://openalex.org/W2000378155","https://openalex.org/W2000496441","https://openalex.org/W2003562401","https://openalex.org/W2005867761","https://openalex.org/W2013520568","https://openalex.org/W2021444563","https://openalex.org/W2033375528","https://openalex.org/W2050774813","https://openalex.org/W2052471911","https://openalex.org/W2073213328","https://openalex.org/W2073526315","https://openalex.org/W2075679933","https://openalex.org/W2088860253","https://openalex.org/W2092879591","https://openalex.org/W2110057699","https://openalex.org/W2116635252","https://openalex.org/W2125168178","https://openalex.org/W2131976213","https://openalex.org/W2137261892","https://openalex.org/W2138469650","https://openalex.org/W2146337514","https://openalex.org/W2159457208","https://openalex.org/W2161273286","https://openalex.org/W2461581138","https://openalex.org/W2730312060","https://openalex.org/W2766056185","https://openalex.org/W2794369551","https://openalex.org/W2800367941","https://openalex.org/W2804552830","https://openalex.org/W2902449467","https://openalex.org/W2914997784","https://openalex.org/W2933294973","https://openalex.org/W2951670413","https://openalex.org/W2963027449","https://openalex.org/W2964989731","https://openalex.org/W2972504261","https://openalex.org/W2973243306","https://openalex.org/W2994914558","https://openalex.org/W2999902773","https://openalex.org/W3000511359","https://openalex.org/W3002451359","https://openalex.org/W3009852690","https://openalex.org/W3010522957","https://openalex.org/W3031439051","https://openalex.org/W3042444816","https://openalex.org/W3045183878","https://openalex.org/W3083392211","https://openalex.org/W3084374992","https://openalex.org/W3093223339","https://openalex.org/W3111015203","https://openalex.org/W3119022286","https://openalex.org/W3127316509","https://openalex.org/W3130510188","https://openalex.org/W3161024438","https://openalex.org/W3164962028","https://openalex.org/W3180728306","https://openalex.org/W3199229315","https://openalex.org/W3203187412","https://openalex.org/W3215339101","https://openalex.org/W3217566971","https://openalex.org/W4200228384","https://openalex.org/W4207037817","https://openalex.org/W4220652963","https://openalex.org/W4220875360","https://openalex.org/W4223411185","https://openalex.org/W4224221538","https://openalex.org/W4225100591","https://openalex.org/W4280540675","https://openalex.org/W4281559034","https://openalex.org/W4283322283","https://openalex.org/W4285413549","https://openalex.org/W4292242775","https://openalex.org/W4292849104","https://openalex.org/W4294127978","https://openalex.org/W4294266835","https://openalex.org/W4295197831","https://openalex.org/W4296252123","https://openalex.org/W4303476459","https://openalex.org/W4312155124","https://openalex.org/W4381470030","https://openalex.org/W4384700568","https://openalex.org/W4385396537","https://openalex.org/W4385816884","https://openalex.org/W4388452245","https://openalex.org/W4391160409","https://openalex.org/W4391859057","https://openalex.org/W4392239219","https://openalex.org/W4393930332","https://openalex.org/W4394566381","https://openalex.org/W4394840288","https://openalex.org/W4396556423","https://openalex.org/W4399117938","https://openalex.org/W4401434784","https://openalex.org/W4401620590","https://openalex.org/W4401711061","https://openalex.org/W4402618315","https://openalex.org/W4404925106","https://openalex.org/W4406209901","https://openalex.org/W4406613004","https://openalex.org/W4407410610","https://openalex.org/W4407419977","https://openalex.org/W4408701756","https://openalex.org/W4410552269","https://openalex.org/W4413199161"],"related_works":["https://openalex.org/W2888392499","https://openalex.org/W2478842201","https://openalex.org/W7151365371","https://openalex.org/W3159183362","https://openalex.org/W7220655198","https://openalex.org/W7202083756","https://openalex.org/W2525198313","https://openalex.org/W4362473481","https://openalex.org/W7166504377","https://openalex.org/W7204137869"],"abstract_inverted_index":{"Membrane":[0,250],"transporters":[1,19,129,251],"play":[2],"a":[3,98,106],"central":[4,253],"role":[5],"in":[6,78,105,198],"the":[7,21,73,87,119,158,189,193,208],"absorption,":[8],"distribution,":[9],"metabolism,":[10],"and":[11,57,66,71,109,121,130,163,174,183,195,202,245,258,287],"elimination":[12],"of":[13,23,90,118,123,161,166,192,210,216,237,255,284],"drugs.":[14],"Beyond":[15],"drug":[16,64,128,256],"handling,":[17],"these":[18,48,140],"regulate":[20],"transport":[22],"endogenous":[24],"metabolites,":[25],"contributing":[26],"to":[27,101,126,181,212,222],"physiological":[28],"homeostasis.":[29],"Their":[30],"activity":[31],"is":[32,50],"regulated":[33],"not":[34,82,226],"only":[35,227],"by":[36,42,268],"intrinsic":[37],"cellular":[38],"mechanisms":[39],"but":[40,231],"also":[41,206,232],"signals":[43],"from":[44],"distant":[45],"organs.":[46],"Understanding":[47],"processes":[49],"crucial":[51],"for":[52],"accurately":[53],"predicting":[54],"both":[55],"local":[56],"systemic":[58,217,259],"pharmacokinetics,":[59],"as":[60,228,233],"transporter":[61,91,103,200,243,285],"function":[62,244,286],"influences":[63],"concentrations":[65],"effects":[67],"at":[68],"target":[69],"tissues":[70],"throughout":[72],"organism.":[74],"However,":[75],"most":[76],"current":[77,190],"vitro":[79],"models":[80],"do":[81],"recapitulate":[83],"interorgan":[84,203,263],"interactions":[85],"or":[86,147],"dynamic":[88],"regulation":[89,201,264],"function.":[92],"Microphysiological":[93],"systems,":[94],"particularly":[95],"organ-on-chip,":[96],"offer":[97],"promising":[99],"approach":[100],"studying":[102],"biology":[104],"more":[107],"integrated":[108],"physiologically":[110],"relevant":[111],"context.":[112],"This":[113,219,271],"review":[114,220,272],"provides":[115],"an":[116],"overview":[117],"development":[120],"application":[122],"organ-on-chip":[124,168,211,224,275],"technologies":[125,276],"investigate":[127],"their":[131,262],"regulation.":[132],"Although":[133],"significant":[134],"technical":[135],"progress":[136],"has":[137],"been":[138],"made,":[139],"systems":[141,235],"often":[142],"remain":[143],"focused":[144],"on":[145,153],"engineering":[146],"industrial":[148],"goals,":[149],"with":[150,170],"limited":[151],"impact":[152],"fundamental":[154],"biological":[155,240],"questions.":[156],"Moreover,":[157],"high":[159],"degree":[160],"customization":[162],"widespread":[164],"use":[165],"homemade":[167],"models,":[169],"diverse":[171],"materials,":[172],"geometries,":[173],"cell":[175],"sources,":[176],"have":[177],"created":[178],"substantial":[179],"barriers":[180],"reproducibility":[182],"cross-laboratory":[184],"comparison.":[185],"We":[186,205],"here":[187],"assess":[188],"state":[191],"field":[194],"identify":[196],"gaps":[197],"modeling":[199],"communication.":[204],"explore":[207],"potential":[209],"advance":[213],"our":[214],"understanding":[215],"pharmacology.":[218,291],"aims":[221],"reposition":[223],"platforms":[225],"technological":[229],"demonstrators":[230],"experimental":[234],"capable":[236],"generating":[238],"new":[239],"insights":[241],"into":[242],"organ":[246],"crosstalk.":[247],"SIGNIFICANCE":[248],"STATEMENT:":[249],"are":[252],"regulators":[254],"disposition":[257],"homeostasis,":[260],"yet":[261],"remains":[265],"poorly":[266],"captured":[267],"conventional":[269],"models.":[270],"highlights":[273],"how":[274],"can":[277],"bridge":[278],"this":[279],"gap,":[280],"enabling":[281],"mechanistic":[282],"investigation":[283],"advancing":[288],"predictive,":[289],"human-relevant":[290]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-05-05T00:00:00"}
