{"id":"https://openalex.org/W7160053341","doi":"https://doi.org/10.1161/cir.153.suppl_1.we506","title":"Abstract WE506: The Association of Dairy-Related Metabolites with High Blood Pressure: The Coronary Artery Risk Development in Young Adults Study","display_name":"Abstract WE506: The Association of Dairy-Related Metabolites with High Blood Pressure: The Coronary Artery Risk Development in Young Adults Study","publication_year":2026,"publication_date":"2026-03-24","ids":{"openalex":"https://openalex.org/W7160053341","doi":"https://doi.org/10.1161/cir.153.suppl_1.we506"},"language":"en","primary_location":{"id":"doi:10.1161/cir.153.suppl_1.we506","doi":"https://doi.org/10.1161/cir.153.suppl_1.we506","is_oa":false,"landing_page_url":"https://doi.org/10.1161/cir.153.suppl_1.we506","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114234852","display_name":"Hejingzi Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hejingzi Jia","raw_affiliation_strings":["University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028987104","display_name":"Lyn M. Steffen","orcid":"https://orcid.org/0000-0002-4053-6729","observed_orcids":["https://orcid.org/0000-0002-4053-6729"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lyn Steffen","raw_affiliation_strings":["University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135266618","display_name":"Xia Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xia Zhou","raw_affiliation_strings":["University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097546727","display_name":"Brian Steffen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Steffen","raw_affiliation_strings":["University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135153290","display_name":"Sandra Safo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Safo","raw_affiliation_strings":["University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051805242","display_name":"Elizabeth R. Lusczek","orcid":"https://orcid.org/0000-0003-4680-965X","observed_orcids":["https://orcid.org/0000-0003-4680-965X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Lusczek","raw_affiliation_strings":["University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027370767","display_name":"Mahesh Mathew","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahesh Mathew","raw_affiliation_strings":["University of Minnesota, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108677242","display_name":"James Shikany","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Shikany","raw_affiliation_strings":["UNIVERSITY OF ALABAMA AT BIRMINGHAM, Birmingham, Alabama, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVERSITY OF ALABAMA AT BIRMINGHAM, Birmingham, Alabama, United States","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091161722","display_name":"Venkatesh Locharla Murthy","orcid":"https://orcid.org/0000-0002-7901-1321","observed_orcids":["https://orcid.org/0000-0002-7901-1321"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkatesh Murthy","raw_affiliation_strings":["University of Michigan, Ann Arbor, Michigan, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Ann Arbor, Michigan, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Jacobs","raw_affiliation_strings":["University of Minnesota, Minnetonka, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Minnetonka, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101940763","display_name":"Limeng Liu","orcid":"https://orcid.org/0000-0003-4997-8803","observed_orcids":["https://orcid.org/0000-0003-4997-8803"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Limeng Liu","raw_affiliation_strings":["University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Twin Cities, Minneapolis, Minnesota, United States","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"153","issue":"Suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10866","display_name":"Nutritional Studies and Diet","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12075","display_name":"Sodium Intake and Health","score":0.18729999661445618,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.18649999797344208,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dairy-consumption","display_name":"dairy consumption","score":0.8489999771118164},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8370000123977661},{"id":"https://openalex.org/keywords/serum-metabolomics","display_name":"serum metabolomics","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.5199999809265137},{"id":"https://openalex.org/keywords/young-adults","display_name":"young adults","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cardia-study","display_name":"CARDIA study","score":0.7310000061988831},{"id":"https://openalex.org/keywords/bile-salts","display_name":"bile salts","score":0.5479999780654907},{"id":"https://openalex.org/keywords/vitamin-transport","display_name":"vitamin transport","score":0.5860000252723694},{"id":"https://openalex.org/keywords/nucleosides","display_name":"nucleosides","score":0.8669999837875366},{"id":"https://openalex.org/keywords/organic-acids","display_name":"organic acids","score":0.8190000057220459},{"id":"https://openalex.org/keywords/metal-ions","display_name":"metal ions","score":0.9710000157356262},{"id":"https://openalex.org/keywords/hypertension-prevention","display_name":"hypertension prevention","score":0.4269999861717224},{"id":"https://openalex.org/keywords/diet-and-cardiovascular-disease","display_name":"diet and cardiovascular disease","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9458000063896179},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.8325999975204468},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.8223000168800354},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6373999714851379},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5938000082969666},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.5533999800682068},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5436999797821045},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.3978999853134155},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.39430001378059387},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.35339999198913574},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.34709998965263367},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.33649998903274536},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.31529998779296875},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3147999942302704},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28279998898506165},{"id":"https://openalex.org/C169554166","wikidata":"https://www.wikidata.org/wiki/Q496359","display_name":"Systole","level":4,"score":0.2741999924182892},{"id":"https://openalex.org/C118190526","wikidata":"https://www.wikidata.org/wiki/Q7239981","display_name":"Prehypertension","level":3,"score":0.258899986743927},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.25690001249313354},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.2549000084400177}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/cir.153.suppl_1.we506","doi":"https://doi.org/10.1161/cir.153.suppl_1.we506","is_oa":false,"landing_page_url":"https://doi.org/10.1161/cir.153.suppl_1.we506","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6940075498","https://openalex.org/W1992412612","https://openalex.org/W4406724998","https://openalex.org/W1605533977","https://openalex.org/W4391690853","https://openalex.org/W291194607","https://openalex.org/W1982573508","https://openalex.org/W2132612345","https://openalex.org/W2116076954","https://openalex.org/W2165134388"],"abstract_inverted_index":{"Introduction:":[0],"Hypertension":[1],"is":[2,30],"a":[3,65,181,195,290,369],"major":[4],"risk":[5,67,217,292],"factor":[6],"for":[7,145,322],"cardiovascular":[8],"disease.":[9],"Dairy":[10],"products":[11],"provide":[12],"nutrients":[13],"that":[14,53],"may":[15],"affect":[16],"blood":[17,28,48,70,105,134,191,204,220,265,295,348,363],"pressure,":[18],"but":[19],"evidence":[20],"on":[21],"associations":[22,130],"of":[23,68,131,141,198,211,218,283,293,319],"dairy-related":[24,159,162,256],"metabolites":[25,36,60,163,242,257,352],"with":[26,45,64,101,188,245,262,298,359],"high":[27,47,69,133,190,203,219,264,294,347,362],"pressure":[29,106,111,135,205,221,266,296,349,374],"limited.":[31],"We":[32,51,73,338],"aimed":[33],"to":[34,38,157,184,223,345,371],"identify":[35,158],"related":[37,59],"dairy":[39,55,142,212,246,341],"intake":[40,56,213,247,342],"and":[41,57,100,115,148,329,353],"assess":[42],"their":[43,186,354],"association":[44,187],"incident":[46,132,189,202,263,361],"pressure.":[49,71,192,364],"Hypothesis:":[50],"hypothesized":[52],"higher":[54,340],"its":[58],"would":[61],"be":[62],"associated":[63,244,261,358],"lower":[66,216,291,346,360],"Methods:":[72],"analyzed":[74],"2,171":[75],"adults":[76],"(mean":[77],"age":[78],"32":[79],"years,":[80],"45%":[81],"female,":[82],"58%":[83],"White)":[84],"who":[85],"attended":[86],"the":[87,129,284],"year":[88,137],"7":[89],"Coronary":[90],"Artery":[91],"Risk":[92],"Development":[93],"in":[94,180,208,225,280,300],"Young":[95],"Adults":[96],"(CARDIA)":[97],"exam":[98],"(1992-93)":[99],"metabolomics":[102,367],"data.":[103],"High":[104],"was":[107,165,176,259,343],"defined":[108],"as":[109,178,368],"systolic":[110],"\u2265":[112,117],"130":[113],"mmHg":[114,119],"diastolic":[116],"80":[118],"or":[120],"hypertension":[121],"medicines":[122],"use.":[123],"Cox":[124,182],"proportional":[125],"hazard":[126],"models":[127,154],"assessed":[128],"by":[136,167],"15":[138],"across":[139],"quartiles":[140],"intake,":[143],"adjusting":[144],"demographics,":[146],"lifestyle,":[147],"diet":[149],"quality.":[150],"Multivariable":[151],"linear":[152],"regression":[153],"were":[155,243,356],"used":[156],"metabolites.":[160],"A":[161],"score":[164,288],"derived":[166],"principal":[168,174,253,285],"component":[169,175,254,286],"analysis":[170,316],"(PCA).":[171],"The":[172,251],"first":[173,252],"included":[177],"covariate":[179],"model":[183],"evaluate":[185],"Results:":[193],"Over":[194],"median":[196],"follow-up":[197],"7.5":[199],"years":[200],"(575":[201],"cases),":[206],"participants":[207],"quartile":[209,226,281,301],"4":[210,282],"had":[214,289],"significantly":[215,260],"compared":[222,297],"those":[224,299],"1":[227,287,302],"(hazard":[228],"ratio":[229],"[HR]:":[230],"0.70;":[231],"95%":[232,306],"CI":[233],"0.53,":[234],"0.93;":[235],"P":[236,310],"trend":[237,311],"=":[238,274,277,304,312],"0.03).":[239,278,313],"Twenty-three":[240],"serum":[241],"(See":[248],"Heatmap":[249],"below).":[250],"representing":[255],"patterns":[258,355],"(":[267],"\u0394":[268],"-2LL":[269],"x":[270],"2":[271],",":[272],"df":[273],"4.74,":[275],"p":[276],"Participants":[279],"(HR":[303],"0.78,":[305],"CI:":[307],"0.62,":[308],"0.98,":[309],"Exploratory":[314],"enrichment":[315],"indicated":[317],"activation":[318],"transport":[320],"pathways":[321],"vitamins,":[323],"nucleosides,":[324],"bile":[325],"salts,":[326],"organic":[327],"acids,":[328],"metal":[330],"ions":[331],"(False":[332],"Discovery":[333],"Rate":[334],"<":[335],"0.15).":[336],"Conclusion:":[337],"found":[339],"linked":[344],"risk.":[350],"Dairy-related":[351],"also":[357],"This":[365],"suggests":[366],"tool":[370],"clarify":[372],"diet-blood":[373],"mechanisms.":[375]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-05-05T00:00:00"}
