{"id":"https://openalex.org/W7159945708","doi":"https://doi.org/10.17533/udea.vitae.v33n2a363403","title":"Standardization of the Allium cepa assay: a useful tool in the genotoxic evaluation of plant extracts","display_name":"Standardization of the Allium cepa assay: a useful tool in the genotoxic evaluation of plant extracts","publication_year":2026,"publication_date":"2026-05-01","ids":{"openalex":"https://openalex.org/W7159945708","doi":"https://doi.org/10.17533/udea.vitae.v33n2a363403"},"language":"en","primary_location":{"id":"doi:10.17533/udea.vitae.v33n2a363403","doi":"https://doi.org/10.17533/udea.vitae.v33n2a363403","is_oa":true,"landing_page_url":"https://doi.org/10.17533/udea.vitae.v33n2a363403","pdf_url":null,"source":{"id":"https://openalex.org/S111148215","display_name":"Revista Vitae","issn_l":"0121-4004","issn":["0121-4004","2145-2660"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","publindex-b","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310318837","host_organization_name":"Universidad de Antioquia","host_organization_lineage":["https://openalex.org/P4310318837"],"host_organization_lineage_names":["Universidad de Antioquia"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Vitae","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.17533/udea.vitae.v33n2a363403","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035265492","display_name":"Harriette del Rosario Duran-Sandoval","orcid":"https://orcid.org/0009-0000-1257-2178","observed_orcids":["https://orcid.org/0009-0000-1257-2178"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harriette del Rosario Duran-Sandoval","raw_affiliation_strings":["Secretariat of Education of Bol\u00edvar"],"raw_orcid":"https://orcid.org/0009-0000-1257-2178","affiliations":[{"raw_affiliation_string":"Secretariat of Education of Bol\u00edvar","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000245174","display_name":"Jorge Eliecer Espitia-Baena","orcid":"https://orcid.org/0009-0002-6987-1405","observed_orcids":["https://orcid.org/0009-0002-6987-1405"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge Eliecer Espitia-Baena","raw_affiliation_strings":["Departmental Secretariat of Education of Bol\u00edvar"],"raw_orcid":"https://orcid.org/0009-0002-6987-1405","affiliations":[{"raw_affiliation_string":"Departmental Secretariat of Education of Bol\u00edvar","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077072174","display_name":"Juli\u00e1n Javier Mart\u00ednez Zambrano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153390918","display_name":"University of Cartagena","ror":"https://ror.org/0409zd934","country_code":"CO","type":"education","lineage":["https://openalex.org/I153390918"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Juli\u00e1n Javier Mart\u00ednez Zambrano","raw_affiliation_strings":["University of Cartagena"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cartagena","institution_ids":["https://openalex.org/I153390918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135086586","display_name":"Jose Angel Navas Passos","orcid":"https://orcid.org/0009-0008-6786-2613","observed_orcids":["https://orcid.org/0009-0008-6786-2613"]},"institutions":[{"id":"https://openalex.org/I153390918","display_name":"University of Cartagena","ror":"https://ror.org/0409zd934","country_code":"CO","type":"education","lineage":["https://openalex.org/I153390918"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Angel Navas Passos","raw_affiliation_strings":["University of Cartagena"],"raw_orcid":"https://orcid.org/0009-0008-6786-2613","affiliations":[{"raw_affiliation_string":"University of Cartagena","institution_ids":["https://openalex.org/I153390918"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008664931","display_name":"Luis Alfredo Utria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153390918","display_name":"University of Cartagena","ror":"https://ror.org/0409zd934","country_code":"CO","type":"education","lineage":["https://openalex.org/I153390918"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Luis Alfredo Utria-Acevedo","raw_affiliation_strings":["University of Cartagena"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cartagena","institution_ids":["https://openalex.org/I153390918"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5119076820","display_name":"Antistio Alviz-Amador","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I53110688","display_name":"University of C\u00f3rdoba","ror":"https://ror.org/05yc77b46","country_code":"ES","type":"education","lineage":["https://openalex.org/I53110688"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antistio Alvis Amador","raw_affiliation_strings":["University of C\u00f3rdoba"],"raw_orcid":"https://orcid.org/0000-0002-7324-2487","affiliations":[{"raw_affiliation_string":"University of C\u00f3rdoba","institution_ids":["https://openalex.org/I53110688"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":100,"currency":"USD","value_usd":100},"apc_paid":{"value":100,"currency":"USD","value_usd":100},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27133061,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"33","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allium-cepa-test","display_name":"Allium cepa test","score":0.9330000281333923},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.9160000085830688},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.8130000233650208},{"id":"https://openalex.org/keywords/assay-standardization","display_name":"assay standardization","score":0.8529999852180481},{"id":"https://openalex.org/keywords/protocol-validation","display_name":"protocol validation","score":0.6159999966621399},{"id":"https://openalex.org/keywords/mitotic-index","display_name":"mitotic index","score":0.8029999732971191},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.8610000014305115},{"id":"https://openalex.org/keywords/root-meristem","display_name":"root meristem","score":0.8289999961853027},{"id":"https://openalex.org/keywords/ethanol-extract","display_name":"ethanol extract","score":0.7929999828338623},{"id":"https://openalex.org/keywords/chenopodium-ambrosioides","display_name":"Chenopodium ambrosioides","score":0.9919999837875366},{"id":"https://openalex.org/keywords/momordica-charantia","display_name":"Momordica charantia","score":1.0},{"id":"https://openalex.org/keywords/crescentia-cujete","display_name":"Crescentia cujete","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cordia-dentata","display_name":"Cordia dentata","score":1.0},{"id":"https://openalex.org/keywords/heliotropium-indicum","display_name":"Heliotropium indicum","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C2776460402","wikidata":"https://www.wikidata.org/wiki/Q49391","display_name":"Allium","level":2,"score":0.9611999988555908},{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.8978000283241272},{"id":"https://openalex.org/C66640590","wikidata":"https://www.wikidata.org/wiki/Q4296711","display_name":"Mitotic index","level":3,"score":0.5346999764442444},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.4871000051498413},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.47609999775886536},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4081999957561493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39010000228881836},{"id":"https://openalex.org/C2778415121","wikidata":"https://www.wikidata.org/wiki/Q158094","display_name":"Chenopodium","level":3,"score":0.3165999948978424},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3068000078201294},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.30410000681877136},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C104488531","wikidata":"https://www.wikidata.org/wiki/Q864212","display_name":"Bioassay","level":2,"score":0.28929999470710754},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2849000096321106},{"id":"https://openalex.org/C112570922","wikidata":"https://www.wikidata.org/wiki/Q60528603","display_name":"Contamination","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.26919999718666077},{"id":"https://openalex.org/C33618052","wikidata":"https://www.wikidata.org/wiki/Q6013136","display_name":"In vitro toxicology","level":3,"score":0.2524999976158142},{"id":"https://openalex.org/C3020593341","wikidata":"https://www.wikidata.org/wiki/Q428750","display_name":"Bitter gourd","level":3,"score":0.25209999084472656}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.17533/udea.vitae.v33n2a363403","doi":"https://doi.org/10.17533/udea.vitae.v33n2a363403","is_oa":true,"landing_page_url":"https://doi.org/10.17533/udea.vitae.v33n2a363403","pdf_url":null,"source":{"id":"https://openalex.org/S111148215","display_name":"Revista Vitae","issn_l":"0121-4004","issn":["0121-4004","2145-2660"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","publindex-b","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310318837","host_organization_name":"Universidad de Antioquia","host_organization_lineage":["https://openalex.org/P4310318837"],"host_organization_lineage_names":["Universidad de Antioquia"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Vitae","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:8aeba0f243c04cdf8d471b7e8596f8ca","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8aeba0f243c04cdf8d471b7e8596f8ca","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vitae, Vol 33, Iss 2 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.17533/udea.vitae.v33n2a363403","doi":"https://doi.org/10.17533/udea.vitae.v33n2a363403","is_oa":true,"landing_page_url":"https://doi.org/10.17533/udea.vitae.v33n2a363403","pdf_url":null,"source":{"id":"https://openalex.org/S111148215","display_name":"Revista Vitae","issn_l":"0121-4004","issn":["0121-4004","2145-2660"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","publindex-b","russia-white-list-4","scielo"],"host_organization":"https://openalex.org/P4310318837","host_organization_name":"Universidad de Antioquia","host_organization_lineage":["https://openalex.org/P4310318837"],"host_organization_lineage_names":["Universidad de Antioquia"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista Vitae","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437},{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.4359000027179718}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.6355400681495667}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,95],"Allium":[2,35,178],"cepa":[3,179],"(onion)":[4],"test":[5],"is":[6],"a":[7,119,127],"sensitive":[8],"tool":[9],"for":[10,176,207],"genotoxicity":[11,180],"studies":[12],"used":[13],"worldwide":[14],"to":[15,42],"assess":[16],"environmental":[17,64],"contamination":[18],"and":[19,28,37,73,87,131,149,161,171,193,201],"potential":[20],"toxicity":[21],"of":[22,33,62,71,144,211],"natural":[23],"products.":[24],"OBJECTIVES:":[25],"To":[26],"standardize":[27],"validate":[29],"the":[30,34,39,48,83,177,205],"experimental":[31,54],"parameters":[32],"cepaassay":[36],"apply":[38],"standardized":[40],"protocol":[41,173],"six":[43],"ethanolic":[44,142],"plant":[45],"extracts":[46,143],"from":[47,101],"Colombian":[49],"Caribbean":[50],"flora.":[51],"METHODS:":[52],"Key":[53],"variables":[55],"were":[56,98],"systematically":[57],"evaluated:":[58],"onion":[59],"supplier,":[60],"type":[61,70],"onion,":[63],"conditions,":[65,141],"stimulation":[66,121],"phase,":[67,122,130],"water":[68,107],"replacement,":[69],"water,":[72],"Cd+2":[74,132],"concentration":[75],"as":[76,136,196],"positive":[77,137],"control.":[78,138],"Genotoxicity":[79],"was":[80,174],"assessed":[81],"through":[82],"mitotic":[84],"index":[85,89],"(MI)":[86],"aberration":[88],"(AI)":[90],"in":[91,188],"root":[92],"meristems.":[93],"RESULTS:":[94],"optimal":[96],"conditions":[97],"white":[99],"onions":[100,124],"chain":[102],"store":[103],"P2,":[104],"bottled":[105],"drinking":[106],"with":[108,115],"total":[109],"replacement":[110],"every":[111],"24":[112],"h,":[113],"24\u00b11\u00b0C":[114],"indirect":[116],"fluorescent":[117],"lighting,":[118],"72-h":[120,128],"nine":[123],"per":[125],"concentration,":[126],"exposure":[129],"at":[133],"5":[134],"mg/L":[135],"Under":[139],"these":[140,212],"Chenopodium":[145],"ambrosioides,":[146,190],"Momordica":[147],"charantia,":[148,192],"Tabebuia":[150],"ochracea":[151],"induced":[152],"significant":[153,185],"genotoxic":[154,186],"effects,":[155],"whereas":[156],"Crescentia":[157],"cujete,":[158],"Cordia":[159],"dentata,":[160],"Heliotropium":[162],"indicum":[163],"showed":[164],"no":[165],"adverse":[166],"effects.":[167],"CONCLUSIONS:":[168],"A":[169],"reproducible":[170],"validated":[172],"obtained":[175],"assay.":[181],"Its":[182],"application":[183],"revealed":[184],"activity":[187],"C.":[189],"M.":[191],"T.":[194],"ochracea,":[195],"evidenced":[197],"by":[198],"decreased":[199],"MI":[200],"increased":[202],"AI,":[203],"underscoring":[204],"need":[206],"further":[208],"toxicological":[209],"assessment":[210],"species.":[213]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2026-05-04T00:00:00"}