{"id":"https://openalex.org/W7159628362","doi":"https://doi.org/10.1186/s12964-026-02913-0","title":"Thyroid hormone regulatory system in the mouse retina: integrated transcriptional and translational analysis of deiodinase enzymes, thyroid hormone receptors and thyroid hormone transporters","display_name":"Thyroid hormone regulatory system in the mouse retina: integrated transcriptional and translational analysis of deiodinase enzymes, thyroid hormone receptors and thyroid hormone transporters","publication_year":2026,"publication_date":"2026-04-30","ids":{"openalex":"https://openalex.org/W7159628362","doi":"https://doi.org/10.1186/s12964-026-02913-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/42063076"},"language":"en","primary_location":{"id":"doi:10.1186/s12964-026-02913-0","doi":"https://doi.org/10.1186/s12964-026-02913-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-026-02913-0","pdf_url":null,"source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12964-026-02913-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081187612","display_name":"Alberto Melecchi","orcid":"https://orcid.org/0009-0002-2385-3842","observed_orcids":["https://orcid.org/0009-0002-2385-3842"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Melecchi","raw_affiliation_strings":["Department of Biology, University of Pisa, via S. Zeno 31, Pisa, 56126, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Pisa, via S. Zeno 31, Pisa, 56126, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062951173","display_name":"Elisa Angeloni","orcid":"https://orcid.org/0000-0002-6122-7327","observed_orcids":["https://orcid.org/0000-0002-6122-7327"]},"institutions":[{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisa Angeloni","raw_affiliation_strings":["National Research Council, Institute of Clinical Physiology, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Council, Institute of Clinical Physiology, Pisa, Italy","institution_ids":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068231414","display_name":"Silvana Balzan","orcid":"https://orcid.org/0000-0001-7045-4719","observed_orcids":["https://orcid.org/0000-0001-7045-4719"]},"institutions":[{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvana Balzan","raw_affiliation_strings":["National Research Council, Institute of Clinical Physiology, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Council, Institute of Clinical Physiology, Pisa, Italy","institution_ids":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117523212","display_name":"Sara Calcagno","orcid":"https://orcid.org/0009-0003-6083-0380","observed_orcids":["https://orcid.org/0009-0003-6083-0380"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Calcagno","raw_affiliation_strings":["Department of Experimental and Clinical Biomedical Sciences \"Mario Serio\", University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Biomedical Sciences \"Mario Serio\", University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005630414","display_name":"Alessio Canovai","orcid":"https://orcid.org/0009-0007-9229-4710","observed_orcids":["https://orcid.org/0009-0007-9229-4710"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Canovai","raw_affiliation_strings":["Department of Biology, University of Pisa, via S. Zeno 31, Pisa, 56126, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Pisa, via S. Zeno 31, Pisa, 56126, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028459816","display_name":"Francesca Forini","orcid":"https://orcid.org/0000-0002-4249-6775","observed_orcids":["https://orcid.org/0000-0002-4249-6775"]},"institutions":[{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Forini","raw_affiliation_strings":["National Research Council, Institute of Clinical Physiology, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Council, Institute of Clinical Physiology, Pisa, Italy","institution_ids":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050674972","display_name":"Franziska Lademann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franziska Brinkmann","raw_affiliation_strings":["Department of Medicine III and Center for Healthy Aging, Dresden University of Technology, Dresden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III and Center for Healthy Aging, Dresden University of Technology, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072176931","display_name":"Matteo Lulli","orcid":"https://orcid.org/0000-0002-8528-4094","observed_orcids":["https://orcid.org/0000-0002-8528-4094"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Lulli","raw_affiliation_strings":["Department of Experimental and Clinical Biomedical Sciences \"Mario Serio\", University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Biomedical Sciences \"Mario Serio\", University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020069774","display_name":"Giuseppina Nicolini","orcid":"https://orcid.org/0000-0001-6175-9756","observed_orcids":["https://orcid.org/0000-0001-6175-9756"]},"institutions":[{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giuseppina Nicolini","raw_affiliation_strings":["National Research Council, Institute of Clinical Physiology, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Council, Institute of Clinical Physiology, Pisa, Italy","institution_ids":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053492340","display_name":"Chiara Posarelli","orcid":"https://orcid.org/0000-0003-0222-5177","observed_orcids":["https://orcid.org/0000-0003-0222-5177"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Posarelli","raw_affiliation_strings":["Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046995998","display_name":"Milena Rizzo","orcid":"https://orcid.org/0000-0001-5924-8615","observed_orcids":["https://orcid.org/0000-0001-5924-8615"]},"institutions":[{"id":"https://openalex.org/I4210106076","display_name":"Istituto di Fisiologia Clinica","ror":"https://ror.org/01kdj2848","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Milena Rizzo","raw_affiliation_strings":["National Research Council, Institute of Clinical Physiology, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Council, Institute of Clinical Physiology, Pisa, Italy","institution_ids":["https://openalex.org/I4210106076","https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032736670","display_name":"Rosario Amato","orcid":"https://orcid.org/0000-0002-8386-4714","observed_orcids":["https://orcid.org/0000-0002-8386-4714"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Rosario Amato","raw_affiliation_strings":["Department of Biology, University of Pisa, via S. Zeno 31, Pisa, 56126, Italy. rosario.amato@unipi.it","Interdepartmental Research Center Nutrafood \"Nutraceuticals and Food for Health\", University of Pisa, Pisa, Italy. rosario.amato@unipi.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Pisa, via S. Zeno 31, Pisa, 56126, Italy. rosario.amato@unipi.it","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Interdepartmental Research Center Nutrafood \"Nutraceuticals and Food for Health\", University of Pisa, Pisa, Italy. rosario.amato@unipi.it","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":null,"display_name":"Giovanni Casini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giovanni Casini","raw_affiliation_strings":["Department of Biology, University of Pisa, via S. Zeno 31, Pisa, 56126, Italy. giovanni.casini@unipi.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Pisa, via S. Zeno 31, Pisa, 56126, Italy. giovanni.casini@unipi.it","institution_ids":["https://openalex.org/I108290504"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5032736670"],"corresponding_institution_ids":["https://openalex.org/I108290504"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.23077114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-hormone-signaling","display_name":"thyroid hormone signaling","score":0.9729999899864197},{"id":"https://openalex.org/keywords/retina","display_name":"retina","score":0.871999979019165},{"id":"https://openalex.org/keywords/deiodinases","display_name":"deiodinases","score":0.7139999866485596},{"id":"https://openalex.org/keywords/dio2","display_name":"DIO2","score":0.9160000085830688},{"id":"https://openalex.org/keywords/dio3","display_name":"DIO3","score":1.0},{"id":"https://openalex.org/keywords/thyroid-hormone-receptor","display_name":"thyroid hormone receptor","score":0.9229999780654907},{"id":"https://openalex.org/keywords/mct8","display_name":"MCT8","score":0.8859999775886536},{"id":"https://openalex.org/keywords/oatp1c1","display_name":"OATP1C1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/muller-cells","display_name":"M\u00fcller cells","score":0.765999972820282},{"id":"https://openalex.org/keywords/cone-photoreceptors","display_name":"cone photoreceptors","score":0.996999979019165},{"id":"https://openalex.org/keywords/retinal-layer-thickness","display_name":"retinal layer thickness","score":0.8270000219345093},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.8830000162124634},{"id":"https://openalex.org/keywords/gene-expression-mapping","display_name":"gene expression mapping","score":0.527999997138977},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.7279999852180481},{"id":"https://openalex.org/keywords/amacrine-cells","display_name":"amacrine cells","score":0.6869999766349792},{"id":"https://openalex.org/keywords/retinal-ganglion-cells","display_name":"retinal ganglion cells","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C171269688","wikidata":"https://www.wikidata.org/wiki/Q17914005","display_name":"DIO2","level":5,"score":0.8942000269889832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7322999835014343},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.6434000134468079},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6115000247955322},{"id":"https://openalex.org/C2780188069","wikidata":"https://www.wikidata.org/wiki/Q4133186","display_name":"Ganglion cell layer","level":3,"score":0.5662000179290771},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5450999736785889},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5393999814987183},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5160999894142151},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46799999475479126},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4577000141143799},{"id":"https://openalex.org/C109115496","wikidata":"https://www.wikidata.org/wiki/Q2539644","display_name":"Thyroid hormone receptor","level":3,"score":0.4422999918460846},{"id":"https://openalex.org/C2778417266","wikidata":"https://www.wikidata.org/wiki/Q24781273","display_name":"Deiodinase","level":4,"score":0.43529999256134033},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3734000027179718},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3319000005722046},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32499998807907104},{"id":"https://openalex.org/C2781040256","wikidata":"https://www.wikidata.org/wiki/Q7316761","display_name":"Retinal degeneration","level":3,"score":0.31679999828338623},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.3158000111579895},{"id":"https://openalex.org/C160860887","wikidata":"https://www.wikidata.org/wiki/Q18031986","display_name":"Thyroid hormone receptor alpha","level":5,"score":0.30309998989105225},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2939000129699707},{"id":"https://openalex.org/C149574134","wikidata":"https://www.wikidata.org/wiki/Q18031987","display_name":"Thyroid hormone receptor beta","level":5,"score":0.2721000015735626},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.26820001006126404},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.2662000060081482},{"id":"https://openalex.org/C124224327","wikidata":"https://www.wikidata.org/wiki/Q21120164","display_name":"PAX8","level":4,"score":0.26409998536109924},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.25360000133514404},{"id":"https://openalex.org/C2777302934","wikidata":"https://www.wikidata.org/wiki/Q18031655","display_name":"SOX10","level":4,"score":0.25040000677108765}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007453","descriptor_name":"Iodide Peroxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007453","descriptor_name":"Iodide Peroxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007453","descriptor_name":"Iodide Peroxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007453","descriptor_name":"Iodide Peroxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007453","descriptor_name":"Iodide Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007453","descriptor_name":"Iodide Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007453","descriptor_name":"Iodide Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007453","descriptor_name":"Iodide Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011988","descriptor_name":"Receptors, Thyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027361","descriptor_name":"Organic Anion Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027361","descriptor_name":"Organic Anion Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027361","descriptor_name":"Organic Anion Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027361","descriptor_name":"Organic Anion Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027361","descriptor_name":"Organic Anion Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027361","descriptor_name":"Organic Anion Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027361","descriptor_name":"Organic Anion Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027361","descriptor_name":"Organic Anion Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12964-026-02913-0","doi":"https://doi.org/10.1186/s12964-026-02913-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-026-02913-0","pdf_url":null,"source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},{"id":"pmid:42063076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42063076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell communication and signaling : CCS","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6d068ff9f56b4f6eaf021be268251185","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6d068ff9f56b4f6eaf021be268251185","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Communication and Signaling, Vol 24, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:flore.unifi.it:2158/1492592","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2158/1492592","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13374361","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42063076/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Commun Signal","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12964-026-02913-0","doi":"https://doi.org/10.1186/s12964-026-02913-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12964-026-02913-0","pdf_url":null,"source":{"id":"https://openalex.org/S138104925","display_name":"Cell Communication and Signaling","issn_l":"1478-811X","issn":["1478-811X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Communication and Signaling","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4043000042438507}],"sustainable_development_goals_aurora":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.5151576995849609}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1426453505","display_name":null,"funder_award_id":"20227LC4SK","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G4420542754","display_name":"Die Rolle von Schilddr\u00fcsenhormonen und ihren Rezeptoren in der Knochendefektheilung","funder_award_id":"455890087","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7737513894","display_name":null,"funder_award_id":"20227LC4SK","funder_id":"https://openalex.org/F4320331528","funder_display_name":"Ministero dell'Universit\u00e0 e della Ricerca"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320331528","display_name":"Ministero dell'Universit\u00e0 e della Ricerca","ror":"https://ror.org/0341vw408"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W99772692","https://openalex.org/W266477159","https://openalex.org/W1589173706","https://openalex.org/W1960721561","https://openalex.org/W1986420581","https://openalex.org/W1992268803","https://openalex.org/W1993618816","https://openalex.org/W1994960533","https://openalex.org/W2006030979","https://openalex.org/W2007870279","https://openalex.org/W2014183412","https://openalex.org/W2016552348","https://openalex.org/W2017941990","https://openalex.org/W2025979279","https://openalex.org/W2030319714","https://openalex.org/W2059837402","https://openalex.org/W2060971080","https://openalex.org/W2061055842","https://openalex.org/W2067357578","https://openalex.org/W2069003539","https://openalex.org/W2073100952","https://openalex.org/W2082055613","https://openalex.org/W2082068065","https://openalex.org/W2086295261","https://openalex.org/W2099545629","https://openalex.org/W2101123075","https://openalex.org/W2104878795","https://openalex.org/W2105008550","https://openalex.org/W2135361279","https://openalex.org/W2142718693","https://openalex.org/W2149097868","https://openalex.org/W2161240378","https://openalex.org/W2163106706","https://openalex.org/W2167058119","https://openalex.org/W2169249307","https://openalex.org/W2263398705","https://openalex.org/W2411181147","https://openalex.org/W2515518593","https://openalex.org/W2519675996","https://openalex.org/W2561745822","https://openalex.org/W2620839605","https://openalex.org/W2766436509","https://openalex.org/W2797070177","https://openalex.org/W2800929874","https://openalex.org/W2809429856","https://openalex.org/W2811095894","https://openalex.org/W2964405640","https://openalex.org/W2969993267","https://openalex.org/W2989561443","https://openalex.org/W3044145717","https://openalex.org/W3080579343","https://openalex.org/W3089871235","https://openalex.org/W3136215060","https://openalex.org/W3159885095","https://openalex.org/W4200159595","https://openalex.org/W4220687134","https://openalex.org/W4293764498","https://openalex.org/W4301398896","https://openalex.org/W4310493701","https://openalex.org/W4316468927","https://openalex.org/W4321435938","https://openalex.org/W4360618914","https://openalex.org/W4385497773","https://openalex.org/W4396743479","https://openalex.org/W4400412170","https://openalex.org/W4404360231","https://openalex.org/W4404644284","https://openalex.org/W4408051966","https://openalex.org/W4411865632","https://openalex.org/W4414714496","https://openalex.org/W7128682801","https://openalex.org/W7128820087"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Thyroid":[1],"hormone":[2],"(TH)":[3],"signaling":[4,345],"is":[5,54],"involved":[6],"in":[7,16,30,114,130,147,168,195,237,247,256,261,265,272,284,290,310,327,346],"complex":[8],"processes":[9],"regulating":[10,340],"development":[11],"and":[12,35,74,80,85,87,94,132,152,162,183,204,220,228,241,244,252,264,287,289,337,344,348],"energy":[13],"balance,":[14],"especially":[15],"organs":[17],"with":[18,150,157,198,232],"high-rate":[19],"metabolism":[20],"such":[21],"as":[22],"the":[23,42,46,49,59,70,103,123,169,187,217,226,257,323,328],"retina.":[24,218],"Despite":[25],"evidence":[26],"of":[27,32,41,45,48,58,69,77,109,126,138,171,186,216,235,245,304,322],"TH":[28,51,82,88,111,127,307,324,342],"involvement":[29],"regulation":[31],"retinal":[33,50,71,104,163,258,274,291],"functions":[34],"disease":[36],"susceptibility,":[37],"a":[38,66,332],"comprehensive":[39],"analysis":[40,137],"tissue":[43],"distribution":[44],"components":[47],"regulatory":[52,112,128,325],"system":[53,326],"lacking.":[55],"The":[56,142,319],"aims":[57],"present":[60,320],"study":[61],"were":[62,144,166,222,254,282],"(i)":[63],"to":[64,101,225],"provide":[65],"detailed":[67],"description":[68],"expression":[72,125,234],"sites":[73],"localization":[75,154],"patterns":[76],"deiodinases":[78],"(DIO2":[79],"DIO3),":[81],"receptors":[83],"(THR\u03b1":[84],"THR\u03b2),":[86],"transporters":[89,308],"(monocarboxylate":[90],"transporter":[91],"8,":[92],"MCT8,":[93],"organic":[95],"anion-transporting":[96],"polypeptide":[97],"1C1,":[98],"OATP1C1);":[99],"(ii)":[100],"recapitulate":[102],"alterations":[105,281],"following":[106,294],"genetic":[107,299],"deletions":[108],"specific":[110,115],"elements":[113,129],"knockout":[116],"(KO)":[117],"mice.":[118,173],"METHODS:":[119],"We":[120],"first":[121],"predicted":[122],"cell-specific":[124],"mouse":[131,148,329],"human":[133],"retina":[134,330],"via":[135],"bioinformatic":[136],"single-cell":[139],"RNAseq":[140],"databases.":[141],"results":[143],"subsequently":[145],"validated":[146],"retinas":[149,170],"RNAscope":[151],"protein":[153,205],"was":[155,177,194,208,269],"assessed":[156],"immunofluorescence.":[158],"Cone":[159],"photoreceptor":[160],"morphology":[161,288],"layer":[164,292],"thicknesses":[165],"evaluated":[167],"KO":[172,278],"RESULTS:":[174],"Dio2":[175,296],"mRNA":[176,203],"expressed":[178,209,271],"by":[179,210],"M\u00fcller":[180,262],"glial":[181],"cells":[182,240],"neuronal":[184],"populations":[185,215],"inner":[188,227],"retina,":[189,230],"while":[190],"prominent":[191,233],"DIO2":[192],"immunoreactivity":[193],"cone":[196,248,285],"photoreceptors,":[197],"an":[199],"evident":[200],"mismatch":[201],"between":[202],"localization.":[206],"DIO3":[207],"virtually":[211],"all":[212],"neural":[213],"cell":[214],"THR\u03b1":[219,236],"THR\u03b2":[221,246],"predominantly":[223],"localized":[224],"outer":[229],"respectively,":[231],"putative":[238],"amacrine":[239],"ganglion":[242,275],"cells,":[243],"photoreceptors.":[249],"Both":[250],"MCT8":[251,268],"OATP1C1":[253],"detected":[255],"pigment":[259],"epithelium,":[260],"glia,":[263],"blood":[266],"vessels.":[267],"also":[270],"some":[273],"cells.":[276],"In":[277,301],"mice,":[279],"drastic":[280],"observed":[283],"density":[286],"thickness":[293],"either":[295],"or":[297,306],"Dio3":[298],"deletion.":[300],"contrast,":[302],"deletion":[303],"Thrs":[305],"resulted":[309],"only":[311],"minor":[312],"changes,":[313],"indicating":[314],"potential":[315],"compensatory":[316],"mechanisms.":[317],"CONCLUSIONS:":[318],"mapping":[321],"provides":[331],"framework":[333],"for":[334],"understanding":[335],"molecular":[336],"cellular":[338],"mechanisms":[339],"local":[341],"availability":[343],"health":[347],"disease.":[349]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2026-05-02T00:00:00"}