{"id":"https://openalex.org/W7157829801","doi":"https://doi.org/10.3892/etm.2026.13173","title":"Changes in iron metabolism after primary PCI in patients with STEMI and ischemia\u2011reperfusion injury","display_name":"Changes in iron metabolism after primary PCI in patients with STEMI and ischemia\u2011reperfusion injury","publication_year":2026,"publication_date":"2026-04-28","ids":{"openalex":"https://openalex.org/W7157829801","doi":"https://doi.org/10.3892/etm.2026.13173","pmid":"https://pubmed.ncbi.nlm.nih.gov/42125552","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13158925"},"language":"en","primary_location":{"id":"doi:10.3892/etm.2026.13173","doi":"https://doi.org/10.3892/etm.2026.13173","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2026.13173","pdf_url":"http://www.spandidos-publications.com/10.3892/etm.2026.13173/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.spandidos-publications.com/10.3892/etm.2026.13173/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000471597","display_name":"Zuoyan Wang","orcid":"https://orcid.org/0009-0002-7004-6138","observed_orcids":["https://orcid.org/0009-0002-7004-6138"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210154593","display_name":"Beijing Shijitan Hospital","ror":"https://ror.org/0569k1630","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154593"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zuoyan Wang","raw_affiliation_strings":["Department of Cardiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210154593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134873817","display_name":"Yang Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210154593","display_name":"Beijing Shijitan Hospital","ror":"https://ror.org/0569k1630","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154593"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Zhang","raw_affiliation_strings":["Department of Cardiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210154593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134839608","display_name":"Kai Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210154593","display_name":"Beijing Shijitan Hospital","ror":"https://ror.org/0569k1630","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154593"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Zhang","raw_affiliation_strings":["Department of Cardiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210154593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132672967","display_name":"X F Huang","orcid":"https://orcid.org/0000-0002-3511-3019","observed_orcids":["https://orcid.org/0000-0002-3511-3019","https://orcid.org/0000-0001-9744-8802","https://orcid.org/0000-0002-5668-4320","https://orcid.org/0000-0002-8446-7120"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210154593","display_name":"Beijing Shijitan Hospital","ror":"https://ror.org/0569k1630","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154593"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Huang","raw_affiliation_strings":["Department of Cardiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210154593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5134830270","display_name":"Jianjun Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210154593","display_name":"Beijing Shijitan Hospital","ror":"https://ror.org/0569k1630","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154593"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianjun Peng","raw_affiliation_strings":["Department of Cardiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210154593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5134830270"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210154593"],"apc_list":null,"apc_paid":null,"fwci":4.1574,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.92260003,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":95},"biblio":{"volume":"31","issue":"6","first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.026900000870227814,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-metabolism","display_name":"iron metabolism","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9010000228881836},{"id":"https://openalex.org/keywords/st-elevation-myocardial-infarction","display_name":"ST-elevation myocardial infarction","score":0.996999979019165},{"id":"https://openalex.org/keywords/primary-percutaneous-coronary-intervention","display_name":"primary percutaneous coronary intervention","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hepcidin","display_name":"hepcidin","score":1.0},{"id":"https://openalex.org/keywords/heme","display_name":"heme","score":0.9490000009536743},{"id":"https://openalex.org/keywords/heme-oxygenase-1","display_name":"heme oxygenase-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.795799970626831},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.7020000219345093},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6582000255584717},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.645799994468689},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.6236000061035156},{"id":"https://openalex.org/C2776768029","wikidata":"https://www.wikidata.org/wiki/Q14882371","display_name":"Hepcidin","level":3,"score":0.6025999784469604},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5551000237464905},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5257999897003174},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.4336000084877014},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.41609999537467957},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.38929998874664307},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3732999861240387},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3564000129699707},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.32690000534057617},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2824000120162964},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25929999351501465},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.2529999911785126}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3892/etm.2026.13173","doi":"https://doi.org/10.3892/etm.2026.13173","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2026.13173","pdf_url":"http://www.spandidos-publications.com/10.3892/etm.2026.13173/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13158925","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13158925/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13158925/pdf/etm-31-06-13173.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Ther Med","raw_type":"Text"},{"id":"pmid:42125552","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42125552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and therapeutic medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/etm.2026.13173","doi":"https://doi.org/10.3892/etm.2026.13173","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2026.13173","pdf_url":"http://www.spandidos-publications.com/10.3892/etm.2026.13173/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7157829801.pdf","grobid_xml":"https://content.openalex.org/works/W7157829801.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2964591960","https://openalex.org/W4239319452","https://openalex.org/W7164924823","https://openalex.org/W2606238573","https://openalex.org/W7127973084","https://openalex.org/W4408362262","https://openalex.org/W2968365563","https://openalex.org/W4399140391","https://openalex.org/W4281958710","https://openalex.org/W7039525423"],"abstract_inverted_index":{"Within":[0],"the":[1,4,9,36,109,117,121,125,147,152,171,178,184],"present":[2,43],"study,":[3],"aim":[5],"was":[6,129,143,175],"to":[7,31,58,93,107],"investigate":[8],"dynamic":[10],"changes":[11,110],"in":[12,16,111,139,146,165,173,177,181,187,204,211,248],"iron":[13,113],"metabolism":[14,114,233],"parameters":[15],"patients":[17,50,212],"with":[18,35,51,151,183,213,252],"ST-segment":[19],"elevation":[20,172],"myocardial":[21],"infarction":[22],"(STEMI)":[23],"undergoing":[24,53],"primary":[25,54],"percutaneous":[26],"coronary":[27],"intervention":[28],"(PCI)":[29],"and":[30,65,76,91,98,141,158,167,189,193,206,215,219,234,236],"evaluate":[32],"their":[33],"association":[34,229],"occurrence":[37],"of":[38,127,241],"ischemia-reperfusion":[39],"injury":[40],"(IRI).":[41],"The":[42,137],"single-center,":[44],"prospective":[45],"observational":[46],"study":[47],"enrolled":[48,123],"68":[49,122],"STEMI":[52,214],"PCI":[55],"from":[56],"January":[57],"December":[59],"2024.":[60],"Clinical":[61],"characteristics,":[62],"laboratory":[63],"data":[64],"echocardiographic":[66],"findings":[67],"were":[68,71,88,105,196,208],"collected.":[69],"Patients":[70],"classified":[72],"into":[73],"IRI":[74,83,128,148,157,179,192,235],"(n=30)":[75],"non-IRI":[77,153,159,194],"(n=38)":[78],"groups":[79,160,195],"based":[80],"on":[81],"predefined":[82],"criteria.":[84],"Venous":[85],"blood":[86],"samples":[87],"obtained":[89],"pre-":[90],"post-PCI":[92,202],"measure":[94],"ferritin,":[95],"hepcidin,":[96],"heme":[97,99,166,174,188,218],"oxygenase-1":[100],"(HO-1)":[101],"levels.":[102],"Statistical":[103],"analyses":[104],"conducted":[106],"compare":[108],"these":[112],"indices":[115],"between":[116,191,230],"two":[118],"groups.":[119],"Among":[120],"patients,":[124],"incidence":[126],"44.1%.":[130],"Ferritin":[131],"showed":[132,221],"a":[133],"significant":[134],"increase":[135],"post-PCI.":[136],"rise":[138],"ferritin":[140,205],"hepcidin":[142,207],"more":[144,209],"pronounced":[145,210],"group":[149,180],"compared":[150],"group.":[154],"Although":[155],"both":[156],"exhibited":[161],"an":[162,228],"upward":[163,223],"trend":[164],"HO-1":[168,190,220],"after":[169],"PCI,":[170],"higher":[176],"comparison":[182],"HO-1.":[185],"Differences":[186],"not":[197],"statistically":[198],"significant.":[199],"In":[200],"conclusion,":[201],"rises":[203],"IRI,":[216],"while":[217],"non-significant":[222],"trends.":[224],"These":[225],"results":[226],"indicated":[227],"altered":[231],"iron/heme":[232],"therefore":[237],"support":[238],"further":[239],"evaluation":[240],"ferritin/hepcidin":[242],"as":[243],"candidate":[244],"biomarkers,":[245],"pending":[246],"validation":[247],"larger":[249],"multicenter":[250],"studies":[251],"multivariable":[253],"adjustment.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-04-30T00:00:00"}