{"id":"https://openalex.org/W7155372218","doi":"https://doi.org/10.64898/2026.04.22.720226","title":"Chromosome-arm-specific telomere length governs dual modes of structural genome evolution in IDH-mutant astrocytoma","display_name":"Chromosome-arm-specific telomere length governs dual modes of structural genome evolution in IDH-mutant astrocytoma","publication_year":2026,"publication_date":"2026-04-23","ids":{"openalex":"https://openalex.org/W7155372218","doi":"https://doi.org/10.64898/2026.04.22.720226","pmid":"https://pubmed.ncbi.nlm.nih.gov/42079062","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13131789"},"language":"en","primary_location":{"id":"doi:10.64898/2026.04.22.720226","doi":"https://doi.org/10.64898/2026.04.22.720226","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.04.22.720226","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/04/23/2026.04.22.720226.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/04/23/2026.04.22.720226.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020117076","display_name":"Maryam Jehangir","orcid":"https://orcid.org/0000-0001-5121-770X","observed_orcids":["https://orcid.org/0000-0001-5121-770X"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam Jehangir","raw_affiliation_strings":["Division of Bioinnovation and Genome Sciences, The Translational Genomics Research Institute (TGen), Phoenix, Arizona"],"raw_orcid":"https://orcid.org/0000-0001-5121-770X","affiliations":[{"raw_affiliation_string":"Division of Bioinnovation and Genome Sciences, The Translational Genomics Research Institute (TGen), Phoenix, Arizona","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036150458","display_name":"Kristen L. Drucker","orcid":"https://orcid.org/0000-0001-6244-5863","observed_orcids":["https://orcid.org/0000-0001-6244-5863"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen L. Drucker","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota","Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0001-6244-5863","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059379437","display_name":"Ay\u015fe G\u00f6k\u00e7e Ke\u015fk\u00fc\u015f","orcid":"https://orcid.org/0000-0002-3934-8587","observed_orcids":["https://orcid.org/0000-0002-3934-8587"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayse Keskus","raw_affiliation_strings":["Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland"],"raw_orcid":"https://orcid.org/0000-0002-3934-8587","affiliations":[{"raw_affiliation_string":"Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082851461","display_name":"T. Rhyker Ranallo-Benavidez","orcid":"https://orcid.org/0000-0003-3137-8439","observed_orcids":["https://orcid.org/0000-0003-3137-8439"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. Rhyker Ranallo-Benavidez","raw_affiliation_strings":["Division of Bioinnovation and Genome Sciences, The Translational Genomics Research Institute (TGen), Phoenix, Arizona"],"raw_orcid":"https://orcid.org/0000-0003-3137-8439","affiliations":[{"raw_affiliation_string":"Division of Bioinnovation and Genome Sciences, The Translational Genomics Research Institute (TGen), Phoenix, Arizona","institution_ids":["https://openalex.org/I1284308235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011593637","display_name":"Orl\u00e9na Benamozig","orcid":"https://orcid.org/0009-0002-5250-748X","observed_orcids":["https://orcid.org/0009-0002-5250-748X"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Orlena Benamozig","raw_affiliation_strings":["Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israe"],"raw_orcid":"https://orcid.org/0009-0002-5250-748X","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israe","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061858273","display_name":"Thomas Kollmeyer","orcid":"https://orcid.org/0000-0002-0694-3224","observed_orcids":["https://orcid.org/0000-0002-0694-3224"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Kollmeyer","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0002-0694-3224","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002503019","display_name":"Terry C. Burns","orcid":"https://orcid.org/0000-0001-7633-3045","observed_orcids":["https://orcid.org/0000-0001-7633-3045","https://orcid.org/0000-0002-0703-7717"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terry C. Burns","raw_affiliation_strings":["Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069689120","display_name":"Caterina Giannini","orcid":"https://orcid.org/0000-0003-2757-6782","observed_orcids":["https://orcid.org/0000-0003-2757-6782"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caterina Giannini","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0003-2757-6782","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023410987","display_name":"Benjamin R. Kipp","orcid":"https://orcid.org/0000-0001-9477-0118","observed_orcids":["https://orcid.org/0000-0001-9477-0118"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin R. Kipp","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0001-9477-0118","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003329463","display_name":"Stephen James Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Murphy","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050943376","display_name":"Amber R. Bridgeman","orcid":"https://orcid.org/0000-0003-0499-3954","observed_orcids":["https://orcid.org/0000-0003-0499-3954"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amber R. Bridgeman","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0003-0499-3954","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047506227","display_name":"Jesse R. Walsh","orcid":"https://orcid.org/0000-0001-6048-1166","observed_orcids":["https://orcid.org/0000-0001-6048-1166"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jesse R. Walsh","raw_affiliation_strings":["Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0001-6048-1166","affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109130160","display_name":"Ramanath Majumdar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ramanath Majumdar","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134412203","display_name":"Daniel H. Lachance","orcid":"https://orcid.org/0000-0001-8653-2259","observed_orcids":["https://orcid.org/0000-0001-8653-2259"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Lachance","raw_affiliation_strings":["Department of Neurology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0001-8653-2259","affiliations":[{"raw_affiliation_string":"Department of Neurology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040994175","display_name":"Jeanette E. Eckel\u2010Passow","orcid":"https://orcid.org/0000-0002-6113-1114","observed_orcids":["https://orcid.org/0000-0002-6113-1114"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeanette Eckel-Passow","raw_affiliation_strings":["Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":"https://orcid.org/0000-0002-6113-1114","affiliations":[{"raw_affiliation_string":"Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037999107","display_name":"Ofer Shoshani","orcid":"https://orcid.org/0000-0001-8918-9935","observed_orcids":["https://orcid.org/0000-0001-8918-9935"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Ofer Shoshani","raw_affiliation_strings":["Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israe"],"raw_orcid":"https://orcid.org/0000-0001-8918-9935","affiliations":[{"raw_affiliation_string":"Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israe","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025147358","display_name":"Mikhail Kolmogorov","orcid":"https://orcid.org/0000-0002-5489-9045","observed_orcids":["https://orcid.org/0000-0002-5489-9045"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210149717","display_name":"Center for Cancer Research","ror":"https://ror.org/05bjen692","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikhail Kolmogorov","raw_affiliation_strings":["Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland"],"raw_orcid":"https://orcid.org/0000-0002-5489-9045","affiliations":[{"raw_affiliation_string":"Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4210149717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060720802","display_name":"Robert Brian Jenkins","orcid":"https://orcid.org/0000-0002-4049-694X","observed_orcids":["https://orcid.org/0000-0002-4049-694X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B. Jenkins","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013176436","display_name":"Floris P Barthel","orcid":"https://orcid.org/0000-0002-7425-4180","observed_orcids":["https://orcid.org/0000-0002-7425-4180"]},"institutions":[{"id":"https://openalex.org/I1284308235","display_name":"Translational Genomics Research Institute","ror":"https://ror.org/02hfpnk21","country_code":"US","type":"facility","lineage":["https://openalex.org/I1284308235"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Floris P. Barthel","raw_affiliation_strings":["Division of Bioinnovation and Genome Sciences, The Translational Genomics Research Institute (TGen), Phoenix, Arizona"],"raw_orcid":"https://orcid.org/0000-0002-7425-4180","affiliations":[{"raw_affiliation_string":"Division of Bioinnovation and Genome Sciences, The Translational Genomics Research Institute (TGen), Phoenix, Arizona","institution_ids":["https://openalex.org/I1284308235"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5013176436"],"corresponding_institution_ids":["https://openalex.org/I1284308235"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.5220000147819519,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.29910001158714294,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.05559999868273735,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idh-mutant-astrocytoma","display_name":"IDH-mutant astrocytoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/alternative-lengthening-of-telomeres","display_name":"alternative lengthening of telomeres","score":0.9490000009536743},{"id":"https://openalex.org/keywords/telomere-length-heterogeneity","display_name":"telomere length heterogeneity","score":0.9559999704360962},{"id":"https://openalex.org/keywords/structural-variants","display_name":"structural variants","score":0.8539999723434448},{"id":"https://openalex.org/keywords/extrachromosomal-dna","display_name":"extrachromosomal DNA","score":0.8669999837875366},{"id":"https://openalex.org/keywords/copy-number-variation","display_name":"copy number variation","score":0.8080000281333923},{"id":"https://openalex.org/keywords/chromothripsis","display_name":"chromothripsis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/breakage-fusion-bridge-cycles","display_name":"breakage-fusion-bridge cycles","score":0.9629999995231628},{"id":"https://openalex.org/keywords/structural-fragility","display_name":"structural fragility","score":0.6729999780654907},{"id":"https://openalex.org/keywords/centromeric-breakpoints","display_name":"centromeric breakpoints","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.970300018787384},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6991999745368958},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.6565999984741211},{"id":"https://openalex.org/C99983632","wikidata":"https://www.wikidata.org/wiki/Q1087765","display_name":"Chromothripsis","level":5,"score":0.6380000114440918},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.6037999987602234},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5645999908447266},{"id":"https://openalex.org/C89684784","wikidata":"https://www.wikidata.org/wiki/Q5422184","display_name":"Extrachromosomal DNA","level":4,"score":0.4580000042915344},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.40630000829696655},{"id":"https://openalex.org/C2776879488","wikidata":"https://www.wikidata.org/wiki/Q3959366","display_name":"Shelterin","level":5,"score":0.376800000667572},{"id":"https://openalex.org/C174600577","wikidata":"https://www.wikidata.org/wiki/Q5533491","display_name":"Genome evolution","level":4,"score":0.37540000677108765},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3736000061035156},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.3400000035762787},{"id":"https://openalex.org/C202265312","wikidata":"https://www.wikidata.org/wiki/Q7697810","display_name":"Telomere-binding protein","level":5,"score":0.3305000066757202},{"id":"https://openalex.org/C151020129","wikidata":"https://www.wikidata.org/wiki/Q7625067","display_name":"Structural variation","level":4,"score":0.32269999384880066},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.31459999084472656},{"id":"https://openalex.org/C206936463","wikidata":"https://www.wikidata.org/wiki/Q634179","display_name":"Breakpoint","level":4,"score":0.30649998784065247},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.30059999227523804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2689000070095062},{"id":"https://openalex.org/C169802333","wikidata":"https://www.wikidata.org/wiki/Q424473","display_name":"Repeated sequence","level":4,"score":0.25760000944137573},{"id":"https://openalex.org/C149187182","wikidata":"https://www.wikidata.org/wiki/Q22325217","display_name":"Replisome","level":5,"score":0.2556000053882599},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.25119999051094055}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.64898/2026.04.22.720226","doi":"https://doi.org/10.64898/2026.04.22.720226","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.04.22.720226","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/04/23/2026.04.22.720226.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:13131789","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13131789/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13131789/pdf/nihpp-2026.04.22.720226v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmid:42079062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42079062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.64898/2026.04.22.720226","doi":"https://doi.org/10.64898/2026.04.22.720226","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.04.22.720226","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/04/23/2026.04.22.720226.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4629423607","display_name":null,"funder_award_id":"HT9425","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G5123049177","display_name":"(PQ3) UNDERSTANDING THE INTERACTIONS BETWEEN GERMLINE AND SOMATIC ALTERATIONS in the PATHOGENESIS OF GLIOMAS","funder_award_id":"R01CA230712","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6560693493","display_name":"GENOMIC DISSECTION OF STRUCTURAL MUTATIONS FOLLOWING TELOMERE DYSFUNCTION IN GLIOBLASTOMA CELLS AND PATIENTS","funder_award_id":"HT94252310844","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G9000902377","display_name":"Using germline and somatic genetics to elucidate glioma risk and improve patient outcomes","funder_award_id":"1r01ca298083-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320312414","display_name":"Oxford Nanopore Technologies","ror":"https://ror.org/04hyfx005"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7155372218.pdf","grobid_xml":"https://content.openalex.org/works/W7155372218.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W571060166","https://openalex.org/W1986009297","https://openalex.org/W1999626396","https://openalex.org/W2102619694","https://openalex.org/W2103453025","https://openalex.org/W2108234281","https://openalex.org/W2110227850","https://openalex.org/W2128016314","https://openalex.org/W2131117209","https://openalex.org/W2133174470","https://openalex.org/W2197269124","https://openalex.org/W2263206910","https://openalex.org/W2406250479","https://openalex.org/W2532728099","https://openalex.org/W2532734448","https://openalex.org/W2581179619","https://openalex.org/W2583363792","https://openalex.org/W2757232748","https://openalex.org/W2795441313","https://openalex.org/W2887032603","https://openalex.org/W2913360660","https://openalex.org/W2920347438","https://openalex.org/W2922503170","https://openalex.org/W2952922105","https://openalex.org/W2980663762","https://openalex.org/W3016718031","https://openalex.org/W3044175205","https://openalex.org/W3049406491","https://openalex.org/W3116548071","https://openalex.org/W4205921397","https://openalex.org/W4210813622","https://openalex.org/W4220999759","https://openalex.org/W4282932245","https://openalex.org/W4292790981","https://openalex.org/W4313430580","https://openalex.org/W4376256177","https://openalex.org/W4382363287","https://openalex.org/W4390500910","https://openalex.org/W4397021684","https://openalex.org/W4401390974","https://openalex.org/W4409194484","https://openalex.org/W4412600755","https://openalex.org/W4414061056","https://openalex.org/W4417345282","https://openalex.org/W7132827158","https://openalex.org/W7133301272"],"related_works":["https://openalex.org/W7140111574","https://openalex.org/W4416140967","https://openalex.org/W7157530701","https://openalex.org/W3002295425","https://openalex.org/W2767987602","https://openalex.org/W4403048761","https://openalex.org/W1223729236","https://openalex.org/W2987817017","https://openalex.org/W2792875887","https://openalex.org/W4404237687"],"abstract_inverted_index":{"IDH-mutant":[0,35],"astrocytomas":[1],"maintain":[2],"telomeres":[3,9,103,113],"through":[4],"the":[5],"alternative":[6],"lengthening":[7],"of":[8,33,84,130],"(ALT)":[10],"pathway,":[11],"producing":[12],"extreme":[13],"inter-arm":[14],"telomere":[15,51,86,93,125],"length":[16,94,126],"heterogeneity,":[17],"yet":[18],"how":[19],"this":[20],"heterogeneity":[21],"shapes":[22],"structural":[23,39,90,131],"genome":[24,132],"evolution":[25,133],"remains":[26],"unknown.":[27],"Using":[28],"Oxford":[29],"Nanopore":[30],"long-read":[31],"sequencing":[32],"20":[34],"astrocytomas,":[36],"we":[37],"profiled":[38],"variants":[40],"(SVs),":[41],"copy":[42],"number":[43],"variants,":[44],"extrachromosomal":[45],"DNA":[46],"(ecDNA)":[47],"and":[48,64,71,80,118],"measured":[49],"allele-specific":[50],"lengths":[52],"from":[53],"individual":[54],"long":[55,111],"reads.":[56],"We":[57],"identified":[58],"pervasive":[59],"complex":[60],"rearrangements,":[61],"including":[62],"chromothripsis":[63],"foldback":[65],"events":[66],"consistent":[67],"with":[68,101,110],"breakage-fusion-bridge":[69],"cycles,":[70],"widespread":[72],"ecDNAs.":[73],"SV":[74],"breakpoints":[75],"were":[76,114],"enriched":[77,115],"at":[78],"telomeric":[79],"centromeric":[81],"regions":[82],"regardless":[83],"local":[85],"length,":[87],"revealing":[88],"constitutive":[89],"fragility.":[91],"Arm-level":[92],"analysis":[95],"uncovered":[96],"a":[97,128],"dual-mode":[98],"model:":[99],"arms":[100,109],"short":[102],"preferentially":[104],"harbored":[105],"breakage-associated":[106],"events,":[107],"while":[108],"ALT-maintained":[112],"for":[116],"ecDNA":[117],"amplification-associated":[119],"events.":[120],"These":[121],"findings":[122],"identify":[123],"chromosome-arm-specific":[124],"as":[127],"determinant":[129],"in":[134],"ALT-driven":[135],"tumors.":[136]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-04-24T00:00:00"}