{"id":"https://openalex.org/W7155352802","doi":"https://doi.org/10.3389/fimmu.2026.1718883","title":"The role of the microbiome in gynecological cancers: implications for diagnosis and treatment","display_name":"The role of the microbiome in gynecological cancers: implications for diagnosis and treatment","publication_year":2026,"publication_date":"2026-04-23","ids":{"openalex":"https://openalex.org/W7155352802","doi":"https://doi.org/10.3389/fimmu.2026.1718883","pmid":"https://pubmed.ncbi.nlm.nih.gov/42112384","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13149462"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1718883","doi":"https://doi.org/10.3389/fimmu.2026.1718883","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1718883","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1718883/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1718883/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104316828","display_name":"Precious Adeoye Oyedokun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45230691","display_name":"Ladoke Akintola University of Technology","ror":"https://ror.org/043hyzt56","country_code":"NG","type":"education","lineage":["https://openalex.org/I45230691"]}],"countries":["NG"],"is_corresponding":true,"raw_author_name":"Precious Adeoye Oyedokun","raw_affiliation_strings":["Axon Plus Consulting","Department of Computer Science, Ladoke Akintola University of Technology","Department of Physiology, Ladoke Akintola University of Technology","Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Axon Plus Consulting","institution_ids":[]},{"raw_affiliation_string":"Department of Computer Science, Ladoke Akintola University of Technology","institution_ids":["https://openalex.org/I45230691"]},{"raw_affiliation_string":"Department of Physiology, Ladoke Akintola University of Technology","institution_ids":["https://openalex.org/I45230691"]},{"raw_affiliation_string":"Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134403353","display_name":"Bobola Timothy Oyeleke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45230691","display_name":"Ladoke Akintola University of Technology","ror":"https://ror.org/043hyzt56","country_code":"NG","type":"education","lineage":["https://openalex.org/I45230691"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Bobola Timothy Oyeleke","raw_affiliation_strings":["Department of Medical Laboratory Science, Ladoke Akintola University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science, Ladoke Akintola University of Technology","institution_ids":["https://openalex.org/I45230691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034713529","display_name":"Oluwanisola Akanji Onigbinde","orcid":"https://orcid.org/0000-0001-5473-1034","observed_orcids":["https://orcid.org/0000-0001-5473-1034"]},"institutions":[{"id":"https://openalex.org/I4210131067","display_name":"Nile University","ror":"https://ror.org/03kyeae64","country_code":"UG","type":"education","lineage":["https://openalex.org/I4210131067"]},{"id":"https://openalex.org/I4387152308","display_name":"Nile University","ror":"https://ror.org/009daqn45","country_code":"SD","type":"education","lineage":["https://openalex.org/I4387152308"]},{"id":"https://openalex.org/I57629906","display_name":"Nile University","ror":"https://ror.org/03cg7cp61","country_code":"EG","type":"education","lineage":["https://openalex.org/I57629906"]}],"countries":["EG","SD","UG"],"is_corresponding":false,"raw_author_name":"Onigbinde Oluwanisola Akanji","raw_affiliation_strings":["Department of Anatomy, Nile University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Nile University","institution_ids":["https://openalex.org/I4210131067","https://openalex.org/I4387152308","https://openalex.org/I57629906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134411867","display_name":"Abraham Ololade Oyelaran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45230691","display_name":"Ladoke Akintola University of Technology","ror":"https://ror.org/043hyzt56","country_code":"NG","type":"education","lineage":["https://openalex.org/I45230691"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Abraham Ololade Oyelaran","raw_affiliation_strings":["Department of Medical Laboratory Science, Ladoke Akintola University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science, Ladoke Akintola University of Technology","institution_ids":["https://openalex.org/I45230691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134406904","display_name":"Kehinde Philip O","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45230691","display_name":"Ladoke Akintola University of Technology","ror":"https://ror.org/043hyzt56","country_code":"NG","type":"education","lineage":["https://openalex.org/I45230691"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Kehinde Philip O","raw_affiliation_strings":["Department of Medical Laboratory Science, Ladoke Akintola University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science, Ladoke Akintola University of Technology","institution_ids":["https://openalex.org/I45230691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098316173","display_name":"Grace Bosede Akanbi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45230691","display_name":"Ladoke Akintola University of Technology","ror":"https://ror.org/043hyzt56","country_code":"NG","type":"education","lineage":["https://openalex.org/I45230691"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Grace Bosede Akanbi","raw_affiliation_strings":["Department of Physiology, Ladoke Akintola University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Ladoke Akintola University of Technology","institution_ids":["https://openalex.org/I45230691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134423981","display_name":"Philip Olagbede Oyedokun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45230691","display_name":"Ladoke Akintola University of Technology","ror":"https://ror.org/043hyzt56","country_code":"NG","type":"education","lineage":["https://openalex.org/I45230691"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Philip Olagbede Oyedokun","raw_affiliation_strings":["Axon Plus Consulting","Department of Computer Science, Ladoke Akintola University of Technology","Department of Physiology, Ladoke Akintola University of Technology","Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Axon Plus Consulting","institution_ids":[]},{"raw_affiliation_string":"Department of Computer Science, Ladoke Akintola University of Technology","institution_ids":["https://openalex.org/I45230691"]},{"raw_affiliation_string":"Department of Physiology, Ladoke Akintola University of Technology","institution_ids":["https://openalex.org/I45230691"]},{"raw_affiliation_string":"Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134459434","display_name":"Marvelous Dasola Oyedokun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45230691","display_name":"Ladoke Akintola University of Technology","ror":"https://ror.org/043hyzt56","country_code":"NG","type":"education","lineage":["https://openalex.org/I45230691"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Marvelous Dasola Oyedokun","raw_affiliation_strings":["Axon Plus Consulting","Department of Nursing Science, Ladoke Akintola University of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Axon Plus Consulting","institution_ids":[]},{"raw_affiliation_string":"Department of Nursing Science, Ladoke Akintola University of Technology","institution_ids":["https://openalex.org/I45230691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134378149","display_name":"Chikezie Chinelo Naomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134542131","display_name":"University of Ilorin","ror":"https://ror.org/032kdwk38","country_code":"NG","type":"education","lineage":["https://openalex.org/I134542131"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Chikezie Chinelo Naomi","raw_affiliation_strings":["Department of Anatomy, University of Ilorin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of Ilorin","institution_ids":["https://openalex.org/I134542131"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075387913","display_name":"Imoleayo Oyeniran Oluwatosin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I11957088","display_name":"Michigan Technological University","ror":"https://ror.org/0036rpn28","country_code":"US","type":"education","lineage":["https://openalex.org/I11957088"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oyeniran Oluwatosin Imoleayo","raw_affiliation_strings":["Department of Kinesiology and Integrative Physiology, Michigan Technological University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Kinesiology and Integrative Physiology, Michigan Technological University","institution_ids":["https://openalex.org/I11957088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005025493","display_name":"Roland Eghoghosoa Akhigbe","orcid":"https://orcid.org/0000-0002-3874-5927","observed_orcids":["https://orcid.org/0000-0002-3874-5927"]},"institutions":[{"id":"https://openalex.org/I45230691","display_name":"Ladoke Akintola University of Technology","ror":"https://ror.org/043hyzt56","country_code":"NG","type":"education","lineage":["https://openalex.org/I45230691"]}],"countries":["NG"],"is_corresponding":true,"raw_author_name":"Roland Eghoghosoa Akhigbe","raw_affiliation_strings":["Department of Physiology, Ladoke Akintola University of Technology","Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Ladoke Akintola University of Technology","institution_ids":["https://openalex.org/I45230691"]},{"raw_affiliation_string":"Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5005025493","https://openalex.org/A5104316828"],"corresponding_institution_ids":["https://openalex.org/I45230691"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.9181,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.7979351,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"17","issue":null,"first_page":"1718883","last_page":"1718883"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.2563000023365021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gynecologic-cancer","display_name":"gynecologic cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/microbiome","display_name":"microbiome","score":0.7160000205039978},{"id":"https://openalex.org/keywords/dysbiosis","display_name":"dysbiosis","score":0.9359999895095825},{"id":"https://openalex.org/keywords/lactobacillus-depletion","display_name":"Lactobacillus depletion","score":0.9419999718666077},{"id":"https://openalex.org/keywords/fusobacterium","display_name":"Fusobacterium","score":0.890999972820282},{"id":"https://openalex.org/keywords/atopobium","display_name":"Atopobium","score":0.9810000061988831},{"id":"https://openalex.org/keywords/sneathia","display_name":"Sneathia","score":0.9929999709129333},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.921999990940094},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/estrobolome","display_name":"estrobolome","score":0.8159999847412109},{"id":"https://openalex.org/keywords/estrogen-metabolism","display_name":"estrogen metabolism","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9020000100135803},{"id":"https://openalex.org/keywords/immunosurveillance","display_name":"immune surveillance","score":0.6019999980926514},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.7889999747276306},{"id":"https://openalex.org/keywords/noninvasive-biomarkers","display_name":"non-invasive biomarkers","score":0.824999988079071},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.8510000109672546},{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":0.996999979019165},{"id":"https://openalex.org/keywords/vaginal-microbiota-transplantation","display_name":"vaginal microbiota transplantation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/fecal-microbiota-transplantation","display_name":"fecal microbiota transplantation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.5789999961853027},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.7567999958992004},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.7559999823570251},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6046000123023987},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5181000232696533},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48330000042915344},{"id":"https://openalex.org/C2779952448","wikidata":"https://www.wikidata.org/wiki/Q804521","display_name":"Bacterial vaginosis","level":2,"score":0.4828000068664551},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4797999858856201},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4661000072956085},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.45660001039505005},{"id":"https://openalex.org/C190944805","wikidata":"https://www.wikidata.org/wiki/Q3922751","display_name":"Human Microbiome Project","level":4,"score":0.453000009059906},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.44449999928474426},{"id":"https://openalex.org/C91478284","wikidata":"https://www.wikidata.org/wiki/Q6623796","display_name":"Human microbiome","level":3,"score":0.4124999940395355},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.4041999876499176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39660000801086426},{"id":"https://openalex.org/C2777744392","wikidata":"https://www.wikidata.org/wiki/Q5880","display_name":"Vagina","level":2,"score":0.3779999911785126},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.37529999017715454},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.375},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.3336000144481659},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3249000012874603},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.3206000030040741},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.3151000142097473},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.31209999322891235},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.296099990606308},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.2930000126361847},{"id":"https://openalex.org/C2992397963","wikidata":"https://www.wikidata.org/wiki/Q189790","display_name":"Anaerobic bacteria","level":3,"score":0.29100000858306885},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.2824999988079071},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.2782999873161316}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005833","descriptor_name":"Genital Neoplasms, Female","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005833","descriptor_name":"Genital Neoplasms, Female","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005833","descriptor_name":"Genital Neoplasms, Female","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005833","descriptor_name":"Genital Neoplasms, Female","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005833","descriptor_name":"Genital Neoplasms, Female","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2026.1718883","doi":"https://doi.org/10.3389/fimmu.2026.1718883","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1718883","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1718883/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13149462","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13149462/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13149462/pdf/fimmu-17-1718883.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:42112384","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42112384","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.mtu.edu:michigantech-p2-3741","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.mtu.edu/michigantech-p2/2678","pdf_url":"https://digitalcommons.mtu.edu/context/michigantech-p2/article/3741/viewcontent/fimmu_17_1718883.pdf","source":{"id":"https://openalex.org/S4377196391","display_name":"Digital Commons - Michigan Tech (Michigan Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I11957088","host_organization_name":"Michigan Technological University","host_organization_lineage":["https://openalex.org/I11957088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Michigan Tech Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:8313c7cdfad74d2482b0cbba9470ec43","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8313c7cdfad74d2482b0cbba9470ec43","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1718883","doi":"https://doi.org/10.3389/fimmu.2026.1718883","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1718883","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1718883/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7155352802.pdf","grobid_xml":"https://content.openalex.org/works/W7155352802.grobid-xml"},"referenced_works_count":140,"referenced_works":["https://openalex.org/W1750240395","https://openalex.org/W1919603305","https://openalex.org/W1969370081","https://openalex.org/W1970288360","https://openalex.org/W1974335344","https://openalex.org/W1992893880","https://openalex.org/W2045724295","https://openalex.org/W2059128083","https://openalex.org/W2065870105","https://openalex.org/W2073924079","https://openalex.org/W2074892332","https://openalex.org/W2084312540","https://openalex.org/W2103347596","https://openalex.org/W2109020166","https://openalex.org/W2118860200","https://openalex.org/W2121344236","https://openalex.org/W2140679462","https://openalex.org/W2144262446","https://openalex.org/W2157616888","https://openalex.org/W2168456538","https://openalex.org/W2341191157","https://openalex.org/W2342602136","https://openalex.org/W2491738998","https://openalex.org/W2555461010","https://openalex.org/W2591838483","https://openalex.org/W2592355527","https://openalex.org/W2601255746","https://openalex.org/W2608380735","https://openalex.org/W2673776326","https://openalex.org/W2782223764","https://openalex.org/W2793603001","https://openalex.org/W2797068438","https://openalex.org/W2807270740","https://openalex.org/W2807649309","https://openalex.org/W2892187731","https://openalex.org/W2900494132","https://openalex.org/W2911589499","https://openalex.org/W2923679108","https://openalex.org/W2942541983","https://openalex.org/W2945346908","https://openalex.org/W2952102703","https://openalex.org/W2963362732","https://openalex.org/W2981527939","https://openalex.org/W2992109307","https://openalex.org/W2997977059","https://openalex.org/W3005116291","https://openalex.org/W3007674389","https://openalex.org/W3028171076","https://openalex.org/W3043207992","https://openalex.org/W3083039032","https://openalex.org/W3097675243","https://openalex.org/W3111298271","https://openalex.org/W3121708936","https://openalex.org/W3128646645","https://openalex.org/W3167785563","https://openalex.org/W3172074343","https://openalex.org/W3185327195","https://openalex.org/W3198493551","https://openalex.org/W3199477224","https://openalex.org/W3202445173","https://openalex.org/W3212424037","https://openalex.org/W3216621316","https://openalex.org/W4212907025","https://openalex.org/W4214694168","https://openalex.org/W4280644068","https://openalex.org/W4281912364","https://openalex.org/W4283826714","https://openalex.org/W4286510420","https://openalex.org/W4290744543","https://openalex.org/W4293427630","https://openalex.org/W4293531189","https://openalex.org/W4303700008","https://openalex.org/W4307135828","https://openalex.org/W4312220103","https://openalex.org/W4315754639","https://openalex.org/W4315874510","https://openalex.org/W4323311502","https://openalex.org/W4361018507","https://openalex.org/W4365455033","https://openalex.org/W4366425576","https://openalex.org/W4367311688","https://openalex.org/W4367626341","https://openalex.org/W4379598727","https://openalex.org/W4380237605","https://openalex.org/W4380925462","https://openalex.org/W4381546216","https://openalex.org/W4385483606","https://openalex.org/W4385715629","https://openalex.org/W4385767030","https://openalex.org/W4386386548","https://openalex.org/W4386590254","https://openalex.org/W4387362776","https://openalex.org/W4388272575","https://openalex.org/W4389150053","https://openalex.org/W4390976620","https://openalex.org/W4391233173","https://openalex.org/W4392236338","https://openalex.org/W4393319413","https://openalex.org/W4393944473","https://openalex.org/W4394842195","https://openalex.org/W4394862431","https://openalex.org/W4394962599","https://openalex.org/W4395071452","https://openalex.org/W4395662675","https://openalex.org/W4396721964","https://openalex.org/W4396914960","https://openalex.org/W4399090061","https://openalex.org/W4399601604","https://openalex.org/W4399674162","https://openalex.org/W4400179134","https://openalex.org/W4400587691","https://openalex.org/W4400973732","https://openalex.org/W4401025734","https://openalex.org/W4401277230","https://openalex.org/W4401655798","https://openalex.org/W4403586549","https://openalex.org/W4403616399","https://openalex.org/W4404734535","https://openalex.org/W4406395266","https://openalex.org/W4406712511","https://openalex.org/W4406936081","https://openalex.org/W4407207050","https://openalex.org/W4407230002","https://openalex.org/W4408162741","https://openalex.org/W4408413592","https://openalex.org/W4408540888","https://openalex.org/W4408655682","https://openalex.org/W4409404340","https://openalex.org/W4409986760","https://openalex.org/W4410234779","https://openalex.org/W4410338584","https://openalex.org/W4410416749","https://openalex.org/W4411127845","https://openalex.org/W4411254388","https://openalex.org/W4412617375","https://openalex.org/W4412686039","https://openalex.org/W4413311336","https://openalex.org/W4414590999","https://openalex.org/W7140914890","https://openalex.org/W7160861266"],"related_works":["https://openalex.org/W4213055981","https://openalex.org/W3172074343","https://openalex.org/W3184478911","https://openalex.org/W7201997844","https://openalex.org/W4391815591","https://openalex.org/W4404774396","https://openalex.org/W3007674389","https://openalex.org/W4389485694","https://openalex.org/W4323051818","https://openalex.org/W4412595256"],"abstract_inverted_index":{"Gynecological":[0],"malignancies":[1],"such":[2,71],"as":[3,72,128,153],"cancer":[4,192],"of":[5,62,68,89,140],"the":[6,39,60,100,104,172],"cervix,":[7],"ovary,":[8],"endometrium,":[9],"vulva,":[10],"and":[11,27,49,66,75,96,106,118,138,165,179,185,195],"vagina":[12],"pose":[13],"a":[14,43,129],"severe":[15],"global":[16],"health":[17],"burden.":[18],"Although":[19],"conventionally":[20],"attributed":[21],"to":[22,177],"genetic":[23],"mutation,":[24],"hormonal":[25],"imbalance,":[26],"chronic":[28,84],"viral":[29],"infection,":[30],"including":[31,157],"high-risk":[32],"human":[33,40],"papillomavirus,":[34],"recent":[35],"evidence":[36,55],"suggests":[37],"that":[38,56],"microbiome":[41,175],"plays":[42],"central":[44],"role":[45],"in":[46,79,103,142],"their":[47],"pathogenesis":[48],"development.":[50],"This":[51,169],"review":[52,170],"summarizes":[53],"existing":[54],"microbial":[57,93,123],"dysbiosis,":[58],"specifically":[59],"depletion":[61],"beneficial":[63],"Lactobacillus":[64],"species":[65],"overrepresentation":[67],"anaerobic":[69],"organisms":[70],"Fusobacterium,":[73],"Atopobium,":[74],"Sneathia,":[76],"is":[77],"implicated":[78],"carcinogenesis":[80],"pathways.":[81],"These":[82],"include":[83],"inflammation,":[85],"immune":[86,119],"modulation,":[87],"loss":[88],"epithelial":[90],"barrier":[91],"integrity,":[92],"metabolite":[94],"toxicity,":[95],"estrogen":[97],"metabolism":[98],"by":[99],"estrobolome.":[101],"Dysbiosis":[102],"gut":[105],"reproductive":[107],"tract":[108],"has":[109],"been":[110],"associated":[111,183],"with":[112],"HPV":[113],"persistence,":[114],"tumor":[115],"microenvironment":[116],"remodeling,":[117],"surveillance/therapy":[120],"resistance.":[121],"Consequently,":[122],"signatures":[124],"are":[125,150],"being":[126,151],"investigated":[127],"potentially":[130],"successful":[131],"non-invasive":[132],"biomarker":[133],"for":[134],"early":[135],"diagnosis,":[136],"prognosis,":[137],"monitoring":[139],"therapy":[141],"gynecological":[143,191],"oncology.":[144],"In":[145],"addition,":[146],"emergent":[147],"microbiome-based":[148],"therapies":[149],"considered":[152],"potential":[154],"adjunct":[155],"therapies,":[156],"probiotics,":[158],"prebiotics,":[159],"dietary":[160],"manipulation,":[161],"vaginal":[162],"microbiota":[163,167],"transplantation,":[164],"fecal":[166],"transplantation.":[168],"connects":[171],"basic":[173],"research":[174,176],"translational":[178],"clinical":[180],"practice,":[181],"identifies":[182],"limitations,":[184],"highlights":[186],"how":[187],"it":[188],"may":[189],"transform":[190],"prevention,":[193],"detection,":[194],"treatment.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2026-04-24T00:00:00"}