{"id":"https://openalex.org/W7155196847","doi":"https://doi.org/10.1016/j.joca.2026.01.175","title":"METHYLATION STATUS OF SINGLE CpG SITES IN BOTH IL1B AND IL8 PROMOTERS IS RELATED TO CRITICAL CLINICAL OUTCOMES IN KNEE OSTEOARTHRITIC PATIENTS FROM THE OSTEOARTHRITIS INITIATIVE","display_name":"METHYLATION STATUS OF SINGLE CpG SITES IN BOTH IL1B AND IL8 PROMOTERS IS RELATED TO CRITICAL CLINICAL OUTCOMES IN KNEE OSTEOARTHRITIC PATIENTS FROM THE OSTEOARTHRITIS INITIATIVE","publication_year":2026,"publication_date":"2026-04-01","ids":{"openalex":"https://openalex.org/W7155196847","doi":"https://doi.org/10.1016/j.joca.2026.01.175"},"language":"en","primary_location":{"id":"doi:10.1016/j.joca.2026.01.175","doi":"https://doi.org/10.1016/j.joca.2026.01.175","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.joca.2026.01.175","pdf_url":null,"source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030841519","display_name":"Margarita Blanco-Blanco","orcid":"https://orcid.org/0000-0003-0663-5392","observed_orcids":["https://orcid.org/0000-0003-0663-5392"]},"institutions":[{"id":"https://openalex.org/I4210160015","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a","ror":"https://ror.org/04c9g9234","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210160015"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Margarita Blanco-Blanco","raw_affiliation_strings":["Instituto de Investigacion Biomedica de A Coruna","Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigacion Biomedica de A Coruna","institution_ids":["https://openalex.org/I4210160015"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a","institution_ids":["https://openalex.org/I4210160015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066517713","display_name":"Ignacio Rego P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160015","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a","ror":"https://ror.org/04c9g9234","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210160015"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ignacio Rego Perez","raw_affiliation_strings":["Instituto de Investigacion Biomedica de A Coruna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigacion Biomedica de A Coruna","institution_ids":["https://openalex.org/I4210160015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032450234","display_name":"Carmen N\u00fa\u00f1ez-Carro","orcid":"https://orcid.org/0000-0003-3034-4835","observed_orcids":["https://orcid.org/0000-0003-3034-4835"]},"institutions":[{"id":"https://openalex.org/I4210160015","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a","ror":"https://ror.org/04c9g9234","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210160015"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen N\u00fa\u00f1ez-Carro","raw_affiliation_strings":["Instituto de Investigacion Biomedica de A Coruna","Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigacion Biomedica de A Coruna","institution_ids":["https://openalex.org/I4210160015"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a","institution_ids":["https://openalex.org/I4210160015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120022973","display_name":"Silvia Cadah\u00eda-Lema","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160015","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a","ror":"https://ror.org/04c9g9234","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210160015"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Silvia Cadah\u00eda-Lema","raw_affiliation_strings":["Instituto de Investigacion Biomedica de A Coruna","Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigacion Biomedica de A Coruna","institution_ids":["https://openalex.org/I4210160015"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a","institution_ids":["https://openalex.org/I4210160015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019811024","display_name":"Francisco Javier Blanco","orcid":"https://orcid.org/0000-0001-9821-7635","observed_orcids":["https://orcid.org/0000-0001-9821-7635","https://orcid.org/0000-0003-2545-4319"]},"institutions":[{"id":"https://openalex.org/I4210160015","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a","ror":"https://ror.org/04c9g9234","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210160015"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco J. Blanco","raw_affiliation_strings":["Instituto de Investigacion Biomedica de A Coruna"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigacion Biomedica de A Coruna","institution_ids":["https://openalex.org/I4210160015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009488449","display_name":"Mar\u00eda C. de Andr\u00e9s","orcid":"https://orcid.org/0000-0003-2260-6356","observed_orcids":["https://orcid.org/0000-0003-2260-6356"]},"institutions":[{"id":"https://openalex.org/I4210160015","display_name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a","ror":"https://ror.org/04c9g9234","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210160015"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda C. de Andr\u00e9s","raw_affiliation_strings":["Instituto de Investigacion Biomedica de A Coruna","Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigacion Biomedica de A Coruna","institution_ids":["https://openalex.org/I4210160015"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a","institution_ids":["https://openalex.org/I4210160015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210160015"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":null,"first_page":"S139","last_page":"S139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7689999938011169,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7689999938011169,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.22460000216960907,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/knee-osteoarthritis","display_name":"knee osteoarthritis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/epigenetic-biomarkers","display_name":"epigenetic biomarkers","score":0.9049999713897705},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8149999976158142},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.7200000286102295},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8097000122070312},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.8082000017166138},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6259999871253967},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.590499997138977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5895000100135803},{"id":"https://openalex.org/C68324877","wikidata":"https://www.wikidata.org/wiki/Q421859","display_name":"Interleukin 8","level":3,"score":0.5892999768257141},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.5636000037193298},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5419999957084656},{"id":"https://openalex.org/C2779286237","wikidata":"https://www.wikidata.org/wiki/Q3569749","display_name":"WOMAC","level":4,"score":0.4523000121116638},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.44769999384880066},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.28290000557899475},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27230000495910645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26350000500679016},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.26010000705718994}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.joca.2026.01.175","doi":"https://doi.org/10.1016/j.joca.2026.01.175","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.joca.2026.01.175","pdf_url":null,"source":{"id":"https://openalex.org/S13054843","display_name":"Osteoarthritis and Cartilage","issn_l":"1063-4584","issn":["1063-4584","1522-9653"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Osteoarthritis and Cartilage","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2154895488","https://openalex.org/W2081097268","https://openalex.org/W2035729336","https://openalex.org/W2321672228","https://openalex.org/W6939831939","https://openalex.org/W7138212538","https://openalex.org/W2226061304","https://openalex.org/W2101721792","https://openalex.org/W1795358129","https://openalex.org/W1914059421"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-04-23T00:00:00"}
