{"id":"https://openalex.org/W7155193853","doi":"https://doi.org/10.1111/iju.70455","title":"Niraparib With Abiraterone Acetate Plus Prednisone as First\u2010Line Therapy in Patients With Metastatic Castration\u2010Resistant Prostate Cancer With Homologous Recombination Repair Gene Alterations: Final Analysis of the Asian Subgroup From the MAGNITUDE Study","display_name":"Niraparib With Abiraterone Acetate Plus Prednisone as First\u2010Line Therapy in Patients With Metastatic Castration\u2010Resistant Prostate Cancer With Homologous Recombination Repair Gene Alterations: Final Analysis of the Asian Subgroup From the MAGNITUDE Study","publication_year":2026,"publication_date":"2026-04-01","ids":{"openalex":"https://openalex.org/W7155193853","doi":"https://doi.org/10.1111/iju.70455","pmid":"https://pubmed.ncbi.nlm.nih.gov/42015879"},"language":"en","primary_location":{"id":"doi:10.1111/iju.70455","doi":"https://doi.org/10.1111/iju.70455","is_oa":false,"landing_page_url":"https://doi.org/10.1111/iju.70455","pdf_url":null,"source":{"id":"https://openalex.org/S134892809","display_name":"International Journal of Urology","issn_l":"0919-8172","issn":["0919-8172","1442-2042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101763457","display_name":"Dingwei Ye","orcid":"https://orcid.org/0000-0003-4974-3780","observed_orcids":["https://orcid.org/0000-0003-4974-3780","https://orcid.org/0000-0002-6761-5195","https://orcid.org/0000-0003-0704-7453","https://orcid.org/0000-0003-2993-2525"]},"institutions":[{"id":"https://openalex.org/I4210093194","display_name":"Fudan University Shanghai Cancer Center","ror":"https://ror.org/00my25942","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093194"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dingwei Ye","raw_affiliation_strings":["Department of Urology Fudan University Shanghai Cancer Center  Shanghai China"],"raw_orcid":"https://orcid.org/0000-0003-2993-2525","affiliations":[{"raw_affiliation_string":"Department of Urology Fudan University Shanghai Cancer Center  Shanghai China","institution_ids":["https://openalex.org/I4210093194"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108672655","display_name":"Marniza Bte Saad","orcid":"https://orcid.org/0000-0003-3768-4808","observed_orcids":["https://orcid.org/0000-0003-3768-4808"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Marniza Saad","raw_affiliation_strings":["Department of Clinical Oncology, Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063822726","display_name":"Ji Youl Lee","orcid":"https://orcid.org/0000-0001-6775-1157","observed_orcids":["https://orcid.org/0000-0001-6775-1157"]},"institutions":[{"id":"https://openalex.org/I4210160144","display_name":"The Catholic University of Korea Seoul St. Mary's Hospital","ror":"https://ror.org/056cn0e37","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210160144","https://openalex.org/I4405260414","https://openalex.org/I87111246"]},{"id":"https://openalex.org/I87111246","display_name":"Catholic University of Korea","ror":"https://ror.org/01fpnj063","country_code":"KR","type":"education","lineage":["https://openalex.org/I87111246"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Youl Lee","raw_affiliation_strings":["Department of Urology Cancer Center, Seoul St. Mary's Hospital The Catholic University of Korea  Seoul South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology Cancer Center, Seoul St. Mary's Hospital The Catholic University of Korea  Seoul South Korea","institution_ids":["https://openalex.org/I4210160144","https://openalex.org/I87111246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081458527","display_name":"Wonho Jung","orcid":"https://orcid.org/0000-0003-4954-3543","observed_orcids":["https://orcid.org/0000-0003-4954-3543"]},"institutions":[{"id":"https://openalex.org/I4405259018","display_name":"Keimyung University Daegu Dongsan Hospital","ror":"https://ror.org/01jk65d91","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210128080","https://openalex.org/I4405259018"]},{"id":"https://openalex.org/I4405261187","display_name":"Keimyung University Dongsan Hospital","ror":"https://ror.org/04xxe0935","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210128080","https://openalex.org/I4405261187"]},{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Wonho Jung","raw_affiliation_strings":["Department of Urology Keimyung University Dongsan Hospital  Daegu South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology Keimyung University Dongsan Hospital  Daegu South Korea","institution_ids":["https://openalex.org/I4405259018","https://openalex.org/I4405261187","https://openalex.org/I52010207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134274982","display_name":"See\u2010Tong Pang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]},{"id":"https://openalex.org/I4210116208","display_name":"Linkou Chang Gung Memorial Hospital","ror":"https://ror.org/02dnn6q67","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"See\u2010Tong Pang","raw_affiliation_strings":["Department of Urology, Chang Gung Memorial Hospital Chang Gung University  Taoyuan Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Chang Gung Memorial Hospital Chang Gung University  Taoyuan Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970","https://openalex.org/I4210116208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100754578","display_name":"Lei Li","orcid":"https://orcid.org/0000-0003-4928-8722","observed_orcids":["https://orcid.org/0000-0003-4928-8722"]},"institutions":[{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Li","raw_affiliation_strings":["Department of Urology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"],"raw_orcid":"https://orcid.org/0000-0003-4928-8722","affiliations":[{"raw_affiliation_string":"Department of Urology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China","institution_ids":["https://openalex.org/I4210121771"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041526616","display_name":"Howard Gurney","orcid":"https://orcid.org/0000-0003-0217-5261","observed_orcids":["https://orcid.org/0000-0003-0217-5261"]},"institutions":[{"id":"https://openalex.org/I99043593","display_name":"Macquarie University","ror":"https://ror.org/01sf06y89","country_code":"AU","type":"education","lineage":["https://openalex.org/I99043593"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Howard Gurney","raw_affiliation_strings":["Macquarie University Hospital  Sydney New South Wales Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Macquarie University Hospital  Sydney New South Wales Australia","institution_ids":["https://openalex.org/I99043593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000156180","display_name":"Gerhardt Attard","orcid":"https://orcid.org/0000-0002-4811-7983","observed_orcids":["https://orcid.org/0000-0002-4811-7983"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gerhardt Attard","raw_affiliation_strings":["Research Department of Oncology University College London  London UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Department of Oncology University College London  London UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005231494","display_name":"Kim N. Chi","orcid":"https://orcid.org/0000-0002-3782-7226","observed_orcids":["https://orcid.org/0000-0002-3782-7226"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kim N. Chi","raw_affiliation_strings":["Department of Medical Oncology University of British Columbia, BC Cancer \u2010 Vancouver Center  Vancouver British Columbia Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology University of British Columbia, BC Cancer \u2010 Vancouver Center  Vancouver British Columbia Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015365593","display_name":"Suneel Dinkar Mundle","orcid":"https://orcid.org/0000-0003-4867-172X","observed_orcids":["https://orcid.org/0000-0003-4867-172X"]},"institutions":[{"id":"https://openalex.org/I1330063522","display_name":"Johnson & Johnson (United States)","ror":"https://ror.org/03qd7mz70","country_code":"US","type":"company","lineage":["https://openalex.org/I1330063522"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suneel Mundle","raw_affiliation_strings":["Johnson & Johnson New Brunswick New Jersey USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson New Brunswick New Jersey USA","institution_ids":["https://openalex.org/I1330063522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037641250","display_name":"Jianmin Zhuo","orcid":"https://orcid.org/0009-0004-6575-6244","observed_orcids":["https://orcid.org/0009-0004-6575-6244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianmin Zhuo","raw_affiliation_strings":["Johnson & Johnson Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson Shanghai China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102682923","display_name":"Anildeep Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102399","display_name":"Johnson & Johnson (Singapore)","ror":"https://ror.org/01cjdx044","country_code":"SG","type":"company","lineage":["https://openalex.org/I4210102399"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Anildeep Singh","raw_affiliation_strings":["Johnson & Johnson Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson Singapore","institution_ids":["https://openalex.org/I4210102399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134223160","display_name":"Yun Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102399","display_name":"Johnson & Johnson (Singapore)","ror":"https://ror.org/01cjdx044","country_code":"SG","type":"company","lineage":["https://openalex.org/I4210102399"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Yun Lin","raw_affiliation_strings":["Johnson & Johnson Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johnson & Johnson Singapore","institution_ids":["https://openalex.org/I4210102399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5134240747","display_name":"Shahneen Sandhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shahneen Sandhu","raw_affiliation_strings":["Division of Cancer Medicine Peter MacCallum Cancer Center and the University of Melbourne  Melbourne Victoria Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cancer Medicine Peter MacCallum Cancer Center and the University of Melbourne  Melbourne Victoria Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I2800555584"]}]}],"institutions":[],"countries_distinct_count":9,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5101763457"],"corresponding_institution_ids":["https://openalex.org/I4210093194"],"apc_list":{"value":3570,"currency":"USD","value_usd":3570},"apc_paid":null,"fwci":4.0361,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.90601469,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"33","issue":"4","first_page":"e70455","last_page":"e70455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5981000065803528,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5981000065803528,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.3937999904155731,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/niraparib","display_name":"niraparib","score":0.9789999723434448},{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.781000018119812},{"id":"https://openalex.org/keywords/parp-inhibitors","display_name":"PARP inhibitors","score":0.718999981880188},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.890999972820282},{"id":"https://openalex.org/keywords/asian-patients","display_name":"Asian patients","score":0.6679999828338623},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.890999972820282},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8080000281333923},{"id":"https://openalex.org/keywords/time-to-psa-progression","display_name":"time to PSA progression","score":0.8240000009536743},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6809999942779541},{"id":"https://openalex.org/keywords/parp-inhibitor-resistance","display_name":"PARP inhibitor resistance","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9178000092506409},{"id":"https://openalex.org/C2775832370","wikidata":"https://www.wikidata.org/wiki/Q27888393","display_name":"Abiraterone acetate","level":5,"score":0.796999990940094},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.7831000089645386},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7210000157356262},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.6553999781608582},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5805000066757202},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.519599974155426},{"id":"https://openalex.org/C2776421732","wikidata":"https://www.wikidata.org/wiki/Q27888393","display_name":"Abiraterone","level":5,"score":0.4749000072479248},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43529999256134033},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4296000003814697},{"id":"https://openalex.org/C142716871","wikidata":"https://www.wikidata.org/wiki/Q408305","display_name":"CYP17A1","level":3,"score":0.3066999912261963},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.29910001158714294},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C64894306","wikidata":"https://www.wikidata.org/wiki/Q849622","display_name":"Homologous chromosome","level":3,"score":0.2904999852180481},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.251800000667572},{"id":"https://openalex.org/C2909513124","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA Damage Repair","level":4,"score":0.250900000333786}],"mesh":[{"descriptor_ui":"D000067856","descriptor_name":"Poly(ADP-ribose) Polymerase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000069501","descriptor_name":"Abiraterone Acetate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000069501","descriptor_name":"Abiraterone Acetate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000069501","descriptor_name":"Abiraterone Acetate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000077982","descriptor_name":"Progression-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001208","descriptor_name":"Asia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D007191","descriptor_name":"Indazoles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D059767","descriptor_name":"Recombinational DNA Repair","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D064129","descriptor_name":"Prostatic Neoplasms, Castration-Resistant","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/iju.70455","doi":"https://doi.org/10.1111/iju.70455","is_oa":false,"landing_page_url":"https://doi.org/10.1111/iju.70455","pdf_url":null,"source":{"id":"https://openalex.org/S134892809","display_name":"International Journal of Urology","issn_l":"0919-8172","issn":["0919-8172","1442-2042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Urology","raw_type":"journal-article"},{"id":"pmid:42015879","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42015879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of urology : official journal of the Japanese Urological Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332194","display_name":"Johnson and Johnson","ror":"https://ror.org/03qd7mz70"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1578291413","https://openalex.org/W2278392405","https://openalex.org/W2601578278","https://openalex.org/W2801878088","https://openalex.org/W2908857416","https://openalex.org/W2951552980","https://openalex.org/W3090483776","https://openalex.org/W3120833111","https://openalex.org/W3216246920","https://openalex.org/W4281289331","https://openalex.org/W4304182933","https://openalex.org/W4311768807","https://openalex.org/W4360608257","https://openalex.org/W4382794886","https://openalex.org/W4387581619","https://openalex.org/W4390430980","https://openalex.org/W4410085374"],"related_works":["https://openalex.org/W4382794886","https://openalex.org/W4379878551","https://openalex.org/W4360608257","https://openalex.org/W4310753925","https://openalex.org/W4212780237","https://openalex.org/W4389280739","https://openalex.org/W4410085374","https://openalex.org/W7156303778","https://openalex.org/W4324136916","https://openalex.org/W4415941989"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Patients":[1],"with":[2,24,51,63,72,120,220,236,246,256,262],"homologous":[3],"recombination":[4],"repair":[5],"gene":[6],"altered":[7],"(HRR+)":[8],"metastatic":[9],"castration-resistant":[10],"prostate":[11],"cancer":[12],"(mCRPC)":[13],"have":[14],"a":[15],"poor":[16],"prognosis":[17],"but":[18],"achieved":[19],"clinical":[20],"benefits":[21,166],"when":[22],"treated":[23],"first-line":[25,244],"niraparib":[26,73,140,247],"and":[27,94,180,200,258],"abiraterone":[28],"acetate":[29],"plus":[30],"prednisone":[31],"(niraparib":[32],"+":[33,65,74,78,122,141,238,248,254],"AAP)":[34],"in":[35,58,108,138,147,170,196,204,250],"the":[36,47,101,109,139,148,197,205,221,232,263],"MAGNITUDE":[37,45],"trial.":[38],"We":[39],"report":[40],"final":[41,228],"exploratory":[42,229],"results":[43],"from":[44,243],"for":[46,100],"subgroup":[48,116],"of":[49,83,129,216,231,273],"patients":[50],"Breast":[52],"Cancer":[53],"gene-positive":[54],"(BRCA+)":[55],"mCRPC":[56,66,123,239],"enrolled":[57],"Asia":[59],"(NCT03748641).":[60],"METHODS:":[61],"Participants":[62],"HRR":[64],"were":[67,98,167],"randomized":[68],"1:1":[69],"to":[70,172,182,241,252],"treatment":[71,245],"AAP":[75,142,249],"or":[76],"placebo":[77,253],"AAP.":[79],"The":[80,114,213],"primary":[81],"endpoint":[82],"radiographic":[84],"progression-free":[85],"survival":[86,96,192],"(rPFS)":[87],"by":[88,133],"blinded":[89],"independent":[90],"central":[91],"review":[92],"(BICR)":[93],"secondary":[95],"endpoints":[97],"calculated":[99],"BRCA+":[102],"Asian":[103,110,115,233],"subgroup.":[104],"Safety":[105],"was":[106,135,193,201,218],"assessed":[107],"HRR+":[111],"population.":[112,224,266],"RESULTS:":[113],"included":[117],"35":[118],"participants":[119,235],"BRCA":[121,237],"(all":[124],"BRCA2+).":[125],"After":[126],"34.99":[127],"months":[128,137,146,203],"follow-up,":[130],"median":[131],"rPFS":[132],"BICR":[134],"38.6":[136],"group":[143,150,199,207],"versus":[144],"8.3":[145],"placebo+AAP":[149,206],"(hazard":[151],"ratio":[152],"[HR]":[153],"0.33,":[154],"95%":[155,177,187,210],"confidence":[156],"interval":[157],"[CI]":[158],"0.13-0.83,":[159],"nominal":[160],"p-value":[161],"=":[162],"0.0141).":[163],"Clinically":[164],"relevant":[165],"also":[168],"observed":[169],"time":[171,181],"PSA":[173],"progression":[174],"(HR":[175,185,208],"0.32,":[176],"CI":[178,188,211],"0.13-0.83),":[179],"cytotoxic":[183],"chemotherapy":[184],"0.098,":[186],"0.01-0.68).":[189],"Median":[190],"overall":[191],"not":[194],"reached":[195],"niraparib+AAP":[198,217],"24.0":[202],"0.67,":[209],"0.27-1.71).":[212],"safety":[214],"profile":[215],"consistent":[219,261],"main":[222],"study":[223,265],"CONCLUSIONS:":[225],"In":[226],"this":[227],"analysis":[230],"subgroup,":[234],"continued":[240],"benefit":[242],"comparison":[251],"AAP,":[255],"efficacy":[257],"toxicity":[259],"profiles":[260],"global":[264],"TRIAL":[267],"REGISTRATION:":[268],"United":[269],"States":[270],"National":[271],"Library":[272],"Medicine":[274],"(https://clinicaltrials.gov);":[275],"NCT03748641.":[276]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-04-23T00:00:00"}
