{"id":"https://openalex.org/W7155168317","doi":"https://doi.org/10.3390/bioengineering13050484","title":"Decellularized Rat Lung Extracellular Matrix as an In Vitro Platform for Canine Yolk Sac\u2013Derived Endothelial Precursor Cells for Pulmonary Endothelium Reconstruction Studies","display_name":"Decellularized Rat Lung Extracellular Matrix as an In Vitro Platform for Canine Yolk Sac\u2013Derived Endothelial Precursor Cells for Pulmonary Endothelium Reconstruction Studies","publication_year":2026,"publication_date":"2026-04-22","ids":{"openalex":"https://openalex.org/W7155168317","doi":"https://doi.org/10.3390/bioengineering13050484","pmid":"https://pubmed.ncbi.nlm.nih.gov/42194241"},"language":"en","primary_location":{"id":"doi:10.3390/bioengineering13050484","doi":"https://doi.org/10.3390/bioengineering13050484","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bioengineering13050484","pdf_url":null,"source":{"id":"https://openalex.org/S4210179121","display_name":"Bioengineering","issn_l":"2306-5354","issn":["2306-5354"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/bioengineering13050484","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031151576","display_name":"Leandro Norberto da Silva-J\u00fanior","orcid":"https://orcid.org/0000-0003-2628-8746","observed_orcids":["https://orcid.org/0000-0003-2628-8746"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Leandro Norberto da Silva-J\u00fanior","raw_affiliation_strings":["Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-2628-8746","affiliations":[{"raw_affiliation_string":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049410743","display_name":"Mar\u00eda Ang\u00e9lica Miglino","orcid":"https://orcid.org/0000-0003-4979-115X","observed_orcids":["https://orcid.org/0000-0003-4979-115X"]},"institutions":[{"id":"https://openalex.org/I4210112693","display_name":"Universidade de Mar\u00edlia","ror":"https://ror.org/01w96sp43","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210112693"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Angelica Miglino","raw_affiliation_strings":["Postgraduate Program in Animal Health, Production and Environment, University of Marilia (UNIMAR), Marilia 17525-902, Brazil","Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marilia 17525-902, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postgraduate Program in Animal Health, Production and Environment, University of Marilia (UNIMAR), Marilia 17525-902, Brazil","institution_ids":["https://openalex.org/I4210112693"]},{"raw_affiliation_string":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marilia 17525-902, Brazil","institution_ids":["https://openalex.org/I4210112693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037728520","display_name":"Bianca de Oliveira Horvath-Pereira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bianca de Oliveira Horvath-Pereira","raw_affiliation_strings":["Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024534161","display_name":"Jo\u00e3o V\u00edctor Barbosa Ten\u00f3rio Fireman","orcid":"https://orcid.org/0000-0003-1329-6587","observed_orcids":["https://orcid.org/0000-0003-1329-6587"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Victor Barbosa Ten\u00f3rio Fireman","raw_affiliation_strings":["Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-1329-6587","affiliations":[{"raw_affiliation_string":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134307591","display_name":"Giovanna Macedo da Siqueira","orcid":"https://orcid.org/0009-0000-3705-6313","observed_orcids":["https://orcid.org/0009-0000-3705-6313"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Giovanna Macedo da Siqueira","raw_affiliation_strings":["Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil"],"raw_orcid":"https://orcid.org/0009-0000-3705-6313","affiliations":[{"raw_affiliation_string":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077587330","display_name":"Maria Laura dos Reis Ferre Pereira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Laura dos Reis Ferre Pereira","raw_affiliation_strings":["Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134276260","display_name":"Let\u00edcia dos Santos Bezerra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Let\u00edcia dos Santos Bezerra","raw_affiliation_strings":["Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134307023","display_name":"Lu\u00eds Vicente Franco de Oliveira","orcid":"https://orcid.org/0000-0002-3852-9415","observed_orcids":["https://orcid.org/0000-0002-3852-9415"]},"institutions":[{"id":"https://openalex.org/I3018035901","display_name":"Universidade Evangelica de Goi\u00e1s","ror":"https://ror.org/02zpkjt27","country_code":"BR","type":"education","lineage":["https://openalex.org/I3018035901"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lu\u00eds Vicente Franco de Oliveira","raw_affiliation_strings":["Laboratory of Pulmonary and Exercise Immunology (LABPEI), Evangelical University of Goi\u00e1s (UniEvang\u00e9lica), An\u00e1polis 75083-515, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-3852-9415","affiliations":[{"raw_affiliation_string":"Laboratory of Pulmonary and Exercise Immunology (LABPEI), Evangelical University of Goi\u00e1s (UniEvang\u00e9lica), An\u00e1polis 75083-515, Brazil","institution_ids":["https://openalex.org/I3018035901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042365202","display_name":"Samuel de Sousa Morais","orcid":"https://orcid.org/0009-0009-7895-2398","observed_orcids":["https://orcid.org/0009-0009-7895-2398"]},"institutions":[{"id":"https://openalex.org/I4405260354","display_name":"Centro Universit\u00e1rio de Adamantina","ror":"https://ror.org/03m5xaf46","country_code":"BR","type":"education","lineage":["https://openalex.org/I4405260354"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Samuel de Sousa Morais","raw_affiliation_strings":["Medical School, University Center of Adamantina (FAI), Adamantina 17800-000, Brazil"],"raw_orcid":"https://orcid.org/0009-0009-7895-2398","affiliations":[{"raw_affiliation_string":"Medical School, University Center of Adamantina (FAI), Adamantina 17800-000, Brazil","institution_ids":["https://openalex.org/I4405260354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012931770","display_name":"M\u00e1rcia Zilioli Bellini","orcid":"https://orcid.org/0000-0002-7933-7938","observed_orcids":["https://orcid.org/0000-0002-7933-7938"]},"institutions":[{"id":"https://openalex.org/I4405260354","display_name":"Centro Universit\u00e1rio de Adamantina","ror":"https://ror.org/03m5xaf46","country_code":"BR","type":"education","lineage":["https://openalex.org/I4405260354"]},{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"M\u00e1rcia Zilioli Bellini","raw_affiliation_strings":["Medical School, University Center of Adamantina (FAI), Adamantina 17800-000, Brazil","Postgraduate Program in Sciences, Biomaterials Area, S\u00e3o Paulo State University (FOA/UNESP), Ara\u00e7atuba 16015-050, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-7933-7938","affiliations":[{"raw_affiliation_string":"Medical School, University Center of Adamantina (FAI), Adamantina 17800-000, Brazil","institution_ids":["https://openalex.org/I4405260354"]},{"raw_affiliation_string":"Postgraduate Program in Sciences, Biomaterials Area, S\u00e3o Paulo State University (FOA/UNESP), Ara\u00e7atuba 16015-050, Brazil","institution_ids":["https://openalex.org/I879563668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056140522","display_name":"Carlos Henrique Bertoni Reis","orcid":"https://orcid.org/0000-0001-9001-6345","observed_orcids":["https://orcid.org/0000-0001-9001-6345"]},"institutions":[{"id":"https://openalex.org/I4210112693","display_name":"Universidade de Mar\u00edlia","ror":"https://ror.org/01w96sp43","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210112693"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Carlos Henrique Bertoni Reis","raw_affiliation_strings":["Beneficent Hospital (HBU), University of Marilia (UNIMAR), Marilia 17525-160, Brazil","Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marilia 17525-902, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-9001-6345","affiliations":[{"raw_affiliation_string":"Beneficent Hospital (HBU), University of Marilia (UNIMAR), Marilia 17525-160, Brazil","institution_ids":["https://openalex.org/I4210112693"]},{"raw_affiliation_string":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marilia 17525-902, Brazil","institution_ids":["https://openalex.org/I4210112693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047090996","display_name":"Rog\u00e9rio Leone Buchaim","orcid":"https://orcid.org/0000-0002-5881-2218","observed_orcids":["https://orcid.org/0000-0002-5881-2218"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rogerio Leone Buchaim","raw_affiliation_strings":["Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, Brazil","Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-5881-2218","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054992596","display_name":"Daniela Vieira Buchaim","orcid":"https://orcid.org/0000-0002-9914-1262","observed_orcids":["https://orcid.org/0000-0002-9914-1262"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405260354","display_name":"Centro Universit\u00e1rio de Adamantina","ror":"https://ror.org/03m5xaf46","country_code":"BR","type":"education","lineage":["https://openalex.org/I4405260354"]},{"id":"https://openalex.org/I879563668","display_name":"Universidade Estadual Paulista (Unesp)","ror":"https://ror.org/00987cb86","country_code":"BR","type":"education","lineage":["https://openalex.org/I879563668"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Daniela Vieira Buchaim","raw_affiliation_strings":["Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil","Medical School, University Center of Adamantina (FAI), Adamantina 17800-000, Brazil","Postgraduate Department, Dentistry School, Faculty of the Midwest Paulista (FACOP), Piratininga 17499-010, Brazil","Postgraduate Program in Clinical Research, Center for Studies of Venoms and Venomous Animals (CEVAP), Faculty of Medicine, S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Anatomy of Domestic and Wild Animals, Faculty of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo (FMVZ/USP), S\u00e3o Paulo 05508-270, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Medical School, University Center of Adamantina (FAI), Adamantina 17800-000, Brazil","institution_ids":["https://openalex.org/I4405260354"]},{"raw_affiliation_string":"Postgraduate Department, Dentistry School, Faculty of the Midwest Paulista (FACOP), Piratininga 17499-010, Brazil","institution_ids":[]},{"raw_affiliation_string":"Postgraduate Program in Clinical Research, Center for Studies of Venoms and Venomous Animals (CEVAP), Faculty of Medicine, S\u00e3o Paulo State University (UNESP), Botucatu 18618-687, Brazil","institution_ids":["https://openalex.org/I879563668"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5054992596"],"corresponding_institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405260354","https://openalex.org/I879563668"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28842647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"5","first_page":"484","last_page":"484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/re-endothelialization","display_name":"re-endothelialization","score":0.9190000295639038},{"id":"https://openalex.org/keywords/canine-cells","display_name":"canine cells","score":0.3959999978542328},{"id":"https://openalex.org/keywords/rat-lung","display_name":"rat lung","score":0.43799999356269836},{"id":"https://openalex.org/keywords/bioreactors","display_name":"bioreactors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/recellularization","display_name":"recellularization","score":0.7300000190734863},{"id":"https://openalex.org/keywords/lung-transplantation","display_name":"lung transplantation","score":0.6629999876022339},{"id":"https://openalex.org/keywords/decellularization-protocols","display_name":"decellularization protocols","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cytocompatibility","display_name":"cytocompatibility","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.9228000044822693},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6292999982833862},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5501999855041504},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.5439000129699707},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5397999882698059},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.489300012588501},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48339998722076416},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.44679999351501465},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43479999899864197},{"id":"https://openalex.org/C2781448352","wikidata":"https://www.wikidata.org/wiki/Q1637912","display_name":"Lung transplantation","level":3,"score":0.4101000130176544},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.39309999346733093},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38659998774528503},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.35530000925064087},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3310000002384186},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.3305000066757202},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.3264999985694885},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.31439998745918274},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.2962000072002411},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.29490000009536743},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.29339998960494995},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.2863999903202057},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.28110000491142273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27219998836517334},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.271699994802475},{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.2660999894142151},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.2587999999523163},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.25679999589920044}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/bioengineering13050484","doi":"https://doi.org/10.3390/bioengineering13050484","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bioengineering13050484","pdf_url":null,"source":{"id":"https://openalex.org/S4210179121","display_name":"Bioengineering","issn_l":"2306-5354","issn":["2306-5354"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering","raw_type":"journal-article"},{"id":"pmid:42194241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42194241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13203212","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42194241/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13203212/pdf/bioengineering-13-00484.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioengineering (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:80e51f2b6ca640bd8f9a661f608072d8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/80e51f2b6ca640bd8f9a661f608072d8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bioengineering, Vol 13, Iss 5, p 484 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/bioengineering13050484","doi":"https://doi.org/10.3390/bioengineering13050484","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bioengineering13050484","pdf_url":null,"source":{"id":"https://openalex.org/S4210179121","display_name":"Bioengineering","issn_l":"2306-5354","issn":["2306-5354"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioengineering","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2094284068","display_name":null,"funder_award_id":"302545/2025\u20135","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G4024461143","display_name":null,"funder_award_id":"88887.509854/2020-00","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G7617671098","display_name":"Optimization of endothelialization in decellularized lung","funder_award_id":"19/24185-6","funder_id":"https://openalex.org/F4320320997","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo"}],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W1974741230","https://openalex.org/W1987602789","https://openalex.org/W1994412421","https://openalex.org/W2018599317","https://openalex.org/W2023167946","https://openalex.org/W2030443193","https://openalex.org/W2038882246","https://openalex.org/W2041180426","https://openalex.org/W2041881239","https://openalex.org/W2045360522","https://openalex.org/W2047611832","https://openalex.org/W2059486645","https://openalex.org/W2061976395","https://openalex.org/W2068102665","https://openalex.org/W2107291281","https://openalex.org/W2123001094","https://openalex.org/W2130806934","https://openalex.org/W2188641538","https://openalex.org/W2220452782","https://openalex.org/W2314454902","https://openalex.org/W2562029537","https://openalex.org/W2573812776","https://openalex.org/W2609961151","https://openalex.org/W2622467784","https://openalex.org/W2736722603","https://openalex.org/W2762682646","https://openalex.org/W2784050294","https://openalex.org/W2792088252","https://openalex.org/W2794644644","https://openalex.org/W2806196907","https://openalex.org/W2808215161","https://openalex.org/W2883313178","https://openalex.org/W2886815959","https://openalex.org/W2897296789","https://openalex.org/W2900990059","https://openalex.org/W2901112013","https://openalex.org/W2903926815","https://openalex.org/W2904211489","https://openalex.org/W2912061295","https://openalex.org/W2918080412","https://openalex.org/W2939266832","https://openalex.org/W2953630665","https://openalex.org/W2962645530","https://openalex.org/W2963725548","https://openalex.org/W2963868917","https://openalex.org/W2989571936","https://openalex.org/W2998455918","https://openalex.org/W3005768133","https://openalex.org/W3007642601","https://openalex.org/W3012560487","https://openalex.org/W3016832953","https://openalex.org/W3022674864","https://openalex.org/W3023967492","https://openalex.org/W3038015165","https://openalex.org/W3045362637","https://openalex.org/W3045665724","https://openalex.org/W3047167594","https://openalex.org/W3095797262","https://openalex.org/W3116072713","https://openalex.org/W3118595066","https://openalex.org/W3128007172","https://openalex.org/W3131544320","https://openalex.org/W3135659056","https://openalex.org/W3142324733","https://openalex.org/W3156653097","https://openalex.org/W3157186884","https://openalex.org/W3158384809","https://openalex.org/W3163400744","https://openalex.org/W3171441467","https://openalex.org/W3175201732","https://openalex.org/W3177365686","https://openalex.org/W3180370092","https://openalex.org/W3183656746","https://openalex.org/W3196101090","https://openalex.org/W3215147066","https://openalex.org/W3215587298","https://openalex.org/W3217781170","https://openalex.org/W4220761888","https://openalex.org/W4280647292","https://openalex.org/W4282921942","https://openalex.org/W4283368353","https://openalex.org/W4285091192","https://openalex.org/W4285392874","https://openalex.org/W4288074822","https://openalex.org/W4289754821","https://openalex.org/W4296015236","https://openalex.org/W4297541631","https://openalex.org/W4307423195","https://openalex.org/W4309459581","https://openalex.org/W4311179688","https://openalex.org/W4312155319","https://openalex.org/W4315779700","https://openalex.org/W4317567855","https://openalex.org/W4318923417","https://openalex.org/W4319722881","https://openalex.org/W4323668406","https://openalex.org/W4327558579","https://openalex.org/W4383698321","https://openalex.org/W4383957391","https://openalex.org/W4384557714","https://openalex.org/W4386788355","https://openalex.org/W4386848412","https://openalex.org/W4387389461","https://openalex.org/W4388131403","https://openalex.org/W4391437061","https://openalex.org/W4392242220","https://openalex.org/W4394758519","https://openalex.org/W4396863511","https://openalex.org/W4400941241","https://openalex.org/W4401705169","https://openalex.org/W4402630388","https://openalex.org/W4402642278","https://openalex.org/W4402751989","https://openalex.org/W4409120824"],"related_works":[],"abstract_inverted_index":{"Pulmonary":[0],"bioengineering":[1],"holds":[2],"significant":[3],"promise":[4],"for":[5,12,47,94,185,229],"the":[6,33,38,109,112,128,149,161,172,177,186,195,214,224],"development":[7],"of":[8,36,111,127,163,213,226],"functional":[9],"lungs":[10,46,78],"suitable":[11],"transplantation":[13],"in":[14,105,155,167,192,223],"patients":[15],"with":[16,68,96,122,194],"terminal":[17],"lung":[18],"diseases;":[19],"however,":[20],"it":[21],"encounters":[22],"considerable":[23],"challenges.":[24],"The":[25,145],"inherent":[26],"structural":[27],"complexity,":[28],"diverse":[29],"cellular":[30,205],"composition,":[31],"and":[32,91,100,141,208],"intricate":[34],"process":[35,129],"re-endothelialization":[37,56,187],"pulmonary":[39,230],"vasculature":[40],"complicate":[41],"efforts":[42],"to":[43,52,81,160,171],"reconstruct":[44],"viable":[45],"transplantation.":[48,231],"This":[49],"study":[50],"aimed":[51],"establish":[53],"an":[54],"innovative":[55],"technique":[57],"utilizing":[58],"decellularized":[59],"scaffolds,":[60],"integrating":[61],"canine":[62],"yolk":[63,101],"sac-derived":[64],"endothelial":[65],"precursor":[66],"cells":[67,104,182,202],"mechanical":[69,119],"respiratory":[70,120,199],"stimuli":[71],"within":[72],"a":[73,82,156,220],"bioreactor":[74,196],"framework.":[75],"Wistar":[76],"rat":[77],"were":[79],"subjected":[80,170],"decellularization":[83,152],"protocol":[84,153],"employing":[85],"SDS":[86],"+":[87],"Triton":[88],"X-100":[89],"0.5%":[90],"subsequently":[92],"assessed":[93],"cytocompatibility":[95],"murine":[97],"fibroblasts":[98],"(3T3)":[99],"sac":[102],"(YS)":[103],"fragments.":[106,168],"Following":[107],"this,":[108],"recellularization":[110,175,212],"whole-lung":[113],"scaffold":[114,158,174],"was":[115,130],"evaluated":[116],"under":[117],"constant":[118],"stimulation":[121],"YS":[123,181],"cells.":[124],"Each":[125],"stage":[126],"rigorously":[131],"analyzed":[132],"using":[133],"histological":[134],"staining,":[135],"DAPI,":[136],"scanning":[137],"electron":[138],"microscopy":[139],"(SEM),":[140],"genomic":[142],"DNA":[143],"quantification.":[144],"findings":[146],"reveal":[147],"that":[148,180],"implemented":[150],"alternating":[151],"resulted":[154],"structured":[157],"conducive":[159],"culture":[162],"various":[164],"cell":[165],"types":[166],"When":[169],"complete":[173],"model,":[176],"results":[178,218],"indicated":[179],"are":[183],"advantageous":[184],"process.":[188],"Moreover,":[189],"when":[190],"employed":[191],"conjunction":[193],"model":[197],"incorporating":[198],"stimulation,":[200],"these":[201],"demonstrated":[203],"enhanced":[204],"diffusion":[206],"capacity":[207],"facilitated":[209],"more":[210],"homogeneous":[211],"entire":[215],"organ.":[216],"These":[217],"signify":[219],"notable":[221],"advancement":[222],"reconstruction":[225],"new":[227],"tissues":[228]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2026-04-23T00:00:00"}