{"id":"https://openalex.org/W7155013239","doi":"https://doi.org/10.21203/rs.3.rs-9391601/v1","title":"Retrospective Analysis Of The Combined Effects Of Vitamin E And Pentoxifylline In Post- Radiation Recovery Of Head And Neck Cancer Patients At Tertiary Care Center, Anand","display_name":"Retrospective Analysis Of The Combined Effects Of Vitamin E And Pentoxifylline In Post- Radiation Recovery Of Head And Neck Cancer Patients At Tertiary Care Center, Anand","publication_year":2026,"publication_date":"2026-04-20","ids":{"openalex":"https://openalex.org/W7155013239","doi":"https://doi.org/10.21203/rs.3.rs-9391601/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-9391601/v1","doi":"https://doi.org/10.21203/rs.3.rs-9391601/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9391601/v1","pdf_url":"https://www.researchsquare.com/article/rs-9391601/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-9391601/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077034198","display_name":"Vishal A Patel","orcid":"https://orcid.org/0000-0002-6740-6764","observed_orcids":["https://orcid.org/0000-0002-6740-6764"]},"institutions":[{"id":"https://openalex.org/I4210109742","display_name":"Shree Krishna Hospital","ror":"https://ror.org/01drdtp87","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210109742"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vishal A. Patel","raw_affiliation_strings":["Shree Krishna Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shree Krishna Hospital","institution_ids":["https://openalex.org/I4210109742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103028297","display_name":"Sohilkhan Riyazkhan Pathan","orcid":"https://orcid.org/0000-0002-5381-9621","observed_orcids":["https://orcid.org/0000-0002-5381-9621"]},"institutions":[{"id":"https://openalex.org/I4210109742","display_name":"Shree Krishna Hospital","ror":"https://ror.org/01drdtp87","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210109742"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sohilkhan R. Pathan","raw_affiliation_strings":["Shree Krishna Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shree Krishna Hospital","institution_ids":["https://openalex.org/I4210109742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072787912","display_name":"Nirav N Asarawala","orcid":"https://orcid.org/0009-0003-3755-0225","observed_orcids":["https://orcid.org/0009-0003-3755-0225"]},"institutions":[{"id":"https://openalex.org/I4210109742","display_name":"Shree Krishna Hospital","ror":"https://ror.org/01drdtp87","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210109742"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nirav Asarawala","raw_affiliation_strings":["Shree Krishna Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shree Krishna Hospital","institution_ids":["https://openalex.org/I4210109742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008391978","display_name":"Kruti B Sharma","orcid":"https://orcid.org/0000-0002-1461-2978","observed_orcids":["https://orcid.org/0000-0002-1461-2978"]},"institutions":[{"id":"https://openalex.org/I4210109742","display_name":"Shree Krishna Hospital","ror":"https://ror.org/01drdtp87","country_code":"IN","type":"healthcare","lineage":["https://openalex.org/I4210109742"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kruti B. Sharma","raw_affiliation_strings":["Shree Krishna Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shree Krishna Hospital","institution_ids":["https://openalex.org/I4210109742"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5133233212","display_name":"Harshit Prashant Desai","orcid":"https://orcid.org/0009-0003-3627-1224","observed_orcids":["https://orcid.org/0009-0003-3627-1224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harshit Prashant Desai","raw_affiliation_strings":["Anand Pharmacy College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anand Pharmacy College","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.7056000232696533,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment","score":0.7056000232696533,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.13670000433921814,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.10989999771118164,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.8690000176429749},{"id":"https://openalex.org/keywords/pentoxifylline","display_name":"pentoxifylline","score":1.0},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9110000133514404},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.7269999980926514},{"id":"https://openalex.org/keywords/radiation-induced-complications","display_name":"radiation complications","score":0.7059999704360962},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9399999976158142},{"id":"https://openalex.org/keywords/xerostomia","display_name":"xerostomia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.7850000262260437},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.4320000112056732},{"id":"https://openalex.org/keywords/radiation-dose","display_name":"radiation dose","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9700000286102295},{"id":"https://openalex.org/C2780404050","wikidata":"https://www.wikidata.org/wiki/Q416331","display_name":"Pentoxifylline","level":2,"score":0.7092000246047974},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.6949999928474426},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.6259999871253967},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5975000262260437},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5547999739646912},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5509999990463257},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46950000524520874},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.4666999876499176},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.4320000112056732},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4219000041484833},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.38260000944137573},{"id":"https://openalex.org/C2780037786","wikidata":"https://www.wikidata.org/wiki/Q3357479","display_name":"Osteoradionecrosis","level":3,"score":0.3450999855995178},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34119999408721924},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.33899998664855957},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.3192000091075897},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.30300000309944153},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.2563000023365021},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.25429999828338623}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-9391601/v1","doi":"https://doi.org/10.21203/rs.3.rs-9391601/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9391601/v1","pdf_url":"https://www.researchsquare.com/article/rs-9391601/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-9391601/v1","doi":"https://doi.org/10.21203/rs.3.rs-9391601/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-9391601/v1","pdf_url":"https://www.researchsquare.com/article/rs-9391601/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7155013239.pdf","grobid_xml":"https://content.openalex.org/works/W7155013239.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1484334610","https://openalex.org/W1870202012","https://openalex.org/W1968015048","https://openalex.org/W1975546762","https://openalex.org/W1996698690","https://openalex.org/W2010908868","https://openalex.org/W2015116686","https://openalex.org/W2016081624","https://openalex.org/W2017032626","https://openalex.org/W2028262552","https://openalex.org/W2037682211","https://openalex.org/W2054951424","https://openalex.org/W2086484602","https://openalex.org/W2108868516","https://openalex.org/W2123393844","https://openalex.org/W2136772857","https://openalex.org/W2137048483","https://openalex.org/W2473786944","https://openalex.org/W2565571317","https://openalex.org/W2771789368","https://openalex.org/W2990156858","https://openalex.org/W2997271239"],"related_works":["https://openalex.org/W4411481789","https://openalex.org/W2046698320","https://openalex.org/W2017032626","https://openalex.org/W2982921825","https://openalex.org/W2105238477","https://openalex.org/W2061582569","https://openalex.org/W2046884630","https://openalex.org/W2799766530","https://openalex.org/W4297330276","https://openalex.org/W2003330736"],"abstract_inverted_index":{"Abstract":[0],"Introduction":[1],"Radiation":[2,224],"therapy":[3],"is":[4,293],"a":[5,109,117,208,246,285],"cornerstone":[6],"of":[7,26,48,71,255],"cancer":[8,61,102,125,158,273,314],"treatment,":[9],"but":[10],"its":[11,276],"side":[12,85,141,212,280],"effects,":[13,213],"including":[14],"pain,":[15,78],"delayed":[16],"wound":[17,55,80,136,268],"healing,":[18,56,81,269],"and":[19,29,57,73,82,93,113,116,127,139,145,174,188,198,243,257,266,302],"radiation-induced":[20,84,211,279],"complications,":[21],"significantly":[22,161],"impact":[23,277],"patients'":[24],"quality":[25],"life.":[27],"Pentoxifylline":[28,72,256],"Vitamin":[30,74,114,258],"E":[31,75,259],"have":[32],"been":[33],"suggested":[34],"as":[35],"adjunct":[36],"therapies":[37],"to":[38,67,166,237,261,295,309],"mitigate":[39],"these":[40,49,307],"adverse":[41],"effects.":[42],"This":[43,64,95],"study":[44,65,97],"evaluates":[45],"the":[46,69,151,202,231,304],"efficacy":[47],"agents":[50],"in":[51,60,76,87,150,156,184,210,218,230,271,313],"improving":[52],"pain":[53,134,163,264],"scores,":[54,135],"radiation-related":[58,140],"complications":[59],"patients.":[62],"Aim":[63],"aims":[66],"assess":[68],"effectiveness":[70],"reducing":[77],"enhancing":[79],"minimizing":[83],"effects":[86,142,281,308],"patients":[88,103,229,315],"undergoing":[89,316],"radiation":[90,105,132,240,317],"therapy.":[91,318],"Materials":[92],"Methods":[94],"retrospective":[96],"analyzed":[98],"clinical":[99],"data":[100],"from":[101],"receiving":[104],"therapy,":[106],"divided":[107],"into":[108],"treatment":[110,128,152,203,232,250,297],"group":[111,204,233],"(Pentoxifylline":[112],"E)":[115],"control":[118],"group.":[119],"Patients":[120,149],"were":[121,143,234],"categorized":[122],"based":[123],"on":[124,131,278],"stage":[126],"regimens.":[129],"Data":[130],"dosage,":[133],"healing":[137,180],"rates,":[138],"collected":[144],"statistically":[146,191],"analyzed.":[147],"Results":[148],"group,":[153],"particularly":[154,270],"those":[155],"advanced":[157,272],"stages,":[159],"experienced":[160],"lower":[162],"scores":[164],"compared":[165],"controls":[167],"(p-values":[168],"<":[169],"0.0001":[170],"for":[171,176],"Stage":[172,177],"2":[173],"0.0004":[175],"4).":[178],"Wound":[179],"was":[181],"notably":[182],"faster":[183],"Stages":[185],"2,":[186],"3,":[187],"4,":[189],"with":[190,214,284,288],"significant":[192,263],"improvements":[193],"(p":[194,221],"=":[195,222],"0.01,":[196],"0.03,":[197],"0.05,":[199],"respectively).":[200],"However,":[201,275],"did":[205],"not":[206],"show":[207],"reduction":[209],"an":[215],"unexpected":[216],"increase":[217],"xerostomia":[219],"cases":[220],"0.0026).":[223],"dose":[225],"analysis":[226],"revealed":[227],"that":[228],"more":[235,248],"likely":[236],"receive":[238],"higher":[239],"doses":[241],"(66Gy/33#":[242],"70Gy/33#),":[244],"suggesting":[245],"potentially":[247],"aggressive":[249],"approach.":[251],"Conclusion":[252],"The":[253],"combination":[254],"appears":[260],"provide":[262],"relief":[265],"improved":[267],"stages.":[274],"remains":[282],"unclear,":[283],"potential":[286],"association":[287],"increased":[289],"xerostomia.":[290],"Further":[291],"research":[292],"required":[294],"optimize":[296],"protocols,":[298],"refine":[299],"dosage":[300],"strategies,":[301],"explore":[303],"mechanisms":[305],"underlying":[306],"improve":[310],"supportive":[311],"care":[312]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-04-21T00:00:00"}
