{"id":"https://openalex.org/W7154995342","doi":"https://doi.org/10.1136/bmjopen-2026-118509","title":"Linezolid in addition to standard antibiotic treatment for Staphylococcus aureus bacteraemia: study protocol for a randomised, placebo-controlled trial","display_name":"Linezolid in addition to standard antibiotic treatment for Staphylococcus aureus bacteraemia: study protocol for a randomised, placebo-controlled trial","publication_year":2026,"publication_date":"2026-04-01","ids":{"openalex":"https://openalex.org/W7154995342","doi":"https://doi.org/10.1136/bmjopen-2026-118509","pmid":"https://pubmed.ncbi.nlm.nih.gov/42009378","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13110666"},"language":"en","primary_location":{"id":"doi:10.1136/bmjopen-2026-118509","doi":"https://doi.org/10.1136/bmjopen-2026-118509","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2026-118509","pdf_url":null,"source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1136/bmjopen-2026-118509","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090410012","display_name":"Natalie Rose","orcid":"https://orcid.org/0000-0001-5102-4385","observed_orcids":["https://orcid.org/0000-0001-5102-4385"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Natalie Rose","raw_affiliation_strings":["Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland","Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-5102-4385","affiliations":[{"raw_affiliation_string":"Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056868595","display_name":"Nadine Saskia Bernasconi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nadine S Bernasconi","raw_affiliation_strings":["Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038969384","display_name":"Michaela Schumacher","orcid":"https://orcid.org/0009-0007-6572-0825","observed_orcids":["https://orcid.org/0009-0007-6572-0825"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michaela Schumacher","raw_affiliation_strings":["Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069046577","display_name":"Laura Werlen","orcid":"https://orcid.org/0000-0001-5042-8353","observed_orcids":["https://orcid.org/0000-0001-5042-8353"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Laura Werlen","raw_affiliation_strings":["Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055811523","display_name":"David B\u00fcchel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"David B\u00fcchel","raw_affiliation_strings":["Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072427468","display_name":"Maja Weisser","orcid":"https://orcid.org/0000-0002-0134-1929","observed_orcids":["https://orcid.org/0000-0002-0134-1929"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Maja Weisser","raw_affiliation_strings":["Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091569561","display_name":"Severin B. Vogt","orcid":"https://orcid.org/0009-0007-3650-3549","observed_orcids":["https://orcid.org/0009-0007-3650-3549"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Severin B Vogt","raw_affiliation_strings":["Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland","Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]},{"raw_affiliation_string":"Division of Clinical Pharmacology and Toxicology, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020914898","display_name":"Elisabeth Wehrle\u2010Wieland","orcid":"https://orcid.org/0000-0003-4769-636X","observed_orcids":["https://orcid.org/0000-0003-4769-636X"]},"institutions":[{"id":"https://openalex.org/I4210135747","display_name":"St. Claraspital","ror":"https://ror.org/04ahnxd67","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210135747"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Elisabeth Wehrle-Wieland","raw_affiliation_strings":["Division of Infectious Diseases, Claraspital Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4769-636X","affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Claraspital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I4210135747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003985003","display_name":"Anna Conen","orcid":"https://orcid.org/0000-0002-5216-4109","observed_orcids":["https://orcid.org/0000-0002-5216-4109"]},"institutions":[{"id":"https://openalex.org/I4210161075","display_name":"Kantonsspital Aarau","ror":"https://ror.org/056tb3809","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210161075"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Anna Conen","raw_affiliation_strings":["Department of Infectious Diseases and Infection Prevention, Cantonal Hospital Aarau, Aarau, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Infection Prevention, Cantonal Hospital Aarau, Aarau, Switzerland","institution_ids":["https://openalex.org/I4210161075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041740623","display_name":"Maria Christine Thurnheer","orcid":"https://orcid.org/0000-0003-1357-0347","observed_orcids":["https://orcid.org/0000-0003-1357-0347"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Maria C Thurnheer","raw_affiliation_strings":["Department of Infectious Diseases, University Hospital Inselspital and University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University Hospital Inselspital and University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083317336","display_name":"Yonas Martin","orcid":"https://orcid.org/0009-0005-7245-9042","observed_orcids":["https://orcid.org/0009-0005-7245-9042"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Yonas Martin","raw_affiliation_strings":["Department of Infectious Diseases, University Hospital Inselspital and University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, University Hospital Inselspital and University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061468742","display_name":"Mich\u00e8le Birrer","orcid":"https://orcid.org/0000-0002-7203-482X","observed_orcids":["https://orcid.org/0000-0002-7203-482X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mich\u00e8le Birrer","raw_affiliation_strings":["Department of General Internal Medicine / Infectious Diseases, H\u00f4pital du Jura, Del\u00e9mont, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Internal Medicine / Infectious Diseases, H\u00f4pital du Jura, Del\u00e9mont, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044411998","display_name":"Marco Bongiovanni","orcid":"https://orcid.org/0000-0003-2999-3707","observed_orcids":["https://orcid.org/0000-0003-2999-3707"]},"institutions":[{"id":"https://openalex.org/I4210095212","display_name":"Ente Ospedaliero Cantonale","ror":"https://ror.org/00sh19a92","country_code":"CH","type":"other","lineage":["https://openalex.org/I4210095212"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marco Bongiovanni","raw_affiliation_strings":["Division of Infectious Diseases, Ente Ospedaliero Cantonale, Lugano, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-2999-3707","affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Ente Ospedaliero Cantonale, Lugano, Switzerland","institution_ids":["https://openalex.org/I4210095212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002998900","display_name":"Werner C. Albrich","orcid":"https://orcid.org/0000-0003-0607-7159","observed_orcids":["https://orcid.org/0000-0003-0607-7159"]},"institutions":[{"id":"https://openalex.org/I2799884508","display_name":"Kantonsspital St. Gallen","ror":"https://ror.org/00gpmb873","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2799884508"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Werner C Albrich","raw_affiliation_strings":["Division of Infectious Diseases, Infection Prevention and Travel Medicine, HOCH Health Ostschweiz, Cantonal Hospital St. Gallen, St. Gallen, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Infection Prevention and Travel Medicine, HOCH Health Ostschweiz, Cantonal Hospital St. Gallen, St. Gallen, Switzerland","institution_ids":["https://openalex.org/I2799884508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109863719","display_name":"Urs Karrer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099681","display_name":"Kantonsspital Winterthur","ror":"https://ror.org/014gb2s11","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210099681"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Urs Karrer","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, Cantonal Hospital Winterthur, Winterthur, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Cantonal Hospital Winterthur, Winterthur, Switzerland","institution_ids":["https://openalex.org/I4210099681"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027623183","display_name":"Adrian Schibli","orcid":"https://orcid.org/0009-0009-5170-0254","observed_orcids":["https://orcid.org/0009-0009-5170-0254"]},"institutions":[{"id":"https://openalex.org/I4405256532","display_name":"Stadtspital Z\u00fcrich","ror":"https://ror.org/04933pe04","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4405256532"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Adrian Schibli","raw_affiliation_strings":["Division of Infectious Diseases and Infection Prevention, Stadtspital Z\u00fcrich, Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0009-0009-5170-0254","affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases and Infection Prevention, Stadtspital Z\u00fcrich, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I4405256532"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111777312","display_name":"St\u00e9phan Harbarth","orcid":"https://orcid.org/0000-0002-3551-1025","observed_orcids":["https://orcid.org/0000-0002-3551-1025"]},"institutions":[{"id":"https://openalex.org/I4210105654","display_name":"World Health Organization","ror":"https://ror.org/01f80g185","country_code":"CH","type":"government","lineage":["https://openalex.org/I4210105654"]},{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stephan Harbarth","raw_affiliation_strings":["Infection Control Program and World Health Organization Collaborating Centre, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Control Program and World Health Organization Collaborating Centre, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland","institution_ids":["https://openalex.org/I4210105654","https://openalex.org/I4210106256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046834405","display_name":"Matthaios Papadimitriou\u2010Olivgeris","orcid":"https://orcid.org/0000-0003-0565-5105","observed_orcids":["https://orcid.org/0000-0003-0565-5105"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthaios Papadimitriou-Olivgeris","raw_affiliation_strings":["Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019888759","display_name":"Matthias Briel","orcid":"https://orcid.org/0000-0002-2070-5230","observed_orcids":["https://orcid.org/0000-0002-2070-5230"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthias Briel","raw_affiliation_strings":["CLEAR-Methods Center, Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-2070-5230","affiliations":[{"raw_affiliation_string":"CLEAR-Methods Center, Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045122423","display_name":"Barbara Katharina Hasse","orcid":"https://orcid.org/0000-0001-7196-3734","observed_orcids":["https://orcid.org/0000-0001-7196-3734"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Barbara Hasse","raw_affiliation_strings":["Department of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Zurich, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases and Hospital Epidemiology, University Hospital and University of Zurich, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065892521","display_name":"Nina Khanna","orcid":"https://orcid.org/0000-0002-2642-419X","observed_orcids":["https://orcid.org/0000-0002-2642-419X"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nina Khanna","raw_affiliation_strings":["Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036284138","display_name":"Richard K\u00fcehl","orcid":"https://orcid.org/0000-0002-4959-0983","observed_orcids":["https://orcid.org/0000-0002-4959-0983"]},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Richard Kuehl","raw_affiliation_strings":["Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, University Hospital Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027799494","display_name":"Benjamin Speich","orcid":"https://orcid.org/0000-0002-3301-8085","observed_orcids":["https://orcid.org/0000-0002-3301-8085"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]},{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Benjamin Speich","raw_affiliation_strings":["CLEAR-Methods Center, Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-3301-8085","affiliations":[{"raw_affiliation_string":"CLEAR-Methods Center, Division of Clinical Epidemiology, Department of Clinical Research, University Hospital Basel and University of Basel, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5027799494"],"corresponding_institution_ids":["https://openalex.org/I1850255","https://openalex.org/I2802542264"],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":3.6237,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.85575764,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"16","issue":"4","first_page":"e118509","last_page":"e118509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linezolid","display_name":"linezolid","score":0.9150000214576721},{"id":"https://openalex.org/keywords/staphylococcus-aureus-bacteremia","display_name":"Staphylococcus aureus bacteremia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/adjunctive-antibiotic-therapy","display_name":"adjunctive antibiotic therapy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/desirability-of-outcome-ranking","display_name":"desirability of outcome ranking","score":0.8429999947547913},{"id":"https://openalex.org/keywords/win-ratio","display_name":"win ratio","score":0.9359999895095825},{"id":"https://openalex.org/keywords/patient-important-outcomes","display_name":"patient-relevant outcomes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.6809999942779541},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6029999852180481},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.6100000143051147},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.4699999988079071},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.48100000619888306},{"id":"https://openalex.org/keywords/sample-size-calculation","display_name":"sample size determination","score":0.46700000762939453},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.3720000088214874},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9785000085830688},{"id":"https://openalex.org/C2781414143","wikidata":"https://www.wikidata.org/wiki/Q411377","display_name":"Linezolid","level":5,"score":0.8452000021934509},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.5989000201225281},{"id":"https://openalex.org/C2779443120","wikidata":"https://www.wikidata.org/wiki/Q650912","display_name":"Bacteremia","level":3,"score":0.5260999798774719},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.4918999969959259},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4918999969959259},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48260000348091125},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4372999966144562},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.42179998755455017},{"id":"https://openalex.org/C2993769353","wikidata":"https://www.wikidata.org/wiki/Q7598360","display_name":"Standard of care","level":2,"score":0.4101000130176544},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.34599998593330383},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.34040001034736633},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.3244999945163727},{"id":"https://openalex.org/C2779473907","wikidata":"https://www.wikidata.org/wiki/Q886695","display_name":"Blood culture","level":3,"score":0.314300000667572},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3028999865055084},{"id":"https://openalex.org/C202953159","wikidata":"https://www.wikidata.org/wiki/Q382695","display_name":"Intention-to-treat analysis","level":3,"score":0.28929999470710754},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.2858000099658966},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.2842000126838684},{"id":"https://openalex.org/C3018162438","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Adjunctive treatment","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.2694000005722046},{"id":"https://openalex.org/C2777184939","wikidata":"https://www.wikidata.org/wiki/Q7920253","display_name":"Ventilator-associated pneumonia","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.26159998774528503},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.25290000438690186},{"id":"https://openalex.org/C2776345407","wikidata":"https://www.wikidata.org/wiki/Q3776920","display_name":"Bacterial pneumonia","level":3,"score":0.25220000743865967},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.25029999017715454}],"mesh":[{"descriptor_ui":"D000069349","descriptor_name":"Linezolid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000069349","descriptor_name":"Linezolid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013203","descriptor_name":"Staphylococcal Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013557","descriptor_name":"Switzerland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016470","descriptor_name":"Bacteremia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1136/bmjopen-2026-118509","doi":"https://doi.org/10.1136/bmjopen-2026-118509","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2026-118509","pdf_url":null,"source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13110666","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13110666/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13110666/pdf/bmjopen-16-4.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"Text"},{"id":"pmid:42009378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42009378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:aou:unige:195714","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:195714","pdf_url":"https://access.archive-ouverte.unige.ch/access/metadata/0b5432bc-2c6d-4bb2-8f64-dc909ef0427b/download","source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ open, vol. 16, no. 4 (2026) e118509","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:f447b4c480624c45a863f8fb78bc40b3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f447b4c480624c45a863f8fb78bc40b3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ Open, Vol 16, Iss 4 (2026)","raw_type":"article"},{"id":"pmh:oai:iris.unil.ch:iris/281592","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/281592","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"review article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/248224","doi":null,"is_oa":true,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/248224","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rose, N., Bernasconi, N. S., Schumacher, M., Werlen, L., B\u00fcchel, D., Weisser, M., Vogt, S. B., Wehrle-Wieland, E., Conen, A., Thurnheer, M. C., Martin, Y., Birrer, M., Bongiovanni, M., Albrich, W. C., Karrer, U., Schibli, A., Harbarth, S., Papadimitriou-Olivgeris, M., Briel, M., \u2026 Speich, B. (2026). Linezolid in addition to standard antibiotic treatment for bacteraemia: study protocol for a randomised, placebo-controlled trial. BMJ Open, 16, e118509. https://doi.org/10.1136/bmjopen-2026-118509","raw_type":"Journal Article"},{"id":"doi:10.48620/97171","doi":"https://doi.org/10.48620/97171","is_oa":true,"landing_page_url":"https://doi.org/10.48620/97171","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1136/bmjopen-2026-118509","doi":"https://doi.org/10.1136/bmjopen-2026-118509","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2026-118509","pdf_url":null,"source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[{"id":"https://openalex.org/G6195871157","display_name":"Combination antibiotic treatment with linezolid for Staphylococcus aureus bacteraemia: a randomised controlled trial","funder_award_id":"221668","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G7055605064","display_name":"Epstein-Barr Virus-specific T Memory Stem Cell Therapy to Treat EBV-driven Lymphomas/Diseases","funder_award_id":"204944","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G8930325261","display_name":null,"funder_award_id":"180541","funder_id":"https://openalex.org/F4320318378","funder_display_name":"National Center of Competence in Research AntiResist"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320316261","display_name":"Universit\u00e4tsspital Basel","ror":"https://ror.org/04k51q396"},{"id":"https://openalex.org/F4320318378","display_name":"National Center of Competence in Research AntiResist","ror":null},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7154995342.pdf","grobid_xml":"https://content.openalex.org/works/W7154995342.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1561537332","https://openalex.org/W2038554762","https://openalex.org/W2074503728","https://openalex.org/W2105084079","https://openalex.org/W2108719432","https://openalex.org/W2116814997","https://openalex.org/W2122120354","https://openalex.org/W2127585723","https://openalex.org/W2136609531","https://openalex.org/W2142015145","https://openalex.org/W2215751437","https://openalex.org/W2560710930","https://openalex.org/W2736496254","https://openalex.org/W2890344481","https://openalex.org/W2891181302","https://openalex.org/W2896665945","https://openalex.org/W2941040405","https://openalex.org/W2948089944","https://openalex.org/W2952452550","https://openalex.org/W2981376284","https://openalex.org/W3005955238","https://openalex.org/W3011668159","https://openalex.org/W3027529392","https://openalex.org/W3047242974","https://openalex.org/W3126519621","https://openalex.org/W3134906591","https://openalex.org/W3198130468","https://openalex.org/W3202908281","https://openalex.org/W3210011810","https://openalex.org/W4214754383","https://openalex.org/W4221049296","https://openalex.org/W4281672245","https://openalex.org/W4282827653","https://openalex.org/W4283120909","https://openalex.org/W4283121599","https://openalex.org/W4309503005","https://openalex.org/W4310398802","https://openalex.org/W4318262992","https://openalex.org/W4318960299","https://openalex.org/W4376130123","https://openalex.org/W4379193892","https://openalex.org/W4387077543","https://openalex.org/W4389386984","https://openalex.org/W4409230997","https://openalex.org/W4411258775","https://openalex.org/W4412045966"],"related_works":["https://openalex.org/W7167604257","https://openalex.org/W2045768636","https://openalex.org/W7098352076","https://openalex.org/W7133080982","https://openalex.org/W7023697236","https://openalex.org/W2898562381","https://openalex.org/W2137275237","https://openalex.org/W2170814318","https://openalex.org/W2170146384","https://openalex.org/W2737817887"],"abstract_inverted_index":{"Introduction":[0],"Staphylococcus":[1],"aureus":[2,5,54,81,129,209,244],"(":[3],"S.":[4,53,80,128,208,243],")":[6],"bacteraemia":[7,82,130,210],"is":[8],"a":[9,25,35,97,191,279,292,303,362,366],"common":[10],"and":[11,20,40,61,92,119,165,252,256,310,322,341,382,409],"severe":[12],"infection.":[13],"With":[14],"mortality":[15],"rates":[16],"ranging":[17],"from":[18,229,316],"20\u201330%":[19],"long-term":[21],"impairments":[22],"in":[23,47,77,88,109,112,286,370,406,410],"over":[24],"third":[26],"of":[27,72,107,149,151,202,240,260,296,307,386],"survivors,":[28],"better":[29,280],"treatments":[30],"are":[31],"urgently":[32],"needed.":[33],"Linezolid,":[34],"well-established":[36],"treatment":[37,139,250],"for":[38,180,207,320,343],"pneumonia":[39],"complicated":[41],"skin":[42],"infections,":[43],"has":[44],"been":[45],"shown":[46],"preclinical":[48],"studies":[49],"to":[50,58,67,74,84,168,231,238,249,267,284,349,354],"strongly":[51],"suppress":[52],"virulence":[55],"factors":[56],"critical":[57],"bacterial":[59],"persistence":[60],"tissue":[62],"damage.":[63],"Hence,":[64],"we":[65,189,197],"aim":[66],"investigate":[68],"whether":[69,274],"the":[70,143,152,156,200,212,224,269,287,317,334,337,371,379,383,387],"addition":[71],"linezolid":[73,172,277],"standard":[75,137],"therapy":[76],"patients":[78,118,123,161,275,285,298,329,352],"with":[79,114,127],"leads":[83],"an":[85,358],"overall":[86],"improvement":[87],"patient-relevant":[89,187],"outcomes.":[90],"Methods":[91],"analysis":[93],"We":[94,290],"will":[95,131,135,162,198,264,330,393,403],"conduct":[96],"two-arm,":[98],"parallel-group,":[99],"multicentre,":[100],"randomised":[101,166],"controlled":[102],"trial":[103],"(Linezolid":[104],"Plus":[105],"Standard":[106],"Care)":[108],"12":[110],"hospitals":[111],"Switzerland":[113,324],"blinded":[115],"treating":[116,144],"physicians,":[117],"outcome":[120,203,214,222],"assessors.":[121],"Hospitalised":[122],"aged":[124],"\u226518":[125],"years":[126],"be":[132,163,331,394,404],"eligible.":[133],"Patients":[134],"receive":[136,169],"antibiotic":[138],"as":[140,211,396,398],"prescribed":[141],"by":[142,336],"physician.":[145],"Within":[146],"72":[147],"hours":[148],"collection":[150],"blood":[153,159],"sample":[154,294],"yielding":[155],"first":[157],"positive":[158],"culture,":[160],"enrolled":[164],"1:1":[167],"either":[170],"adjunctive":[171],"(600":[173],"mg":[174],"orally":[175],"two":[176],"times":[177],"per":[178],"day":[179],"5":[181],"days)":[182],"or":[183,365],"placebo.":[184],"To":[185],"determine":[186],"outcomes,":[188],"implemented":[190],"comprehensive":[192],"patient-representative":[193],"consultation":[194],"process.":[195],"Consequently,":[196],"use":[199],"desirability":[201],"ranking":[204],"(DOOR)":[205],"established":[206],"primary":[213],"at":[215,302],"90":[216],"days.":[217],"The":[218,389],"hierarchical":[219],"composite":[220],"DOOR":[221,281],"includes":[223],"following":[225],"four":[226],"components,":[227],"ranked":[228],"most":[230],"least":[232],"important:":[233],"(1)":[234],"survival,":[235],"(2)":[236],"return":[237],"level":[239,306],"function":[241],"before":[242],"infection,":[245],"(3)":[246],"complications":[247],"leading":[248],"changes":[251],"serious":[253],"adverse":[254],"reactions;":[255],"(4)":[257],"hospital":[258],"length":[259],"stay.":[261],"This":[262],"approach":[263],"allow":[265],"us":[266],"analyse":[268],"win":[270],"ratio,":[271],"that":[272],"is,":[273],"receiving":[276],"have":[278],"rank":[282],"compared":[283],"placebo":[288],"group.":[289],"calculated":[291],"target":[293],"size":[295],"606":[297],"providing":[299],"90%":[300],"power":[301],"two-sided":[304],"significance":[305],"0.05.":[308],"Ethics":[309,318],"dissemination":[311],"Ethical":[312],"approval":[313],"was":[314],"received":[315],"committee":[319],"Northern":[321],"Central":[323],"(BASEC":[325],"number":[326,424],"2025-00655).":[327],"Eligible":[328],"informed":[332,356],"about":[333],"study":[335,339],"local":[338],"team":[340],"asked":[342],"written":[344],"consent":[345,392],"if":[346],"they":[347],"wish":[348],"participate.":[350],"For":[351],"unable":[353],"provide":[355],"consent,":[357],"appropriate":[359],"substitute":[360],"(ie,":[361],"close":[363],"relative":[364],"physician":[367],"not":[368],"involved":[369],"research":[372],"project)":[373],"may":[374],"make":[375],"decisions":[376],"based":[377],"on":[378],"presumed":[380],"wishes":[381],"best":[384],"interest":[385],"patient.":[388],"patient\u2019s":[390],"own":[391],"obtained":[395],"soon":[397],"their":[399],"condition":[400],"permits.":[401],"Results":[402],"published":[405],"peer-reviewed":[407],"journals":[408],"laymen's":[411],"terms":[412],"through":[413],"various":[414],"channels":[415],"(social":[416],"media,":[417],"Swiss":[418],"national":[419],"portal":[420],"HumRes).":[421],"Trial":[422],"registration":[423],"NCT06958835":[425],".":[426]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-04-21T00:00:00"}