{"id":"https://openalex.org/W7154754177","doi":"https://doi.org/10.1016/j.celrep.2026.117257","title":"Non-canonical proteolytic activation of RNase L by SARS-CoV-2 3CLpro offsets inactivation of OAS1 p46 antiviral signaling","display_name":"Non-canonical proteolytic activation of RNase L by SARS-CoV-2 3CLpro offsets inactivation of OAS1 p46 antiviral signaling","publication_year":2026,"publication_date":"2026-04-01","ids":{"openalex":"https://openalex.org/W7154754177","doi":"https://doi.org/10.1016/j.celrep.2026.117257","pmid":"https://pubmed.ncbi.nlm.nih.gov/42001419"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2026.117257","doi":"https://doi.org/10.1016/j.celrep.2026.117257","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.117257","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.celrep.2026.117257","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087432219","display_name":"Peter A. Bell","orcid":"https://orcid.org/0000-0001-6143-5444","observed_orcids":["https://orcid.org/0000-0001-6143-5444"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405266127","display_name":"Centre for Blood Research","ror":"https://ror.org/00h0nxd66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405266127"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peter A. Bell","raw_affiliation_strings":["Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068059933","display_name":"Kaushal Baid","orcid":"https://orcid.org/0000-0002-4354-7941","observed_orcids":["https://orcid.org/0000-0002-4354-7941"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]},{"id":"https://openalex.org/I4405267350","display_name":"Vaccine and Infectious Disease Organization","ror":"https://ror.org/02bb7m071","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405267350"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kaushal Baid","raw_affiliation_strings":["Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Rd, Saskatoon, SK S7N 5E3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Rd, Saskatoon, SK S7N 5E3, Canada","institution_ids":["https://openalex.org/I32625721","https://openalex.org/I4405267350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133838127","display_name":"Christina Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405266127","display_name":"Centre for Blood Research","ror":"https://ror.org/00h0nxd66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405266127"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christina Pan","raw_affiliation_strings":["Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047276286","display_name":"Peter M. Grin","orcid":"https://orcid.org/0000-0001-9504-9664","observed_orcids":["https://orcid.org/0000-0001-9504-9664"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405266127","display_name":"Centre for Blood Research","ror":"https://ror.org/00h0nxd66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405266127"]}],"countries":["CA","CH"],"is_corresponding":false,"raw_author_name":"Peter M. Grin","raw_affiliation_strings":["Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Infectious Diseases and Pathology, Vetsuisse Faculty, University of Bern, Bern, 3147 Mittelh\u00e4usern, CH, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Infectious Diseases and Pathology, Vetsuisse Faculty, University of Bern, Bern, 3147 Mittelh\u00e4usern, CH, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I141945490","https://openalex.org/I4405266127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058064251","display_name":"Hugo C\u00e9sar Ramos de Jesus","orcid":"https://orcid.org/0000-0001-8223-094X","observed_orcids":["https://orcid.org/0000-0001-8223-094X"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405266127","display_name":"Centre for Blood Research","ror":"https://ror.org/00h0nxd66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405266127"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hugo C.R. de Jesus","raw_affiliation_strings":["Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043803485","display_name":"Reinhild Kappelhoff","orcid":"https://orcid.org/0000-0001-9810-7751","observed_orcids":["https://orcid.org/0000-0001-9810-7751"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405266127","display_name":"Centre for Blood Research","ror":"https://ror.org/00h0nxd66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405266127"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Reinhild Kappelhoff","raw_affiliation_strings":["Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032983117","display_name":"Isabel Pablos","orcid":"https://orcid.org/0000-0001-8052-3853","observed_orcids":["https://orcid.org/0000-0001-8052-3853"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405266127","display_name":"Centre for Blood Research","ror":"https://ror.org/00h0nxd66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405266127"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Isabel Pablos","raw_affiliation_strings":["Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101587699","display_name":"Georgina S. Butler","orcid":"https://orcid.org/0000-0003-1172-1578","observed_orcids":["https://orcid.org/0000-0003-1172-1578"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405266127","display_name":"Centre for Blood Research","ror":"https://ror.org/00h0nxd66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405266127"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Georgina S. Butler","raw_affiliation_strings":["Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067967906","display_name":"Sauhard Shrivastava","orcid":"https://orcid.org/0000-0002-8747-0368","observed_orcids":["https://orcid.org/0000-0002-8747-0368"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]},{"id":"https://openalex.org/I4405267350","display_name":"Vaccine and Infectious Disease Organization","ror":"https://ror.org/02bb7m071","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405267350"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sauhard Shrivastava","raw_affiliation_strings":["Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Rd, Saskatoon, SK S7N 5E3, Canada; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Rd, Saskatoon, SK S7N 5E3, Canada; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada","institution_ids":["https://openalex.org/I32625721","https://openalex.org/I4405267350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130658719","display_name":"Ansalna Ansari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]},{"id":"https://openalex.org/I4405267350","display_name":"Vaccine and Infectious Disease Organization","ror":"https://ror.org/02bb7m071","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405267350"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ansalna Ansari","raw_affiliation_strings":["Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Rd, Saskatoon, SK S7N 5E3, Canada; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Rd, Saskatoon, SK S7N 5E3, Canada; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada","institution_ids":["https://openalex.org/I32625721","https://openalex.org/I4405267350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050567215","display_name":"Arinjay Banerjee","orcid":"https://orcid.org/0000-0002-2821-8357","observed_orcids":["https://orcid.org/0000-0002-2821-8357"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]},{"id":"https://openalex.org/I4405267350","display_name":"Vaccine and Infectious Disease Organization","ror":"https://ror.org/02bb7m071","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405267350"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Arinjay Banerjee","raw_affiliation_strings":["Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Rd, Saskatoon, SK S7N 5E3, Canada; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: arinjay.banerjee@usask.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Rd, Saskatoon, SK S7N 5E3, Canada; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: arinjay.banerjee@usask.ca","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I185261750","https://openalex.org/I32625721","https://openalex.org/I4405267350"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053252393","display_name":"Christopher M. Overall","orcid":"https://orcid.org/0000-0001-5844-2731","observed_orcids":["https://orcid.org/0000-0001-5844-2731"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4405266127","display_name":"Centre for Blood Research","ror":"https://ror.org/00h0nxd66","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405266127"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Christopher M. Overall","raw_affiliation_strings":["Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: chris.overall@ubc.ca"],"raw_orcid":"https://orcid.org/0000-0001-5844-2731","affiliations":[{"raw_affiliation_string":"Centre for Blood Research, The Life Sciences Institute, 2350 Life Sciences Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: chris.overall@ubc.ca","institution_ids":["https://openalex.org/I141945490","https://openalex.org/I4405266127"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5050567215","https://openalex.org/A5053252393"],"corresponding_institution_ids":["https://openalex.org/I141945490","https://openalex.org/I185261750","https://openalex.org/I32625721","https://openalex.org/I4405266127","https://openalex.org/I4405267350"],"apc_list":{"value":5620,"currency":"USD","value_usd":5620},"apc_paid":{"value":5620,"currency":"USD","value_usd":5620},"fwci":5.3923,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.95255966,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"45","issue":"4","first_page":"117257","last_page":"117257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.8920000195503235},{"id":"https://openalex.org/keywords/rnase-l","display_name":"RNase L","score":0.8560000061988831},{"id":"https://openalex.org/keywords/oligoadenylate-synthetase","display_name":"oligoadenylate synthetase","score":0.8859999775886536},{"id":"https://openalex.org/keywords/proteolytic-activation","display_name":"proteolytic activation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.5669999718666077},{"id":"https://openalex.org/keywords/antiviral-restriction","display_name":"antiviral restriction","score":0.6850000023841858},{"id":"https://openalex.org/keywords/oas3","display_name":"OAS3","score":0.8949999809265137},{"id":"https://openalex.org/keywords/dsrna-sensing","display_name":"dsRNA sensing","score":0.6779999732971191},{"id":"https://openalex.org/keywords/viral-polyprotein-processing","display_name":"viral polyprotein processing","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7458000183105469},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.498199999332428},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42890000343322754},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.39500001072883606},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3944000005722046},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3785000145435333},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3345000147819519},{"id":"https://openalex.org/C69766542","wikidata":"https://www.wikidata.org/wiki/Q3430179","display_name":"RNase H","level":5,"score":0.30889999866485596},{"id":"https://openalex.org/C3019223276","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Proteolytic enzymes","level":3,"score":0.3052000105381012},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.2996000051498413},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.27799999713897705},{"id":"https://openalex.org/C79750893","wikidata":"https://www.wikidata.org/wiki/Q3430180","display_name":"Ribonuclease III","level":5,"score":0.2621000111103058},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.26089999079704285}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.celrep.2026.117257","doi":"https://doi.org/10.1016/j.celrep.2026.117257","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.117257","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmid:42001419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42001419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell reports","raw_type":"Journal Article"},{"id":"doi:10.48620/97808","doi":"https://doi.org/10.48620/97808","is_oa":true,"landing_page_url":"https://doi.org/10.48620/97808","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2026.117257","doi":"https://doi.org/10.1016/j.celrep.2026.117257","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2026.117257","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320338068","display_name":"Institute of Musculoskeletal Health and Arthritis","ror":"https://ror.org/03vpfss84"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W998749893","https://openalex.org/W1969119726","https://openalex.org/W1972043325","https://openalex.org/W1972387348","https://openalex.org/W1989069389","https://openalex.org/W2000831618","https://openalex.org/W2024701689","https://openalex.org/W2041530476","https://openalex.org/W2047502244","https://openalex.org/W2069310363","https://openalex.org/W2101083359","https://openalex.org/W2128702837","https://openalex.org/W2165094405","https://openalex.org/W2201713963","https://openalex.org/W2263177460","https://openalex.org/W2600241225","https://openalex.org/W2606439133","https://openalex.org/W2613629789","https://openalex.org/W2783766444","https://openalex.org/W2952264760","https://openalex.org/W2971561550","https://openalex.org/W3004080087","https://openalex.org/W3011701533","https://openalex.org/W3036881316","https://openalex.org/W3038664249","https://openalex.org/W3081089847","https://openalex.org/W3087663653","https://openalex.org/W3094021184","https://openalex.org/W3096715247","https://openalex.org/W3105512395","https://openalex.org/W3112105690","https://openalex.org/W3115414062","https://openalex.org/W3132221372","https://openalex.org/W3158741652","https://openalex.org/W3189646261","https://openalex.org/W3192533878","https://openalex.org/W3194700665","https://openalex.org/W3198918001","https://openalex.org/W3203249973","https://openalex.org/W3205310050","https://openalex.org/W4206699848","https://openalex.org/W4212904481","https://openalex.org/W4214678806","https://openalex.org/W4280514957","https://openalex.org/W4285391095","https://openalex.org/W4288080864","https://openalex.org/W4312018826","https://openalex.org/W4319459693","https://openalex.org/W4378516289","https://openalex.org/W4383186410","https://openalex.org/W4399248692","https://openalex.org/W4399780171","https://openalex.org/W4400243215","https://openalex.org/W4405300018"],"related_works":["https://openalex.org/W7131123658","https://openalex.org/W2263177460","https://openalex.org/W7162310291","https://openalex.org/W3194700665","https://openalex.org/W3033007822","https://openalex.org/W2231530063","https://openalex.org/W7117472785","https://openalex.org/W7120101806","https://openalex.org/W7211946448","https://openalex.org/W2888054020"],"abstract_inverted_index":{"During":[0],"SARS-CoV-2":[1,26],"infection,":[2],"the":[3,18,44,125],"key":[4],"protective":[5],"oligoadenylate":[6],"synthetase":[7],"(OAS)":[8],"that":[9,25,62,107,116,124,138],"activates":[10,156],"RNase":[11,66,80,89,109,127,157],"L":[12,67,81,90,110,128],"upon":[13],"sensing":[14],"viral":[15,151],"dsRNA":[16],"is":[17],"membrane-anchored":[19],"OAS1":[20],"isoform":[21],"p46.":[22],"We":[23,59,122],"show":[24,61],"3C-like":[27],"main":[28],"protease":[29],"(3CL":[30],"pro":[31,33,64,118,130,147],"/M":[32],")":[34],"efficiently":[35],"cleaves":[36,65],"p46":[37,51,143],"at":[38,68],"381":[39],"STLQ":[40],"384":[41],"\u2193A,":[42],"excising":[43],"prenylated-Cys":[45],"397":[46],"membrane":[47],"anchor,":[48],"which":[49],"releases":[50],"from":[52],"endomembranes":[53],"and":[54,78,115,162],"thereby":[55],"antagonizes":[56],"antiviral":[57,86,93,140,160],"restriction.":[58],"further":[60],"3CL":[63,117,129,146],"406":[69],"SCLQ":[70],"409":[71],"\u2193S,":[72],"removing":[73],"an":[74,164],"inhibitory":[75],"N-terminal":[76],"domain":[77],"generating":[79],"(410\u2013741),":[82],"a":[83,135],"proteolytically":[84],"activated":[85],"effector.":[87],"Non-cleavable":[88],"(Gln409Ala)":[91],"lacks":[92],"activity":[94],"in":[95],"infected":[96],"p46-null":[97],"cells,":[98],"confirming":[99],"this":[100],"non-canonical":[101],"activation":[102],"mechanism.":[103],"RNA":[104,113],"sequencing":[105],"shows":[106],"protease-activated":[108],"alters":[111],"host":[112],"targeting":[114],"reduces":[119],"OAS3":[120],"transcripts.":[121],"propose":[123],"conserved":[126],"cleavage":[131],"motif":[132],"functions":[133],"as":[134],"failsafe":[136],"\"tripwire\"":[137],"preserves":[139],"restriction":[141,161],"despite":[142],"evasion.":[144,170],"Thus,":[145],"not":[148],"only":[149],"processes":[150],"polyproteins":[152],"but":[153],"also":[154],"directly":[155],"L,":[158],"triggering":[159],"revealing":[163],"intrinsic":[165],"evolutionary":[166],"constraint":[167],"on":[168],"immune":[169]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2026-04-18T00:00:00"}